Published in J Biol Chem on August 22, 2007
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol (2012) 4.86
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci (2010) 2.37
Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci (2010) 2.36
DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J (2012) 2.21
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell (2013) 1.99
Mechanisms and molecular probes of sirtuins. Chem Biol (2008) 1.90
The role of sirtuins in the control of metabolic homeostasis. Ann N Y Acad Sci (2009) 1.62
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem (2012) 1.58
The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther (2013) 1.57
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell (2013) 1.52
Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. Diabetes (2010) 1.48
SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells. J Biol Chem (2010) 1.46
The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem (2008) 1.45
Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS One (2008) 1.41
Mitochondrial protein acetylation regulates metabolism. Essays Biochem (2012) 1.40
SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28
Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27
Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations. Eur J Endocrinol (2009) 1.23
Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell (2014) 1.20
Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning. J Cereb Blood Flow Metab (2011) 1.18
Structure of mouse ADP-ribosylhydrolase 3 (mARH3). Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 1.17
Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J Biol Chem (2010) 1.17
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. Handb Exp Pharmacol (2011) 1.16
Alcohol-induced protein hyperacetylation: mechanisms and consequences. World J Gastroenterol (2009) 1.15
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
Mitochondrial energy and redox signaling in plants. Antioxid Redox Signal (2013) 1.12
Mitochondrial sirtuins and their relationships with metabolic disease and cancer. Antioxid Redox Signal (2015) 1.09
Functional localization of two poly(ADP-ribose)-degrading enzymes to the mitochondrial matrix. Mol Cell Biol (2007) 1.08
Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substrates. J Biomed Biotechnol (2010) 1.08
Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem (2013) 1.07
Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice. J Gerontol A Biol Sci Med Sci (2012) 1.07
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation. Handb Exp Pharmacol (2011) 1.02
SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY) (2011) 1.01
Retracted Sirtuin-4 modulates sensitivity to induction of the mitochondrial permeability transition pore. Biochim Biophys Acta (2012) 1.01
Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer Metab (2014) 1.00
Differential network analysis for the identification of condition-specific pathway activity and regulation. Bioinformatics (2013) 0.99
Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. Annu Rev Physiol (2012) 0.98
SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY) (2013) 0.94
Mitochondrial sirtuins and metabolic homeostasis. Best Pract Res Clin Endocrinol Metab (2012) 0.92
The diversity of histone versus nonhistone sirtuin substrates. Genes Cancer (2013) 0.92
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell Metab (2017) 0.92
Regulation of sirtuin function by posttranslational modifications. Front Pharmacol (2012) 0.91
Mitochondrial acetylation and diseases of aging. J Aging Res (2011) 0.91
The human sirtuin family: evolutionary divergences and functions. Hum Genomics (2011) 0.90
Metabolism leaves its mark on the powerhouse: recent progress in post-translational modifications of lysine in mitochondria. Front Physiol (2014) 0.89
Urea cycle regulation by mitochondrial sirtuin, SIRT5. Aging (Albany NY) (2009) 0.89
Role of sirtuins in ischemia-reperfusion injury. World J Gastroenterol (2013) 0.89
Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells. PLoS One (2014) 0.88
Circulating levels of sirtuin 4, a potential marker of oxidative metabolism, related to coronary artery disease in obese patients suffering from NAFLD, with normal or slightly increased liver enzymes. Oxid Med Cell Longev (2014) 0.87
Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase. Mol Biol Cell (2012) 0.87
Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion (2013) 0.87
Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. PLoS One (2011) 0.86
The molecular genetics of sirtuins: association with human longevity and age-related diseases. Int J Mol Epidemiol Genet (2010) 0.85
Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming. Dis Model Mech (2014) 0.84
Effects of Oxidative Stress on Mesenchymal Stem Cell Biology. Oxid Med Cell Longev (2016) 0.84
Side chain specificity of ADP-ribosylation by a sirtuin. FEBS J (2009) 0.83
Pharmacological manipulations of CNS sirtuins: potential effects on metabolic homeostasis. Pharmacol Res (2010) 0.83
Sirtuin biology and relevance to diabetes treatment. Diabetes Manag (Lond) (2012) 0.83
Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans. Genetics (2015) 0.82
Differential expression of sirtuin family members in the developing, adult, and aged rat brain. Front Aging Neurosci (2014) 0.82
The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism. Plant Physiol (2014) 0.82
The sirtuins in the pathogenesis of cancer. Clin Epigenetics (2010) 0.81
NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents. Proc Natl Acad Sci U S A (2014) 0.81
Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling. Mol Aspects Med (2013) 0.81
Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality. J Biol Chem (2013) 0.80
Mitochondrial sirtuins as therapeutic targets for age-related disorders. Genes Cancer (2013) 0.80
Respected Sir(2): magic target for diabetes. Cellscience (2008) 0.80
Mitochondrial Sirtuins in Cancer: Emerging Roles and Therapeutic Potential. Cancer Res (2016) 0.79
Sirtuins, aging, and cardiovascular risks. Age (Dordr) (2015) 0.79
Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects. Br J Pharmacol (2014) 0.79
Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids. PLoS One (2013) 0.79
Sirtuin deacetylases as therapeutic targets in the nervous system. Neurotherapeutics (2013) 0.79
Sirtuins in glucose and lipid metabolism. Oncotarget (2017) 0.78
Molecular mechanisms of protein induced hyperinsulinaemic hypoglycaemia. World J Diabetes (2014) 0.78
Sirtuins as novel players in the pathogenesis of diabetes mellitus. World J Diabetes (2014) 0.78
Post-translational modifications in mitochondria: protein signaling in the powerhouse. Cell Mol Life Sci (2016) 0.77
Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism. Mol Cells (2015) 0.76
