The role of alpha-synuclein in both neuroprotection and neurodegeneration.

Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic Acids Res (2008) 1.40

Recent advances in our understanding of neurodegeneration. J Neural Transm (Vienna) (2009) 1.27

Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology (2007) 1.20

α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J Neurosci (2011) 1.16

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem (2009) 1.06

Curcumin modulates α-synuclein aggregation and toxicity. ACS Chem Neurosci (2012) 1.03

Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease. PLoS One (2011) 0.98

Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. Mol Neurodegener (2007) 0.91

From QTL to candidate gene: a genetic approach to alcoholism research. Curr Drug Abuse Rev (2009) 0.90

Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases. PLoS One (2012) 0.89

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. Metallomics (2014) 0.89

Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy? Neurobiol Dis (2010) 0.88

Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring rats. J Neurochem (2006) 0.87

α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. PLoS One (2012) 0.87

Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus. J Neural Transm (Vienna) (2008) 0.86

Molecular implications of repeated aggression: Th, Dat1, Snca and Bdnf gene expression in the VTA of victorious male mice. PLoS One (2009) 0.84

Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons. Mol Neurodegener (2011) 0.83

Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease. BMC Neurosci (2011) 0.83

Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data. Free Radic Biol Med (2008) 0.82

In vitro aggregation assays for the characterization of α-synuclein prion-like properties. Prion (2014) 0.81

New insights on Parkinson's disease genes: the link between mitochondria impairment and neuroinflammation. J Neural Transm (Vienna) (2015) 0.80

Snca and Bdnf gene expression in the VTA and raphe nuclei of midbrain in chronically victorious and defeated male mice. PLoS One (2010) 0.77

Melatonin as a mitochondrial protector in neurodegenerative diseases. Cell Mol Life Sci (2017) 0.75

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med (2009) 1.95

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of α-synuclein in Parkinson's disease models. Hum Mol Genet (2013) 1.94

Preliminary observations on the spawning conditions of the European amphioxus (Branchiostoma lanceolatum) in captivity. J Exp Zool B Mol Dev Evol (2004) 1.33

Insights into spawning behavior and development of the European amphioxus (Branchiostoma lanceolatum). J Exp Zool B Mol Dev Evol (2007) 1.29

Evolution and cell biology of dopamine receptors in vertebrates. Biol Cell (2003) 1.28

Does alpha-synuclein modulate dopaminergic synaptic content and tone at the synapse? FASEB J (2004) 1.26

The adult central nervous cholinergic system of a neurogenetic model animal, the zebrafish Danio rerio. Brain Res (2004) 1.25

Inflammation in the early stages of neurodegenerative pathology. J Neuroimmunol (2011) 1.21

Parkin promotes intracellular Abeta1-42 clearance. Hum Mol Genet (2009) 1.18

Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila. Nat Neurosci (2012) 1.17

alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. FEBS Lett (2004) 1.14

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models. Hum Mol Genet (2011) 1.12

The evolution of dopamine systems in chordates. Front Neuroanat (2011) 1.11

Dopamine inhibits luteinizing hormone synthesis and release in the juvenile European eel: a neuroendocrine lock for the onset of puberty. Biol Reprod (2004) 1.09

Two tyrosine hydroxylase genes in vertebrates New dopaminergic territories revealed in the zebrafish brain. Mol Cell Neurosci (2010) 1.08

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress. FASEB J (2003) 1.07

Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. FASEB J (2006) 1.06

Beta-amyloid1-42 gene transfer model exhibits intraneuronal amyloid, gliosis, tau phosphorylation, and neuronal loss. J Biol Chem (2010) 1.05

A phylotypic stage in vertebrate brain development: GABA cell patterns in zebrafish compared with mouse. J Comp Neurol (2006) 1.03

Diminished parkin solubility and co-localization with intraneuronal amyloid-β are associated with autophagic defects in Alzheimer's disease. J Alzheimers Dis (2013) 1.01

Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells. J Biol Chem (2006) 1.01

Androgen-dependent stimulation of brain dopaminergic systems in the female European eel (Anguilla anguilla). Endocrinology (2006) 1.01

The degeneration of dopamine neurons in Parkinson's disease: insights from embryology and evolution of the mesostriatocortical system. Ann N Y Acad Sci (2004) 1.00

Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6). J Biol Chem (2012) 0.97

Mutations in the lipid-binding domain of alpha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity. Mol Cell Neurosci (2003) 0.96

Tyrosine kinase inhibition increases functional parkin-Beclin-1 interaction and enhances amyloid clearance and cognitive performance. EMBO Mol Med (2013) 0.96

NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain. Mol Cell Neurosci (2008) 0.95

Secondary neurogenesis in the brain of the African clawed frog, Xenopus laevis, as revealed by PCNA, Delta-1, Neurogenin-related-1, and NeuroD expression. J Comp Neurol (2005) 0.94

