Published in Invest Ophthalmol Vis Sci on February 01, 2005
Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res (2010) 1.39
Animal models of age related macular degeneration. Mol Aspects Med (2012) 1.39
Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration. Adv Exp Med Biol (2010) 1.00
Drusenoid maculopathy in rhesus monkeys (Macaca mulatta): effects of age and gender. Graefes Arch Clin Exp Ophthalmol (2008) 0.99
Exacerbation of retinal degeneration and choroidal neovascularization induced by subretinal injection of Matrigel in CCL2/MCP-1-deficient mice. Ophthalmic Res (2005) 0.96
Immune mechanisms in inflammatory and degenerative eye disease. Trends Immunol (2015) 0.90
Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration. J Inflamm Res (2008) 0.80
Plasma proteome analysis on cynomolgus monkey (Macaca fascicularis) pedigrees with early onset drusen formation. Exp Anim (2014) 0.77
Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis. PLoS One (2016) 0.75
Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells Int (2017) 0.75
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet (2006) 8.33
A first-generation linkage disequilibrium map of human chromosome 22. Nature (2002) 7.03
A chemical platform for improved induction of human iPSCs. Nat Methods (2009) 4.54
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell (2010) 3.82
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A (2010) 3.33
The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: a HuGE review and meta-analysis. Am J Epidemiol (2012) 2.87
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A (2011) 2.39
Retinal phenotypes in patients homozygous for the G1961E mutation in the ABCA4 gene. Invest Ophthalmol Vis Sci (2012) 2.26
Genotyping microarray (disease chip) for Leber congenital amaurosis: detection of modifier alleles. Invest Ophthalmol Vis Sci (2005) 2.20
Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells. Am J Hum Genet (2005) 2.20
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet (2011) 1.98
AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet (2010) 1.89
Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. Hum Mol Genet (2007) 1.87
Analysis of the ABCA4 gene by next-generation sequencing. Invest Ophthalmol Vis Sci (2011) 1.87
Microarray-based mutation analysis of the ABCA4 (ABCR) gene in autosomal recessive cone-rod dystrophy and retinitis pigmentosa. Eur J Hum Genet (2004) 1.84
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A (2004) 1.80
Modeling retinal degeneration using patient-specific induced pluripotent stem cells. PLoS One (2011) 1.78
Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A (2005) 1.75
New best1 mutations in autosomal recessive bestrophinopathy. Retina (2015) 1.75
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A (2013) 1.73
Mutation analysis of 272 Spanish families affected by autosomal recessive retinitis pigmentosa using a genotyping microarray. Mol Vis (2010) 1.64
Microarray-based mutation detection and phenotypic characterization of patients with Leber congenital amaurosis. Invest Ophthalmol Vis Sci (2006) 1.63
Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Biochemistry (2006) 1.63
Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. Cell (2013) 1.61
Genetic testing for retinal dystrophies and dysfunctions: benefits, dilemmas and solutions. Clin Experiment Ophthalmol (2007) 1.58
Reston Ebolavirus antibodies in bats, the Philippines. Emerg Infect Dis (2011) 1.54
Intravitreal injection of autologous plasmin enzyme for macular edema associated with branch retinal vein occlusion. Am J Ophthalmol (2010) 1.52
Complement factor H polymorphisms in Japanese population with age-related macular degeneration. Mol Vis (2006) 1.51
Engraftment and tumor formation after allogeneic in utero transplantation of primate embryonic stem cells. Transplantation (2003) 1.51
Molecular composition of drusen and possible involvement of anti-retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey (Macaca fascicularis). FASEB J (2005) 1.47
Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice. Hum Mol Genet (2003) 1.45
A seed for Alzheimer amyloid in the brain. J Neurosci (2004) 1.45
LOXL1 variants in elderly Japanese patients with exfoliation syndrome/glaucoma, primary open-angle glaucoma, normal tension glaucoma, and cataract. Mol Vis (2008) 1.42
Complement, age-related macular degeneration and a vision of the future. Arch Ophthalmol (2010) 1.42
