| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Nitrate, nitrite and N-nitroso compounds.
|
Eur J Pharmacol
|
1994
|
1.81
|
|
2
|
Sensory irritation to mixtures of formaldehyde, acrolein, and acetaldehyde in rats.
|
Arch Toxicol
|
1996
|
1.62
|
|
3
|
Two-year feeding amd multigeneration studies in rats on five chemically modified starches.
|
Food Cosmet Toxicol
|
1974
|
1.42
|
|
4
|
Procedures for health risk assessment in Europe.
|
Regul Toxicol Pharmacol
|
2001
|
1.41
|
|
5
|
Subacute toxicity of a mixture of nine chemicals in rats: detecting interactive effects with a fractionated two-level factorial design.
|
Fundam Appl Toxicol
|
1997
|
1.18
|
|
6
|
Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10 ppm formaldehyde.
|
J Appl Toxicol
|
1989
|
1.17
|
|
7
|
Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study.
|
Toxicology
|
1986
|
1.09
|
|
8
|
Respiratory tract tumors in hamsters after intratracheal instillations of benzo(a)pyrene alone and with furfural.
|
Cancer Res
|
1972
|
1.05
|
|
9
|
Toxicology of simple and complex mixtures.
|
Trends Pharmacol Sci
|
2001
|
1.03
|
|
10
|
Toxicological evaluation and risk assessment of chemical mixtures.
|
Crit Rev Toxicol
|
1998
|
1.02
|
|
11
|
Changes in the nasal epithelium of rats exposed by inhalation to mixtures of formaldehyde, acetaldehyde, and acrolein.
|
Fundam Appl Toxicol
|
1996
|
1.01
|
|
12
|
Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
|
Food Chem Toxicol
|
2002
|
1.00
|
|
13
|
Subchronic inhalation toxicity of amorphous silicas and quartz dust in rats.
|
Food Chem Toxicol
|
1991
|
0.97
|
|
14
|
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. Flavor and Extract Manufacturers Association.
|
Food Chem Toxicol
|
2002
|
0.96
|
|
15
|
Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine.
|
Eur J Cancer Clin Oncol
|
1982
|
0.95
|
|
16
|
Repeated exposure to acrolein vapour: subacute studies in hamsters, rats and rabbits.
|
Toxicology
|
1978
|
0.95
|
|
17
|
Inhalation toxicity of acetaldehyde in rats. I. Acute and subacute studies.
|
Toxicology
|
1982
|
0.93
|
|
18
|
Subacute (4-wk) oral toxicity of a combination of four nephrotoxins in rats: comparison with the toxicity of the individual compounds.
|
Food Chem Toxicol
|
1993
|
0.92
|
|
19
|
Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action.
|
Food Chem Toxicol
|
1997
|
0.92
|
|
20
|
Letter: Dose-response correlation for the induction of respiratory-tract tumours in Syrian golden hamsters by intratracheal instillations of benzo(a)pyrene.
|
Eur J Cancer
|
1973
|
0.91
|
|
21
|
Ultrastructure of pulmonary adenomas induced by intratracheal instillation of diethylnitrosamine in Syrian golden hamsters.
|
Eur J Cancer
|
1973
|
0.90
|
|
22
|
Two-year drinking-water study of formaldehyde in rats.
|
Food Chem Toxicol
|
1989
|
0.89
|
|
23
|
One-year time-sequence inhalation toxicity study of vinyl chloride in rats. II. Morphological changes in the respiratory tract, ceruminous glands, brain, kidneys, heart and spleen.
|
Toxicology
|
1980
|
0.89
|
|
24
|
Safety evaluation of yeast grown on hydrocarbons. II. One-year feeding study in rats with yeast grown on pure n-paraffins.
|
Food Cosmet Toxicol
|
1970
|
0.88
|
|
25
|
Use of factorial designs in combination toxicity studies.
|
Food Chem Toxicol
|
1997
|
0.88
|
|
26
|
Safety evaluation of yeast grown on hydrocarbons. I. One-year feeding study in rats with yeast grown on gas oil.
|
Food Cosmet Toxicol
|
1970
|
0.88
|
|
27
|
Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats.
|
Fundam Appl Toxicol
|
1994
|
0.86
|
|
28
|
Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions.
|
Food Chem Toxicol
|
2002
|
0.86
|
|
29
|
Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds.
|
Food Chem Toxicol
|
1993
|
0.85
|
|
30
|
4-week oral toxicity study of a combination of eight chemicals in rats: comparison with the toxicity of the individual compounds.
