A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils.

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Published in Food Chem Toxicol on March 01, 2005

Authors

R L Smith1, S M Cohen, J Doull, V J Feron, J I Goodman, L J Marnett, P S Portoghese, W J Waddell, B M Wagner, R L Hall, N A Higley, C Lucas-Gavin, T B Adams

Author Affiliations

1: Division of Biomedical Sciences, Section of Molecular Toxicology, Imperial College School of Medicine, South Kensington, London SW7 2AZ, UK.

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The nomenclature of cell death: recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists. Toxicol Pathol (1999) 3.73

Port site metastases after laparoscopic colorectal surgery for cure of malignancy. Br J Surg (1995) 3.64

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Cellular applications of 31P and 13C nuclear magnetic resonance. Science (1979) 3.14

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell (2000) 3.10

Immunofluorescent detection of antibody to lymphocytic choriomeningitis virus in man. J Immunol (1966) 2.98

Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice. J Pharmacol Exp Ther (1991) 2.96

Dpp gradient formation in the Drosophila wing imaginal disc. Cell (2000) 2.91

Wingless gradient formation in the Drosophila wing. Curr Biol (2000) 2.83

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res (2001) 2.69

The "cause of death" is dying. Mod Pathol (1993) 2.68

Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development (1997) 2.55

Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. J Biol Chem (2000) 2.48

International Union of Pharmacology. XII. Classification of opioid receptors. Pharmacol Rev (1996) 2.43

Mortality and mental health: evidence from the Midtown Manhattan Restudy. Soc Sci Med (1977) 2.36

Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development (1995) 2.36

Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs. Nature (1994) 2.33

apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins. Genes Dev (1992) 2.33

Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Arch Ophthalmol (1991) 2.31

13C NMR studies of gluconeogenesis in rat liver cells: utilization of labeled glycerol by cells from euthyroid and hyperthyroid rats. Proc Natl Acad Sci U S A (1979) 2.19

Binaltorphimine and nor-binaltorphimine, potent and selective kappa-opioid receptor antagonists. Life Sci (1987) 2.19

Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology (1999) 2.16

Reduced nicotinamide adenine dinucleotide-nitrate reductase of Chlorella vulgaris. Purification, prosthetic groups, and molecular properties. J Biol Chem (1975) 2.12

The future of environmental and toxicologic pathology. Hum Pathol (1996) 2.10

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The fetal larynx and pharynx: structure and development on two- and three-dimensional ultrasound. Ultrasound Obstet Gynecol (2013) 2.03

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Experience in Treatment of War Burns. Br Med J (1940) 1.93

Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell (1992) 1.91

Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila. Cell (1993) 1.90

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Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function. Genes Dev (1998) 1.87

Prostaglandin endoperoxide synthase: structure and catalysis. Biochim Biophys Acta (1991) 1.87

Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver. Science (1994) 1.86

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Epidemiology and etiology of bladder cancer. Semin Surg Oncol (1997) 1.83

Prostaglandin and thromboxane biosynthesis. Pharmacol Ther (1991) 1.81

Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis. Cancer Res (1979) 1.81

Nitrate, nitrite and N-nitroso compounds. Eur J Pharmacol (1994) 1.81

A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities. J Med Chem (1980) 1.80

Rubella antibody in IgG and IgM immunoglobulins detected by immunofluorescence. J Lab Clin Med (1968) 1.80

Na+ transport in normal and CF human bronchial epithelial cells is inhibited by BAY 39-9437. Am J Physiol Lung Cell Mol Physiol (2001) 1.80

Antagonistic interactions between wingless and decapentaplegic responsible for dorsal-ventral pattern in the Drosophila Leg. Science (1996) 1.79

Structural insights into the stereochemistry of the cyclooxygenase reaction. Nature (2000) 1.79

Maximal power across the lifespan. J Gerontol A Biol Sci Med Sci (2000) 1.78

A Drosophila homologue of human Sp1 is a head-specific segmentation gene. Nature (1993) 1.75

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors. Proc Natl Acad Sci U S A (2000) 1.75

DNA sequences required for expression of a Dictyostelium actin gene. EMBO J (1986) 1.75

Assessment of major and daily stressful events during adolescence: the Adolescent Perceived Events Scale. J Consult Clin Psychol (1987) 1.74

