Published in J Biol Chem on January 25, 2005
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor. Nat Med (2012) 3.89
Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest (2007) 3.01
Synergistic interaction of dietary cholesterol and dietary fat in inducing experimental steatohepatitis. Hepatology (2013) 2.64
Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease. J Gastroenterol (2010) 2.06
Role of the gut in lipid homeostasis. Physiol Rev (2012) 1.73
Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol. J Biol Chem (2009) 1.71
Molecular processes that handle -- and mishandle -- dietary lipids. J Clin Invest (2008) 1.60
Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles. Biochim Biophys Acta (2007) 1.38
NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe. Lipids Health Dis (2005) 1.37
Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport. Annu Rev Physiol (2011) 1.28
Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.26
Niemann-Pick C1-Like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis. J Lipid Res (2010) 1.26
NPC1L1 and cholesterol transport. FEBS Lett (2010) 1.19
Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption. J Lipid Res (2009) 1.16
Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. J Biol Chem (2009) 1.09
The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J Biol Chem (2011) 1.07
Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters. Am J Physiol Gastrointest Liver Physiol (2008) 1.06
Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex. Traffic (2007) 1.05
Absorption of vitamin A and carotenoids by the enterocyte: focus on transport proteins. Nutrients (2013) 1.04
NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein. Biochem J (2005) 1.03
Retracted Visualization of lipid metabolism in the zebrafish intestine reveals a relationship between NPC1L1-mediated cholesterol uptake and dietary fatty acid. Chem Biol (2012) 1.00
HNF1alpha and SREBP2 are important regulators of NPC1L1 in human liver. J Lipid Res (2010) 0.99
Effects of ezetimibe add-on therapy for high-risk patients with dyslipidemia. Lipids Health Dis (2009) 0.97
Dietary cholesterol reverses resistance to diet-induced weight gain in mice lacking Niemann-Pick C1-Like 1. J Lipid Res (2010) 0.94
NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells. Biochem J (2007) 0.94
Novel gene-by-environment interactions: APOB and NPC1L1 variants affect the relationship between dietary and total plasma cholesterol. J Lipid Res (2013) 0.94
Molecular characterization of the NPC1L1 variants identified from cholesterol low absorbers. J Biol Chem (2010) 0.93
The phospholipid monolayer associated with perilipin-enriched lipid droplets is a highly organized rigid membrane structure. Am J Physiol Endocrinol Metab (2011) 0.91
Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine. J Lipid Res (2012) 0.91
Targets for current pharmacologic therapy in cholesterol gallstone disease. Gastroenterol Clin North Am (2010) 0.90
Therapy of gallstone disease: What it was, what it is, what it will be. World J Gastrointest Pharmacol Ther (2012) 0.90
Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent. J Lipid Res (2009) 0.88
Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart. Oxid Med Cell Longev (2015) 0.87
Nutrition and nonalcoholic Fatty liver disease: the significance of cholesterol. Int J Hepatol (2012) 0.86
NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease. Lipids Health Dis (2010) 0.86
Sensing of dietary lipids by enterocytes: a new role for SR-BI/CLA-1. PLoS One (2009) 0.86
Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease? World J Gastroenterol (2010) 0.85
Effect of ezetimibe on plasma cholesterol levels, cholesterol absorption, and secretion of biliary cholesterol in laboratory opossums with high and low responses to dietary cholesterol. Metabolism (2008) 0.85
Intestinal and hepatic niemann-pick c1-like 1. Diabetes Metab J (2013) 0.85
Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep (2015) 0.85
CCR2 and CD44 promote inflammatory cell recruitment during fatty liver formation in a lithogenic diet fed mouse model. PLoS One (2013) 0.84
NPC1L1 knockout protects against colitis-associated tumorigenesis in mice. BMC Cancer (2015) 0.84
Decreased NPC1L1 expression in the liver from Chinese female gallstone patients. Lipids Health Dis (2010) 0.83
