|
1
|
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity.
|
Proc Natl Acad Sci U S A
|
1998
|
3.17
|
|
2
|
Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy.
|
Arch Gen Psychiatry
|
1999
|
2.78
|
|
3
|
Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
|
Proc Natl Acad Sci U S A
|
1993
|
2.77
|
|
4
|
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR.
|
Proc Natl Acad Sci U S A
|
1999
|
2.76
|
|
5
|
Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole.
|
Mol Psychiatry
|
2008
|
2.42
|
|
6
|
High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo.
|
Proc Natl Acad Sci U S A
|
1983
|
2.40
|
|
7
|
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling.
|
Proc Natl Acad Sci U S A
|
1997
|
2.12
|
|
8
|
Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR.
|
J Cereb Blood Flow Metab
|
1995
|
1.98
|
|
9
|
NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain.
|
J Cereb Blood Flow Metab
|
1992
|
1.89
|
|
10
|
Homonuclear 1H double-resonance difference spectroscopy of the rat brain in vivo.
|
Proc Natl Acad Sci U S A
|
1984
|
1.76
|
|
11
|
Increased tricarboxylic acid cycle flux in rat brain during forepaw stimulation detected with 1H[13C]NMR.
|
Proc Natl Acad Sci U S A
|
1996
|
1.74
|
|
12
|
The flux from glucose to glutamate in the rat brain in vivo as determined by 1H-observed, 13C-edited NMR spectroscopy.
|
J Cereb Blood Flow Metab
|
1990
|
1.74
|
|
13
|
13C NMR study of transamination during acetate utilization by Saccharomyces cerevisiae.
|
Proc Natl Acad Sci U S A
|
1981
|
1.70
|
|
14
|
Cerebral metabolic studies in vivo by 31P NMR.
|
Proc Natl Acad Sci U S A
|
1983
|
1.69
|
|
15
|
Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI.
|
NMR Biomed
|
2001
|
1.69
|
|
16
|
In vivo carbon-13 nuclear magnetic resonance studies of mammals.
|
Science
|
1981
|
1.61
|
|
17
|
In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain during.
|
J Neurochem
|
2001
|
1.55
|
|
18
|
Detection of cerebral lactate in vivo during hypoxemia by 1H NMR at relatively low field strengths (1.9 T).
|
Proc Natl Acad Sci U S A
|
1984
|
1.51
|
|
19
|
Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy.
|
Neurology
|
1985
|
1.49
|
|
20
|
1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo.
|
Proc Natl Acad Sci U S A
|
1985
|
1.44
|
|
21
|
Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy.
|
Arch Gen Psychiatry
|
2001
|
1.43
|
|
22
|
Dynamic magnetic resonance imaging of the rat brain during forepaw stimulation.
|
J Cereb Blood Flow Metab
|
1994
|
1.38
|
|
23
|
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics.
|
Philos Trans R Soc Lond B Biol Sci
|
1999
|
1.32
|
|
24
|
High-resolution CMR(O2) mapping in rat cortex: a multiparametric approach to calibration of BOLD image contrast at 7 Tesla.
|
J Cereb Blood Flow Metab
|
2000
|
1.32
|
|
25
|
Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase-deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling.
|
J Neurochem
|
2007
|
1.17
|
|
26
|
Glutamine is the major precursor for GABA synthesis in rat neocortex in vivo following acute GABA-transaminase inhibition.
|
Brain Res
|
2001
|
1.14
|
|
27
|
Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein.
|
Brain Res
|
2001
|
1.13
|
|
28
|
Oxidative glucose metabolism in rat brain during single forepaw stimulation: a spatially localized 1H[13C] nuclear magnetic resonance study.
|
J Cereb Blood Flow Metab
|
1997
|
1.12
|
|
29
|
NMR determination of intracerebral glucose concentration and transport kinetics in rat brain.
|
J Cereb Blood Flow Metab
|
1992
|
1.12
|
|
30
|
Effect of hypoglycemic encephalopathy upon amino acids, high-energy phosphates, and pHi in the rat brain in vivo: detection by sequential 1H and 31P NMR spectroscopy.
|
J Neurochem
|
1985
|
1.07
|
|
31
|
Dependence of oxygen delivery on blood flow in rat brain: a 7 tesla nuclear magnetic resonance study.
|
J Cereb Blood Flow Metab
|
2000
|
1.07
|
|
32
|
Human brain beta-hydroxybutyrate and lactate increase in fasting-induced ketosis.
