Lipid-based systemic delivery of siRNA.

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Published in Adv Drug Deliv Rev on March 26, 2009

Authors

Yu-Cheng Tseng1, Subho Mozumdar, Leaf Huang

Author Affiliations

1: Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature (1998) 72.56

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12

Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18

Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol (2009) 19.99

Functional siRNAs and miRNAs exhibit strand bias. Cell (2003) 19.15

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A (1995) 18.16

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell (2004) 16.10

Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature (1996) 15.91

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res (1986) 15.83

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell (2005) 15.26

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature (2004) 12.75

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans. Plant Cell (1990) 10.56

Drug delivery systems: entering the mainstream. Science (2004) 9.27

Activation of the interferon system by short-interfering RNAs. Nat Cell Biol (2003) 8.63

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A (2002) 8.57

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nat Biotechnol (2002) 8.31

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther (1999) 8.28

Single processing center models for human Dicer and bacterial RNase III. Cell (2004) 8.19

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RNAi-mediated gene silencing in non-human primates. Nature (2006) 7.60

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature (2008) 7.10

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA (2006) 7.06

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Induction of an interferon response by RNAi vectors in mammalian cells. Nat Genet (2003) 6.49

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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol (2006) 6.30

Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc Natl Acad Sci U S A (2002) 6.09

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nat Biotechnol (2005) 5.99

Openings between defective endothelial cells explain tumor vessel leakiness. Am J Pathol (2000) 5.94

Modulation of HIV-1 replication by RNA interference. Nature (2002) 5.90

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RNA interference in adult mice. Nature (2002) 5.33

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High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther (1999) 5.17

siRNA function in RNAi: a chemical modification analysis. RNA (2003) 4.93

Total silencing by intron-spliced hairpin RNAs. Nature (2000) 4.78

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Intravesical antisense therapy for cystitis using TAT-peptide nucleic acid conjugates. Mol Pharm (2006) 0.84

Systemic administration of naked DNA encoding interleukin 12 for the treatment of human papillomavirus DNA-positive tumor. Hum Gene Ther (2002) 0.84

How does the cell overcome LCP nanoparticle-induced calcium toxicity? Mol Pharm (2013) 0.83

Cancer immunotherapy and nanomedicine. Pharm Res (2010) 0.83

Gene transfer to subdermal tissues via a new gene gun design. Hum Gene Ther (2003) 0.83

Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene. Cancer Res (2002) 0.83

Intelligent design of multifunctional lipid-coated nanoparticle platforms for cancer therapy. Ther Deliv (2012) 0.83

Preparation, characterization and in vitro drug release studies of novel polymeric nanoparticles. Int J Pharm (2006) 0.83

Novel nonviral vectors target cellular signaling pathways: regulated gene expression and reduced toxicity. J Pharmacol Exp Ther (2007) 0.82

Using hydrophilic ionic liquid, [bmim]BF4-ethylene glycol system as a novel media for the rapid synthesis of copper nanoparticles. PLoS One (2012) 0.82

Smart polymeric nanoparticles for cancer gene delivery. Mol Pharm (2015) 0.82

Incorporation of histone derived recombinant protein for enhanced disassembly of core-membrane structured liposomal nanoparticles for efficient siRNA delivery. J Control Release (2013) 0.81

Lipid-mediated delivery of oligonucleotide to pulmonary endothelium. Am J Respir Cell Mol Biol (2002) 0.81