Published in Eur J Hum Genet on March 04, 2009
The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited. Prog Retin Eye Res (2009) 3.40
Therapeutic targets in age-related macular disease. J Clin Invest (2010) 1.68
Association assessment of copy number polymorphism and risk of age-related macular degeneration. Ophthalmology (2011) 1.46
Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism. BMC Genomics (2016) 1.41
Molecular signature of primary retinal pigment epithelium and stem-cell-derived RPE cells. Hum Mol Genet (2010) 1.40
Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people. Am J Epidemiol (2011) 1.19
Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies. Hum Mutat (2011) 1.17
Genetics of age-related macular degeneration: current concepts, future directions. Semin Ophthalmol (2011) 1.16
Mechanism of inflammation in age-related macular degeneration. Mediators Inflamm (2012) 1.14
Lipids, lipoproteins, and age-related macular degeneration. J Lipids (2011) 1.05
Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration. PLoS One (2013) 0.96
Beyond AREDS: is there a place for antioxidant therapy in the prevention/treatment of eye disease? Invest Ophthalmol Vis Sci (2011) 0.93
Role of antioxidant enzymes and small molecular weight antioxidants in the pathogenesis of age-related macular degeneration (AMD). Biogerontology (2013) 0.92
Complement pathway biomarkers and age-related macular degeneration. Eye (Lond) (2015) 0.86
Risk factors and biomarkers of age-related macular degeneration. Prog Retin Eye Res (2016) 0.85
R102G polymorphism of the C3 gene associated with exudative age-related macular degeneration in a French population. Mol Vis (2010) 0.82
Genome-wide analyses identify common variants associated with macular telangiectasia type 2. Nat Genet (2017) 0.81
Cumulative association between age-related macular degeneration and less studied genetic variants in PLEKHA1/ARMS2/HTRA1: a meta and gene-cluster analysis. Mol Biol Rep (2013) 0.81
Apolipoprotein E gene and age-related macular degeneration in a Chinese population. Mol Vis (2011) 0.81
Complement factor H Val62Ile variant and risk of age-related macular degeneration: a meta-analysis. Mol Vis (2013) 0.80
The ERCC6 gene and age-related macular degeneration. PLoS One (2010) 0.80
Multicenter cohort association study of SLC2A1 single nucleotide polymorphisms and age-related macular degeneration. Mol Vis (2012) 0.76
Alterations of choroidal blood flow regulation in young healthy subjects with complement factor H polymorphism. PLoS One (2013) 0.76
Ocular surface temperature in age-related macular degeneration. J Ophthalmol (2014) 0.75
Copy number variations and gene polymorphisms of complement components in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome. Sci Rep (2015) 0.75
Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10
Complement factor H variant increases the risk of age-related macular degeneration. Science (2005) 17.95
Complement factor H polymorphism and age-related macular degeneration. Science (2005) 17.79
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet (2006) 8.33
Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet (2005) 6.36
The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1. Control Clin Trials (1999) 6.24
Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet (2005) 4.91
Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46
Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat Genet (2007) 4.23
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat Genet (2008) 4.16
A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. Nat Genet (2006) 3.96
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol (2001) 3.49
Familial aggregation of age-related maculopathy. Am J Ophthalmol (1997) 2.77
Meta-analysis of genome scans of age-related macular degeneration. Hum Mol Genet (2005) 2.34
Structural basis for complement factor H linked age-related macular degeneration. J Exp Med (2007) 2.02
A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy. Ophthalmic Genet (2002) 1.49
Cigarette smoking, CFH, APOE, ELOVL4, and risk of neovascular age-related macular degeneration. Arch Ophthalmol (2007) 1.37
Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking. PLoS Med (2007) 1.27
Toll-like receptor polymorphisms and age-related macular degeneration. Invest Ophthalmol Vis Sci (2008) 1.18
Bringing age-related macular degeneration into focus. Nat Genet (2008) 1.04
Smoking and the risk of age-related macular degeneration: a meta-analysis. Ann Epidemiol (2008) 1.04
Determinants of health related quality of life and health state utility in patients with age related macular degeneration: the association of contrast sensitivity and visual acuity. Qual Life Res (2006) 1.03
Joint effects of smoking history and APOE genotypes in age-related macular degeneration. Mol Vis (2005) 1.02
A twin study on age-related macular degeneration. Trans Am Ophthalmol Soc (1994) 1.00
Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration. Arch Ophthalmol (2003) 0.99
Age-Related Eye Disease Study severity scale and simplified severity scale for age-related macular degeneration. Arch Ophthalmol (2005) 0.95
The potential preventive effects of vitamins for cataract and age-related macular degeneration. Int J Vitam Nutr Res (1999) 0.88
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A (2005) 13.44
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell (2003) 12.50
Retracted Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome. Science (2009) 10.76
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet (2006) 8.33
The genome of the sea urchin Strongylocentrotus purpuratus. Science (2006) 6.41
Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor. Cell (2012) 5.62
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proc Natl Acad Sci U S A (2008) 4.76
Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet (2007) 4.69
ABCA3 gene mutations in newborns with fatal surfactant deficiency. N Engl J Med (2004) 4.64
Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst (2006) 3.96
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation. Nat Genet (2013) 3.87
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates. J Virol (2005) 3.63
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A (2010) 3.33
Beta blockers and breast cancer mortality: a population- based study. J Clin Oncol (2011) 2.99
