Published in J Biol Chem on January 31, 2005
SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers. Mol Aspects Med (2013) 1.26
Cholangiocyte anion exchange and biliary bicarbonate excretion. World J Gastroenterol (2006) 1.08
Na+/H+ exchangers in renal regulation of acid-base balance. Semin Nephrol (2006) 1.06
Na+/H+ exchangers: physiology and link to hypertension and organ ischemia. Curr Opin Nephrol Hypertens (2005) 1.05
AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon. Am J Physiol Gastrointest Liver Physiol (2010) 1.04
Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3. J Biomed Biotechnol (2010) 1.02
A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice. Gastroenterology (2010) 1.01
Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity. Am J Physiol Cell Physiol (2008) 1.00
Traditional and emerging roles for the SLC9 Na+/H+ exchangers. Pflugers Arch (2013) 0.99
Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice. Am J Pathol (2006) 0.98
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases. J Biol Chem (2008) 0.92
NHE4 is critical for the renal handling of ammonia in rodents. J Clin Invest (2010) 0.91
Epidermal growth factor inhibits intestinal NHE8 expression via reducing its basal transcription. Am J Physiol Cell Physiol (2010) 0.89
Transcriptional inhibition of intestinal NHE8 expression by glucocorticoids involves Pax5. Am J Physiol Gastrointest Liver Physiol (2010) 0.87
NHE8 plays important roles in gastric mucosal protection. Am J Physiol Gastrointest Liver Physiol (2012) 0.86
Mouse models of gastric carcinogenesis. J Gastric Cancer (2014) 0.84
CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor. Am J Physiol Regul Integr Comp Physiol (2010) 0.84
Slc26a3/Dra and Slc26a6 in Murine Ameloblasts. J Dent Res (2015) 0.80
Loss of NHE8 expression impairs ocular surface function in mice. Am J Physiol Cell Physiol (2014) 0.80
Na(+)/H(+) exchange and hypoxic pulmonary hypertension. Pulm Circ (2015) 0.80
Proximal tubular NHEs: sodium, protons and calcium? Am J Physiol Renal Physiol (2013) 0.79
Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3. J Gastroenterol (2010) 0.79
Volume density, distribution, and ultrastructure of secretory and basolateral membranes and mitochondria predict parietal cell secretory (dys)function. J Biomed Biotechnol (2010) 0.77
Loss of the NHE2 Na+/H+ exchanger in mice results in dilation of folliculo-stellate cell canaliculi. J Biomed Biotechnol (2011) 0.76
Intestinal NHE8 is highly expressed in goblet cells and its expression is subject to TNF-α regulation. Am J Physiol Gastrointest Liver Physiol (2015) 0.76
Mouse slc9a8 mutants exhibit retinal defects due to retinal pigmented epithelium dysfunction. Invest Ophthalmol Vis Sci (2015) 0.76
Salt secretion is linked to acid-base regulation of ionocytes in seawater-acclimated medaka: new insights into the salt-secreting mechanism. Sci Rep (2016) 0.75
Transgenic and gene knockout mice in gastric cancer research. Oncotarget (2016) 0.75
Determinants of Cation Permeation and Drug Sensitivity in Predicted Transmembrane Helix 9 and Adjoining Exofacial Re-entrant Loop 5 of Na+/H+ Exchanger NHE1. J Biol Chem (2015) 0.75
Pathophysiology of Intestinal Na(+)/H(+) exchange. Cell Mol Gastroenterol Hepatol (2017) 0.75
Escherichia coli Heat-Stable Enterotoxin Mediates Na+/H+ Exchanger 4 Inhibition Involving cAMP in T84 Human Intestinal Epithelial Cells. PLoS One (2015) 0.75
Regulation of gastric acid secretion by the serum and glucocorticoid inducible kinase isoform SGK3. J Gastroenterol (2010) 0.75
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70
TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J Clin Invest (2002) 2.35
Origin of cardiac fibroblasts and the role of periostin. Circ Res (2009) 2.33
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest (2010) 2.28
Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. J Biol Chem (2004) 1.90
Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome. J Am Soc Nephrol (2004) 1.84
Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev (2003) 1.84
Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation. Mol Pharmacol (2004) 1.76
Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. Mol Pharmacol (2005) 1.71
Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter. J Biol Chem (2006) 1.68
Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proc Natl Acad Sci U S A (2005) 1.67
The epithelial sodium/proton exchanger, NHE3, is necessary for renal and intestinal calcium (re)absorption. Am J Physiol Renal Physiol (2011) 1.66
Mice with a null mutation in the NHE1 Na+-H+ exchanger are resistant to cardiac ischemia-reperfusion injury. Circ Res (2003) 1.63
Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology (2009) 1.55
Mice with a targeted disruption of the AE2 Cl-/HCO3- exchanger are achlorhydric. J Biol Chem (2004) 1.50
Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice. J Biol Chem (2002) 1.49
Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome. J Biol Chem (2002) 1.46
Intestinal NaCl transport in NHE2 and NHE3 knockout mice. Am J Physiol Gastrointest Liver Physiol (2002) 1.42
Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development. Dev Dyn (2009) 1.39
TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression. Development (2002) 1.37
Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice. J Biol Chem (2002) 1.34
PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum. Am J Physiol Gastrointest Liver Physiol (2006) 1.33
Cardiac-specific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of low-flow ischemia. Circulation (2003) 1.32
Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load. J Clin Invest (2003) 1.32
Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter. Am J Physiol Heart Circ Physiol (2002) 1.32
Na(+)-dependent chloride transporter (NKCC1)-null mice exhibit less gray and white matter damage after focal cerebral ischemia. J Cereb Blood Flow Metab (2005) 1.31
TGFbeta1 and Treg cells: alliance for tolerance. Trends Mol Med (2007) 1.30
Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. J Biol Chem (2004) 1.28
Phenotypes of SERCA and PMCA knockout mice. Biochem Biophys Res Commun (2004) 1.27
Na-K-Cl cotransporter-mediated intracellular Na+ accumulation affects Ca2+ signaling in astrocytes in an in vitro ischemic model. J Neurosci (2004) 1.25
Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS. J Neurosci (2007) 1.25
Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity. Am J Physiol Heart Circ Physiol (2003) 1.24
Cyp1a1(-/-) male mice: protection against high-dose TCDD-induced lethality and wasting syndrome, and resistance to intrahepatocyte lipid accumulation and uroporphyria. Toxicol Appl Pharmacol (2004) 1.23
Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes. J Biol Chem (2007) 1.22
Decreased neuronal death in Na+/H+ exchanger isoform 1-null mice after in vitro and in vivo ischemia. J Neurosci (2005) 1.21
Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage. J Immunol (2008) 1.19
Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Proc Natl Acad Sci U S A (2008) 1.18
Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol Endocrinol (2002) 1.17
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J Clin Invest (2009) 1.17
Double knockout of pendrin and Na-Cl cotransporter (NCC) causes severe salt wasting, volume depletion, and renal failure. Proc Natl Acad Sci U S A (2012) 1.16
SLC26A9 is expressed in gastric surface epithelial cells, mediates Cl-/HCO3- exchange, and is inhibited by NH4+. Am J Physiol Cell Physiol (2005) 1.15
The S1P2 sphingosine 1-phosphate receptor is essential for auditory and vestibular function. Hear Res (2006) 1.15
Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis. Gastroenterology (2002) 1.15
Plasma membrane calcium ATPase deficiency causes neuronal pathology in the spinal cord: a potential mechanism for neurodegeneration in multiple sclerosis and spinal cord injury. FASEB J (2004) 1.15
Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. Am J Physiol Cell Physiol (2006) 1.15
Astrocytes from Na(+)-K(+)-Cl(-) cotransporter-null mice exhibit absence of swelling and decrease in EAA release. Am J Physiol Cell Physiol (2002) 1.14
TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. J Immunol (2003) 1.13
Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice. J Cell Biochem (2008) 1.12
ERK1/2-p90RSK-mediated phosphorylation of Na+/H+ exchanger isoform 1. A role in ischemic neuronal death. J Biol Chem (2007) 1.11
Gastric achlorhydria in H/K-ATPase-deficient (Atp4a(-/-)) mice causes severe hyperplasia, mucocystic metaplasia and upregulation of growth factors. J Gastroenterol Hepatol (2005) 1.10
Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology (2007) 1.10
The effects of intracellular Ca2+ on cardiac K+ channel expression and activity: novel insights from genetically altered mice. J Physiol (2004) 1.10
SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarcoendoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells. Diabetes (2002) 1.09
Characterization of the P5 subfamily of P-type transport ATPases in mice. Biochem Biophys Res Commun (2004) 1.09
Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab (2013) 1.09
NBCe1 mediates the acute stimulation of astrocytic glycolysis by extracellular K+. J Neurosci (2011) 1.08
Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. Free Radic Biol Med (2007) 1.08
Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol (2004) 1.07
Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced hearing loss in mice. Hear Res (2002) 1.07
Increased tolerance to oxygen and glucose deprivation in astrocytes from Na(+)/H(+) exchanger isoform 1 null mice. Am J Physiol Cell Physiol (2004) 1.06
Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev Dyn (2011) 1.06
Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants. Ann N Y Acad Sci (2003) 1.04
Hypotension in NKCC1 null mice: role of the kidneys. Am J Physiol Renal Physiol (2005) 1.04
AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colon. Am J Physiol Gastrointest Liver Physiol (2010) 1.04
The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling. J Mol Cell Cardiol (2006) 1.04
In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea. J Biol Chem (2002) 1.04
NHE2 is the main apical NHE in mouse colonic crypts but an alternative Na+-dependent acid extrusion mechanism is upregulated in NHE2-null mice. Am J Physiol Gastrointest Liver Physiol (2006) 1.03