|
Food Chem Toxicol
|
1990
|
0.85
|
|
31
|
Carcinogenic response of the nasal cavity to inhaled chemical mixtures.
|
Mutat Res
|
1997
|
0.85
|
|
32
|
Short-term toxicity studies on some salts and oxides of tin in rats.
|
Food Cosmet Toxicol
|
1973
|
0.85
|
|
33
|
Lifespan oral toxicity study of vinyl chloride in rats.
|
Food Cosmet Toxicol
|
1981
|
0.85
|
|
34
|
Inhalation toxicity of acetaldehyde in rats. IV. Progression and regression of nasal lesions after discontinuation of exposure.
|
Toxicology
|
1987
|
0.84
|
|
35
|
Effects of alkali-treated proteins: feeding studies with free and protein-bound lysinoalanine in rats and other animals.
|
J Nutr
|
1976
|
0.84
|
|
36
|
Chronic (89-week) feeding study with hydroxypropyl distarch phosphate, starch acetate, lactose and sodium alginate in mice.
|
Food Chem Toxicol
|
1986
|
0.84
|
|
37
|
An evaluation of the criterion "organ weight" under conditions of growth retardation.
|
Food Cosmet Toxicol
|
1973
|
0.84
|
|
38
|
Inhalation toxicity of acetaldehyde in rats. II. Carcinogenicity study: interim results after 15 months.
|
Toxicology
|
1984
|
0.84
|
|
39
|
Subchronic (13-week) inhalation toxicity study of formaldehyde in rats.
|
J Appl Toxicol
|
1987
|
0.84
|
|
40
|
Repeated exposure to acetaldehyde vapor. Studies in Syrian golden hamsters.
|
Arch Environ Health
|
1975
|
0.83
|
|
41
|
Nutritional effects of alkali-treated soyprotein in rats.
|
J Nutr
|
1974
|
0.83
|
|
42
|
Chronic inhalation toxicity and carcinogenicity study of methyl bromide in Wistar rats.
|
Food Chem Toxicol
|
1991
|
0.82
|
|
43
|
Induction of hyperplasia in the bladder epithelium of rats by a dietary excess of acid or base: implications for toxicity/carcinogenicity testing.
|
Food Chem Toxicol
|
1988
|
0.82
|
|
44
|
One-year inhalation toxicity study of formaldehyde in male rats with a damaged or undamaged nasal mucosa.
|
J Appl Toxicol
|
1988
|
0.82
|
|
45
|
Comparative study of the ultrastructure of Tracheal and pulmonary tumours induced by multiple intratracheal instillations of diethylnitrosamine in Syrian golden hamsters.
|
Eur J Cancer
|
1975
|
0.82
|
|
46
|
Effects of exposure to furfural vapour in hamsters simultaneously treated with benzo[alpha] pyrene or diethylnitrosamine.
|
Toxicology
|
1978
|
0.82
|
|
47
|
Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking-water study in rats.
|
Food Chem Toxicol
|
1988
|
0.82
|
|
48
|
The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients.
|
Food Chem Toxicol
|
2011
|
0.81
|
|
49
|
Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats.
|
Food Chem Toxicol
|
1991
|
0.81
|
|
50
|
Safety assessment of lactate esters.
|
Regul Toxicol Pharmacol
|
1998
|
0.81
|
|
51
|
Nature and histogenesis of sulfite-induced gastric lesions in rats.
|
Exp Mol Pathol
|
1982
|
0.81
|
|
52
|
Gastric lesions in rats after the feeding of sulphite.
|
Pathol Eur
|
1972
|
0.81
|
|
53
|
The toxicity of sulphite. I. Long-term feeding and multigeneration studies in rats.
|
Food Cosmet Toxicol
|
1972
|
0.80
|
|
54
|
Chronic inhalation toxicity and carcinogenicity study of propylene oxide in Wistar rats.
|
Food Chem Toxicol
|
1988
|
0.80
|
|
55
|
A critical appraisal of intratracheal instillation of benzo[a]pyrene to Syrian golden hamsters as a model in respiratory tract carcinogenesis.
|
Cancer Lett
|
1995
|
0.80
|
|
56
|
Immunocytochemical identification of DNA adducts, O6-methylguanine and 7-methylguanine, in respiratory and other tissues of rat, mouse and Syrian hamster exposed to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
|
Carcinogenesis
|
1994
|
0.80
|
|
57
|
Statistically designed experiments to screen chemical mixtures for possible interactions.
|
Environ Health Perspect
|
1998
|
0.80
|
|
58
|
Safety evaluation of chemical mixtures and combinations of chemical and non-chemical stressors.
