Published in Trends Biochem Sci on February 01, 2005
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol Direct (2006) 11.31
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures. Cell Stem Cell (2009) 8.62
Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs. RNA (2005) 5.20
MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol (2008) 4.45
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A (2007) 4.15
Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila. Genes Dev (2005) 4.06
The Arabidopsis NFYA5 transcription factor is regulated transcriptionally and posttranscriptionally to promote drought resistance. Plant Cell (2008) 3.14
RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev (2007) 3.13
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell (2014) 2.90
Gene and genon concept: coding versus regulation. A conceptual and information-theoretic analysis of genetic storage and expression in the light of modern molecular biology. Theory Biosci (2007) 2.89
Tissue-dependent paired expression of miRNAs. Nucleic Acids Res (2007) 2.82
MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proc Natl Acad Sci U S A (2006) 2.80
Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing. EMBO J (2007) 2.79
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab (2007) 2.52
Lipid-based systemic delivery of siRNA. Adv Drug Deliv Rev (2009) 2.28
Argonaute--a database for gene regulation by mammalian microRNAs. Nucleic Acids Res (2006) 2.26
Delivery of siRNA therapeutics: barriers and carriers. AAPS J (2010) 2.15
Current tools for the identification of miRNA genes and their targets. Nucleic Acids Res (2009) 2.12
Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription. RNA (2008) 1.95
Hypoxia response and microRNAs: no longer two separate worlds. J Cell Mol Med (2008) 1.93
MicroRNAs as effectors of brain function with roles in ischemia and injury, neuroprotection, and neurodegeneration. J Cereb Blood Flow Metab (2010) 1.92
Formation of GW bodies is a consequence of microRNA genesis. EMBO Rep (2006) 1.92
Unique folding of precursor microRNAs: quantitative evidence and implications for de novo identification. RNA (2006) 1.85
Extensive 3' modification of plant small RNAs is modulated by helper component-proteinase expression. Proc Natl Acad Sci U S A (2005) 1.82
Loss of function of OsDCL1 affects microRNA accumulation and causes developmental defects in rice. Plant Physiol (2005) 1.77
Computational models with thermodynamic and composition features improve siRNA design. BMC Bioinformatics (2006) 1.69
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements. Biol Direct (2009) 1.58
The BTG2 protein is a general activator of mRNA deadenylation. EMBO J (2008) 1.54
MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS One (2009) 1.44
Tissue-specific RNAi reveals that WT1 expression in nurse cells controls germ cell survival and spermatogenesis. Genes Dev (2006) 1.34
Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? J Clin Invest (2007) 1.34
Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease. BMC Genomics (2008) 1.32
microRNAs and genetic diseases. Pathogenetics (2009) 1.32
Micromanaging vascular biology: tiny microRNAs play big band. J Vasc Res (2009) 1.31
RNAi mechanisms and applications. Biotechniques (2008) 1.30
Function and translational regulation of mRNA in developing axons. Semin Cell Dev Biol (2007) 1.27
Posttranscriptional gene silencing in nuclei. Proc Natl Acad Sci U S A (2010) 1.23
MicroRNA: biological and computational perspective. Genomics Proteomics Bioinformatics (2005) 1.23
MicroRNA-guided processing impairs Plum pox virus replication, but the virus readily evolves to escape this silencing mechanism. J Virol (2006) 1.21
Asymmetry of intronic pre-miRNA structures in functional RISC assembly. Gene (2005) 1.19
Xenopus microRNA genes are predominantly located within introns and are differentially expressed in adult frog tissues via post-transcriptional regulation. Genome Res (2007) 1.14
Over-expression of rice OsAGO7 gene induces upward curling of the leaf blade that enhanced erect-leaf habit. Planta (2007) 1.12
RNAi for treating hepatitis B viral infection. Pharm Res (2007) 1.05
Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification. Nucleic Acids Res (2006) 1.04
Tissue-specific differences in cytosine methylation and their association with differential gene expression in sorghum. Plant Physiol (2011) 1.03
Evidence for antisense transcription associated with microRNA target mRNAs in Arabidopsis. PLoS Genet (2009) 1.00
microRNAs: tiny regulators of synapse function in development and disease. J Cell Mol Med (2008) 0.98
MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett (2015) 0.97
Targeted delivery of mutant tolerant anti-coxsackievirus artificial microRNAs using folate conjugated bacteriophage Phi29 pRNA. PLoS One (2011) 0.96
Improved identification of enriched peptide RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry. Nucleic Acids Res (2007) 0.95
