Published in Planta Med on December 06, 2007
Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents. Front Microbiol (2012) 0.98
Design, synthesis and antimycobacterial activities of 1-methyl-2-alkenyl-4(1H)-quinolones. Bioorg Med Chem (2010) 0.91
Synergistic anticancer effects of polyphyllin I and evodiamine on freshly-removed human gastric tumors. PLoS One (2013) 0.86
Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research. Front Pharmacol (2016) 0.85
Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties. J Cell Mol Med (2010) 0.78
Low-cytotoxic synthetic bromorutaecarpine exhibits anti-inflammation and activation of transient receptor potential vanilloid type 1 activities. Biomed Res Int (2013) 0.77
Efficacy of traditional Chinese medicine in treating cancer. Biomed Rep (2015) 0.75
Study of the cytotoxic/toxic potential of the novel anticancer selenodiazoloquinolone on fibroblast cells and 3D skin model. Interdiscip Toxicol (2017) 0.75
An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med (2005) 4.24
Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci (2011) 2.40
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest (2002) 1.90
Cameroonian medicinal plants: pharmacology and derived natural products. Front Pharmacol (2010) 1.80
Chemotherapy-induced resistance by ATP-binding cassette transporter genes. Biochim Biophys Acta (2007) 1.79
Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier. Mol Pharmacol (2004) 1.67
Molecular principles of cancer invasion and metastasis (review). Int J Oncol (2009) 1.66
Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide. Mol Pharmacol (2005) 1.54
Brain delivery of camptothecin by means of solid lipid nanoparticles: formulation design, in vitro and in vivo studies. Int J Pharm (2012) 1.51
Evidence-based Chinese medicine for cancer therapy. J Ethnopharmacol (2007) 1.47
Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts. J Ethnopharmacol (2011) 1.46
Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1. Mol Pharmacol (2004) 1.42
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J Biol Chem (2010) 1.41
Antimicrobial activity of clove and rosemary essential oils alone and in combination. Phytother Res (2007) 1.39
New Analytical Monographs on TCM Herbal Drugs for Quality Proof. Forsch Komplementmed (2016) 1.39
Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes. Cancer Res (2004) 1.32
Artesunate derived from traditional Chinese medicine induces DNA damage and repair. Cancer Res (2008) 1.31
Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev (2014) 1.28
Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate. Biochem Pharmacol (2004) 1.28
Modulation of human BCRP (ABCG2) activity by anti-HIV drugs. J Antimicrob Chemother (2007) 1.27
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar. J Med Chem (2009) 1.25
The quest for modernisation of traditional Chinese medicine. BMC Complement Altern Med (2013) 1.24
Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation. Clin Infect Dis (2008) 1.23
Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells. Mol Cancer Ther (2008) 1.22
Use of CpG island microarrays to identify colorectal tumors with a high degree of concurrent methylation. Methods (2002) 1.21
Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components. Molecules (2012) 1.20
Artesunate in the treatment of metastatic uveal melanoma--first experiences. Oncol Rep (2005) 1.19
Cloning and characterization of a novel apolipoprotein A-I binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. Genomics (2002) 1.18
Molecular modes of action of cantharidin in tumor cells. Biochem Pharmacol (2005) 1.17
Modulation of p-glycoprotein transport function at the blood-brain barrier. Exp Biol Med (Maywood) (2005) 1.16
The anti-malaria drug artesunate inhibits replication of cytomegalovirus in vitro and in vivo. Antiviral Res (2005) 1.14
17-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity. J Cereb Blood Flow Metab (2010) 1.14
Leishmaniasis: drug resistance and natural products (review). Int J Mol Med (2008) 1.13
New constituents of Leontopodium alpinum and their in vitro leukotriene biosynthesis inhibitory activity. Planta Med (2004) 1.13
Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants. PLoS One (2011) 1.12
ABCA3 as a possible cause of drug resistance in childhood acute myeloid leukemia. Clin Cancer Res (2006) 1.11
Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats. Int Immunopharmacol (2002) 1.11
Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res (2005) 1.10
Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells. Mol Cancer Ther (2011) 1.10
Quinolone alkaloids from Evodia rutaecarpa: a potent new group of antimycobacterial compounds. Int J Antimicrob Agents (2005) 1.09
Antiviral effect of artemisinin from Artemisia annua against a model member of the Flaviviridae family, the bovine viral diarrhoea virus (BVDV). Planta Med (2006) 1.09
Polo-like kinase 1 as target for cancer therapy. Exp Hematol Oncol (2012) 1.09
Molecular biology of cantharidin in cancer cells. Chin Med (2007) 1.08
Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition. J Biol Chem (2012) 1.08
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. J Nat Prod (2011) 1.08