|
Rev Environ Health
|
2004
|
0.79
|
|
59
|
One-year time sequence inhalation toxicity study of vinyl chloride in rats. I. Growth, mortality, haematology, clinical chemistry and organ weights.
|
Toxicology
|
1979
|
0.79
|
|
60
|
Empirical approaches to risk estimation and prediction.
|
IARC Sci Publ
|
1999
|
0.79
|
|
61
|
Effects of exposure to acetaldehyde in syrian hamsters simultaneously treated with benzo(a)pyrene or diethylnitrosamine.
|
Prog Exp Tumor Res
|
1979
|
0.79
|
|
62
|
Effects of exposure to acrolein vapor in hamsters simultaneously treated with benzo[a]pyrene or diethylnitrosamine.
|
J Toxicol Environ Health
|
1977
|
0.79
|
|
63
|
Significance of particle size of benzo(a)pyrene for the induction of respiratory tract tumours in hamsters.
|
Int J Cancer
|
1980
|
0.79
|
|
64
|
Pathogenesis of blood-filled cavities in estrogen-induced anterior pituitary tumors in male Sprague-Dawley rats.
|
Toxicol Pathol
|
1992
|
0.79
|
|
65
|
Toxicity of formaldehyde and acrolein mixtures: in vitro studies using nasal epithelial cells.
|
Exp Toxicol Pathol
|
1996
|
0.78
|
|
66
|
Toxicology of sulphiting agents. I: Animal studies.
|
Food Addit Contam
|
1993
|
0.78
|
|
67
|
An analysis of the possibility for health implications of joint actions and interactions between food additives.
|
Regul Toxicol Pharmacol
|
2000
|
0.78
|
|
68
|
Vitamin A and beta-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture.
|
Cancer Lett
|
1995
|
0.78
|
|
69
|
Magnetic resonance imaging compared with hormonal effects and histopathology of estrogen-induced pituitary lesions in the rat.
|
Carcinogenesis
|
1991
|
0.78
|
|
70
|
Effects of the exposure profile on the inhalation toxicity of carbon tetrachloride in male rats.
|
J Appl Toxicol
|
1987
|
0.78
|
|
71
|
The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients.
|
Food Chem Toxicol
|
2005
|
0.78
|
|
72
|
Subchronic (13-week) inhalation toxicity study of formaldehyde in male rats: 8-hour intermittent versus 8-hour continuous exposures.
|
Toxicol Lett
|
1989
|
0.77
|
|
73
|
Effects of a dietary load of acid or base on changes induced by lactose in rats.
|
Food Chem Toxicol
|
1995
|
0.77
|
|
74
|
Sub-acute versus sub-chronic oral toxicity study in rats: comparative study of 82 compounds.
|
J Appl Toxicol
|
1984
|
0.77
|
|
75
|
Inhibition of tolbutamide 4-methylhydroxylation by a series of non-steroidal anti-inflammatory drugs in V79-NH cells expressing human cytochrome P4502C10.
|
Xenobiotica
|
1996
|
0.77
|
|
76
|
Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments.
|
Exp Toxicol Pathol
|
2008
|
0.77
|
|
77
|
Subacute (4-week) inhalation toxicity study of formaldehyde in male rats: 8-hour intermittent versus 8-hour continuous exposures.
|
J Appl Toxicol
|
1987
|
0.77
|
|
78
|
Cytotoxic and adaptive effects in rat nasal epithelium after 3-day and 13-week exposure to low concentrations of formaldehyde vapour.
|
Toxicology
|
1988
|
0.77
|
|
79
|
The FEMA GRAS assessment of phenethyl alcohol, aldehyde, acid, and related acetals and esters used as flavor ingredients.
|
Food Chem Toxicol
|
2005
|
0.77
|
|
80
|
Biochemical and histopathological changes in nasal epithelium of rats after 3-day intermittent exposure to formaldehyde and ozone alone or in combination.
|
Toxicol Lett
|
1994
|
0.77
|
|
81
|
Repeated exposure to furfural vapour: 13-week study in Syrian golden hamsters.
|
Zentralbl Bakteriol B
|
1979
|
0.77
|
|
82
|
Repeated exposure to alpha-ethylacrolein vapour: subacute toxicity study in rats.
|
Toxicology
|
1981
|
0.77
|
|
83
|
Estimation of toxicity of chemical mixtures through modeling of chemical interactions.
|
Environ Health Perspect
|
1998
|
0.77
|
|
84
|
Mucosal cysts in the gastrointestinal tract of beagle dogs.
|
Lab Anim
|
1971
|
0.77
|
|
85
|
The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients.
