Published in J Nutr on February 01, 2005
Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev (2008) 5.74
Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. J Neurochem (2006) 1.26
Reactive oxygen species: impact on skeletal muscle. Compr Physiol (2011) 1.14
Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection. J Neurochem (2009) 1.07
Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administration. Pharmacology (2009) 1.00
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetin. Lipids Health Dis (2011) 0.98
gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals. Oxid Med Cell Longev (2010) 0.95
Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice. Free Radic Biol Med (2005) 0.95
Tocotrienol-rich fraction prevents cell cycle arrest and elongates telomere length in senescent human diploid fibroblasts. J Biomed Biotechnol (2011) 0.92
Effects of Low-Dose versus High-Dose γ-Tocotrienol on the Bone Cells Exposed to the Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis. Evid Based Complement Alternat Med (2012) 0.88
Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation. Nutr J (2012) 0.87
Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts. Clinics (Sao Paulo) (2012) 0.83
Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts. Oxid Med Cell Longev (2012) 0.81
Expression of senescence-associated microRNAs and target genes in cellular aging and modulation by tocotrienol-rich fraction. Oxid Med Cell Longev (2014) 0.81
Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction. Arch Med Sci (2011) 0.79
Effect of γ-tocotrienol in counteracting oxidative stress and joint damage in collagen-induced arthritis in rats. Exp Ther Med (2014) 0.78
Comparative effect of Piper betle, Chlorella vulgaris and tocotrienol-rich fraction on antioxidant enzymes activity in cellular ageing of human diploid fibroblasts. BMC Complement Altern Med (2013) 0.78
γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules. Br J Cancer (2016) 0.77
The effects of combined free radical scavenger and sildenafil therapy on age-associated erectile dysfunction: An animal model. Urol Ann (2014) 0.76
Modulation of Cell Cycle Profile by Chlorella vulgaris Prevents Replicative Senescence of Human Diploid Fibroblasts. Evid Based Complement Alternat Med (2013) 0.75
Tissue distribution of emulsified γ-tocotrienol and its long-term biological effects after subcutaneous administration. Lipids Health Dis (2014) 0.75
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS One (2009) 1.71
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem (2005) 1.64
Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice. Free Radic Biol Med (2005) 1.51
Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegener Dis (2008) 1.42
Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels. FASEB J (2007) 1.31
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem (2004) 1.28
Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease? Antioxid Redox Signal (2007) 1.28
Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease. Biochem Pharmacol (2003) 1.24
Oligomeric and fibrillar species of beta-amyloid (A beta 42) both impair mitochondrial function in P301L tau transgenic mice. J Mol Med (Berl) (2008) 1.23
Statin effects on cholesterol micro-domains in brain plasma membranes. Biochem Pharmacol (2003) 1.17
Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem (2007) 1.16
Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J Pharmacol Exp Ther (2004) 1.16
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol (2002) 1.13
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal (2012) 1.12
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons. Mol Cell Neurosci (2006) 1.11
Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol Res (2007) 1.11
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. Neurobiol Dis (2009) 1.09
From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease. Mol Neurobiol (2012) 1.07
Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation. J Biol Chem (2008) 1.06
Statins and neuroprotection: a prescription to move the field forward. Ann N Y Acad Sci (2010) 1.05
Increased apoptotic cell death in sporadic and genetic Alzheimer's disease. Ann N Y Acad Sci (2003) 1.04
Age-related impairment of human T lymphocytes' activation: specific differences between CD4(+) and CD8(+) subsets. Mech Ageing Dev (2002) 1.04
Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains. Brain Res (2003) 1.01
Piracetam improves mitochondrial dysfunction following oxidative stress. Br J Pharmacol (2006) 1.01
Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761. Ann N Y Acad Sci (2005) 1.00
A new link to mitochondrial impairment in tauopathies. Mol Neurobiol (2012) 1.00
Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes. Mol Neurobiol (2012) 0.99
Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment. Pharmacol Res (2009) 0.99
Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder - evidence from clinical trials. Wien Med Wochenschr (2010) 0.99
Isoprenoids, small GTPases and Alzheimer's disease. Biochim Biophys Acta (2010) 0.98
Cholesterol asymmetry in synaptic plasma membranes. J Neurochem (2011) 0.96
Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol (2010) 0.96
Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment. Neurobiol Dis (2006) 0.96