Characterization of mouse orthologue of ELOVL4: genomic organization and spatial and temporal expression. Genomics (2004) 1.41
Mutant macaque factor IX T262A: a tool for hemophilia B gene therapy studies in macaques. Thromb Res (2010) 1.41
Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy. Ophthalmology (2010) 1.38
Cone photoreceptor abnormalities correlate with vision loss in patients with Stargardt disease. Invest Ophthalmol Vis Sci (2011) 1.37
Bat coronaviruses and experimental infection of bats, the Philippines. Emerg Infect Dis (2010) 1.32
Spatial and temporal expression of MFRP and its interaction with CTRP5. Invest Ophthalmol Vis Sci (2006) 1.30
Visual acuity in patients with Leber's congenital amaurosis and early childhood-onset retinitis pigmentosa. Ophthalmology (2010) 1.30
CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci (2006) 1.29
Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma. Invest Ophthalmol Vis Sci (2004) 1.28
Atrophic macular degeneration mutations in ELOVL4 result in the intracellular misrouting of the protein. Genomics (2004) 1.28
Quantitative fundus autofluorescence in recessive Stargardt disease. Invest Ophthalmol Vis Sci (2014) 1.27
G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull's eye maculopathy. Exp Eye Res (2009) 1.26
Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest (2005) 1.24
Stargardt-like macular dystrophy protein ELOVL4 exerts a dominant negative effect by recruiting wild-type protein into aggresomes. Mol Vis (2005) 1.23
Behavioral alterations in response to fear-provoking stimuli and tranylcypromine induced by perinatal exposure to bisphenol A and nonylphenol in male rats. Environ Health Perspect (2004) 1.22
Salivary gland progenitor cells induced by duct ligation differentiate into hepatic and pancreatic lineages. Hepatology (2003) 1.22
Dominant mutations in RP1L1 are responsible for occult macular dystrophy. Am J Hum Genet (2010) 1.21
Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. Invest Ophthalmol Vis Sci (2006) 1.21
Correlation of integrity of cone outer segment tips line with retinal sensitivity after half-dose photodynamic therapy for chronic central serous chorioretinopathy. Am J Ophthalmol (2012) 1.21
A homozygosity-based search for mutations in patients with autosomal recessive retinitis pigmentosa, using microsatellite markers. Invest Ophthalmol Vis Sci (2004) 1.20
Sequencing arrays for screening multiple genes associated with early-onset human retinal degenerations on a high-throughput platform. Invest Ophthalmol Vis Sci (2005) 1.18
Multilocus analysis of age-related macular degeneration. Eur J Hum Genet (2009) 1.18
Mitochondrial DNA sequence phylogeny of 4 populations of the widely distributed cynomolgus macaque (Macaca fascicularis fascicularis). J Hered (2008) 1.17
Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation (2010) 1.17
Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. Hum Mol Genet (2003) 1.16
Phenotypic features of patients with NR2E3 mutations. Arch Ophthalmol (2009) 1.16
Evaluating the arrayed primer extension resequencing assay of TP53 tumor suppressor gene. Proc Natl Acad Sci U S A (2002) 1.16
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. Ophthalmology (2012) 1.16
Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Hum Gene Ther (2002) 1.15
Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease. Invest Ophthalmol Vis Sci (2006) 1.14
HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration. Mol Vis (2007) 1.14
Clinical characteristics and genetic background of congenital long-QT syndrome diagnosed in fetal, neonatal, and infantile life: a nationwide questionnaire survey in Japan. Circ Arrhythm Electrophysiol (2009) 1.14
Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population. J Ocul Biol Dis Infor (2009) 1.13
Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice. Hum Mol Genet (2010) 1.13
Molecular testing for hereditary retinal disease as part of clinical care. Arch Ophthalmol (2007) 1.12
Exotic small mammals as potential reservoirs of zoonotic Bartonella spp. Emerg Infect Dis (2009) 1.12
Evolutionarily conserved ELOVL4 gene expression in the vertebrate retina. Invest Ophthalmol Vis Sci (2003) 1.11
Atypical L-type bovine spongiform encephalopathy (L-BSE) transmission to cynomolgus macaques, a non-human primate. Jpn J Infect Dis (2011) 1.10
Complement factor H: spatial and temporal expression and localization in the eye. Invest Ophthalmol Vis Sci (2006) 1.10
A CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degeneration. Hum Mol Genet (2011) 1.09