Published in Diabetes on February 01, 2005
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature (2011) 4.78
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30
Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol (2008) 4.10
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci (2008) 2.99
AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol Cell Biol (2005) 2.56
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr (2012) 2.27
Endoplasmic reticulum stress and pancreatic β-cell death. Trends Endocrinol Metab (2011) 2.01
Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes (2012) 1.98
Blockade of interleukin 1 in type 1 diabetes mellitus. Nat Rev Endocrinol (2010) 1.95
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88
Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol (2011) 1.80
Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation (2010) 1.58
Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Sci Transl Med (2013) 1.55
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem (2010) 1.49
Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal (2014) 1.47
Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes (2008) 1.46
Tauroursodeoxycholic acid mitigates high fat diet-induced cardiomyocyte contractile and intracellular Ca2+ anomalies. PLoS One (2013) 1.44
Endoplasmic reticulum stress in beta-cells and development of diabetes. Curr Opin Pharmacol (2009) 1.41
The binary switch that controls the life and death decisions of ER stressed β cells. Curr Opin Cell Biol (2010) 1.41
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem (2010) 1.39
Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes (2009) 1.39
Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest (2015) 1.38
Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes (2008) 1.38
Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes (2010) 1.36
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med (2011) 1.34
12-Lipoxygenase Products Reduce Insulin Secretion and {beta}-Cell Viability in Human Islets. J Clin Endocrinol Metab (2010) 1.31
Endoplasmic-reticulum calcium depletion and disease. Cold Spring Harb Perspect Biol (2011) 1.31
Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis. Cell Death Differ (2010) 1.30
Quantification of basal and stimulated ROS levels as predictors of islet potency and function. Am J Transplant (2007) 1.24
Evidence of diminished glucose stimulation and endoplasmic reticulum function in nonoscillatory pancreatic islets. Endocrinology (2008) 1.20
Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem (2011) 1.20
GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet (2013) 1.19
Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner. Endocrinology (2008) 1.18
Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. J Virol (2006) 1.14
Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Diabetes (2006) 1.13
Endoplasmic reticulum chaperon tauroursodeoxycholic acid alleviates obesity-induced myocardial contractile dysfunction. J Mol Cell Cardiol (2010) 1.12
Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass. Diabetes (2012) 1.11
PPAR-γ activation restores pancreatic islet SERCA2 levels and prevents β-cell dysfunction under conditions of hyperglycemic and cytokine stress. Mol Endocrinol (2012) 1.10
C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells. Cell Death Differ (2012) 1.10
Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL. J Cell Mol Med (2007) 1.08
Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling. Cell Calcium (2010) 1.07
Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli. Diabetes (2009) 1.06
Inflammasomes and metabolic disorders: old genes in modern diseases. Mol Cell (2014) 1.06
Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem (2009) 1.05
Differential regulation of CHOP-10/GADD153 gene expression by MAPK signaling in pancreatic beta-cells. Proc Natl Acad Sci U S A (2007) 1.04
Impaired MEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment. Diabetes (2012) 1.01
Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice. Endocrinology (2013) 1.01
The binary switch between life and death of endoplasmic reticulum-stressed beta cells. Curr Opin Endocrinol Diabetes Obes (2010) 0.99
Cytokines in the Progression of Pancreatic β-Cell Dysfunction. Int J Endocrinol (2010) 0.99
Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin. J Biol Chem (2013) 0.98
Calcium efflux from the endoplasmic reticulum leads to β-cell death. Endocrinology (2013) 0.97
Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun (2013) 0.97
IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis. J Cell Physiol (2009) 0.96
JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells. PLoS One (2008) 0.96
Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? Apoptosis (2009) 0.95
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes. Cell Calcium (2011) 0.95
Wolfram Syndrome: Diagnosis, Management, and Treatment. Curr Diab Rep (2016) 0.95
Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells. J Biol Chem (2010) 0.94
Translational control of inducible nitric oxide synthase by p38 MAPK in islet β-cells. Mol Endocrinol (2012) 0.92
Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med (2014) 0.91
Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival. Endocrinology (2010) 0.91
Multiple chromatin-bound protein kinases assemble factors that regulate insulin gene transcription. Proc Natl Acad Sci U S A (2009) 0.91
