Published in J Mol Med (Berl) on August 16, 2008
Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci U S A (2009) 2.04
Soluble Aβ oligomer production and toxicity. J Neurochem (2011) 1.83
Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A (2011) 1.76
Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron (2012) 1.58
Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta. PLoS One (2010) 1.37
Aβ oligomer-induced synapse degeneration in Alzheimer's disease. Cell Mol Neurobiol (2011) 1.33
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications. Biochim Biophys Acta (2009) 1.26
Recent progress in understanding Alzheimer's β-amyloid structures. Trends Biochem Sci (2011) 1.24
Amyloid-Beta interaction with mitochondria. Int J Alzheimers Dis (2011) 1.18
Convergence of amyloid-beta and tau pathologies on mitochondria in vivo. Mol Neurobiol (2010) 1.16
Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol (2009) 1.12
Alzheimer's disease: insights from Drosophila melanogaster models. Trends Biochem Sci (2009) 1.03
Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria. J Alzheimers Dis (2011) 1.01
Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis. Acta Neuropathol (2012) 0.97
Structural insights into Aβ42 oligomers using site-directed spin labeling. J Biol Chem (2013) 0.97
Modes of Aβ toxicity in Alzheimer's disease. Cell Mol Life Sci (2011) 0.94
Neurotoxic 43-kDa TAR DNA-binding protein (TDP-43) triggers mitochondrion-dependent programmed cell death in yeast. J Biol Chem (2011) 0.93
Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J (2011) 0.90
RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's disease. Front Biosci (Schol Ed) (2012) 0.89
The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by beta-amyloid peptide. Br J Pharmacol (2010) 0.86
Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy. Proc Natl Acad Sci U S A (2013) 0.85
Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology. Front Aging Neurosci (2014) 0.85
An update on the toxicity of Abeta in Alzheimer's disease. Neuropsychiatr Dis Treat (2008) 0.85
Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomers. J Biol Chem (2014) 0.85
Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction. J Neurosci (2013) 0.85
Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure. PLoS One (2010) 0.82
New insights in the amyloid-Beta interaction with mitochondria. J Aging Res (2012) 0.81
The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice. Exp Neurol (2010) 0.81
Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam. Front Neurosci (2010) 0.81
Inhibition of the mitochondrial enzyme ABAD restores the amyloid-β-mediated deregulation of estradiol. PLoS One (2011) 0.78
Animal models for Alzheimer's disease and frontotemporal dementia: a perspective. ASN Neuro (2009) 0.78
Lessons from two prevalent amyloidoses-what amylin and Aβ have in common. Front Aging Neurosci (2013) 0.78
ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice. J Biomed Biotechnol (2011) 0.78
Therapeutic Effect of Yi-Chi-Tsung-Ming-Tang on Amyloid β-Induced Alzheimer's Disease-Like Phenotype via an Increase of Acetylcholine and Decrease of Amyloid β. Evid Based Complement Alternat Med (2012) 0.77
Alzheimer's disease models and functional genomics-How many needles are there in the haystack? Front Physiol (2012) 0.77
Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway. PLoS One (2016) 0.76
Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice. Front Mol Neurosci (2017) 0.75
Sodium dodecyl sulphate modulates the fibrillation of human serum albumin in a dose-dependent manner and impacts the PC12 cells retraction. Colloids Surf B Biointerfaces (2014) 0.75
Amyloid precursor protein and tau transgenic models of Alzheimer's disease: insights from the past and directions for the future. Future Neurol (2010) 0.75
The protective effect of trihexyphenidyl on the beta-amyloid peptide (25-35)-induced cytotoxicity in PC12 cells. Clin Exp Med (2010) 0.75
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell (2010) 7.52
Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci (2010) 3.61
Cardiolipin stabilizes respiratory chain supercomplexes. J Biol Chem (2003) 3.16
High-resolution electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. J Mol Biol (2007) 2.67
FTIR reveals structural differences between native beta-sheet proteins and amyloid fibrils. Protein Sci (2004) 2.31
K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J Physiol (2002) 2.18
Functional modules and structural basis of conformational coupling in mitochondrial complex I. Science (2010) 2.12
Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc Natl Acad Sci U S A (2009) 2.04
Concanamycin A, the specific inhibitor of V-ATPases, binds to the V(o) subunit c. J Biol Chem (2002) 2.01
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis (2006) 1.96
Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy. Proc Natl Acad Sci U S A (2008) 1.89
LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs. EMBO J (2011) 1.89
The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex. J Biol Chem (2008) 1.87
Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. J Mol Biol (2008) 1.86
A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I. Biochem J (2011) 1.80
The aggregation kinetics of Alzheimer's beta-amyloid peptide is controlled by stochastic nucleation. Protein Sci (2005) 1.74
Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. Adv Exp Med Biol (2012) 1.73
Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS One (2009) 1.71
Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils. Proc Natl Acad Sci U S A (2007) 1.68
Significance of respirasomes for the assembly/stability of human respiratory chain complex I. J Biol Chem (2004) 1.68
Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci U S A (2008) 1.64
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem (2005) 1.64
Comparison of Alzheimer Abeta(1-40) and Abeta(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A (2009) 1.61
Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron (2012) 1.58
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils. Nat Chem Biol (2011) 1.54
Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice. Free Radic Biol Med (2005) 1.51
Pronuclear injection for the production of transgenic mice. Nat Protoc (2007) 1.50
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol (2009) 1.50
Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I. Mol Cell Biol (2009) 1.46
Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS One (2011) 1.45
Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice. Neurodegener Dis (2008) 1.42
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity. Proc Natl Acad Sci U S A (2010) 1.42
The iron-sulphur protein Ind1 is required for effective complex I assembly. EMBO J (2008) 1.42
Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondria. J Physiol (2002) 1.41
Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils. J Mol Biol (2007) 1.39
Raft lipids as common components of human extracellular amyloid fibrils. Proc Natl Acad Sci U S A (2005) 1.38
Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta. PLoS One (2010) 1.37
Structural polymorphism of Alzheimer Abeta and other amyloid fibrils. Prion (2009) 1.35
Primary support cultures of hippocampal and substantia nigra neurons. Nat Protoc (2009) 1.33
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. Neurobiol Aging (2010) 1.32
Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels. FASEB J (2007) 1.31
Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex. Cell Metab (2012) 1.29
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem (2004) 1.28
Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease? Antioxid Redox Signal (2007) 1.28
Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice. Am J Pathol (2003) 1.24
Solid-state NMR spectroscopic investigation of Aβ protofibrils: implication of a β-sheet remodeling upon maturation into terminal amyloid fibrils. Angew Chem Int Ed Engl (2011) 1.24
Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease. Biochem Pharmacol (2003) 1.24
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A (2010) 1.24
Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS One (2009) 1.23
Secondary mitochondrial dysfunction in propionic aciduria: a pathogenic role for endogenous mitochondrial toxins. Biochem J (2006) 1.23
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease. J Biol Chem (2009) 1.21
Divergent phosphorylation pattern of tau in P301L tau transgenic mice. Eur J Neurosci (2008) 1.21
Superoxide radical formation by pure complex I (NADH:ubiquinone oxidoreductase) from Yarrowia lipolytica. J Biol Chem (2005) 1.20
beta-Amyloid induces paired helical filament-like tau filaments in tissue culture. J Biol Chem (2003) 1.19
Architecture of complex I and its implications for electron transfer and proton pumping. Biochim Biophys Acta (2009) 1.19
Identification of the mitochondrial ND3 subunit as a structural component involved in the active/deactive enzyme transition of respiratory complex I. J Biol Chem (2008) 1.17
Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein. J Neurochem (2007) 1.16
Similarities in the thermodynamics and kinetics of aggregation of disease-related Abeta(1-40) peptides. Protein Sci (2007) 1.16
The proton pumping stoichiometry of purified mitochondrial complex I reconstituted into proteoliposomes. Biochim Biophys Acta (2006) 1.16
Convergence of amyloid-beta and tau pathologies on mitochondria in vivo. Mol Neurobiol (2010) 1.16
Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. J Pharmacol Exp Ther (2004) 1.16
Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative polymerase chain reaction. Anal Biochem (2004) 1.15
Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol (2002) 1.13
Role for glyoxalase I in Alzheimer's disease. Proc Natl Acad Sci U S A (2004) 1.12
Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β. J Mol Neurosci (2011) 1.12
Subunit mass fingerprinting of mitochondrial complex I. Biochim Biophys Acta (2008) 1.12
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal (2012) 1.12
Subunit composition of mitochondrial complex I from the yeast Yarrowia lipolytica. Biochim Biophys Acta (2004) 1.12
Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761). Pharmacol Res (2007) 1.11
Exploring the ubiquinone binding cavity of respiratory complex I. J Biol Chem (2007) 1.10
HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism. J Biol Chem (2004) 1.10
Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients. Neurobiol Dis (2009) 1.09
Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. Proc Natl Acad Sci U S A (2011) 1.09