The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res (2002) 2.75
Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis. Am J Obstet Gynecol (2008) 2.60
MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population. J Natl Cancer Inst (2005) 2.57
ABCA3 mutations associated with pediatric interstitial lung disease. Am J Respir Crit Care Med (2005) 2.52
Leisure time physical activity of moderate to vigorous intensity and mortality: a large pooled cohort analysis. PLoS Med (2012) 2.45
Retinal phenotypes in patients homozygous for the G1961E mutation in the ABCA4 gene. Invest Ophthalmol Vis Sci (2012) 2.26
Genotyping microarray (disease chip) for Leber congenital amaurosis: detection of modifier alleles. Invest Ophthalmol Vis Sci (2005) 2.20
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells. Proc Natl Acad Sci U S A (2011) 2.12
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet (2011) 1.98
ABCG2: a perspective. Adv Drug Deliv Rev (2008) 1.97
Genome-wide association study of glioma and meta-analysis. Hum Genet (2012) 1.96
Fruit and vegetable intake and risk of breast cancer by hormone receptor status. J Natl Cancer Inst (2013) 1.94
Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. Carcinogenesis (2007) 1.91
Analysis of the ABCA4 gene by next-generation sequencing. Invest Ophthalmol Vis Sci (2011) 1.87
Microarray-based mutation analysis of the ABCA4 (ABCR) gene in autosomal recessive cone-rod dystrophy and retinitis pigmentosa. Eur J Hum Genet (2004) 1.84
Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. Proc Natl Acad Sci U S A (2009) 1.81
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. J Natl Cancer Inst (2013) 1.81
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A (2004) 1.80
Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A (2005) 1.75
New best1 mutations in autosomal recessive bestrophinopathy. Retina (2015) 1.75
Physical and mental health of homebound older adults: an overlooked population. J Am Geriatr Soc (2010) 1.69
Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut (2012) 1.66
Mutation analysis of 272 Spanish families affected by autosomal recessive retinitis pigmentosa using a genotyping microarray. Mol Vis (2010) 1.64
Microarray-based mutation detection and phenotypic characterization of patients with Leber congenital amaurosis. Invest Ophthalmol Vis Sci (2006) 1.63
Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Biochemistry (2006) 1.63
Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology (2006) 1.59
Genetic testing for retinal dystrophies and dysfunctions: benefits, dilemmas and solutions. Clin Experiment Ophthalmol (2007) 1.58
Common genetic variants and modification of penetrance of BRCA2-associated breast cancer. PLoS Genet (2010) 1.56
The Drakensberg declaration on the control of rheumatic fever and rheumatic heart disease in Africa. S Afr Med J (2006) 1.53
Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proc Natl Acad Sci U S A (2006) 1.53
Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genet (2008) 1.53
The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. J Biol Chem (2006) 1.52
Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res (2004) 1.52
Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control (2009) 1.52
Postoophorectomy estrogen use and breast cancer risk. Obstet Gynecol (2012) 1.46
Association assessment of copy number polymorphism and risk of age-related macular degeneration. Ophthalmology (2011) 1.46
Genome-wide association studies of cancer. J Clin Oncol (2010) 1.45
Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. Nat Genet (2013) 1.45
Complement, age-related macular degeneration and a vision of the future. Arch Ophthalmol (2010) 1.42
Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem (2007) 1.41
ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia. J Clin Oncol (2012) 1.39
Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy. Ophthalmology (2010) 1.38
Surfactant composition and function in patients with ABCA3 mutations. Pediatr Res (2006) 1.37
An exhaustive DNA micro-satellite map of the human genome using high performance computing. Genomics (2003) 1.33
Unique features of TRIM5alpha among closely related human TRIM family members. Virology (2006) 1.33
HIV-1 infection in individuals with the CCR5-Delta32/Delta32 genotype: acquisition of syncytium-inducing virus at seroconversion. J Acquir Immune Defic Syndr (2002) 1.33
Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Top Curr Chem (2013) 1.31
Visual acuity in patients with Leber's congenital amaurosis and early childhood-onset retinitis pigmentosa. Ophthalmology (2010) 1.30
Mutational analysis of ABCG2: role of the GXXXG motif. Biochemistry (2004) 1.29
New insights on the evolution of the SMN1 and SMN2 region: simulation and meta-analysis for allele and haplotype frequency calculations. Eur J Hum Genet (2004) 1.28
Quantitative fundus autofluorescence in recessive Stargardt disease. Invest Ophthalmol Vis Sci (2014) 1.27
The new sequencer on the block: comparison of Life Technology's Proton sequencer to an Illumina HiSeq for whole-exome sequencing. Hum Genet (2013) 1.27
A high-throughput cell-based assay for inhibitors of ABCG2 activity. J Biomol Screen (2006) 1.26
G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull's eye maculopathy. Exp Eye Res (2009) 1.26
Estimated risk of radiation-induced breast cancer from mammographic screening for young BRCA mutation carriers. J Natl Cancer Inst (2009) 1.26
Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry (2010) 1.24
Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics. J Oncol (2010) 1.24
Body mass, estrogen levels, and hot flashes in midlife women. Am J Obstet Gynecol (2005) 1.22
Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. Am J Clin Nutr (2012) 1.21
Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer. Carcinogenesis (2012) 1.20
The ABC transporter gene family of Daphnia pulex. BMC Genomics (2009) 1.20
Novel methylated biomarkers and a robust assay to detect circulating tumor DNA in metastatic breast cancer. Cancer Res (2014) 1.19
Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people. Am J Epidemiol (2011) 1.19
Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancer. Gigascience (2012) 1.18
New inhibitors of ABCG2 identified by high-throughput screening. Mol Cancer Ther (2007) 1.18