Nor-binaltorphimine, a highly selective kappa-opioid antagonist in analgesic and receptor binding assays. J Pharmacol Exp Ther (1988) 1.73

Evolutionary origin of insect wings from ancestral gills. Nature (1997) 1.71

Immunochemical characterization of related families of glycoproteins in desmosomes. J Biol Chem (1983) 1.70

IkappaB kinase, a molecular target for inhibition by 4-hydroxy-2-nonenal. J Biol Chem (2001) 1.68

Dpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc. Development (1998) 1.67

Analysis with intact tissue with 31P NMR. Annu Rev Biophys Bioeng (1979) 1.67

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Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development (1996) 1.65

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem (2000) 1.63

Sensory irritation to mixtures of formaldehyde, acrolein, and acetaldehyde in rats. Arch Toxicol (1996) 1.62

Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures. AIDS (1990) 1.61

Allocation of the thoracic imaginal primordia in the Drosophila embryo. Development (1993) 1.60

Is early oral feeding safe after elective colorectal surgery? A prospective randomized trial. Ann Surg (1995) 1.60

Proximal-distal axis formation in the Drosophila leg. Nature (1997) 1.57

Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal. Proc Natl Acad Sci U S A (1998) 1.57

Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutat Res (1985) 1.56

Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Crit Rev Toxicol (2007) 1.54

Effects of kappa opioids on cocaine self-administration by rhesus monkeys. J Pharmacol Exp Ther (1997) 1.52

The binding of arachidonic acid in the cyclooxygenase active site of mouse prostaglandin endoperoxide synthase-2 (COX-2). A putative L-shaped binding conformation utilizing the top channel region. J Biol Chem (1999) 1.52

Specification of the wing by localized expression of wingless protein. Nature (1996) 1.52

Shaping morphogen gradients. Cell (2001) 1.52

Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature (1995) 1.51

31P nuclear magnetic relaxation studies of phosphocreatine in intact muscle: determination of intracellular free magnesium. Proc Natl Acad Sci U S A (1977) 1.47

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Immunological comparison of desmosomal components from several bovine tissues. J Cell Biochem (1984) 1.46

Risk of fetal loss in twin pregnancies undergoing second trimester amniocentesis(1). Obstet Gynecol (2001) 1.45

Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin. J Biol Chem (1985) 1.45

Duplex DNA catalyzes the chemical rearrangement of a malondialdehyde deoxyguanosine adduct. Proc Natl Acad Sci U S A (1999) 1.44

The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing. Cell (2001) 1.44

Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Arch Biochem Biophys (1988) 1.43

Regulation of LIM homeodomain activity in vivo: a tetramer of dLDB and apterous confers activity and capacity for regulation by dLMO. Mol Cell (1999) 1.43

Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing. Development (1995) 1.43

Mutagenicity in Escherichia coli of the major DNA adduct derived from the endogenous mutagen malondialdehyde. Proc Natl Acad Sci U S A (1997) 1.43

Two-year feeding amd multigeneration studies in rats on five chemically modified starches. Food Cosmet Toxicol (1974) 1.42

Ulnar compression neuropathy secondary to the anconeus epitrochlearis muscle. J Hand Surg Am (1988) 1.42

Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radic Biol Med (2005) 1.42

Simultaneous 13C and 31P NMR studies of perfused rat liver. Effects of insulin and glucagon and a 13C NMR assay of free Mg2+. J Biol Chem (1983) 1.41

Procedures for health risk assessment in Europe. Regul Toxicol Pharmacol (2001) 1.41

Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. Cancer Res (1999) 1.40

Estimation of toxic hazard--a decision tree approach. Food Cosmet Toxicol (1978) 1.40

Peroxynitrite, the coupling product of nitric oxide and superoxide, activates prostaglandin biosynthesis. Proc Natl Acad Sci U S A (1996) 1.40

Amputation Under Ice Anaesthesia [Abridged]. Proc R Soc Med (1944) 1.40

The self-appointed purifiers of science. Mod Pathol (1992) 1.39

Total and direct-reacting bilirubin values by automated methods compared with liquid chromatography and with manual methods for determining delta bilirubin. Clin Chem (1990) 1.39

Cyclooxygenase enzymes: catalysis and inhibition. Curr Opin Struct Biol (2001) 1.39