Published in Am J Respir Cell Mol Biol on January 27, 2005
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55
The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4. J Biol Chem (2011) 2.20
Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat Immunol (2009) 2.06
Regulation of reactive oxygen species generation in cell signaling. Mol Cells (2011) 1.85
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal (2009) 1.71
Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans. PLoS Pathog (2011) 1.59
Mechanisms of acid and base secretion by the airway epithelium. J Membr Biol (2006) 1.57
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NADPH oxidases in lung biology and pathology: host defense enzymes, and more. Free Radic Biol Med (2007) 1.50
Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med (2008) 1.44
Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization. Mol Cell Biol (2009) 1.41
Respiratory epithelial gene expression in patients with mild and severe cystic fibrosis lung disease. Am J Respir Cell Mol Biol (2006) 1.39
Mechanisms and function of DUOX in epithelia of the lung. Antioxid Redox Signal (2009) 1.38
Dual oxidases. Philos Trans R Soc Lond B Biol Sci (2005) 1.37
Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation. FASEB J (2008) 1.36
The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells. J Immunol (2008) 1.35
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
Epidermal growth factor receptor activation by epidermal growth factor mediates oxidant-induced goblet cell metaplasia in human airway epithelium. Am J Respir Cell Mol Biol (2006) 1.30
NOX enzymes and pulmonary disease. Antioxid Redox Signal (2009) 1.29
Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease. Am J Respir Cell Mol Biol (2006) 1.25
The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett (2006) 1.23
ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli. J Biol Chem (2009) 1.21
Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections. Trends Microbiol (2012) 1.18
Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli. Free Radic Biol Med (2009) 1.17
NOX enzymes and Toll-like receptor signaling. Semin Immunopathol (2008) 1.13
Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells. J Cell Sci (2009) 1.11
An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1/Th2 nitrative stress in human severe asthma. Mucosal Immunol (2014) 1.09
Biomphalaria glabrata transcriptome: identification of cell-signalling, transcriptional control and immune-related genes from open reading frame expressed sequence tags (ORESTES). Dev Comp Immunol (2006) 1.08
Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways. J Immunol (2010) 1.04
Role of DUOX in gut inflammation: lessons from Drosophila model of gut-microbiota interactions. Front Cell Infect Microbiol (2014) 1.03
Inhibitory action of NoxA1 on dual oxidase activity in airway cells. J Biol Chem (2008) 1.01
Nox enzymes in immune cells. Semin Immunopathol (2008) 1.01
Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1. J Virol (2011) 1.00
NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone. Am J Physiol Heart Circ Physiol (2012) 0.99
NADPH oxidases: a perspective on reactive oxygen species production in tumor biology. Antioxid Redox Signal (2013) 0.99
The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. Toxicol Lett (2009) 0.98
ATP-mediated transactivation of the epidermal growth factor receptor in airway epithelial cells involves DUOX1-dependent oxidation of Src and ADAM17. PLoS One (2013) 0.98
Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. Am J Respir Cell Mol Biol (2011) 0.97
Regulation of hydrogen peroxide release in circulating hemocytes of the planorbid snail Biomphalaria glabrata. Dev Comp Immunol (2007) 0.96
Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin. Immunol Res (2009) 0.96
Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa. FEBS Lett (2010) 0.95
Genetic disorders coupled to ROS deficiency. Redox Biol (2015) 0.94
Recent insights into the cell biology of thyroid angiofollicular units. Endocr Rev (2013) 0.93
IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
The effect of inhaled chromium on different exhaled breath condensate biomarkers among chrome-plating workers. Environ Health Perspect (2006) 0.91
Nox enzymes in allergic airway inflammation. Biochim Biophys Acta (2011) 0.91
Dual oxidase-1 is required for airway epithelial cell migration and bronchiolar reepithelialization after injury. Am J Respir Cell Mol Biol (2012) 0.91
Perinatal lamb model of respiratory syncytial virus (RSV) infection. Viruses (2012) 0.91
IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response. Cell Res (2013) 0.90
Increased concentration of iodide in airway secretions is associated with reduced respiratory syncytial virus disease severity. Am J Respir Cell Mol Biol (2014) 0.90
