Published in Diabetes on February 01, 2005
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. J Clin Invest (2007) 2.03
Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets. J Biol Chem (2008) 1.25
Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells. PLoS One (2009) 0.96
Increased glucose metabolism and glycerolipid formation by fatty acids and GPR40 receptor signaling underlies the fatty acid potentiation of insulin secretion. J Biol Chem (2014) 0.95
NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat Med (2016) 0.88
The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy. Endocrinology (2008) 0.87
Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. Exp Cell Res (2008) 0.86
Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. Diabetes (2014) 0.83
Fatty acid metabolism and the basis of brown adipose tissue function. Adipocyte (2015) 0.82
Regulation of islet beta-cell pyruvate metabolism: interactions of prolactin, glucose, and dexamethasone. Endocrinology (2010) 0.81
Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes. PLoS One (2016) 0.75
TYPE OF SUPPLEMENTED SIMPLE SUGAR, NOT MERELY CALORIE INTAKE, DETERMINES ADVERSE EFFECTS ON METABOLISM AND AORTIC FUNCTION IN FEMALE RATS. Am J Physiol Heart Circ Physiol (2016) 0.75
Lower Expression of SLC27A1 Enhances Intramuscular Fat Deposition in Chicken via Down-Regulated Fatty Acid Oxidation Mediated by CPT1A. Front Physiol (2017) 0.75
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet (2009) 5.43
Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet (2011) 3.50
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology (2003) 2.86
Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology (2003) 2.76
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol (2003) 2.55
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One (2008) 2.47
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov (2004) 2.46
AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest (2013) 2.44
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation. Hepatology (2011) 2.39
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem (2007) 2.37
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem (2009) 2.28
Fatty acid signaling in the beta-cell and insulin secretion. Diabetes (2006) 2.22
Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes (2003) 2.16
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem (2002) 2.11
Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol (2004) 2.10
Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells. Endocrinology (2005) 1.71
Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass. Diabetes (2010) 1.66
Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J (2013) 1.65
Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin. J Biol Chem (2003) 1.61
Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc Natl Acad Sci U S A (2005) 1.59
Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. J Clin Invest (2011) 1.55
Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes (2009) 1.51
A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion. J Biol Chem (2007) 1.51
AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. Am J Physiol Endocrinol Metab (2005) 1.51
Mitochondrial fusion proteins: dual regulators of morphology and metabolism. Semin Cell Dev Biol (2010) 1.44
Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait. Phytomedicine (2006) 1.44
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes (2004) 1.43
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J Biol Chem (2008) 1.40
Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion. J Biol Chem (2005) 1.39
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Endocrinology (2003) 1.32
Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1. Diabetes (2004) 1.29
A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem (2005) 1.28
Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem (2009) 1.27
Mitochondrial dysfunction in pancreatic β cells. Trends Endocrinol Metab (2012) 1.27
The islet beta-cell: fuel responsive and vulnerable. Trends Endocrinol Metab (2008) 1.27
Hepatic glucose sensing is required to preserve β cell glucose competence. J Clin Invest (2013) 1.27
Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome. Am J Med Genet A (2010) 1.26
Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes (2006) 1.22
New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci (Lond) (2005) 1.19
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart. Am J Physiol Endocrinol Metab (2005) 1.17
MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity. J Clin Invest (2012) 1.17
Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J Biol Chem (2010) 1.17
Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells. J Cell Physiol (2010) 1.16
Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. J Lipid Res (2009) 1.12
Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes. Diabetologia (2013) 1.11
Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. FASEB J (2008) 1.10
Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites. Diabetes (2002) 1.10
Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation. Endocrinology (2004) 1.10
The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells. J Biol Chem (2004) 1.09
Minireview: new roles for peripheral dopamine on metabolic control and tumor growth: let's seek the balance. Endocrinology (2010) 1.08
Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia. Mol Pain (2009) 1.07
Oleate promotes the proliferation of breast cancer cells via the G protein-coupled receptor GPR40. J Biol Chem (2005) 1.06
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance. Am J Physiol Endocrinol Metab (2006) 1.06
Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis. J Biol Chem (2008) 1.06
The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction. J Biol Chem (2003) 1.06
Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes (2002) 1.05
A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice. Ann Surg (2004) 1.05
Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction. J Biol Chem (2009) 1.04
The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress. Biochem Soc Trans (2008) 1.03
Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells. Endocrinology (2010) 1.03
Selected plant species from the Cree pharmacopoeia of northern Quebec possess anti-diabetic potential. Can J Physiol Pharmacol (2006) 1.03
Molecular genetics of HMG-CoA lyase deficiency. Mol Genet Metab (2007) 1.03
Evaluation of the antidiabetic potential of selected medicinal plant extracts from the Canadian boreal forest used to treat symptoms of diabetes: part II. Can J Physiol Pharmacol (2009) 1.01
Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. Proc Natl Acad Sci U S A (2011) 1.00
Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells. FEBS Lett (2002) 0.99
Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. J Biol Chem (2002) 0.99
Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis. Aging (Albany NY) (2011) 0.99
Inhibition of mitochondrial Na+-Ca2+ exchanger increases mitochondrial metabolism and potentiates glucose-stimulated insulin secretion in rat pancreatic islets. Diabetes (2003) 0.98
Adenosine 5'-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes. Endocrinology (2005) 0.98
Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. J Biol Chem (2009) 0.98
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion. Diabetes (2012) 0.97
Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. J Biol Chem (2002) 0.96
Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress. Clin Biochem Rev (2009) 0.96
Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J Biol Chem (2012) 0.96
Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells. PLoS One (2009) 0.96
PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction. J Lipid Res (2009) 0.95
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight. Biochem Pharmacol (2008) 0.95
Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion. Biochem J (2002) 0.95