The silent defense: micro-RNA directed defense against HIV-1 replication. Retrovirology (2007) 0.95
Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles. J RNAi Gene Silencing (2006) 0.94
CLL cells respond to B-Cell receptor stimulation with a microRNA/mRNA signature associated with MYC activation and cell cycle progression. PLoS One (2013) 0.93
MicroRNAs in pancreatic ductal adenocarcinoma. World J Gastroenterol (2011) 0.93
An intron sense suppression construct targeting soybean FAD2-1 requires a double-stranded RNA-producing inverted repeat T-DNA insert. Plant Physiol (2010) 0.92
Structural domains in RNAi. FEBS Lett (2005) 0.92
Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila. Dev Biol (2008) 0.91
MicroRNA Role in Thyroid Cancer Development. J Thyroid Res (2011) 0.91
Mir-434-5p mediates skin whitening and lightening. Clin Cosmet Investig Dermatol (2008) 0.90
Plant small RNAs: biogenesis, mode of action and their roles in abiotic stresses. Genomics Proteomics Bioinformatics (2011) 0.89
Modeling recursive RNA interference. PLoS Comput Biol (2008) 0.89
Non coding RNA and brain. BMC Neurosci (2006) 0.89
aubergine gene overexpression in somatic tissues of aubergine(sting) mutants interferes with the RNAi pathway of a yellow hairpin dsRNA in Drosophila melanogaster. Genetics (2008) 0.88
Glypican-1 regulates anaphase promoting complex/cyclosome substrates and cell cycle progression in endothelial cells. Mol Biol Cell (2008) 0.87
Expression, purification, and analysis of recombinant Drosophila Dicer-1 and Dicer-2 enzymes. Methods Mol Biol (2008) 0.87
A large-scale functional screen identifies Nova1 and Ncoa3 as regulators of neuronal miRNA function. EMBO J (2015) 0.87
Partners in dicing. Genome Biol (2006) 0.87
Mechanisms of RNAi: mRNA cleavage fragments may indicate stalled RISC. J RNAi Gene Silencing (2005) 0.87
Optimized models for design of efficient miR30-based shRNAs. Front Genet (2012) 0.86
The microRNAs involved in human myeloid differentiation and myelogenous/myeloblastic leukemia. J Cell Mol Med (2008) 0.85
The biology of circulating microRNAs in cardiovascular disease. Eur J Clin Invest (2015) 0.85
Function of chloride intracellular channel 1 in gastric cancer cells. World J Gastroenterol (2012) 0.84
The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes. Biomed Res Int (2014) 0.84
A Comprehensive Prescription for Plant miRNA Identification. Front Plant Sci (2017) 0.83
Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studies. Virus Res (2012) 0.82
Mutation of the RDR1 gene caused genome-wide changes in gene expression, regional variation in small RNA clusters and localized alteration in DNA methylation in rice. BMC Plant Biol (2014) 0.82
Epigenetic mechanisms of genomic imprinting: common themes in the regulation of imprinted regions in mammals, plants, and insects. Genet Res Int (2012) 0.82
Real-time monitoring of miRNA function in pancreatic cell lines using recombinant AAV-based miRNA Asensors. PLoS One (2013) 0.81
Targeting miRNAs for pancreatic cancer therapy. Curr Pharm Des (2014) 0.81
Non-coding RNAs in Exosomes: New Players in Cancer Biology. Curr Genomics (2015) 0.80
How many antiviral small interfering RNAs may be encoded by the mammalian genomes? Biol Direct (2010) 0.80
Delivery of cancer therapeutics to extracellular and intracellular targets: Determinants, barriers, challenges and opportunities. Adv Drug Deliv Rev (2015) 0.79
Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix. Gene Ther Mol Biol (2005) 0.79
Thermodynamic basis of selectivity in guide-target-mismatched RNA interference. Proteins (2012) 0.79
A novel method of modifying immune responses by vaccination with lipiodol-siRNA mixtures. J Transl Med (2006) 0.78
RNA Quality Control as a Key to Suppressing RNA Silencing of Endogenous Genes in Plants. Mol Plant (2016) 0.78
Construction of permanently inducible miRNA-based expression vectors using site-specific recombinases. BMC Biotechnol (2011) 0.77
Tat-regulated expression of RNA interference: triggers for the treatment of HIV infection. Curr HIV/AIDS Rep (2008) 0.77
Function and anatomy of plant siRNA pools derived from hairpin transgenes. Plant Methods (2007) 0.77
Non coding RNAs and viruses in the framework of the phylogeny of the genes, epigenesis and heredity. Int J Mol Sci (2012) 0.76
Generation of marker-free transgenic plants concurrently resistant to a DNA geminivirus and a RNA tospovirus. Sci Rep (2014) 0.76
Virus-derived small RNAs in the penaeid shrimp Fenneropenaeus chinensis during acute infection of the DNA virus WSSV. Sci Rep (2016) 0.75
MicroRNAs and cardiovascular medicine. SAGE Open Med (2014) 0.75
Antisense gene silencing: therapy for neurodegenerative disorders? Genes (Basel) (2013) 0.75
Short intron-derived ncRNAs. Nucleic Acids Res (2017) 0.75
Mechanism of repeat-associated microRNAs in fragile X syndrome. Neural Plast (2012) 0.75
Using RNAi to improve plant nutritional value: from mechanism to application. Trends Biotechnol (2004) 0.80