Published in Exp Biol Med (Maywood) on February 01, 2005
The biology of brain metastases-translation to new therapies. Nat Rev Clin Oncol (2011) 2.16
NanoART, neuroAIDS and CNS drug delivery. Nanomedicine (Lond) (2009) 1.55
Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J (2008) 1.39
Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice. J Cancer Res Clin Oncol (2007) 1.10
The blood-brain barrier: an engineering perspective. Front Neuroeng (2013) 1.09
Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats. Neurosci Lett (2006) 1.00
P-glycoprotein trafficking at the blood-brain barrier altered by peripheral inflammatory hyperalgesia. J Neurochem (2012) 0.97
Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia. Cell Physiol Biochem (2008) 0.96
Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases. Neuro Oncol (2008) 0.95
P-glycoprotein acts as an immunomodulator during neuroinflammation. PLoS One (2009) 0.90
Tau as a therapeutic target for Alzheimer's disease. Curr Alzheimer Res (2011) 0.89
Qualitative prediction of blood-brain barrier permeability on a large and refined dataset. J Comput Aided Mol Des (2011) 0.89
Mechanisms of the penetration of blood-borne substances into the brain. Curr Neuropharmacol (2009) 0.86
TRPV1 activation results in disruption of the blood-brain barrier in the rat. Br J Pharmacol (2005) 0.84
Immunological response as a source to variability in drug metabolism and transport. Front Pharmacol (2012) 0.84
Physiology and pathophysiology of the blood-brain barrier: P-glycoprotein and occludin trafficking as therapeutic targets to optimize central nervous system drug delivery. J Investig Med (2012) 0.82
The biological significance of brain barrier mechanisms: help or hindrance in drug delivery to the central nervous system? F1000Res (2016) 0.81
Specific increase in MDR1 mediated drug-efflux in human brain endothelial cells following co-exposure to HIV-1 and saquinavir. PLoS One (2013) 0.81
Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system. Int J Nanomedicine (2014) 0.81
Relationship between therapeutic efficacy of doxorubicin-transferrin conjugate and expression of P-glycoprotein in chronic erythromyeloblastoid leukemia cells sensitive and resistant to doxorubicin. Cell Oncol (Dordr) (2014) 0.79
High glucose decreases expression and activity of p-glycoprotein in cultured human retinal pigment epithelium possibly through iNOS induction. PLoS One (2012) 0.77
Posterior Reversible Encephalopathy Syndrome during Recovery from Acute Kidney Injury after Hepatitis A Infection. Case Rep Nephrol Urol (2012) 0.76
Induction of Drug Transporters Alters Disposition of Risperidone - A Study in Mice. Pharmaceutics (2010) 0.75
The Role of Nanoparticle in Brain Permeability: An in-vitro BBB Model. Iran J Pharm Res (2016) 0.75
A Role for P-Glycoprotein in Clearance of Alzheimer Amyloid β -Peptide from the Brain. Curr Alzheimer Res (2016) 0.75
Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery. Biomed Res Int (2015) 0.75
Inhibition of blood-brain barrier efflux transporters promotes seizure in pregnant rats: Role of circulating factors. Brain Behav Immun (2017) 0.75
Phase III study of cisplatin with or without paclitaxel in stage IVB, recurrent, or persistent squamous cell carcinoma of the cervix: a gynecologic oncology group study. J Clin Oncol (2004) 3.85
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J (2005) 3.60
Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology Group Study. J Clin Oncol (2005) 2.94
Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci (2011) 2.40
Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer. Cancer Res (2009) 2.23
Somatic LKB1 mutations promote cervical cancer progression. PLoS One (2009) 2.21
Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol Pharmacol (2007) 1.97
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest (2002) 1.90
Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem (2002) 1.87
Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy. Pharmacol Rev (2008) 1.83
Neuropsychiatric symptoms in Alzheimer's disease. Alzheimers Dement (2011) 1.81
Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol Pharmacol (2006) 1.76
Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol Pharmacol (2004) 1.67
The outdoor air pollution and brain health workshop. Neurotoxicology (2012) 1.60
Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. Mol Pharmacol (2005) 1.54
Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells. Reprod Sci (2007) 1.54
Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease. Mol Pharmacol (2010) 1.51
Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future. Alzheimers Dement (2013) 1.51
In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Mol Pharmacol (2006) 1.51
Brain delivery of camptothecin by means of solid lipid nanoparticles: formulation design, in vitro and in vivo studies. Int J Pharm (2012) 1.51
Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status. Endocrinology (2008) 1.47
Breast cancer resistance protein and P-glycoprotein in brain cancer: two gatekeepers team up. Curr Pharm Des (2011) 1.47
Is comprehensive surgical staging needed for thorough evaluation of early-stage ovarian carcinoma? Am J Obstet Gynecol (2011) 1.45
Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1. Mol Pharmacol (2004) 1.42
Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier. FASEB J (2008) 1.39
Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. Am J Physiol Renal Physiol (2002) 1.35
Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease. Neurotox Res (2009) 1.35
Multidrug resistance-associated proteins: expression and function in the central nervous system. Pharmacol Rev (2006) 1.33
Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier. J Cereb Blood Flow Metab (2008) 1.32
Ovarian preservation in stage I low-grade endometrial stromal sarcomas. Obstet Gynecol (2005) 1.27
Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. Glia (2007) 1.26