Mitochondrial sirtuins in the heart. Heart Fail Rev (2016) 0.76
In Search of New Therapeutic Targets in Obesity Treatment: Sirtuins. Int J Mol Sci (2016) 0.75
Sirtuins in metabolism, DNA repair and cancer. J Exp Clin Cancer Res (2016) 0.75
SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status. Int J Obes (Lond) (2016) 0.75
The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing. PLoS One (2016) 0.75
Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin. PLoS One (2016) 0.75
Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein. Methods Mol Biol (2016) 0.75
SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation. Exp Cell Res (2016) 0.75
Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme. PLoS One (2016) 0.75
Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology. Immunology (2015) 0.75
Acetylation of Mitochondrial Trifunctional Protein α-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease. Mol Cell Biol (2016) 0.75
Equine skeletal muscle adaptations to exercise and training: evidence of differential regulation of autophagosomal and mitochondrial components. BMC Genomics (2017) 0.75
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J (2003) 6.11
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
Towards an HIV cure: a global scientific strategy. Nat Rev Immunol (2012) 5.52
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J (2005) 4.35
Conserved metabolic regulatory functions of sirtuins. Cell Metab (2008) 3.86
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab (2012) 3.69
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science (2010) 3.29
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A (2007) 2.97
Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology (2003) 2.86
The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol (2003) 2.55
CpG methylation controls reactivation of HIV from latency. PLoS Pathog (2009) 2.51
Epigenetic regulation of HIV-1 latency by cytosine methylation. PLoS Pathog (2009) 2.50
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol (2011) 2.49
Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem (2004) 2.47
Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA. PLoS One (2008) 2.47
Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell (2013) 2.32
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell (2002) 2.20
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell (2012) 2.20
HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity (2003) 2.10
Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J (2002) 2.06
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene (2002) 2.02
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A (2013) 2.01
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88
The nexus of chromatin regulation and intermediary metabolism. Nature (2013) 1.87
Transobturator vaginal tape inside out for the surgical treatment of female stress urinary incontinence: anatomical considerations. J Urol (2005) 1.87
Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks. Adv Immunol (2012) 1.83
Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc Natl Acad Sci U S A (2008) 1.80
Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. J Biol Chem (2004) 1.79
The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem (2006) 1.77
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe (2010) 1.76
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76
Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells. Endocrinology (2005) 1.71
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. FASEB J (2005) 1.70
The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J Neurosci (2009) 1.69
Mitochondrial sirtuins. Biochim Biophys Acta (2010) 1.67
Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem (2002) 1.62
De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res (2010) 1.59
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem (2012) 1.58
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem (2007) 1.55
Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab (2012) 1.52
Immunosenescence and HIV. Curr Opin Immunol (2012) 1.51
Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A (2009) 1.50
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One (2007) 1.50
The original versus a modified inside-out transobturator procedure: 1-year results of a prospective randomized trial. Int Urogynecol J (2010) 1.50
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J (2002) 1.49
MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation. Nat Immunol (2013) 1.48
Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis. Circ Res (2007) 1.46
Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43
Histone deacetylase 4 is required for TGFbeta1-induced myofibroblastic differentiation. Biochim Biophys Acta (2007) 1.43
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell (2003) 1.42
Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res (2012) 1.41
Dopamine D2-like receptors are expressed in pancreatic beta cells and mediate inhibition of insulin secretion. J Biol Chem (2005) 1.39
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol (2012) 1.39
Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol (2013) 1.35
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett (2007) 1.34
Regulatory signal transduction pathways for class IIa histone deacetylases. Curr Opin Pharmacol (2010) 1.34
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer (2010) 1.32
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A (2012) 1.31
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J Med Chem (2008) 1.31
Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int J Cancer (2007) 1.30
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A (2011) 1.29
Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes Dev (2007) 1.29
SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28
Mitochondrial dysfunction in pancreatic β cells. Trends Endocrinol Metab (2012) 1.27
Hepatic glucose sensing is required to preserve β cell glucose competence. J Clin Invest (2013) 1.27
Subtype selective substrates for histone deacetylases. J Med Chem (2004) 1.25
In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion. Int J Biochem Cell Biol (2006) 1.25
Acetylation of mitochondrial proteins. Methods Enzymol (2009) 1.24
Intermediate basal cells of the prostate: in vitro and in vivo characterization. Prostate (2003) 1.23
Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. Am J Pathol (2004) 1.22
Preparation of enzymatically active recombinant class III protein deacetylases. Methods (2005) 1.21
A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PLoS One (2009) 1.21
HIV latency: experimental systems and molecular models. FEMS Microbiol Rev (2012) 1.19
New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci (Lond) (2005) 1.19