Differential expression of dopaminergic cell markers in the adult zebrafish forebrain. J Comp Neurol (2011) 0.94

Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function. J Neurosci Res (2010) 0.93

Abnormal migration of human wild-type alpha-synuclein upon gel electrophoresis. Neurosci Lett (2004) 0.89

Dopamine receptors for every species: gene duplications and functional diversification in Craniates. J Struct Funct Genomics (2003) 0.89

Trypsin disrupts the trafficking of the human dopamine transporter by alpha-synuclein and its A30P mutant. Biochemistry (2004) 0.89

Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance. J Mol Med (Berl) (2013) 0.89

Pitx genes in Tunicates provide new molecular insight into the evolutionary origin of pituitary. Gene (2002) 0.88

Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis. J Neurochem (2013) 0.88

β-amyloid triggers ALS-associated TDP-43 pathology in AD models. Brain Res (2011) 0.88

Differential cytotoxicity of human wild type and mutant alpha-synuclein in human neuroblastoma SH-SY5Y cells in the presence of dopamine. Biochemistry (2004) 0.87

Distribution of tyrosine hydroxylase, dopamine, and serotonin in the central nervous system of amphioxus (Branchiostoma lanceolatum): implications for the evolution of catecholamine systems in vertebrates. J Comp Neurol (2004) 0.87

Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance. Autophagy (2013) 0.87

Phylotypic expression of the bHLH genes Neurogenin2, Neurod, and Mash1 in the mouse embryonic forebrain. J Comp Neurol (2010) 0.87

The dopamine-synthesizing cells in the swimming larva of the tunicate Ciona intestinalis are located only in the hypothalamus-related domain of the sensory vesicle. Eur J Neurosci (2005) 0.86

Fractalkine Mediates Communication between Pathogenic Proteins and Microglia: Implications of Anti-Inflammatory Treatments in Different Stages of Neurodegenerative Diseases. Int J Alzheimers Dis (2012) 0.85

Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models. Mol Cell Neurosci (2011) 0.85

Regulatory gene expressions in the ascidian ventral sensory vesicle: evolutionary relationships with the vertebrate hypothalamus. Dev Biol (2005) 0.84

Mitochondrial dysfunction in skeletal muscle of amyloid precursor protein-overexpressing mice. J Biol Chem (2012) 0.84

Emotions and motivated behavior converge on an amygdala-like structure in the zebrafish. Eur J Neurosci (2014) 0.83

Cloning and developmental expression patterns of Dlx2, Lhx7 and Lhx9 in the medaka fish (Oryzias latipes). Mech Dev (2004) 0.83

Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric-oxide synthase activation and cytotoxicity. J Biol Chem (2003) 0.83

Dopamine inhibits reproduction in female zebrafish (Danio rerio) via three pituitary D2 receptor subtypes. Endocrinology (2013) 0.82

Evolution of dopamine receptor genes of the D1 class in vertebrates. Mol Biol Evol (2012) 0.82

A quantitative real-time RT-PCR assay for European eel tyrosine hydroxylase. Gen Comp Endocrinol (2005) 0.82

Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models. Exp Neurol (2012) 0.81

Two distinct dopamine D2 receptor genes in the European eel: molecular characterization, tissue-specific transcription, and regulation by sex steroids. Endocrinology (2008) 0.81

Morphological and gene expression similarities suggest that the ascidian neural gland may be osmoregulatory and homologous to vertebrate peri-ventricular organs. Eur J Neurosci (2006) 0.81

Autocrine activation of adenosine A1 receptors blocks D1A but not D1B dopamine receptor desensitization. J Neurochem (2002) 0.79

Delineation of the conserved functional properties of D1A, D1B and D1C dopamine receptor subtypes in vertebrates. Biol Cell (2004) 0.78

Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: ¹³C NMR and magnetic resonance imaging studies in AD models. Neuroscience (2012) 0.78

Diminished expression of constitutive nitric oxide synthases in the kidney of spontaneously hypertensive rat. Clin Exp Hypertens (2003) 0.78

Monoaminergic modulation of photoreception in ascidian: evidence for a proto-hypothalamo-retinal territory. BMC Biol (2012) 0.77

Classification of Dopamine Receptor Genes in Vertebrates: Nine Subtypes in Osteichthyes. Brain Behav Evol (2015) 0.76

Role of Dopaminergic D2 Receptors in the Regulation of Glutamic Acid Decarboxylase Messenger RNA in the Striatum of the Rat. Eur J Neurosci (1992) 0.76

The Relationship between Parkin and Protein Aggregation in Neurodegenerative Diseases. Front Psychiatry (2010) 0.76

Introduction to the Proceedings of the Fifth European Conference on Comparative Neurobiology: evolution and the generation of novelties in the nervous system. Brain Res Bull (2007) 0.75

[An antagonist to GnRH in the control of reproduction in teleost fish: dopaminergic inhibition. Ancestral origin and differential conservation within vertebrates?]. J Soc Biol (2004) 0.75