Transcriptional mechanisms regulating Ca(2+) homeostasis. Cell Calcium (2010) 0.90
Endoplasmic reticulum stress and insulin biosynthesis: a review. Exp Diabetes Res (2012) 0.89
Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. Diabetologia (2013) 0.89
Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metab (2015) 0.89
Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes. Mol Aspects Med (2015) 0.88
Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells. J Biol Chem (2010) 0.87
A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β). Diabetes Obes Metab (2010) 0.86
The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis. BMC Genomics (2013) 0.86
A switch from life to death in endoplasmic reticulum stressed β-cells. Diabetes Obes Metab (2010) 0.86
AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets. Mol Cell Endocrinol (2010) 0.86
12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets. Mol Cell Biol (2014) 0.85
Pancreatic and duodenal homeobox protein 1 (Pdx-1) maintains endoplasmic reticulum calcium levels through transcriptional regulation of sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) in the islet β cell. J Biol Chem (2014) 0.85
Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction. Neuroscience (2011) 0.85
Effect of Bu-Zhong-Yi-Qi-Tang on deficiency of N-glycan/nitric oxide and islet damage induced by streptozotocin in diabetic rats. World J Gastroenterol (2009) 0.85
Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress. Cell Signal (2011) 0.85
The role of endoplasmic reticulum stress in autoimmune-mediated beta-cell destruction in type 1 diabetes. Exp Diabetes Res (2012) 0.85
Abnormal Ca2+ spark/STOC coupling in cerebral artery smooth muscle cells of obese type 2 diabetic mice. PLoS One (2013) 0.84
Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance. Cell Death Dis (2013) 0.84
Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction. Oxid Med Cell Longev (2015) 0.84
Do reciprocal interactions between cell stress proteins and cytokines create a new intra-/extra-cellular signalling nexus? Cell Stress Chaperones (2013) 0.84
An immunohistochemical study of nitrotyrosine expression in pancreatic islets of cases with increasing duration of type 1 diabetes and without diabetes. Histochem Cell Biol (2017) 0.84
Nova1 is a master regulator of alternative splicing in pancreatic beta cells. Nucleic Acids Res (2014) 0.83
Connexin36 contributes to INS-1E cells survival through modulation of cytokine-induced oxidative stress, ER stress and AMPK activity. Cell Death Differ (2013) 0.83
Role of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells. Int J Biol Sci (2006) 0.83
Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes. J Cell Sci (2011) 0.83
Bad news for beta-cell apoptosis. Diabetes (2009) 0.83
Modulation of endothelial cell migration by ER stress and insulin resistance: a role during maternal obesity? Front Pharmacol (2014) 0.83
Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion. Proc Natl Acad Sci U S A (2013) 0.83
A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. J Biol Chem (2014) 0.82
Nitric oxide is a mediator of antiproliferative effects induced by proinflammatory cytokines on pancreatic beta cells. Mediators Inflamm (2013) 0.82
Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. J Cell Mol Med (2014) 0.82
Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass. Diabetes (2011) 0.82
Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction. PLoS One (2011) 0.81
ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes. Ups J Med Sci (2016) 0.81
Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med (2007) 11.62
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol (2009) 4.36
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology (2004) 3.03
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci (2008) 2.99
Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetes. Diabetes Care (2008) 2.87
Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes (2005) 2.61
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care (2009) 2.56
Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials. Lancet (2013) 2.45
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem (2006) 2.26
Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med (Berl) (2003) 2.10
Role of IL-1beta in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes (2010) 1.97
The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet (2012) 1.88
Cytokines and beta-cell biology: from concept to clinical translation. Endocr Rev (2007) 1.72
Poor pregnancy outcome in women with type 2 diabetes. Diabetes Care (2005) 1.71
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes (2009) 1.63
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes (2003) 1.63
Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells. Diabetes (2009) 1.60
Detailed transcriptome atlas of the pancreatic beta cell. BMC Med Genomics (2009) 1.55
Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation. Diabetes (2011) 1.52
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes (2009) 1.50
STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem (2010) 1.49
Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care (2012) 1.46
Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets? Diabetes (2005) 1.45
Total mortality by elevated transferrin saturation in patients with diabetes. Diabetes Care (2013) 1.43
Expression of adiponectin receptors in pancreatic beta cells. Biochem Biophys Res Commun (2003) 1.41