|
J Cereb Blood Flow Metab
|
2000
|
1.07
|
|
33
|
Detection of metabolites in rabbit brain by 13C NMR spectroscopy following administration of [1-13C]glucose.
|
Magn Reson Med
|
1986
|
1.06
|
|
34
|
The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy.
|
Ann Neurol
|
1996
|
1.02
|
|
35
|
Low brain GABA level is associated with poor seizure control.
|
Ann Neurol
|
1996
|
1.01
|
|
36
|
Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivity.
|
Dev Neurosci
|
1998
|
1.00
|
|
37
|
Human brain gamma-aminobutyric acid levels and seizure control following initiation of vigabatrin therapy.
|
J Neurochem
|
1996
|
0.99
|
|
38
|
Effects of acute hyperammonemia on cerebral amino acid metabolism and pHi in vivo, measured by 1H and 31P nuclear magnetic resonance.
|
J Neurochem
|
1989
|
0.96
|
|
39
|
Initial observations on effect of vigabatrin on in vivo 1H spectroscopic measurements of gamma-aminobutyric acid, glutamate, and glutamine in human brain.
|
Epilepsia
|
1995
|
0.95
|
|
40
|
The rate of turnover of cortical GABA from [1-13C]glucose is reduced in rats treated with the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA).
|
Neurochem Res
|
1996
|
0.94
|
|
41
|
15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain.
|
Dev Neurosci
|
1998
|
0.93
|
|
42
|
Inhibition of voltage-dependent sodium channels suppresses the functional magnetic resonance imaging response to forepaw somatosensory activation in the rodent.
|
J Cereb Blood Flow Metab
|
2001
|
0.93
|
|
43
|
Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures.
|
Seizure
|
1999
|
0.91
|
|
44
|
Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain.
|
Magn Reson Med
|
1996
|
0.91
|
|
45
|
In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus.
|
Ann Neurol
|
1984
|
0.89
|
|
46
|
Cerebral metabolism in hyper- and hypocarbia: 31P and 1H nuclear magnetic resonance studies.
|
Neurology
|
1985
|
0.89
|
|
47
|
Human brain GABA levels rise rapidly after initiation of vigabatrin therapy.
|
Neurology
|
1996
|
0.89
|
|
48
|
Human brain GABA levels rise after initiation of vigabatrin therapy but fail to rise further with increasing dose.
|
Neurology
|
1996
|
0.88
|
|
49
|
Homocarnosine and the measurement of neuronal pH in patients with epilepsy.
|
Magn Reson Med
|
1997
|
0.88
|
|
50
|
Vigabatrin increases human brain homocarnosine and improves seizure control.
|
Ann Neurol
|
1998
|
0.86
|
|
51
|
Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro.
|
Brain Res
|
2001
|
0.83
|
|
52
|
Hexokinase in astrocytes: kinetic and regulatory properties.
|
Metab Brain Dis
|
1999
|
0.79
|
|
53
|
Toward absolute quantitation of bold functional MRI.
|
Adv Exp Med Biol
|
1999
|
0.78
|
|
54
|
Brain regional development of the activity of alpha-ketoglutarate dehydrogenase complex in the rat.
|
Brain Res Dev Brain Res
|
2000
|
0.78
|
|
55
|
High resolution NMR studies of cerebral glucose metabolism in rats and humans.
|
Adv Exp Med Biol
|
1991
|
0.77
|
|
56
|
New NMR measurements in epilepsy. Measuring brain GABA in patients with complex partial seizures.
|
Adv Neurol
|
1999
|
0.76
|
|
57
|
NMR-spectroscopic investigation of cerebral reanimation after prolonged ischemia.
|
Acta Neurochir Suppl (Wien)
|
1993
|
0.75
|
|
58
|
Rat brain glucose concentration and transport kinetics determined with 13C nuclear magnetic resonance spectroscopy.
|
Adv Exp Med Biol
|
1993
|
0.75
|
|
59
|
The 13C isotope and nuclear magnetic resonance: unique tools for the study of brain metabolism.
|
Metab Brain Dis
|
1996
|
0.75
|
|
60
|
Glycolysis-citric acid cycle interrelation: a new approach and some insights in cellular and subcellular compartmentation.
|
Dev Neurosci
|
1993
|
0.75
|
|
61
|
Application of multipulse NMR to observe 13C-labeled metabolites in biological systems.
|
Magn Reson Med
|
1985
|
0.75
|