Published in J Pathol on April 01, 2005
Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A (2008) 1.36
PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics. J Cell Physiol (2012) 1.35
PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas. Br J Cancer (2007) 1.34
Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine. Mol Cell Biol (2006) 1.33
Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK. Biochim Biophys Acta (2010) 1.32
Signal transducer and activator of transcription 5b: a new target of breast tumor kinase/protein tyrosine kinase 6. Breast Cancer Res (2007) 1.27
PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One (2010) 1.15
Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells. Breast Cancer Res (2010) 1.14
Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage. Am J Pathol (2009) 1.10
Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients. Br J Cancer (2008) 1.09
Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition. Cancer Biol Ther (2013) 1.06
Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene (2012) 1.02
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression. Cancer Res (2013) 1.02
Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor. Mol Cell Biol (2010) 1.01
Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes. Am J Pathol (2006) 0.97
Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells. Cell Cycle (2010) 0.95
In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues. Br J Cancer (2010) 0.94
Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK. Breast Cancer Res (2011) 0.90
RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. Cell Cycle (2009) 0.90
Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells. J Biol Chem (2013) 0.88
Overexpression of PTK6 (breast tumor kinase) protein--a prognostic factor for long-term breast cancer survival--is not due to gene amplification. Virchows Arch (2009) 0.87
Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models. Oncogenesis (2013) 0.85
PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling. PLoS One (2014) 0.83
Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3. J Biol Chem (2012) 0.82
BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration. PLoS One (2014) 0.81
Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of rapamycin activity. Cancer Lett (2014) 0.81
HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain. Cell Signal (2013) 0.78
Evolution of breast cancer therapeutics: Breast tumour kinase's role in breast cancer and hope for breast tumour kinase targeted therapy. World J Clin Oncol (2014) 0.77
Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res (2016) 0.76
Overexpression of Kinesin Associated Protein 3 (KIFAP3) in Breast Cancer. J Proteomics Bioinform (2012) 0.75
Pathbase: a database of mutant mouse pathology. Nucleic Acids Res (2004) 2.66
Innate immunity in Arabidopsis thaliana: lipopolysaccharides activate nitric oxide synthase (NOS) and induce defense genes. Proc Natl Acad Sci U S A (2004) 2.40
Gap junction remodeling and altered connexin43 expression in the failing human heart. Mol Cell Biochem (2003) 1.61
Induction of systemic resistance in tomato by N-acyl-L-homoserine lactone-producing rhizosphere bacteria. Plant Cell Environ (2006) 1.59
Formalin-fixed paraffin-embedded (FFPE) proteome analysis using gel-free and gel-based proteomics. J Proteome Res (2010) 1.48
Classification of HER2 receptor status in breast cancer tissues by MALDI imaging mass spectrometry. J Proteome Res (2010) 1.48
Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases. Am J Pathol (2002) 1.42
Heterogeneity in the distribution of RET/PTC rearrangements within individual post-Chernobyl papillary thyroid carcinomas. J Clin Endocrinol Metab (2004) 1.38
The effect of the alpha 2-agonist dexmedetomidine and the N-methyl-D-aspartate antagonist S(+)-ketamine on the expression of apoptosis-regulating proteins after incomplete cerebral ischemia and reperfusion in rats. Anesth Analg (2003) 1.34
Nitric oxide is induced by wounding and influences jasmonic acid signaling in Arabidopsis thaliana. Planta (2004) 1.32
Nucleic acids from long-term preserved FFPE tissues are suitable for downstream analyses. Virchows Arch (2012) 1.24
In situ quantitation of the spatial scale of calling distances and population density-independent N-acylhomoserine lactone-mediated communication by rhizobacteria colonized on plant roots. FEMS Microbiol Ecol (2006) 1.20
The gene ENHANCER OF PINOID controls cotyledon development in the Arabidopsis embryo. Development (2005) 1.19
Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Haematologica (2008) 1.17
Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells. J Nutr (2007) 1.16
Helical growth of the Arabidopsis mutant tortifolia1 reveals a plant-specific microtubule-associated protein. Curr Biol (2004) 1.15
IgVH mutational status and clonality analysis of Richter's transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolution. Am J Surg Pathol (2007) 1.14
Radiation resistance due to high expression of miR-21 and G2/M checkpoint arrest in breast cancer cells. Radiat Oncol (2012) 1.12
MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer. Am J Pathol (2011) 1.08
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS One (2009) 1.05
Significance of HER2 low-level copy gain in Barrett's cancer: implications for fluorescence in situ hybridization testing in tissues. Clin Cancer Res (2007) 1.04
Gain of chromosome band 7q11 in papillary thyroid carcinomas of young patients is associated with exposure to low-dose irradiation. Proc Natl Acad Sci U S A (2011) 1.02
The long-term effect of sevoflurane on neuronal cell damage and expression of apoptotic factors after cerebral ischemia and reperfusion in rats. Anesth Analg (2006) 1.02
Ovarian cancer cell proliferation and motility is induced by engagement of integrin alpha(v)beta3/Vitronectin interaction. Biol Chem (2003) 1.01
CD20+ T-cell lymphoma: clinicopathologic analysis of 9 cases and a review of the literature. Am J Surg Pathol (2008) 1.00
Influence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation. Anesthesiology (2004) 0.98
Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation. Proteomics (2011) 0.98
Metabolic assessment of gradual development of moderate experimental colitis in IL-10 deficient mice. J Proteome Res (2009) 0.97
Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer. Mol Biosyst (2011) 0.97
Evaluation of different biomarkers to predict individual radiosensitivity in an inter-laboratory comparison--lessons for future studies. PLoS One (2012) 0.96
Chromosomal imbalances are associated with metastasis-free survival in breast cancer patients. Anal Cell Pathol (2002) 0.96
Multiple chromosomal abnormalities in human liver (pre)neoplasia. J Hepatol (2004) 0.96
Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferation. Exp Cell Res (2009) 0.95
Identification of differentially expressed proteins in triple-negative breast carcinomas using DIGE and mass spectrometry. J Proteome Res (2009) 0.93
Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria. J Pathol (2013) 0.92
Effects of simultaneous knockdown of HER2 and PTK6 on malignancy and tumor progression in human breast cancer cells. Mol Cancer Res (2013) 0.92
The effect of hypothermia on the expression of the apoptosis-regulating protein Bax after incomplete cerebral ischemia and reperfusion in rats. J Neurosurg Anesthesiol (2003) 0.92
Chromosomal changes characterize head and neck cancer with poor prognosis. J Mol Med (Berl) (2008) 0.92
ADAM15 decreases integrin alphavbeta3/vitronectin-mediated ovarian cancer cell adhesion and motility in an RGD-dependent fashion. Int J Biochem Cell Biol (2005) 0.92
De novo discovery of phenotypic intratumour heterogeneity using imaging mass spectrometry. J Pathol (2014) 0.91
Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression. Am J Surg Pathol (2012) 0.91
Time-course of radiation-induced chromosomal aberrations in tumor patients after radiotherapy. Int J Radiat Oncol Biol Phys (2005) 0.90
Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients--a follow-up study. Radiat Oncol (2011) 0.90
Effects of antineoplastic agents on cytoplasmic and membrane-bound heat shock protein 70 (Hsp70) levels. Biol Chem (2002) 0.89
Whole genome amplification for CGH analysis: Linker-adapter PCR as the method of choice for difficult and limited samples. Cytometry A (2004) 0.89
Distinct chromosomal imbalances in nonpolypoid and polypoid colorectal adenomas indicate different genetic pathways in the development of colorectal neoplasms. Am J Pathol (2003) 0.88
Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma. Int J Cancer (2004) 0.88
Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure. Basic Res Cardiol (2013) 0.87
Overexpression of PTK6 (breast tumor kinase) protein--a prognostic factor for long-term breast cancer survival--is not due to gene amplification. Virchows Arch (2009) 0.87
Radiation-induced late effects in two affected individuals of the Lilo radiation accident. Radiat Res (2007) 0.85
Sevoflurane affects neurogenesis after forebrain ischemia in rats. Anesth Analg (2007) 0.83
Chromosomal imbalances in post-chernobyl thyroid tumors. Thyroid (2004) 0.83
TNF-alpha induces apoptosis of parietal cells. Biochem Pharmacol (2003) 0.83
Multicentric investigation of ionising radiation-induced cell death as a predictive parameter of individual radiosensitivity. Apoptosis (2009) 0.82
Multicenter matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) identifies proteomic differences in breast-cancer-associated stroma. J Proteome Res (2014) 0.81
Dynamics of cell adhesion and motility in living cells is altered by a single amino acid change in E-cadherin fused to enhanced green fluorescent protein. Cell Motil Cytoskeleton (2004) 0.80
Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes. Mamm Genome (2009) 0.80
Establishment of an x-ray standard calibration curve by conventional dicentric analysis as prerequisite for accurate radiation dose assessment. Health Phys (2010) 0.80
Label-free protein profiling of formalin-fixed paraffin-embedded (FFPE) heart tissue reveals immediate mitochondrial impairment after ionising radiation. J Proteomics (2012) 0.80
Association of radiation-induced genes with noncancer chronic diseases in Mayak workers occupationally exposed to prolonged radiation. Radiat Res (2015) 0.79
Chromosomal rearrangements in post-Chernobyl papillary thyroid carcinomas: evaluation by spectral karyotyping and automated interphase FISH. J Biomed Biotechnol (2011) 0.79
Xrs2 facilitates crossovers during DNA double-strand gap repair in yeast. DNA Repair (Amst) (2008) 0.78
Cks1 promotion of S phase entry and proliferation is independent of p27Kip1 suppression. Mol Cell Biol (2012) 0.78
Novel candidate genes of thyroid tumourigenesis identified in Trk-T1 transgenic mice. Endocr Relat Cancer (2012) 0.77
Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage. Exp Cell Res (2007) 0.77
Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. Mol Carcinog (2011) 0.77
Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and phosphatidylinositol 3-kinase inhibitors. Exp Cell Res (2002) 0.77
The impact of cysteine-rich intestinal protein 1 (CRIP1) in human breast cancer. Mol Cancer (2013) 0.76
Imaging of placental transport mechanisms: a review. Eur J Obstet Gynecol Reprod Biol (2009) 0.76
Genomic copy number analysis of Chernobyl papillary thyroid carcinoma in the Ukrainian-American Cohort. Carcinogenesis (2015) 0.76
Fas ligand is not constitutively expressed in low-grade B-cell lymphoma and B-lymphoblastoid cells. Eur J Haematol (2003) 0.75
Cerebral ischemia and neurogenesis: a two-time comparison. Neurocrit Care (2008) 0.75
Mechanistic investigations on dimethyl carbonate formation by oxidative carbonylation of methanol over a CuY zeolite: an operando SSITKA/DRIFTS/MS study. Phys Chem Chem Phys (2011) 0.75
Glycerol upgrading over zeolites by batch-reactor liquid-phase oligomerization: heterogeneous versus homogeneous reaction. ChemSusChem (2008) 0.75
Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancer. Biol Chem (2017) 0.75
Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3. J Cell Physiol (2005) 0.75