Sterols and sphingolipids: dynamic duo or partners in crime? Prog Lipid Res (2010) 0.83
Multidisciplinary pharmacotherapeutic options for nonalcoholic Fatty liver disease. Int J Hepatol (2012) 0.83
Fatty acid- and cholesterol transporter protein expression along the human intestinal tract. PLoS One (2010) 0.83
Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver. Biochim Biophys Acta (2011) 0.83
SREBP2 mediates the modulation of intestinal NPC1L1 expression by curcumin. Am J Physiol Gastrointest Liver Physiol (2011) 0.82
Epigenetic modulation of intestinal cholesterol transporter Niemann-Pick C1-like 1 (NPC1L1) gene expression by DNA methylation. J Biol Chem (2014) 0.81
Ezetimibe improves glucose metabolism by ameliorating hepatic function in Japanese patients with type 2 diabetes. J Diabetes Investig (2012) 0.81
Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8). Immunol Endocr Metab Agents Med Chem (2009) 0.81
The clathrin adaptor proteins ARH, Dab2, and numb play distinct roles in Niemann-Pick C1-Like 1 versus low density lipoprotein receptor-mediated cholesterol uptake. J Biol Chem (2014) 0.81
Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine. Am J Physiol Gastrointest Liver Physiol (2010) 0.80
Ezetimibe inhibits hepatic Niemann-Pick C1-Like 1 to facilitate macrophage reverse cholesterol transport in mice. Arterioscler Thromb Vasc Biol (2013) 0.80
Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice. Appl Environ Microbiol (2014) 0.80
Lipid rafts: dream or reality for cholesterol transporters? Eur Biophys J (2007) 0.79
Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression. Mol Metab (2016) 0.79
Nutrition therapy for liver diseases based on the status of nutritional intake. Gastroenterol Res Pract (2012) 0.78
D-Glucose modulates intestinal Niemann-Pick C1-like 1 (NPC1L1) gene expression via transcriptional regulation. Am J Physiol Gastrointest Liver Physiol (2012) 0.78
Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels. Atherosclerosis (2014) 0.78
Physiological role of hepatic NPC1L1 in human cholesterol and lipoprotein metabolism: new perspectives and open questions. J Lipid Res (2012) 0.77
Intestinal nuclear receptors in HDL cholesterol metabolism. J Lipid Res (2014) 0.77
Protein mediators of sterol transport across intestinal brush border membrane. Subcell Biochem (2010) 0.76
Hepatobiliary transport in health and disease. Clin Lipidol (2012) 0.76
Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats. World J Gastroenterol (2015) 0.76
Sterol O-Acyltransferase 2-Driven Cholesterol Esterification Opposes Liver X Receptor-Stimulated Fecal Neutral Sterol Loss. Lipids (2016) 0.75
Bisphenol A promotes cholesterol absorption in Caco-2 cells by up-regulation of NPC1L1 expression. Lipids Health Dis (2017) 0.75
The NPC1L1 Polymorphism 1679C>G Is Associated with Gallstone Disease in Chinese Patients. PLoS One (2016) 0.75
Regulated Inflammation and Lipid Metabolism in Colon mRNA Expressions of Obese Germfree Mice Responding to Enterobacter cloacae B29 Combined with the High Fat Diet. Front Microbiol (2016) 0.75
Standardization of PCR-RFLP analysis of nsSNP rs1468384 of NPC1L1 gene. Indian J Hum Genet (2008) 0.75
Oligodendroglial process formation is differentially affected by modulating the intra- and extracellular cholesterol content. J Mol Neurosci (2012) 0.75
Food Ingredients That Inhibit Cholesterol Absorption. Prev Nutr Food Sci (2017) 0.75
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet (2006) 4.68
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat Genet (2007) 3.47
Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe. J Clin Invest (2007) 3.01
The phosphatase SHP2 regulates the spacing effect for long-term memory induction. Cell (2009) 2.19
Peritraumatic and persistent dissociation in the presumed etiology of PTSD. Am J Psychiatry (2005) 1.94
Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles. Biochim Biophys Acta (2007) 1.38
Measures of interprofessional education and collaboration. J Interprof Care (2010) 1.34
Cyclodextrin induces calcium-dependent lysosomal exocytosis. PLoS One (2010) 1.34
Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Biochim Biophys Acta (2007) 1.28
Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.26
Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes. J Lipid Res (2002) 1.22
Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice. Hum Mol Genet (2002) 1.18
