Published in Endocrinology on January 27, 2005
Adipose tissue: friend or foe? Nat Rev Cardiol (2012) 1.24
Apelin is necessary for the maintenance of insulin sensitivity. Am J Physiol Endocrinol Metab (2009) 1.19
Oxidative stress and metabolic pathologies: from an adipocentric point of view. Oxid Med Cell Longev (2014) 1.16
Abnormal fluid homeostasis in apelin receptor knockout mice. J Endocrinol (2009) 1.08
Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes (2011) 1.05
Leptin, obestatin and apelin levels in patients with obstructive sleep apnoea syndrome. Med Sci Monit (2011) 1.03
Visfatin/Nampt: an adipokine with cardiovascular impact. Mediators Inflamm (2013) 1.03
Regulation of vascular tone by adipocytes. BMC Med (2011) 1.01
HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. Am J Physiol Endocrinol Metab (2007) 1.00
Apelin decreases lipolysis via G(q), G(i), and AMPK-Dependent Mechanisms. Endocrinology (2010) 0.98
The role of obesity in the pathogenesis of hypertension. Nat Clin Pract Nephrol (2008) 0.96
Metabolic effects of obesity: A review. World J Diabetes (2010) 0.94
Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Eur J Endocrinol (2008) 0.94
Reciprocal regulation of plasma apelin and vasopressin by osmotic stimuli. J Am Soc Nephrol (2008) 0.93
Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice. Endocrinology (2012) 0.91
Apelin attenuates the osteoblastic differentiation of vascular smooth muscle cells. PLoS One (2011) 0.91
Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance. Front Endocrinol (Lausanne) (2013) 0.90
Adipocytokines in atherothrombosis: focus on platelets and vascular smooth muscle cells. Mediators Inflamm (2010) 0.90
New aspects of melanocortin signaling: a role for PRCP in α-MSH degradation. Front Neuroendocrinol (2010) 0.87
Central and peripheral apelin receptor distribution in the mouse: species differences with rat. Peptides (2011) 0.87
Resveratrol metabolites modify adipokine expression and secretion in 3T3-L1 pre-adipocytes and mature adipocytes. PLoS One (2013) 0.87
Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis. Biomed Res Int (2014) 0.86
Interrelated reduction of chemerin and plasminogen activator inhibitor-1 serum levels in rheumatoid arthritis after interleukin-6 receptor blockade. Clin Rheumatol (2014) 0.86
Apelin and pulmonary hypertension. Pulm Circ (2011) 0.86
Apelin attenuates oxidative stress in human adipocytes. J Biol Chem (2013) 0.85
World congress on insulin resistance, diabetes, and cardiovascular disease: Part 1. Diabetes Care (2011) 0.85
Adipose tissue and vascular inflammation in coronary artery disease. World J Cardiol (2014) 0.84
Mechanisms of thrombosis in obesity. Curr Opin Hematol (2013) 0.84
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR. Biochem Cell Biol (2014) 0.83
Hypoxia induces apelin expression in human adipocytes. Horm Metab Res (2011) 0.83
The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis. Mamm Genome (2014) 0.82
Evaluation of adipokines: apelin, visfatin, and resistin in children with atopic dermatitis. Mediators Inflamm (2013) 0.82
Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity. FEBS Open Bio (2013) 0.82
Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ. PLoS One (2013) 0.81
Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling. J Biol Chem (2015) 0.81
Pancreatic regulation of glucose homeostasis. Exp Mol Med (2016) 0.81
Apelin serum level in Egyptian patients with chronic hepatitis C. Mediators Inflamm (2011) 0.81
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes. J Biol Chem (2015) 0.81
Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin. Int J Obes (Lond) (2014) 0.81
Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin. Med Sci Monit (2015) 0.81
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg Med Chem Lett (2012) 0.81
What induces watts in WAT? Adipocyte (2016) 0.81
ACE2 deficiency reduces β-cell mass and impairs β-cell proliferation in obese C57BL/6 mice. Am J Physiol Endocrinol Metab (2015) 0.81
Associations of common variants at APLN and hypertension in Chinese subjects with and without diabetes. Exp Diabetes Res (2012) 0.81
Stress-dependent and gender-specific neuroregulatory roles of the apelin receptor in the hypothalamic-pituitary-adrenal axis response to acute stress. J Endocrinol (2013) 0.80
Ontogeny of apelin and its receptor in the rodent gastrointestinal tract. Regul Pept (2009) 0.80
Endothelium as a gatekeeper of fatty acid transport. Trends Endocrinol Metab (2013) 0.79
Adipokines in breast milk: an update. J Clin Res Pediatr Endocrinol (2014) 0.79
Apelin and insulin resistance: another arrow for the quiver? J Diabetes (2011) 0.79
Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current. PLoS One (2015) 0.78