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem (2010) 1.39
1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Endocrinology (2005) 1.39
Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation. Mol Endocrinol (2006) 1.39
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med (2011) 1.34
RNA modifications by oxidation: a novel disease mechanism? Free Radic Biol Med (2012) 1.26
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA. Hum Mol Genet (2010) 1.25
IAPP boosts islet macrophage IL-1 in type 2 diabetes. Nat Immunol (2010) 1.24
An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells. Biochem Soc Trans (2008) 1.22
Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex. Mol Endocrinol (2006) 1.22
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells. Diabetes (2007) 1.22
TiSH--a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC. J Proteomics (2012) 1.19
Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells. Clin Exp Metastasis (2002) 1.16
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes (2012) 1.16
Double-stranded RNA induces pancreatic beta-cell apoptosis by activation of the toll-like receptor 3 and interferon regulatory factor 3 pathways. Diabetes (2008) 1.14
Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. J Nutr Biochem (2007) 1.13
Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells. Diabetes (2005) 1.09
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells. Diabetes (2003) 1.09
The Fas pathway is involved in pancreatic beta cell secretory function. Proc Natl Acad Sci U S A (2007) 1.08
Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes. Biochem Soc Trans (2008) 1.08
The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro. Mol Med (2010) 1.05
Elevated transferrin saturation and risk of diabetes: three population-based studies. Diabetes Care (2011) 1.03
Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory. J Neurosci (2011) 1.03
Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes. Ann Neurol (2012) 1.02
Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis. Ann N Y Acad Sci (2003) 1.01
Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes. Arq Bras Endocrinol Metabol (2008) 1.01
Notch signaling: a mediator of beta-cell de-differentiation in diabetes? Biochem Biophys Res Commun (2005) 1.01
Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta (2007) 1.00
Diabetes and suppressors of cytokine signaling proteins. Diabetes (2007) 0.99
The use of interleukin-1-receptor antagonists in the treatment of diabetes mellitus. Nat Clin Pract Endocrinol Metab (2008) 0.99
High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. PLoS One (2010) 0.97
Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. Hum Mol Genet (2003) 0.97
tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans. PLoS Genet (2013) 0.96
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology (2009) 0.96
JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells. PLoS One (2008) 0.96
Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets. J Clin Endocrinol Metab (2010) 0.95
Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin. Diabetes Metab Res Rev (2013) 0.95
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. Cell Metab (2012) 0.95
Resistance to type 2 diabetes mellitus: a matter of hormesis? Nat Rev Endocrinol (2011) 0.94
Intracellular dyssynchrony of diastolic cytosolic [Ca²⁺] decay in ventricular cardiomyocytes in cardiac remodeling and human heart failure. Circ Res (2013) 0.92
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells. Endocrinology (2009) 0.91
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis. Proc Natl Acad Sci U S A (2011) 0.91
A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death. J Neurosci (2012) 0.90
Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells. Endocrinology (2005) 0.89
Na/Ca exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells. Diabetes (2002) 0.89
Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation. Cell Death Differ (2011) 0.88
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection. Proc Natl Acad Sci U S A (2014) 0.88
Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells. J Biol Chem (2010) 0.87
An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells. Endocrinology (2003) 0.87
Role of Na/Ca exchange and the plasma membrane Ca2+-ATPase in beta cell function and death. Ann N Y Acad Sci (2007) 0.85
Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway. Endocrinology (2011) 0.84
Anti-cytokine therapies in T1D: Concepts and strategies. Clin Immunol (2013) 0.84
Type 1 database mellitus: an inflammatory disease of the islet. Adv Exp Med Biol (2004) 0.83
Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis. Arch Biochem Biophys (2012) 0.82
Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass. Diabetes (2011) 0.82
Is puberty an accelerator of type 1 diabetes in IL6-174CC females? Diabetes (2005) 0.82
Inhibition of beta cell growth and function by bone morphogenetic proteins. Diabetologia (2014) 0.82
A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. J Biol Chem (2014) 0.82
Cytokines and type 1 diabetes: a numbers game. Diabetes (2011) 0.82
Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist. J Neuroinflammation (2014) 0.82
Altering β-cell number through stable alteration of miR-21 and miR-34a expression. Islets (2014) 0.82
Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1. J Biol Chem (2003) 0.82