|
Food Chem Toxicol
|
2005
|
0.77
|
|
86
|
Ultrastructure of hepatic angiosarcoma in rats induced by vinyl chloride.
|
Exp Mol Pathol
|
1981
|
0.77
|
|
87
|
A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils.
|
Food Chem Toxicol
|
2005
|
0.76
|
|
88
|
Complex mixtures: hazard identification and risk assessment.
|
Food Chem Toxicol
|
1997
|
0.76
|
|
89
|
Spontaneous hyperplastic and metaplastic duct epithelium in the sublingual salivary glands of Wistar rats.
|
Lab Anim
|
1986
|
0.76
|
|
90
|
Pulmonary response of hamsters to fibrous glass: chronic effects of repeated intratracheal instillation with or without benzo[a]pyrene.
|
Carcinogenesis
|
1985
|
0.76
|
|
91
|
Acute, subacute, and subchronic inhalation toxicity studies of respirable polymeric methylene diphenyl diisocyanate (polymeric MDI) aerosol in rats.
|
Fundam Appl Toxicol
|
1994
|
0.76
|
|
92
|
Glass fibers and vapor phase components of cigarette smoke as cofactors in experimental respiratory tract carcinogenesis.
|
Carcinog Compr Surv
|
1985
|
0.76
|
|
93
|
Effect of variable versus fixed exposure levels on the toxicity of acetaldehyde in rats.
|
J Appl Toxicol
|
1986
|
0.76
|
|
94
|
Rat pituitary changes observed with magnetic resonance imaging following removal of estrogen stimulus: correlation with histopathology and immunohistology.
|
Carcinogenesis
|
1992
|
0.76
|
|
95
|
Lower respiratory tract tumours in Syrian golden hamsters after intratracheal instillations of diethylnitrosamine alone and with ferric oxide.
|
Eur J Cancer
|
1972
|
0.76
|
|
96
|
The FEMA GRAS assessment of alpha,beta-unsaturated aldehydes and related substances used as flavor ingredients.
|
Food Chem Toxicol
|
2008
|
0.76
|
|
97
|
An analysis of human response to the irritancy of acetone vapors.
|
Crit Rev Toxicol
|
2002
|
0.76
|
|
98
|
Interactive effects of ozone and formaldehyde on the nasal respiratory lining epithelium in rats.
|
J Toxicol Environ Health
|
1990
|
0.75
|
|
99
|
One-year time-sequence inhalation toxicity study of vinyl chloride in rats. III. Morphological changes in the liver.
|
Toxicology
|
1980
|
0.75
|
|
100
|
Drinking water studies of formaldehyde in Sprague-Dawley rats.
|
Toxicol Ind Health
|
1990
|
0.75
|
|
101
|
Chronic toxicity and oncogenicity inhalation study with vinyl acetate in the rat and mouse.
|
Fundam Appl Toxicol
|
1994
|
0.75
|
|
102
|
Tissue damage and nutritional factors in experimental respiratory tract (Co-)carcinogenesis.
|
Environ Health Perspect
|
1983
|
0.75
|
|
103
|
Bioassays for carcinogenicity in animals. Early preneoplastic lesions.
|
IARC Sci Publ
|
1986
|
0.75
|
|
104
|
Naturally occurring endocardial disease in the rat.
|
Arch Pathol
|
1973
|
0.75
|
|
105
|
Safety evaluation of synthetic beta-carotene.
|
Crit Rev Toxicol
|
1999
|
0.75
|
|
106
|
Restoration of the rat nasal septum and turbinates after damage by intranasal electrocoagulation.
|
Z Versuchstierkd
|
1988
|
0.75
|
|
107
|
Clearance of benzo(a)pyrene from the respiratory tract of hamsters following its intratracheal instillation with or without ferric oxide.
|
Zentralbl Bakteriol Orig B
|
1976
|
0.75
|
|
108
|
Evaluation of potential neurotoxic effects of occupational exposure to (L)-lactates.
|
Regul Toxicol Pharmacol
|
2001
|
0.75
|
|
109
|
Relation between benzo[a]pyrene-DNA adducts, cell proliferation and p53 expression in tracheal epithelium of hamsters fed a high beta-carotene diet.
|
Carcinogenesis
|
1995
|
0.75
|
|
110
|
DNA adduct formation and repair in hamster and rat tracheas exposed to benzo[a]pyrene in organ culture.
|
Carcinogenesis
|
1994
|
0.75
|
|
111
|
Repeated exposure to cyclopentenone vapour: long-term study in Syrian golden hamsters.