Increased bone mass in mice lacking the adipokine apelin. Endocrinology (2013) 0.78
Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy. Cancer Sci (2015) 0.78
Apelin is a marker of the progression of liver fibrosis and portal hypertension in patients with biliary atresia. Pediatr Surg Int (2013) 0.78
Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients. Int J Ophthalmol (2014) 0.78
The role of apelin in the retina of diabetic rats. PLoS One (2013) 0.78
Adipokines as potential biomarkers in rheumatoid arthritis. Mediators Inflamm (2014) 0.78
Apelin acts in the subfornical organ to influence neuronal excitability and cardiovascular function. J Physiol (2013) 0.78
G-Protein-coupled receptors as potential drug candidates in preeclampsia: targeting the relaxin/insulin-like family peptide receptor 1 for treatment and prevention. Hum Reprod Update (2016) 0.78
Adipokines protecting CKD. Nephrol Dial Transplant (2013) 0.77
Effect of Ramadan fasting on serum concentration of apelin-13 and new obesity indices in healthy adult men. Med Sci Monit (2014) 0.77
Effects of dietary eicosapentaenoic acid (EPA) supplementation in high-fat fed mice on lipid metabolism and apelin/APJ system in skeletal muscle. PLoS One (2013) 0.77
Effect of Aerobic Exercise on Serum Concentration of Apelin, TNFα and Insulin in Obese Women. Iran J Basic Med Sci (2012) 0.77
Altered glucose homeostasis is associated with increased serum apelin levels in type 2 diabetes mellitus. PLoS One (2012) 0.77
The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge. Front Neurosci (2016) 0.76
Associations between serum apelin-12 levels and obesity-related markers in Chinese children. PLoS One (2014) 0.76
Plasma apelin levels in patients with polycystic ovary syndrome. J Turk Ger Gynecol Assoc (2012) 0.76
Effect of leptin and apelin preconditioning on hepatic ischemia reperfusion injury in rats. Indian J Surg (2012) 0.75
Apelin-13 decreases lipid storage in hypertrophic adipocytes in vitro through the upregulation of AQP7 expression by the PI3K signaling pathway. Med Sci Monit (2014) 0.75
Serum apelin levels in patients with thyroid dysfunction. Int J Clin Exp Med (2015) 0.75
Is the adipose tissue a key target of developmental programming of adult adiposity by maternal undernutrition? Adipocyte (2012) 0.75
The Effect of Aerobic Exercise Training on Plasma Apelin Levels and Pain Threshold in T1DM Rats. Iran Red Crescent Med J (2016) 0.75
Apelin and energy metabolism. Front Physiol (2015) 0.75
Parturition dysfunction in obesity: time to target the pathobiology. Reprod Biol Endocrinol (2015) 0.75
Small expression tags enhance bacterial expression of the first three transmembrane segments of the apelin receptor. Biochem Cell Biol (2014) 0.75
Does polycystic ovary syndrome itself have additional effect on apelin levels? Obstet Gynecol Int (2014) 0.75
Adiponectin and Intelectin-1: Important Adipokine Players in Obesity-Related Colorectal Carcinogenesis. Int J Mol Sci (2017) 0.75
Regulation of apelin and its receptor expression in adipose tissues of obesity rats with hypertension and cultured 3T3-L1 adipocytes. Exp Anim (2014) 0.75
Effect of Spironolactone on Plasma Apelin-12 Levels in Patients with Chronic Systolic Heart Failure. Acta Cardiol Sin (2016) 0.75
Is there an association between obstructive sleep apnea syndrome and periodontal inflammation? Clin Oral Investig (2015) 0.75
Serum omentin-1, vaspin, and apelin levels and central obesity in patients with nonalcoholic fatty liver disease. J Res Med Sci (2017) 0.75
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res (2011) 2.85
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota. Gut (2011) 2.50
Primary prevention of nephrolithiasis is cost-effective for a national healthcare system. BJU Int (2012) 2.13
Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. J Neurosci (2007) 1.93
The g protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Dev Cell (2007) 1.68
Phosphatidic acid mediates demyelination in Lpin1 mutant mice. Genes Dev (2008) 1.61
Spectrum of mutations in Gitelman syndrome. J Am Soc Nephrol (2011) 1.57
LPA1 receptor activation promotes renal interstitial fibrosis. J Am Soc Nephrol (2007) 1.51
Morphologic and functional renal impact of acute kidney injury after prolonged hemorrhagic shock in mice. Crit Care Med (2011) 1.48
Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab (2008) 1.48
Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue. Front Microbiol (2011) 1.46
Interaction of fibroblast growth factor and C-natriuretic peptide signaling in regulation of chondrocyte proliferation and extracellular matrix homeostasis. J Cell Sci (2005) 1.40
Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. J Biol Chem (2003) 1.39
