PubRank

Timothy W Lovenberg

Author PubWeight™ 54.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Oxysterols direct B-cell migration through EBI2. Nature 2011 1.94
2 Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. J Biol Chem 2008 1.75
3 Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J Pharmacol Exp Ther 2009 1.40
4 Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem 2003 1.39
5 Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. J Neurosci 2002 1.33
6 The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem 2003 1.28
7 Behavioral characterization of mice lacking histamine H(3) receptors. Mol Pharmacol 2002 1.26
8 Identification of relaxin-3/INSL7 as a ligand for GPCR142. J Biol Chem 2003 1.19
9 INSL5 is a high affinity specific agonist for GPCR142 (GPR100). J Biol Chem 2004 1.12
10 International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev 2011 1.11
11 Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement. Psychopharmacology (Berl) 2010 1.08
12 R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization. J Biol Chem 2007 1.03
13 A novel form of neurotensin post-translationally modified by arginylation. J Biol Chem 2005 1.01
14 Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents. J Pharmacol Exp Ther 2007 0.99
15 Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Proc Natl Acad Sci U S A 2001 0.97
16 Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors. Mol Pharmacol 2003 0.95
17 Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing. Neuroendocrinology 2005 0.95
18 Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. Mol Pharmacol 2004 0.94
19 3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther 2012 0.92
20 The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety. Alcohol 2010 0.92
21 Non-imidazole heterocyclic histamine H3 receptor antagonists. Bioorg Med Chem Lett 2003 0.90
22 Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor. Eur J Pharmacol 2007 0.90
23 In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. Psychopharmacology (Berl) 2009 0.90
24 Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem 2005 0.89
25 Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission. PLoS One 2011 0.88
26 Molecular and pharmacological characterization of the mouse histamine H3 receptor. Eur J Pharmacol 2003 0.88
27 Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling. Bioorg Med Chem 2007 0.87
28 JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl) 2010 0.87
29 Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br J Pharmacol 2013 0.87
30 Reconsideration of 5-hydroxytryptamine (5-HT)(7) receptor distribution using [(3)H]5-carboxamidotryptamine and [(3)H]8-hydroxy-2-(di-n-propylamino)tetraline: analysis in brain of 5-HT(1A) knockout and 5-HT(1A/1B) double-knockout mice. J Pharmacol Exp Ther 2002 0.86
31 Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species. J Pharmacol Exp Ther 2004 0.86
32 Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site. Mol Pharmacol 2012 0.86
33 Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice. Neuropharmacology 2005 0.85
34 JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. Neuropharmacology 2009 0.85
35 Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder. J Pharmacol Exp Ther 2012 0.84
36 A high-throughput-compatible assay for determining the activity of fatty acid amide hydrolase. Anal Biochem 2003 0.84
37 Aplysamine-1 and related analogs as histamine H3 receptor antagonists. Bioorg Med Chem Lett 2005 0.84
38 A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. J Med Chem 2003 0.83
39 Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development. Bioorg Med Chem Lett 2010 0.83
40 Relaxin-3, INSL5, and their receptors. Results Probl Cell Differ 2008 0.83
41 Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists. Bioorg Med Chem Lett 2004 0.83
42 The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor. Bioorg Med Chem Lett 2011 0.82
43 Relaxin family peptides and receptors in mammalian brain. Ann N Y Acad Sci 2009 0.81
44 Novel human histamine H(3) receptor antagonists. Bioorg Med Chem Lett 2002 0.81
45 Novel non-peptidic neuropeptide Y Y2 receptor antagonists. Bioorg Med Chem Lett 2004 0.81
46 Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J Pharmacol Exp Ther 2003 0.80
47 In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor. Eur J Pharmacol 2008 0.80
48 G-protein-coupled receptor (GPCR)-142 does not contribute to relaxin-3 binding in the mouse brain: further support that relaxin-3 is the physiological ligand for GPCR135. Neuroendocrinology 2006 0.79
49 Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135). Eur J Pharmacol 2008 0.77
50 Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore. Bioorg Med Chem Lett 2006 0.77
51 Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog. Eur J Pharmacol 2005 0.77
52 Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors. Bioorg Med Chem Lett 2007 0.77
53 Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores. Bioorg Med Chem Lett 2007 0.76
54 Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors. Bioorg Med Chem Lett 2007 0.76
55 Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors. Bioorg Med Chem Lett 2007 0.76
56 The discovery of potent selective NPY Y(2) antagonists. Bioorg Med Chem Lett 2013 0.76
57 Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors. Bioorg Med Chem Lett 2006 0.75
58 Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity. Bioorg Med Chem Lett 2007 0.75
59 Novel glycine transporter type-2 reuptake inhibitors. Part 2: beta- and gamma-amino acid derivatives. Bioorg Med Chem 2004 0.75
60 Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines. Eur J Med Chem 2009 0.75
61 2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists. Bioorg Med Chem Lett 2008 0.75
62 Recent progress in relaxin-3-related research. Ann N Y Acad Sci 2005 0.75
63 Inhibitors of the glycine transporter type-2 (GlyT-2): synthesis and biological activity of benzoylpiperidine derivatives. Bioorg Med Chem 2004 0.75
64 Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists. Bioorg Med Chem Lett 2010 0.75
65 Novel glycine transporter type-2 reuptake inhibitors. Part 1: alpha-amino acid derivatives. Bioorg Med Chem 2004 0.75
66 Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate. J Med Chem 2015 0.75
67 Novel imidazole-based histamine H3 antagonists. Bioorg Med Chem Lett 2008 0.75
68 4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists. J Med Chem 2005 0.75
69 Indole- and benzothiophene-based histamine H3 antagonists. Bioorg Med Chem Lett 2010 0.75
70 Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists. Eur J Med Chem 2009 0.75