|
1
|
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.
|
Diabetes
|
2005
|
3.18
|
|
2
|
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress.
|
Endocrinology
|
2004
|
3.03
|
|
3
|
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.
|
J Cell Sci
|
2008
|
2.99
|
|
4
|
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.
|
Diabetes
|
2009
|
1.63
|
|
5
|
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.
|
Diabetes
|
2003
|
1.63
|
|
6
|
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.
|
Diabetes
|
2009
|
1.50
|
|
7
|
Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?
|
Diabetes
|
2005
|
1.45
|
|
8
|
Expression of adiponectin receptors in pancreatic beta cells.
|
Biochem Biophys Res Commun
|
2003
|
1.41
|
|
9
|
1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice.
|
Endocrinology
|
2005
|
1.39
|
|
10
|
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.
|
Mol Endocrinol
|
2006
|
1.39
|
|
11
|
An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.
|
Biochem Soc Trans
|
2008
|
1.22
|
|
12
|
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.
|
Diabetes
|
2007
|
1.22
|
|
13
|
Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells.
|
Clin Exp Metastasis
|
2002
|
1.16
|
|
14
|
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.
|
Diabetes
|
2012
|
1.16
|
|
15
|
Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells.
|
Diabetes
|
2005
|
1.09
|
|
16
|
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.
|
Diabetes
|
2003
|
1.09
|
|
17
|
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes.
|
Ann Neurol
|
2012
|
1.02
|
|
18
|
Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.
|
Endocrinology
|
2002
|
1.02
|
|
19
|
Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes.
|
Arq Bras Endocrinol Metabol
|
2008
|
1.01
|
|
20
|
Notch signaling: a mediator of beta-cell de-differentiation in diabetes?
|
Biochem Biophys Res Commun
|
2005
|
1.01
|
|
21
|
tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans.
|
PLoS Genet
|
2013
|
0.96
|
|
22
|
Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.
|
J Clin Endocrinol Metab
|
2010
|
0.95
|
|
23
|
Resistance to type 2 diabetes mellitus: a matter of hormesis?
|
Nat Rev Endocrinol
|
2011
|
0.94
|
|
24
|
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.
|
Endocrinology
|
2009
|
0.91
|
|
25
|
Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells.
|
J Biol Chem
|
2010
|
0.87
|
|
26
|
An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells.
|
Endocrinology
|
2003
|
0.87
|
|
27
|
A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.
|
J Biol Chem
|
2014
|
0.82
|
|
28
|
Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass.
|
Diabetes
|
2011
|
0.82
|
|
29
|
IL-17A increases the expression of proinflammatory chemokines in human pancreatic islets.
|
Diabetologia
|
2013
|
0.81
|
|
30
|
In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes.
|
Diabetologia
|
2014
|
0.79
|
|
31
|
The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses.
|
Endocrinology
|
2010
|
0.78
|
|
32
|
UCP2 Expression Is Increased in Pancreas From Brain-Dead Donors and Involved in Cytokine-Induced β Cells Apoptosis.
|
Transplantation
|
2017
|
0.75
|