TNFalpha up-regulates apelin expression in human and mouse adipose tissue. FASEB J (2006) 1.34
Experimental challenge to a 'rigorous' BRET analysis of GPCR oligomerization. Nat Methods (2007) 1.32
Hydration biomarkers in free-living adults with different levels of habitual fluid consumption. Br J Nutr (2012) 1.31
Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J (2004) 1.29
Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy. Biochimie (2009) 1.29
Genetic investigation of autosomal recessive distal renal tubular acidosis: evidence for early sensorineural hearing loss associated with mutations in the ATP6V0A4 gene. J Am Soc Nephrol (2006) 1.29
S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool. J Pharmacol Exp Ther (2008) 1.28
Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure. Endocrinology (2008) 1.25
Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer. Cancer Res (2013) 1.24
Risk factors of chronic kidney disease in HIV-infected patients. Clin J Am Soc Nephrol (2011) 1.21
Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice. FEBS Lett (2007) 1.19
Unraveling the obesity and breast cancer links: a role for cancer-associated adipocytes? Endocr Dev (2010) 1.18
Adipose tissue and breast epithelial cells: a dangerous dynamic duo in breast cancer. Cancer Lett (2012) 1.16
The adaptor protein Gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase. J Biol Chem (2006) 1.15
Obesity-induced lymphocyte hyperresponsiveness to chemokines: a new mechanism of Fatty liver inflammation in obese mice. Gastroenterology (2008) 1.15
Apelin, diabetes, and obesity. Endocrine (2011) 1.14
Apelin, a promising target for type 2 diabetes treatment? Trends Endocrinol Metab (2012) 1.14
Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2. J Biol Chem (2005) 1.13
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts. PLoS One (2010) 1.12
The apelin receptor is coupled to Gi1 or Gi2 protein and is differentially desensitized by apelin fragments. J Biol Chem (2006) 1.12
Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. J Lipid Res (2011) 1.11
Mouse model of fracture pain. Anesthesiology (2008) 1.10
LRP1 receptor controls adipogenesis and is up-regulated in human and mouse obese adipose tissue. PLoS One (2009) 1.08
Apelin (65-77) activates extracellular signal-regulated kinases via a PTX-sensitive G protein. Biochem Biophys Res Commun (2002) 1.08
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1. Eur Heart J (2011) 1.06
Expression of the murine msr/apj receptor and its ligand apelin is upregulated during formation of the retinal vessels. Mech Dev (2002) 1.06
Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes (2011) 1.05
GFR estimation using standardized cystatin C in kidney transplant recipients. Am J Kidney Dis (2012) 1.05
Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. Mol Pharmacol (2011) 1.05
Lysophosphatidic acid and renal fibrosis. Biochim Biophys Acta (2008) 1.04
Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy. FEBS Lett (2010) 1.03
Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes. Endocrinology (2009) 1.03
Therapeutic potential of interfering with apelin signalling. Drug Discov Today (2006) 1.03
p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice. Antioxid Redox Signal (2012) 1.02
Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes (2011) 1.02
Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization. J Biol Chem (2008) 1.02
Adipose tissue proadipogenic redox changes in obesity. J Biol Chem (2005) 1.02
The msr/apj gene encoding the apelin receptor is an early and specific marker of the venous phenotype in the retinal vasculature. Gene Expr Patterns (2003) 1.00
Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation. Diabetes (2009) 1.00
Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice. J Neurosci (2012) 0.99
Cancer-associated adipocytes promotes breast tumor radioresistance. Biochem Biophys Res Commun (2011) 0.99
MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin. Eur J Pharmacol (2003) 0.98
Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature. Proc Natl Acad Sci U S A (2012) 0.98
Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans. Am J Physiol Endocrinol Metab (2010) 0.98
Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. J Biol Chem (2006) 0.97
Secretion of a lysophospholipase D activity by adipocytes: involvement in lysophosphatidic acid synthesis. J Lipid Res (2002) 0.97
Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study. Crit Care (2011) 0.97
Is Crohn's creeping fat an adipose tissue? Inflamm Bowel Dis (2011) 0.96
Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis. PLoS One (2011) 0.96
Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice. Antioxid Redox Signal (2011) 0.96