|
1
|
Transition metal speciation in the cell: insights from the chemistry of metal ion receptors.
|
Science
|
2003
|
5.12
|
|
2
|
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria.
|
Proc Natl Acad Sci U S A
|
2006
|
3.30
|
|
3
|
Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR.
|
Science
|
2003
|
3.08
|
|
4
|
Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS.
|
EMBO J
|
2004
|
2.55
|
|
5
|
Activation of superoxide dismutases: putting the metal to the pedal.
|
Biochim Biophys Acta
|
2006
|
2.33
|
|
6
|
Cu(I) recognition via cation-pi and methionine interactions in CusF.
|
Nat Chem Biol
|
2007
|
2.28
|
|
7
|
Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice.
|
Proc Natl Acad Sci U S A
|
2006
|
2.22
|
|
8
|
Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation.
|
J Biol Chem
|
2005
|
2.19
|
|
9
|
The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status.
|
J Biol Chem
|
2004
|
1.97
|
|
10
|
Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria.
|
J Biol Chem
|
2003
|
1.83
|
|
11
|
Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy.
|
ACS Nano
|
2010
|
1.82
|
|
12
|
Metallochaperones and metal-transporting ATPases: a comparative analysis of sequences and structures.
|
Genome Res
|
2002
|
1.80
|
|
13
|
Zinc availability regulates exit from meiosis in maturing mammalian oocytes.
|
Nat Chem Biol
|
2010
|
1.76
|
|
14
|
Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis.
|
J Biol Chem
|
2008
|
1.69
|
|
15
|
Emission ratiometric imaging of intracellular zinc: design of a benzoxazole fluorescent sensor and its application in two-photon microscopy.
|
J Am Chem Soc
|
2004
|
1.66
|
|
16
|
Fluxes in "free" and total zinc are essential for progression of intraerythrocytic stages of Plasmodium falciparum.
|
Chem Biol
|
2012
|
1.59
|
|
17
|
A place for thioether chemistry in cellular copper ion recognition and trafficking.
|
Nat Chem Biol
|
2008
|
1.46
|
|
18
|
Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase.
|
Proc Natl Acad Sci U S A
|
2004
|
1.45
|
|
19
|
Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs.
|
ACS Chem Biol
|
2011
|
1.37
|
|
20
|
Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis.
|
Antioxid Redox Signal
|
2006
|
1.36
|
|
21
|
A physical sciences network characterization of non-tumorigenic and metastatic cells.
|
Sci Rep
|
2013
|
1.33
|
|
22
|
Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide.
|
Mol Cancer Ther
|
2009
|
1.27
|
|
23
|
Lipid encapsulation of arsenic trioxide attenuates cytotoxicity and allows for controlled anticancer drug release.
|
J Am Chem Soc
|
2006
|
1.27
|
|
24
|
Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation.
|
Science
|
2009
|
1.21
|
|
25
|
"Clickable" polymer-caged nanobins as a modular drug delivery platform.
|
J Am Chem Soc
|
2009
|
1.18
|
|
26
|
Polymer-caged lipsomes: a pH-responsive delivery system with high stability.
|
J Am Chem Soc
|
2007
|
1.16
|
|
27
|
A novel nanoparticulate formulation of arsenic trioxide with enhanced therapeutic efficacy in a murine model of breast cancer.
|
Clin Cancer Res
|
2010
|
1.12
|
|
28
|
The PcoC copper resistance protein coordinates Cu(I) via novel S-methionine interactions.
|
J Am Chem Soc
|
2003
|
1.12
|
|
29
|
Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is independent of the MOS-MAPK pathway.
|
Biol Reprod
|
2010
|
1.10
|
|
30
|
Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic.
|
Curr Pharm Des
|
2011
|
1.05
|
|
31
|
Coencapsulation of arsenic- and platinum-based drugs for targeted cancer treatment.
|
Angew Chem Int Ed Engl
|
2009
|
1.04
|
|
32
|
A zinc-dependent mechanism regulates meiotic progression in mammalian oocytes.
|
Biol Reprod
|
2012
|
1.04
|
|
33
|
Spectroscopy of Cu(II)-PcoC and the multicopper oxidase function of PcoA, two essential components of Escherichia coli pco copper resistance operon.
|
Biochemistry
|
2002
|
1.02
|
|
34
|
An atypical linear Cu(I)-S2 center constitutes the high-affinity metal-sensing site in the CueR metalloregulatory protein.
|
J Am Chem Soc
|
2003
|
0.98
|
|
35
|
Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release.
|
Angew Chem Int Ed Engl
|
2010
|
0.98
|
|
36
|
A new zinc-protein coordination site in intracellular metal trafficking: solution structure of the Apo and Zn(II) forms of ZntA(46-118).
|
J Mol Biol
|
2002
|
0.98
|
|
37
|
Role of CTR4 in the Virulence of Cryptococcus neoformans.
|
MBio
|
2012
|
0.96
|
|
38
|
Crystal structure and dimerization equilibria of PcoC, a methionine-rich copper resistance protein from Escherichia coli.
|
J Biol Inorg Chem
|
2002
|
0.95
|
|
39
|
Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy.
|
J Am Chem Soc
|
2010
|
0.94
|
|
40
|
Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.
|
J Endocrinol
|
2010
|
0.90
|
|
41
|
Zinc maintains prophase I arrest in mouse oocytes through regulation of the MOS-MAPK pathway.
|
Biol Reprod
|
2012
|
0.89
|
|
42
|
Size control of arsenic trioxide nanocrystals grown in nanowells.
|
J Am Chem Soc
|
2009
|
0.88
|
|
43
|
Nano-encapsulation of arsenic trioxide enhances efficacy against murine lymphoma model while minimizing its impact on ovarian reserve in vitro and in vivo.
|
PLoS One
|
2013
|
0.88
|
|
44
|
Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy.
|
Mol Cancer Ther
|
2013
|
0.86
|
|
45
|
Accumulation of cadmium in insulin-producing β cells.
|
Islets
|
2012
|
0.85
|
|
46
|
Zinc, insulin, and the liver: a ménage à trois.
|
J Clin Invest
|
2013
|
0.82
|
|
47
|
Anticancer activity of small-molecule and nanoparticulate arsenic(III) complexes.
|
Inorg Chem
|
2013
|
0.82
|
|
48
|
A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans.
|
Metallomics
|
2013
|
0.79
|
|
49
|
Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups.
|
J Mater Chem
|
2012
|
0.79
|
|
50
|
Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes.
|
Angew Chem Int Ed Engl
|
2013
|
0.78
|
|
51
|
Triggered release of pharmacophores from [Ni(HAsO₃)]-loaded polymer-caged nanobin enhances pro-apoptotic activity: a combined experimental and theoretical study.
|
ACS Nano
|
2011
|
0.78
|
|
52
|
Design, Implementation, Simulation, and Visualization of a Highly Efficient RIM Microfluidic Mixer for Rapid Freeze-Quench of Biological Samples.
|
Appl Magn Reson
|
2011
|
0.78
|
|
53
|
Development and modeling of arsenic-trioxide-loaded thermosensitive liposomes for anticancer drug delivery.
|
J Liposome Res
|
2010
|
0.75
|