The role of alkamides as an active principle of echinacea. Planta Med (2007) 1.08
First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases. Int J Cancer (2010) 1.07
Traditionally used Thai medicinal plants: in vitro anti-inflammatory, anticancer and antioxidant activities. J Ethnopharmacol (2010) 1.06
Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate. PLoS One (2007) 1.06
Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum. Biochem Pharmacol (2012) 1.05
Cytotoxicity and modes of action of four Cameroonian dietary spices ethno-medically used to treat cancers: Echinops giganteus, Xylopia aethiopica, Imperata cylindrica and Piper capense. J Ethnopharmacol (2013) 1.04
MicroRNA expression profile of MCF-7 human breast cancer cells and the effect of green tea polyphenon-60. Cancer Genomics Proteomics (2010) 1.04
Cytotoxicity of Thymus vulgaris essential oil towards human oral cavity squamous cell carcinoma. Anticancer Res (2011) 1.04
Echinacea for preventing and treating the common cold. Planta Med (2008) 1.03
Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells. Evid Based Complement Alternat Med (2012) 1.02
Cajanol, a novel anticancer agent from Pigeonpea [Cajanus cajan (L.) Millsp.] roots, induces apoptosis in human breast cancer cells through a ROS-mediated mitochondrial pathway. Chem Biol Interact (2010) 1.02
mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether. Biochem Pharmacol (2002) 1.02
Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells. Nitric Oxide (2008) 1.02
Choroid plexus epithelial monolayers--a cell culture model from porcine brain. Cerebrospinal Fluid Res (2006) 1.01
Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther (2009) 1.01
Therapeutic and diagnostic applications of nanoparticles. Curr Drug Targets (2011) 1.00
Drug resistance in Plasmodium: natural products in the fight against malaria. Mini Rev Med Chem (2009) 1.00
Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Atherosclerosis (2007) 0.99
Development of drug resistance in Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Treatment of human African trypanosomiasis with natural products (Review). Int J Mol Med (2008) 0.98
Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy. J Ethnopharmacol (2011) 0.98
Expression profile of genes in non-small cell lung carcinomas from long-term surviving patients. Clin Cancer Res (2002) 0.97
First study of oral Artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers. Anticancer Res (2011) 0.97
Bioavailability and pharmacokinetics of alkamides from the roots of Echinacea angustifolia in humans. J Clin Pharmacol (2005) 0.96
Antioxidant activities and xanthine oxidase inhibitory effects of extracts and main polyphenolic compounds obtained from Geranium sibiricum L. J Agric Food Chem (2010) 0.95
A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo. BMC Cancer (2006) 0.95
Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense. J Nat Prod (2011) 0.95
Cytotoxicity and Modes of Action of the Methanol Extracts of Six Cameroonian Medicinal Plants against Multidrug-Resistant Tumor Cells. Evid Based Complement Alternat Med (2013) 0.95
P-glycoprotein and its inhibition in tumors by phytochemicals derived from Chinese herbs. J Ethnopharmacol (2011) 0.95
A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein survivin. Radiother Oncol (2012) 0.94
Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med (2004) 0.94
The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots. Planta Med (2005) 0.93
Cytotoxicity and mode of action of four naturally occuring flavonoids from the genus Dorstenia: gancaonin Q, 4-hydroxylonchocarpin, 6-prenylapigenin, and 6,8-diprenyleriodictyol. Planta Med (2011) 0.93
Supercritical carbon dioxide extraction of seed oil from yellow horn (Xanthoceras sorbifolia Bunge.) and its anti-oxidant activity. Bioresour Technol (2009) 0.93
Alkamides from Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells. Biochem Biophys Res Commun (2007) 0.93
Cytotoxicity and modes of action of four naturally occuring benzophenones: 2,2',5,6'-tetrahydroxybenzophenone, guttiferone E, isogarcinol and isoxanthochymol. Phytomedicine (2013) 0.93
Interaction of N-methyl-2-alkenyl-4-quinolones with ATP-dependent MurE ligase of Mycobacterium tuberculosis: antibacterial activity, molecular docking and inhibition kinetics. J Antimicrob Chemother (2011) 0.93
Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries. Br J Pharmacol (2003) 0.92
Optimization of luteolin separation from pigeonpea [Cajanus cajan (L.) Millsp.] leaves by macroporous resins. J Chromatogr A (2006) 0.92
Glutaric aciduria type I and methylmalonic aciduria: simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus. Biochim Biophys Acta (2010) 0.92
Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells. Biochem Pharmacol (2009) 0.92
Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation. Antiviral Res (2011) 0.91
Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines. Genes Chromosomes Cancer (2005) 0.91
Flavonolignans from Avena sativa. J Nat Prod (2005) 0.91
Molecular mechanisms underlying St. John's wort drug interactions. Curr Drug Metab (2008) 0.91