Published in J Biol Chem on April 25, 1992
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest (2006) 4.50
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A (1994) 4.21
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proc Natl Acad Sci U S A (1994) 4.15
Identification of an early-growth-response gene encoding a novel putative protein kinase. Mol Cell Biol (1992) 2.39
Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci U S A (1997) 2.12
Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest (1996) 1.98
Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J Clin Invest (1994) 1.89
Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc Natl Acad Sci U S A (1998) 1.77
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin. Proc Natl Acad Sci U S A (1996) 1.26
Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells. Br J Cancer (1997) 1.16
Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. J Clin Invest (2001) 1.13
Selective cyclo-oxygenase-2 inhibitors aggravate ischaemia-reperfusion injury in the rat stomach. Br J Pharmacol (1999) 1.07
Regulation of cyclooxygenase-2 (COX-2) in rat renal cortex by adrenal glucocorticoids and mineralocorticoids. Proc Natl Acad Sci U S A (1999) 1.07
Eicosanoid lipid mediators in fibrotic lung diseases: ready for prime time? Chest (2008) 1.04
Rapid and transient induction of cyclo-oxygenase 2 by epidermal growth factor in human amnion-derived WISH cells. Biochem J (1997) 0.96
Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties. Proc Natl Acad Sci U S A (2004) 0.94
Induction of prostaglandin endoperoxide synthase-2 in human monocytes associated with cyclo-oxygenase-dependent F2-isoprostane formation. Br J Pharmacol (1996) 0.88
COX in a crystal ball: current status and future promise of prostaglandin research. J Clin Invest (2001) 0.87
Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. Proc Natl Acad Sci U S A (1998) 0.87
Effects of dexamethasone and SB 209670 on the regional haemodynamic responses to lipopolysaccharide in conscious rats. Br J Pharmacol (1996) 0.86
Influence of aminoguanidine and the endothelin antagonist, SB 209670, on the regional haemodynamic effects of endotoxaemia in conscious rats. Br J Pharmacol (1996) 0.86
Can licorice lick colon cancer? J Clin Invest (2009) 0.85
Topical glucocorticoids and the skin--mechanisms of action: an update. Mediators Inflamm (1998) 0.84
Cyclooxygenase-2 and its regulation in inflammation. Mediators Inflamm (1996) 0.84
Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney. Br J Pharmacol (1996) 0.83
Molecular and pharmacological evidence for modulation of kinin B(1) receptor expression by endogenous glucocorticoids hormones in rats. Br J Pharmacol (2001) 0.83
Prostaglandin endoperoxide synthetase isoenzymes: the clinical relevance of selective inhibition. Ann Rheum Dis (1995) 0.82
Cyclooxygenase products stimulate carbon monoxide production by piglet cerebral microvessels. Exp Biol Med (Maywood) (2006) 0.82
Annexin I and dexamethasone effects on phospholipase and cyclooxygenase activity in human synoviocytes. Mediators Inflamm (2000) 0.82
Comparison of three inhaled non-steroidal anti-inflammatory drugs on the airway response to sodium metabisulphite and adenosine 5'-monophosphate challenge in asthma. Thorax (1996) 0.81
Effect of topically applied cyclosporin A on arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation in mouse ear. Inflammation (1997) 0.80
QSAR and classification models of a novel series of COX-2 selective inhibitors: 1,5-diarylimidazoles based on support vector machines. J Comput Aided Mol Des (2004) 0.80
Interleukin-4 and interferon-gamma inhibit prostaglandin production by interleukin-1beta-stimulated human periodontal ligament fibroblasts. Inflammation (1999) 0.78
Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1β and TNF-α. Bone Joint Res (2014) 0.77
Impact of maternal dexamethasone on coronary PGE(2) production and prostaglandin-dependent coronary reactivity. Am J Physiol Regul Integr Comp Physiol (2012) 0.77
Chemoreflex activity increases prostaglandin endoperoxide synthase mRNA expression in the late-gestation fetal sheep brain. Reprod Sci (2011) 0.77
Attenuated prostaglandin formation in peroxisomal-deficient human skin fibroblasts. J Clin Invest (1993) 0.75
Effect of Rec mutations on the activity of colicinogenic factors. J Bacteriol (1967) 7.19
Purification and characterization of colicin E2 and colicin E3. J Biol Chem (1967) 5.74
TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem (1991) 5.62
Comparative study of the events associated with colicin induction. J Bacteriol (1967) 5.14
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription. Cell (2001) 3.97
A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography. Proc Natl Acad Sci U S A (2000) 3.28
The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem (1996) 3.04
Human pharmacokinetic and dosimetry studies of [(18)F]FHBG: a reporter probe for imaging herpes simplex virus type-1 thymidine kinase reporter gene expression. J Nucl Med (2001) 3.03
Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant. Oncogene (1987) 2.86
Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci U S A (1999) 2.71
Variants of 3T3 cells lacking mitogenic response to epidermal growth factor. Proc Natl Acad Sci U S A (1977) 2.65
Imaging of adenoviral-directed herpes simplex virus type 1 thymidine kinase reporter gene expression in mice with radiolabeled ganciclovir. J Nucl Med (1998) 2.58
Epidermal growth factor. Relationship between receptor regulation and mitogenesis in 3T3 cells. J Biol Chem (1978) 2.54
Specific radiolabeling of a cell surface receptor for epidermal growth factor. Proc Natl Acad Sci U S A (1977) 2.39
PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. J Biol Chem (1998) 2.35
PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells. J Biol Chem (2000) 2.26
Repetitive, non-invasive imaging of the dopamine D2 receptor as a reporter gene in living animals. Gene Ther (1999) 2.21
Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response. Nature (1980) 2.18
The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol (1991) 2.06
Imaging transgene expression with radionuclide imaging technologies. Neoplasia (2000) 2.03
Noninvasive methods for quantitating blood time-activity curves from mouse PET images obtained with fluorine-18-fluorodeoxyglucose. J Nucl Med (1998) 1.97
The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. J Biol Chem (1996) 1.96
8-[18F]Fluoropenciclovir: an improved reporter probe for imaging HSV1-tk reporter gene expression in vivo using PET. J Nucl Med (2001) 1.80
Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3. J Biol Chem (1999) 1.77
Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. J Biol Chem (1992) 1.74
The murine neutrophil-chemoattractant chemokines LIX, KC, and MIP-2 have distinct induction kinetics, tissue distributions, and tissue-specific sensitivities to glucocorticoid regulation in endotoxemia. J Leukoc Biol (1998) 1.67
Assays for noninvasive imaging of reporter gene expression. Nucl Med Biol (1999) 1.62
Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate. Oncogene (1989) 1.60
Induction of metallothionein in HeLa cells by dexamethasone and zinc. Eur J Biochem (1981) 1.58
Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264.7 macrophages. J Biol Chem (2000) 1.57
Monitoring gene therapy with reporter gene imaging. Semin Nucl Med (2001) 1.56
Quantification of target gene expression by imaging reporter gene expression in living animals. Nat Med (2000) 1.56
Initiation of 3T3 fibroblast cell division by epidermal growth factor. J Cell Physiol (1975) 1.55
Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain. Proc Natl Acad Sci U S A (1995) 1.50
The RGG domain in hnRNP A2 affects subcellular localization. Exp Cell Res (2000) 1.50
Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3. J Biol Chem (2000) 1.49
Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures. Science (1979) 1.48
Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter. Mol Cell Biol (1987) 1.47
v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element. Mol Cell Biol (1994) 1.42
Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells. J Biol Chem (1993) 1.41
Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. J Biol Chem (1994) 1.40
Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters. J Biol Chem (1991) 1.39
Detection of S-100 protein as an aid to the identification of melanocytic tumors. Int J Cancer (1982) 1.37
v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J Biol Chem (1995) 1.35
The glucocorticoid attenuated response genes GARG-16, GARG-39, and GARG-49/IRG2 encode inducible proteins containing multiple tetratricopeptide repeat domains. Arch Biochem Biophys (1996) 1.35
Occult melanoma in lymph nodes detected by antiserum to S-100 protein. Int J Cancer (1984) 1.29
Induction of transiently expressed genes in PC-12 pheochromocytoma cells. Oncogene (1987) 1.28
Deficits in memory and motor performance in synaptotagmin IV mutant mice. Proc Natl Acad Sci U S A (2000) 1.28
S100 protein: a marker for human malignant melanomas? Lancet (1981) 1.27
Synthesis by a clonal line of rat glial cells of a protein unique to the nervous system. J Cell Physiol (1970) 1.26
Imaging gene expression: principles and assays. J Nucl Cardiol (1999) 1.20
Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum. J Biol Chem (1996) 1.20
Appearance of a brain specific antigen (th S-100 protein) during human foetal development. J Neurochem (1970) 1.18
Prostaglandin synthase-1 and prostaglandin synthase-2 are coupled to distinct phospholipases for the generation of prostaglandin D2 in activated mast cells. J Biol Chem (1997) 1.17
Glucocorticoid-attenuated response genes encode intercellular mediators, including a new C-X-C chemokine. J Biol Chem (1995) 1.17
Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence. DNA (1983) 1.17
Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways. Mol Cell Biol (1989) 1.16