The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis. J Neurochem (2003) 0.95
Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice. Neurobiol Dis (2005) 0.95
Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease. Biochim Biophys Acta (2003) 0.94
Triterpenes promote keratinocyte differentiation in vitro, ex vivo and in vivo: a role for the transient receptor potential canonical (subtype) 6. J Invest Dermatol (2010) 0.93
Cholesterol: Coupling between membrane microenvironment and ABC transporter activity. Biochem Biophys Res Commun (2007) 0.93
A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem (2010) 0.92
Treatment duration (persistence) of basal insulin supported oral therapy (BOT) in Type-2 diabetic patients: comparison of insulin glargine with NPH insulin. Int J Clin Pharmacol Ther (2012) 0.92
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease. Exp Gerontol (2006) 0.91
Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing. Biochim Biophys Acta (2010) 0.90
Effects of antidepressants on the brain/plasma distribution of corticosterone. Neuropsychopharmacology (2006) 0.90
Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. Mol Neurobiol (2012) 0.90
Do tocotrienols have potential as neuroprotective dietary factors? Ageing Res Rev (2011) 0.90
Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. J Neurochem (2014) 0.90
Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels. PLoS One (2013) 0.89
Isoprenoid quantitation in human brain tissue: a validated HPLC-fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP). Anal Bioanal Chem (2008) 0.89
Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation. PLoS One (2011) 0.89
Metabolism of boswellic acids in vitro and in vivo. Drug Metab Dispos (2008) 0.89
The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion. Biochim Biophys Acta (2006) 0.87
Mitochondrial membrane fluidity is consistently increased in different models of Huntington disease: restorative effects of olesoxime. Mol Neurobiol (2014) 0.87
Dimebon ameliorates amyloid-β induced impairments of mitochondrial form and function. J Alzheimers Dis (2012) 0.87
Statins, Bcl-2, and apoptosis: cell death or cell protection? Mol Neurobiol (2013) 0.87
Mitochondria: mitochondrial membranes in brain ageing and neurodegeneration. Int J Biochem Cell Biol (2012) 0.87
Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression. Int Clin Psychopharmacol (2010) 0.87
Generic switch after ramipril patent expiry is not associated with decreased pharmacy refill compliance: a retrospective study using the DAPI database. J Hypertens (2011) 0.87
The interaction of beta-amyloid protein with cellular membranes stimulates its own production. Biochim Biophys Acta (2009) 0.86
Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8. Neurochem Int (2013) 0.85
Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo. J Agric Food Chem (2007) 0.84
Hyperforin activates nonselective cation channels (NSCCs). Br J Pharmacol (2005) 0.84
Increased T-cell reactivity and elevated levels of CD8+ memory T-cells in Alzheimer's disease-patients and T-cell hyporeactivity in an Alzheimer's disease-mouse model: implications for immunotherapy. Neuromolecular Med (2007) 0.84
Simvastatin stimulates production of the antiapoptotic protein Bcl-2 via endothelin-1 and NFATc3 in SH-SY5Y cells. Mol Neurobiol (2010) 0.83
Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. Pharmacol Res (2013) 0.83
Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharm Biotechnol (2010) 0.82
Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol (2004) 0.82
Cellular membrane fluidity in amyloid precursor protein processing. Mol Neurobiol (2014) 0.82
Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death. J Mol Neurosci (2002) 0.82
Statins and neuroprotection: basic pharmacology needed. Mol Neurobiol (2014) 0.81
TRPC6 channel-mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling. J Neurochem (2013) 0.81
Is hypercholesterolemia a risk factor for Alzheimer's disease? Mol Neurobiol (2005) 0.81
Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam. Front Neurosci (2010) 0.81
Plant derived omega-3-fatty acids protect mitochondrial function in the brain. Pharmacol Res (2010) 0.80
Enhancement of proteolytic processing of the beta-amyloid precursor protein by hyperforin. Biochem Pharmacol (2003) 0.80
Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations. J Alzheimers Dis (2006) 0.80
Cholesterol modulates amyloid beta-peptide's membrane interactions. Pharmacopsychiatry (2003) 0.80
The senescence-accelerated mouse-prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals. Pharmacol Res (2013) 0.79
Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin. Genes Nutr (2014) 0.79
Ginkgo biloba extract EGb 761® in the context of current developments in the diagnosis and treatment of age-related cognitive decline and Alzheimer's disease: a research perspective. Int Psychogeriatr (2012) 0.79
Atorvastatin requires geranylgeranyl transferase-I and Rac1 activation to exert neuronal protection and induce plasticity. Neurochem Int (2013) 0.79
Modulation of Pgp function by boswellic acids. Planta Med (2006) 0.79
Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes. Skin Pharmacol Physiol (2015) 0.79