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. J Med Chem (2009) 1.25
Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor. J Neurosci (2010) 1.20
Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Genomics (2002) 1.18
Osteopontin as an adjunct to CA125 in detecting recurrent ovarian cancer. Clin Cancer Res (2004) 1.18
17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity. J Cereb Blood Flow Metab (2010) 1.14
Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. Proc Natl Acad Sci U S A (2012) 1.12
Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. Mol Pharmacol (2010) 1.12
MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity. Glia (2007) 1.11
Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier. FASEB J (2010) 1.09
Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. J Cereb Blood Flow Metab (2010) 1.06
The role of A2E in prevention or enhancement of light damage in human retinal pigment epithelial cells. Photochem Photobiol (2002) 1.03
Implications of EGFR inhibition in ovarian cancer cell proliferation. Gynecol Oncol (2008) 1.02
Scales as outcome measures for Alzheimer's disease. Alzheimers Dement (2009) 1.02
Choroid plexus epithelial monolayers--a cell culture model from porcine brain. Cerebrospinal Fluid Res (2006) 1.01
Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther (2009) 1.01
Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice. Am J Physiol Renal Physiol (2003) 0.99
Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay. J Cereb Blood Flow Metab (2010) 0.98
Aberrant p16 methylation is a biomarker for tobacco exposure in cervical squamous cell carcinogenesis. Am J Obstet Gynecol (2004) 0.97
Toward eradicating HIV reservoirs in the brain: inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers. J Am Chem Soc (2011) 0.96
MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration. FASEB J (2005) 0.96
Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation. J Pharmacol Exp Ther (2009) 0.95
Modulation of drug transporters at the blood-brain barrier. Pharmacology (2004) 0.94
Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity. J Neuroinflammation (2011) 0.94
Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. Neuropharmacology (2009) 0.94
Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS. Neurobiol Dis (2012) 0.93
The Clinical Global Impressions scale: errors in understanding and use. Compr Psychiatry (2008) 0.93
Clinical results and quality of life analysis for the MVAC combination (methotrexate, vinblastine, doxorubicin, and cisplatin) in carcinoma of the uterine cervix: A Gynecologic Oncology Group study. Gynecol Oncol (2005) 0.93
Adenosquamous histology predicts poor outcome in low-risk stage IB1 cervical adenocarcinoma. Gynecol Oncol (2003) 0.93
Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron. Toxicol Appl Pharmacol (2008) 0.92
Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries. Br J Pharmacol (2003) 0.92
Glutaric aciduria type I and methylmalonic aciduria: simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus. Biochim Biophys Acta (2010) 0.92
Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa. Planta Med (2007) 0.91
Stage IIB-IVB cervical adenocarcinoma: prognostic factors and survival. Gynecol Oncol (2002) 0.90
Surveillance of siRNA integrity by FRET imaging. Nucleic Acids Res (2007) 0.90
Characterization of cytochrome P450 protein expression along the entire length of the intestine of male and female rats. Drug Metab Dispos (2008) 0.90
Oral dexamethasone attenuates Doxil-induced palmar-plantar erythrodysesthesias in patients with recurrent gynecologic malignancies. Gynecol Oncol (2004) 0.89
Relevance of multidrug resistance proteins for intestinal drug absorption in vitro and in vivo. Pharmacol Toxicol (2002) 0.89
Uptake of apolipoprotein E fragment coupled liposomes by cultured brain microvessel endothelial cells and intact brain capillaries. J Drug Target (2009) 0.89
Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor. FASEB J (2006) 0.89
Phototoxicity in human retinal pigment epithelial cells promoted by hypericin, a component of St. John's wort. Photochem Photobiol (2007) 0.88
Revision of the criteria for Alzheimer’s disease: A symposium. Alzheimers Dement (2011) 0.88
Signaling pathways that regulate basal ABC transporter activity at the blood- brain barrier. Curr Pharm Des (2014) 0.88
Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters. Mol Pharm (2011) 0.88
Matrix-loaded biodegradable gelatin nanoparticles as new approach to improve drug loading and delivery. Eur J Pharm Biopharm (2010) 0.88
Delivery of nanoparticles to the brain detected by fluorescence microscopy. Eur J Pharm Biopharm (2008) 0.88
In vitro models to evaluate the permeability of poorly soluble drug entities: challenges and perspectives. Eur J Pharm Sci (2011) 0.87
The flounder organic anion transporter fOat has sequence, function, and substrate specificity similarity to both mammalian Oat1 and Oat3. Am J Physiol Regul Integr Comp Physiol (2006) 0.87
A phase II study of gemcitabine (gemzar, LY188011) in the treatment of recurrent or persistent endometrial carcinoma: a gynecologic oncology group study. Gynecol Oncol (2010) 0.87
ABC transporter function and regulation at the blood-spinal cord barrier. J Cereb Blood Flow Metab (2012) 0.87
Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes. Drug Metab Dispos (2007) 0.87
By-passing of P-glycoprotein using immunoliposomes. J Drug Target (2002) 0.87
Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers. J Cereb Blood Flow Metab (2012) 0.86
Fertility-sparing surgery in 101 women with adenocarcinoma in situ of the cervix. Gynecol Oncol (2007) 0.86
Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas. Gynecol Oncol (2010) 0.85
Amorphous solid dispersion enhances permeation of poorly soluble ABT-102: true supersaturation vs. apparent solubility enhancement. Int J Pharm (2012) 0.85