Published in J Biol Chem on July 02, 2007
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
Relaxin-3 stimulates the hypothalamic-pituitary-gonadal axis. Am J Physiol Endocrinol Metab (2008) 0.99
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides. Pharmacol Rev (2015) 0.97
Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity. Br J Pharmacol (2013) 0.89
Structure of the R3/I5 chimeric relaxin peptide, a selective GPCR135 and GPCR142 agonist. J Biol Chem (2008) 0.88
Relaxin-3/RXFP3 system regulates alcohol-seeking. Proc Natl Acad Sci U S A (2013) 0.87
Relaxin' the brain: a case for targeting the nucleus incertus network and relaxin-3/RXFP3 system in neuropsychiatric disorders. Br J Pharmacol (2016) 0.86
A relaxin-like peptide purified from radial nerves induces oocyte maturation and ovulation in the starfish, Asterina pectinifera. Proc Natl Acad Sci U S A (2009) 0.85
The minimal active structure of human relaxin-2. J Biol Chem (2011) 0.85
Distribution, physiology and pharmacology of relaxin-3/RXFP3 systems in brain. Br J Pharmacol (2016) 0.84
Sex-specific effects of relaxin-3 on food intake and body weight gain. Br J Pharmacol (2016) 0.82
Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases? Front Pharmacol (2014) 0.81
Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3. Front Endocrinol (Lausanne) (2013) 0.81
The structural determinants of insulin-like Peptide 3 activity. Front Endocrinol (Lausanne) (2012) 0.80
Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3). Br J Pharmacol (2014) 0.79
In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. PLoS One (2012) 0.79
Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function. PLoS One (2012) 0.79
C-terminus of the B-chain of relaxin-3 is important for receptor activity. PLoS One (2013) 0.78
Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4. Sci Rep (2016) 0.76
Relaxin-3/RXFP3 Signaling and Neuroendocrine Function - A Perspective on Extrinsic Hypothalamic Control. Front Endocrinol (Lausanne) (2013) 0.76
The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4. Naunyn Schmiedebergs Arch Pharmacol (2016) 0.76
Relaxin family peptides: Structure-activity relationship studies. Br J Pharmacol (2016) 0.75
Single-cell microarray analysis in hippocampus CA1: demonstration and validation of cellular heterogeneity. J Neurosci (2003) 2.60
Altered sleep regulation in leptin-deficient mice. Am J Physiol Regul Integr Comp Physiol (2005) 2.22
Comparative study on ChIP-seq data: normalization and binding pattern characterization. Bioinformatics (2009) 2.02
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. J Neurosci (2003) 1.97
Oxysterols direct B-cell migration through EBI2. Nature (2011) 1.94
Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. J Neurosci (2003) 1.88
Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity. J Neurosci (2008) 1.86
Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli. J Clin Invest (2004) 1.82
Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms. Br J Pharmacol (2006) 1.77
Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81. J Biol Chem (2008) 1.75
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J Biol Chem (2002) 1.71
Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats. Hypertension (2010) 1.58
Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J Biol Chem (2001) 1.57
Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Proc Natl Acad Sci U S A (2004) 1.55
A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology. BMC Genomics (2008) 1.49
Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules. J Biol Chem (2006) 1.43
8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents. Eur J Pharmacol (2004) 1.40
Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat. J Pharmacol Exp Ther (2009) 1.40
Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem (2003) 1.39
H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem (2002) 1.38
Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. J Neurosci (2002) 1.33
Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1. Mol Pharmacol (2005) 1.32
Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Endocrinology (2004) 1.29
The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem (2003) 1.28
Behavioral characterization of mice lacking histamine H(3) receptors. Mol Pharmacol (2002) 1.26
Cardiovascular effects of relaxin: from basic science to clinical therapy. Nat Rev Cardiol (2009) 1.26
Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats. Hypertension (2005) 1.22
Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer (2011) 1.22
Evolution of the relaxin-like peptide family. BMC Evol Biol (2005) 1.20
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist. J Med Chem (2005) 1.20
Identification of relaxin-3/INSL7 as a ligand for GPCR142. J Biol Chem (2003) 1.19
Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8). J Pharmacol Exp Ther (2005) 1.17
Nuclei and subnuclei gene expression profiling in mammalian brain. Brain Res (2002) 1.15
Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array. BMC Genomics (2008) 1.15
Membrane receptors: structure and function of the relaxin family peptide receptors. Mol Cell Endocrinol (2010) 1.14
Genomic and functional conservation of sedative-hypnotic targets in the zebrafish. Pharmacogenet Genomics (2007) 1.14
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation. J Biol Chem (2003) 1.14
Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity. J Biol Chem (2005) 1.14
Designer antibacterial peptides kill fluoroquinolone-resistant clinical isolates. J Med Chem (2005) 1.13
Chromatin remodeling and modification during HIV-1 Tat-activated transcription. Curr HIV Res (2003) 1.12
INSL5 is a high affinity specific agonist for GPCR142 (GPR100). J Biol Chem (2004) 1.12
International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B). Pharmacol Rev (2011) 1.11
Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. J Biol Chem (2006) 1.10
Genome-wide mapping of RNA Pol-II promoter usage in mouse tissues by ChIP-seq. Nucleic Acids Res (2010) 1.10
Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2. FASEB J (2008) 1.09
Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement. Psychopharmacology (Berl) (2010) 1.08
The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors. J Biol Chem (2008) 1.06
Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo. Protein Sci (2008) 1.05
Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett (2008) 1.05
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg (2009) 1.04
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest (2005) 1.04
Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms. Mol Pharmacol (2006) 1.03
Inference of hierarchical regulatory network of estrogen-dependent breast cancer through ChIP-based data. BMC Syst Biol (2010) 1.03
Relaxin-3: improved synthesis strategy and demonstration of its high-affinity interaction with the relaxin receptor LGR7 both in vitro and in vivo. Biochemistry (2006) 1.03
Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis. FASEB J (2002) 1.03
The human insulin superfamily of polypeptide hormones. Vitam Horm (2009) 1.02
A novel form of neurotensin post-translationally modified by arginylation. J Biol Chem (2005) 1.01
Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria. Amino Acids (2014) 1.01
Reproductive biology of the relaxin-like factor (RLF/INSL3). Biol Reprod (2002) 1.01
Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS. PLoS One (2012) 1.01
Modulation of DNA methylation by a sesquiterpene lactone parthenolide. J Pharmacol Exp Ther (2009) 0.99
Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. J Biol Chem (2005) 0.99
Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents. J Pharmacol Exp Ther (2007) 0.99
Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions. Mol Pharmacol (2011) 0.99
Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production. Proc Natl Acad Sci U S A (2013) 0.98