Automated normalized FLAIR imaging in MRI-negative patients with refractory focal epilepsy. Epilepsia (2009) 1.15
Tobacco transgenic lines that express fenugreek galactomannan galactosyltransferase constitutively have structurally altered galactomannans in their seed endosperm cell walls. Plant Physiol (2003) 1.10
Niemann-Pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice. Arterioscler Thromb Vasc Biol (2008) 1.06
Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription. Proc Natl Acad Sci U S A (2008) 1.05
NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein. Biochem J (2005) 1.03
Presenting the alternative: cancer and complementary and alternative medicine in the Canadian print media. Support Care Cancer (2007) 1.01
Attentional focusing instructions influence force production and muscular activity during isokinetic elbow flexions. J Strength Cond Res (2009) 1.00
An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease. J Biol Chem (2011) 0.99
Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease. Hum Gene Ther (2002) 0.98
Researcher-decision-maker partnerships in health services research: practical challenges, guiding principles. BMC Health Serv Res (2012) 0.93
Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8. J Lipid Res (2008) 0.93
Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment. Biol Cell (2009) 0.91
Efficacy and safety of fluticasone propionate/salmeterol HFA 134A MDI in patients with mild-to-moderate persistent asthma. J Asthma (2004) 0.89
Targeting of NPC1 to late endosomes involves multiple signals, including one residing within the putative sterol-sensing domain. J Biol Chem (2004) 0.89
Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent. J Lipid Res (2009) 0.88
A meal or a male: the 'whispers' of black widow males do not trigger a predatory response in females. Front Zool (2014) 0.87
The seeds of Lotus japonicus lines transformed with sense, antisense, and sense/antisense galactomannan galactosyltransferase constructs have structurally altered galactomannans in their endosperm cell walls. Plant Physiol (2004) 0.87
Stertorous breathing is a reliably identified sign that helps in the differentiation of epileptic from psychogenic non-epileptic convulsions: an audit. Epilepsy Res (2007) 0.87
Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. J Cell Sci (2006) 0.86
T cell activation is determined by the number of presented antigens. Nano Lett (2013) 0.86
The role of the Niemann-Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis. Curr Opin Lipidol (2006) 0.85
Reduced renin expression and altered gene transcript profiles in multicystic dysplastic kidneys. J Urol (2002) 0.83
Reduced sensitivity of Niemann-Pick C1-deficient cells to theta-toxin (perfringolysin O): sequestration of toxin to raft-enriched membrane vesicles. Histochem Cell Biol (2004) 0.83
Efficacy and safety of fluticasone propionate 44 microg/salmeterol 21 microg administered in a hydrofluoroalkane metered-dose inhaler as an initial asthma maintenance treatment. Ann Allergy Asthma Immunol (2003) 0.82
EEG-fMRI mapping of asymmetrical delta activity in a patient with refractory epilepsy is concordant with the epileptogenic region determined by intracranial EEG. Magn Reson Imaging (2006) 0.82
Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells. Integr Biol (Camb) (2015) 0.81
MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site. PLoS One (2012) 0.80
The Canadian Obesity Network and interprofessional practice: members' views. J Interprof Care (2008) 0.80
PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport. PLoS One (2013) 0.80
Assessment of trauma symptoms in eating-disordered populations. Eat Disord (2007) 0.79
Polarity of alpha-galactosidase A uptake by renal tubule cells. Kidney Int (2002) 0.77
Unusual cortical stimulation findings: connectivity between primary motor and supplementary motor areas. Epilepsy Behav (2010) 0.77
Observational study on homeopathic treatment. J Altern Complement Med (2006) 0.75
Hand-biting and hand-waving paroxysms in epilepsy. BMJ Case Rep (2012) 0.75
When do psychogenic nonepileptic seizures occur on a video/EEG telemetry unit? Epilepsy Behav (2010) 0.75
Neck atonia with a focal stimulation-induced seizure arising from the SMA: pathophysiological considerations. Epilepsy Behav (2012) 0.75
Atmospheric chemistry and the biosphere: general discussion. Faraday Discuss (2017) 0.75