|
Zentralbl Bakteriol Orig B
|
1976
|
0.75
|
|
112
|
Toxicity of beta-chloroprene (2-chlorobutadiene-1,3): acute and subacute toxicity.
|
Toxicol Appl Pharmacol
|
1978
|
0.75
|
|
113
|
Gastric and caecal lesions in pigs following the feeding of sulphite.
|
Tijdschr Diergeneeskd
|
1973
|
0.75
|
|
114
|
Short-term feeding study of thiodiethyleneglycol-bis-(beta-aminocrotonate) in rats.
|
Food Cosmet Toxicol
|
1969
|
0.75
|
|
115
|
Repeated exposure to butenolide vapour: subacute study in Syrian golden hamsters.
|
Toxicology
|
1979
|
0.75
|
|
116
|
Observations on the oral administration and toxicity of vinyl chloride in rats.
|
Food Cosmet Toxicol
|
1975
|
0.75
|
|
117
|
Significance of the dog as 'second animal species' in toxicity testing for establishing the lowest 'no-toxic-effect level'.
|
J Appl Toxicol
|
1986
|
0.75
|
|
118
|
Ciliated cells in vitamin A-deprived cultured hamster tracheal epithelium do divide.
|
In Vitro Cell Dev Biol
|
1988
|
0.75
|
|
119
|
Testing of complex chemical mixtures (for carcinogenicity).
|
IARC Sci Publ
|
1986
|
0.75
|
|
120
|
Basic requirements for long-term assays for carcinogenicity.
|
IARC Monogr Eval Carcinog Risk Chem Hum Suppl
|
1980
|
0.75
|
|
121
|
Spontaneous tumors of the brain in rats. A report of 3 cases.
|
Pathol Vet
|
1968
|
0.75
|
|
122
|
Letter: Rat feeding studies with alkali-treated soy protein.
|
Nutr Rev
|
1974
|
0.75
|
|
123
|
The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients.
|
Food Chem Toxicol
|
2006
|
0.75
|
|
124
|
Restoration of the hamster tracheal wall following injury by electrocoagulation.
|
Exp Mol Pathol
|
1984
|
0.75
|
|
125
|
Safety evaluation of yeast grown on hydrocarbons. IV. Two-year feeding and multigeneration study in rats with yeast grown on pure n-paraffins.
|
Food Cosmet Toxicol
|
1975
|
0.75
|
|
126
|
High survival rate of hamsters given intratracheal instillations of benzo[a]pyrene and ferric oxide and kept on a high beta-carotene diet.
|
Carcinogenesis
|
1994
|
0.75
|
|
127
|
Safety evaluation of natural flavour complexes.
|
Toxicol Lett
|
2004
|
0.75
|
|
128
|
Toxicologic studies of iocetamic acid in rats and dogs.
|
Toxicol Appl Pharmacol
|
1969
|
0.75
|
|
129
|
Adenomatoid odontogenic tumorlike lesion in a male Wistar rat.
|
J Oral Pathol Med
|
1992
|
0.75
|
|
130
|
Pancreatic atrophy and other pathological changes in rats following the feeding of stannous chloride.
|
Pathol Eur
|
1974
|
0.75
|
|
131
|
Pulmonary response of hamsters to fibrous glass. Clearance and morphology after a single intratracheal instillation.
|
Exp Pathol
|
1986
|
0.75
|
|
132
|
Cell proliferation and DNA adducts in hamster tracheal epithelium exposed to benzo[a]pyrene in organ culture.
|
Toxicol In Vitro
|
1996
|
0.75
|
|
133
|
[Carcinogenicity studies in experimental animals. I. Design and performance].
|
Ned Tijdschr Geneeskd
|
1986
|
0.75
|
|
134
|
Safety evaluation of yeast grown on hydrocarbons. 3. Two-year feeding and multigeneration study in rats with yeast grown on gas oil.
|
Food Cosmet Toxicol
|
1971
|
0.75
|
|
135
|
Toxicologic and pharmacologic properties of iocetamic acid, a new oral cholecystographic agent.
|
Toxicol Appl Pharmacol
|
1969
|
0.75
|
|
136
|
Long-term assays for carcinogenicity in animals.
|
IARC Sci Publ
|
1986
|
0.75
|
|
137
|
Electrocoagulation as a method to induce local lesions in the tracheal wall of Syrian hamsters.
|
Z Versuchstierkd
|
1984
|
0.75
|
|
138
|
General toxicity testing: sense and non-sense, science and policy.
|
Fundam Appl Toxicol
|
1984
|
0.75
|
|
139
|
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