The SKPO-1 peroxidase functions in the hypodermis to protect Caenorhabditis elegans from bacterial infection. Genetics (2014) 0.90
Dual oxidase regulates neutrophil recruitment in allergic airways. Free Radic Biol Med (2013) 0.89
Functional activity and tumor-specific expression of dual oxidase 2 in pancreatic cancer cells and human malignancies characterized with a novel monoclonal antibody. Int J Oncol (2013) 0.89
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans. Am J Pathol (2008) 0.89
Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions. Free Radic Biol Med (2011) 0.86
Voltage-gated proton channels. Compr Physiol (2012) 0.85
Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase. Am J Respir Cell Mol Biol (2014) 0.85
Epigenetic silencing of dual oxidase 1 by promoter hypermethylation in human hepatocellular carcinoma. Am J Cancer Res (2014) 0.85
Genetic polymorphisms and susceptibility to lung disease. J Negat Results Biomed (2006) 0.84
All-trans retinoic acid mediates DUOX2 expression and function in respiratory tract epithelium. Am J Physiol Lung Cell Mol Physiol (2010) 0.84
Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells. J Virol (2014) 0.83
NADPH oxidase mediates synergistic effects of IL-17 and TNF-α on CXCL1 expression by epithelial cells after lung ischemia-reperfusion. Am J Physiol Lung Cell Mol Physiol (2013) 0.83
H2O2 stimulates cystic fibrosis transmembrane conductance regulator through an autocrine prostaglandin pathway, using multidrug-resistant protein-4. Am J Respir Cell Mol Biol (2013) 0.82
IFNgamma mediates DUOX2 expression via a STAT-independent signaling pathway. Biochem Biophys Res Commun (2010) 0.82
Expression of dual oxidases and secreted cytokines in chronic rhinosinusitis. Int Forum Allergy Rhinol (2012) 0.81
NADPH oxidases in lung health and disease. Antioxid Redox Signal (2014) 0.81
Catalase overexpression fails to attenuate allergic airways disease in the mouse. J Immunol (2007) 0.80
Lamb model of respiratory syncytial virus-associated lung disease: insights to pathogenesis and novel treatments. ILAR J (2014) 0.80
Molecular heterogeneity and alternative splicing of human lactoperoxidase. Arch Biochem Biophys (2008) 0.80
Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice. Antioxid Redox Signal (2014) 0.79
Localization of the Dual Oxidase BLI-3 and Characterization of Its NADPH Oxidase Domain during Infection of Caenorhabditis elegans. PLoS One (2015) 0.79
Myeloperoxidase-dependent oxidative metabolism of nitric oxide in the cystic fibrosis airway. J Cyst Fibros (2010) 0.78
DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon. Gastroenterol Res Pract (2015) 0.77
Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2. Free Radic Biol Med (2014) 0.77
Implication of NADPH oxidases in the early inflammation process generated by cystic fibrosis cells. ISRN Inflamm (2012) 0.76
DUOX-Mediated Signaling Is Not Required for LPS-Induced Neutrophilic Response in the Airways. PLoS One (2015) 0.75
NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma. Chest (2016) 0.75
Hydrogen Peroxide and Sodium Transport in the Lung and Kidney. Biomed Res Int (2016) 0.75
Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function. Respir Res (2016) 0.75
GnRH Regulates Gonadotropin Gene Expression Through NADPH/Dual Oxidase-Derived Reactive Oxygen Species. Endocrinology (2015) 0.75
Redox mechanisms in age-related lung fibrosis. Redox Biol (2016) 0.75
Bordetella bronchiseptica responses to physiological reactive nitrogen and oxygen stresses. FEMS Microbiol Lett (2008) 0.75
Cigarette Smoke Impairs A2A Adenosine Receptor Mediated Wound Repair through Up-regulation of Duox-1 Expression. Sci Rep (2017) 0.75
Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation. Redox Biol (2017) 0.75
Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol (2009) 1.89
Lactoperoxidase and human airway host defense. Am J Respir Cell Mol Biol (2003) 1.57
Clinical characteristics of subjects with symptoms of alpha1-antitrypsin deficiency older than 60 years. Chest (2008) 1.47
Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia. Am J Respir Cell Mol Biol (2002) 1.43
Purification and characterization of PLUNC from human tracheobronchial secretions. Am J Respir Cell Mol Biol (2003) 1.32
Characterization of ThOX proteins as components of the thyroid H(2)O(2)-generating system. Exp Cell Res (2002) 1.32
Transcellular thiocyanate transport by human airway epithelia. J Physiol (2004) 1.30
Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol (2007) 1.29
Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation. J Biol Chem (2009) 1.29
The lactoperoxidase system links anion transport to host defense in cystic fibrosis. FEBS Lett (2006) 1.23
Prolonged increase in ciliary beat frequency after short-term purinergic stimulation in human airway epithelial cells. J Physiol (2002) 1.22