Transcriptional regulation of the cyclooxygenase-2 gene in activated mast cells. J Biol Chem (2000) 1.15
Epidermal growth factor-toxin A chain conjugates: EGF-ricin A is a potent toxin while EGF-diphtheria fragment A is nontoxic. Cell (1980) 1.13
Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids. J Cell Physiol (1981) 1.13
In vivo glucocorticoids regulate cyclooxygenase-2 but not cyclooxygenase-1 in peritoneal macrophages. J Pharmacol Exp Ther (1994) 1.12
Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals. Eur J Biochem (1981) 1.12
S100 protein is present in cultured human malignant melanomas. Nature (1980) 1.12
Granulocyte-macrophage colony-stimulating factor and tetradecanoyl phorbol acetate induce a distinct, restricted subset of primary-response TIS genes in both proliferating and terminally differentiated myeloid cells. Mol Cell Biol (1989) 1.11
Rat metallothionein-1 structural gene and three pseudogenes, one of which contains 5'-regulatory sequences. Mol Cell Biol (1986) 1.11
Modulation of cell-surface antigens of a murine neuroblastoma. Proc Natl Acad Sci U S A (1974) 1.11
The salt-inducible kinase, SIK, is induced by depolarization in brain. J Neurochem (2000) 1.10
A corrected sequence for the predicted protein from the mitogen-inducible TIS11 primary response gene. Oncogene (1991) 1.10
Extracellular signals, transcriptional responses and cellular specificity. Trends Biochem Sci (1989) 1.09
Metallothionein accumulation in response to cadmium in a clonal rat liver cell line. Toxicol Appl Pharmacol (1978) 1.09
Regulation of the rat metallothionein-I gene by sodium butyrate. Nucleic Acids Res (1986) 1.09
Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal transduction. Gene Ther (2001) 1.08
Tumor promoter-inducible genes are differentially expressed in the developing mouse. Mol Cell Biol (1988) 1.08
KID-1, a protein kinase induced by depolarization in brain. J Biol Chem (1998) 1.08
Metal-dependent binding of a nuclear factor to the rat metallothionein-I promoter. Nucleic Acids Res (1990) 1.07
Tumorigenic methylcholanthrene transformants of C3H/10T1/2 cells have a common nucleotide alteration in the c-Ki-ras gene. Proc Natl Acad Sci U S A (1989) 1.07
The yeast homologue YTIS11, of the mammalian TIS11 gene family is a non-essential, glucose repressible gene. Oncogene (1995) 1.06
Metallothionein in a human cell line: the response of HeLa cells to cadmium and zinc. Toxicol Appl Pharmacol (1979) 1.03
Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor. J Clin Invest (1995) 1.03
Heavy metals induce expression of the TPA-inducible sequence (TIS) genes. J Cell Physiol (1991) 1.01
Transcriptional regulation of the cyclooxygenase-2 gene by diverse ligands in murine osteoblasts. Biochem Biophys Res Commun (1999) 1.01
Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene. Proc Natl Acad Sci U S A (1994) 1.01
Tumor promoter modulation of epidermal growth factor- and nerve growth factor-induced adhesion and growth factor binding of PC-12 pheochromocytoma cells. J Cell Physiol (1980) 1.01
PET imaging of transgene expression. Biol Psychiatry (2000) 1.01
Adrenergic, cholinergic, and inactive human neuroblastoma cell lines with the action-potential Na+ ionophore. Cancer Res (1977) 1.00
Nerve growth factor-mediated induction of tyrosine hydroxylase in a clonal pheochromocytoma cell line. Proc Natl Acad Sci U S A (1978) 1.00
Variants of 3T3 cells lacking mitogenic response to the tumor promoter tetradecanoyl-phorbol-acetate. J Cell Physiol (1981) 1.00
Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Mol Biol Cell (1999) 0.99
Modification of cell surface antigenicity as a function of culture conditions. J Cell Physiol (1971) 0.99
Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells. J Immunol (1995) 0.99
Epidermal growth factor-nonresponsive 3T3 variants do not contain epidermal growth factor receptor-related antigens or mRNA. Proc Natl Acad Sci U S A (1986) 0.98
Differential induction of primary-response (TIS) genes in PC12 pheochromocytoma cells and the unresponsive variant PC12nnr5. J Biol Chem (1991) 0.98
Transforming growth factor beta differentially modulates the inducible nitric oxide synthase gene in distinct cell types. Biochem Biophys Res Commun (1993) 0.98
Characterization of TIS7, a gene induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate. Oncogene (1989) 0.98
Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system. J Neurosci Res (1982) 0.97
Analysis of the secretory phospholipase A2 that mediates prostaglandin production in mast cells. J Biol Chem (1997) 0.97
Cloning and characterization of the human granulocyte chemotactic protein-2 gene. J Immunol (1997) 0.96
Detection of cytoplasmic S-100 protein in primary and metastatic intraocular melanomas. Invest Ophthalmol Vis Sci (1983) 0.96
Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors. Gene Ther (2001) 0.96
Synthesis of 8-[(18)F]fluoroguanine derivatives: in vivo probes for imaging gene expression with positron emission tomography. Nucl Med Biol (2000) 0.96