Lactoperoxidase and hydrogen peroxide metabolism in the airway. Am J Respir Crit Care Med (2002) 1.19
Real-time analysis of cAMP-mediated regulation of ciliary motility in single primary human airway epithelial cells. J Cell Sci (2006) 1.17
Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli. Free Radic Biol Med (2009) 1.17
Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON. Am J Respir Cell Mol Biol (2007) 1.14
Role of hyaluronan and reactive oxygen species in tissue kallikrein-mediated epidermal growth factor receptor activation in human airways. J Biol Chem (2004) 1.13
Developmental regulation of DUOX1 expression and function in human fetal lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2007) 1.10
Hydrogen peroxide-scavenging properties of normal human airway secretions. Am J Respir Crit Care Med (2002) 1.07
Hydrogen peroxide induces DNA single- and double-strand breaks in thyroid cells and is therefore a potential mutagen for this organ. Endocr Relat Cancer (2009) 1.06
The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling. Sci Signal (2010) 1.06
Regulation of human airway ciliary beat frequency by intracellular pH. J Physiol (2004) 1.04
Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume. J Biol Chem (2011) 1.00
Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation. J Biol Chem (2010) 0.98
Norepinephrine transport by the extraneuronal monoamine transporter in human bronchial arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2003) 0.97
Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway. Am J Respir Cell Mol Biol (2006) 0.95
Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. J Biol Chem (2004) 0.93
IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH oxidase-mediated airway antiviral response. Cell Res (2013) 0.90
Mucous solids and liquid secretion by airways: studies with normal pig, cystic fibrosis human, and non-cystic fibrosis human bronchi. Am J Physiol Lung Cell Mol Physiol (2011) 0.89
Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling. Antioxid Redox Signal (2013) 0.89
Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. FEBS Lett (2007) 0.87
Effects of albuterol enantiomers on ciliary beat frequency in ovine tracheal epithelial cells. J Appl Physiol (1985) (2002) 0.86
Albuterol modulates its own transepithelial flux via changes in paracellular permeability. Am J Respir Cell Mol Biol (2011) 0.86
The effect of corticosteroids on the disposal of long-acting beta2-agonists by airway smooth muscle cells. J Allergy Clin Immunol (2007) 0.85
Ciliary beat co-ordination by calcium. Biol Cell (2011) 0.85
Duox1 is the main source of hydrogen peroxide in the rat thyroid cell line PCCl3. Exp Cell Res (2007) 0.84
H2O2 stimulates cystic fibrosis transmembrane conductance regulator through an autocrine prostaglandin pathway, using multidrug-resistant protein-4. Am J Respir Cell Mol Biol (2013) 0.82
Gene expression in RET/PTC3 and E7 transgenic mouse thyroids: RET/PTC3 but not E7 tumors are partial and transient models of human papillary thyroid cancers. Endocrinology (2008) 0.82
Submersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent manner. Am J Respir Cell Mol Biol (2014) 0.82
Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2. Free Radic Biol Med (2012) 0.82
Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis. Mol Endocrinol (2011) 0.82
Transforming growth factor-β1 and cigarette smoke inhibit the ability of β2-agonists to enhance epithelial permeability. Am J Respir Cell Mol Biol (2015) 0.81
Rapid nongenomic actions of inhaled corticosteroids on long-acting β(2)-agonist transport in the airway. Pulm Pharmacol Ther (2011) 0.81
A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice. Am J Respir Cell Mol Biol (2014) 0.81
Molecular heterogeneity and alternative splicing of human lactoperoxidase. Arch Biochem Biophys (2008) 0.80
Exacerbations in subjects with alpha-1 antitrypsin deficiency receiving augmentation therapy. Respir Med (2009) 0.80
Stroma cell-derived factor-1α signaling enhances calcium transients and beating frequency in rat neonatal cardiomyocytes. PLoS One (2013) 0.80
Post-secretory fate of host defence components in mucus. Novartis Found Symp (2002) 0.79
The type of DUOX-dependent ROS production is dictated by defined sequences in DUOXA. Exp Cell Res (2012) 0.78
Comparative analysis of the thyrocytes and T cells: responses to H2O2 and radiation reveals an H2O2-induced antioxidant transcriptional program in thyrocytes. J Clin Endocrinol Metab (2013) 0.77
Systemic ovalbumin sensitization downregulates norepinephrine uptake by rabbit aortic smooth muscle cells. Am J Respir Cell Mol Biol (2002) 0.77
Wood combustion particles induce adverse effects to normal and diseased airway epithelia. Environ Sci Process Impacts (2017) 0.75