Published in Science on May 09, 2003
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Coordination chemistry of bacterial metal transport and sensing. Chem Rev (2009) 2.65
Activation of superoxide dismutases: putting the metal to the pedal. Biochim Biophys Acta (2006) 2.33
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A place for thioether chemistry in cellular copper ion recognition and trafficking. Nat Chem Biol (2008) 1.46
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Detecting and minimizing zinc contamination in physiological solutions. BMC Physiol (2004) 1.32
Metal binding studies and EPR spectroscopy of the manganese transport regulator MntR. Biochemistry (2006) 1.28
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A tautomeric zinc sensor for ratiometric fluorescence imaging: application to nitric oxide-induced release of intracellular zinc. Proc Natl Acad Sci U S A (2004) 1.27
The role of metallothionein in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol (2005) 1.25
Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation. Science (2009) 1.21
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The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis. J Bacteriol (2011) 1.18
Critical roles of bacterioferritins in iron storage and proliferation of cyanobacteria. Plant Physiol (2004) 1.18
Opposite effects of Mn2+ and Zn2+ on PsaR-mediated expression of the virulence genes pcpA, prtA, and psaBCA of Streptococcus pneumoniae. J Bacteriol (2008) 1.16
Copper ions stimulate polyphosphate degradation and phosphate efflux in Acidithiobacillus ferrooxidans. Appl Environ Microbiol (2004) 1.15
Metal ion ligands in hyperaccumulating plants. J Biol Inorg Chem (2005) 1.14
Intracellular trafficking of porphyrins. ACS Chem Biol (2006) 1.13
Bacterial transition metal P(1B)-ATPases: transport mechanism and roles in virulence. Biochemistry (2011) 1.13
Mechanisms of nickel toxicity in microorganisms. Metallomics (2011) 1.12
Direct substitution and assisted dissociation pathways for turning off transcription by a MerR-family metalloregulator. Proc Natl Acad Sci U S A (2012) 1.12
Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation. Biochemistry (2013) 1.12
Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer. Proc Natl Acad Sci U S A (2008) 1.11
Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus. Biochem J (2013) 1.10
The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo. Biochemistry (2005) 1.10
Production of high-quality particulate methane monooxygenase in high yields from Methylococcus capsulatus (bath) with a hollow-fiber membrane bioreactor. J Bacteriol (2003) 1.10
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs). Chem Rev (2014) 1.10
The mechanism of iron homeostasis in the unicellular cyanobacterium synechocystis sp. PCC 6803 and its relationship to oxidative stress. Plant Physiol (2009) 1.10
Resistance mechanisms of Mycobacterium tuberculosis against phagosomal copper overload. Tuberculosis (Edinb) (2012) 1.07
Copper(II) binding to alpha-synuclein, the Parkinson's protein. J Am Chem Soc (2008) 1.05
The metal homeostasis protein, Lsp, of Streptococcus pyogenes is necessary for acquisition of zinc and virulence. Infect Immun (2009) 1.03
Structural explanation for the role of Mn2+ in the activity of phi6 RNA-dependent RNA polymerase. Nucleic Acids Res (2008) 1.02
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Rv2358 and FurB: two transcriptional regulators from Mycobacterium tuberculosis which respond to zinc. J Bacteriol (2005) 1.02
The Bradyrhizobium japonicum Irr protein is a transcriptional repressor with high-affinity DNA-binding activity. J Bacteriol (2008) 1.02
Sinorhizobium meliloti fur-like (Mur) protein binds a fur box-like sequence present in the mntA promoter in a manganese-responsive manner. Appl Environ Microbiol (2007) 1.01
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Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J (2006) 0.99
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A P-type ATPase importer that discriminates between essential and toxic transition metals. Proc Natl Acad Sci U S A (2009) 0.99
Mechanism of metal ion activation of the diphtheria toxin repressor DtxR. Proc Natl Acad Sci U S A (2005) 0.99
Growth phase and metal-dependent transcriptional regulation of the fecA genes in Helicobacter pylori. J Bacteriol (2009) 0.99
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Noncatalytic ions direct the RNA-dependent RNA polymerase of bacterial double-stranded RNA virus ϕ6 from de novo initiation to elongation. J Virol (2011) 0.98
Regulation of resistance to copper in Xanthomonas axonopodis pv. vesicatoria. Appl Environ Microbiol (2005) 0.98
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The crystal structure of yeast copper thionein: the solution of a long-lasting enigma. Proc Natl Acad Sci U S A (2004) 0.97
Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene. Protein Sci (2007) 0.97
Mycobacteria, metals, and the macrophage. Immunol Rev (2015) 0.97
Copper redistribution in Atox1-deficient mouse fibroblast cells. J Biol Inorg Chem (2009) 0.97
Copper efflux is induced during anaerobic amino acid limitation in Escherichia coli to protect iron-sulfur cluster enzymes and biogenesis. J Bacteriol (2013) 0.97
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GeoChip-based analysis of the functional gene diversity and metabolic potential of microbial communities in acid mine drainage. Appl Environ Microbiol (2010) 0.96
The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1. Nucleic Acids Res (2010) 0.96
Selective electrodiffusion of zinc ions in a Zrt-, Irt-like protein, ZIPB. J Biol Chem (2010) 0.95
A Cu(I)-sensing ArsR family metal sensor protein with a relaxed metal selectivity profile. Biochemistry (2008) 0.95
Thermodynamics of copper and zinc distribution in the cyanobacterium Synechocystis PCC 6803. Proc Natl Acad Sci U S A (2011) 0.94
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Reaction-based fluorescent sensor for investigating mobile Zn2+ in mitochondria of healthy versus cancerous prostate cells. Proc Natl Acad Sci U S A (2013) 0.94
The zinc indicator FluoZin-3 is not perturbed significantly by physiological levels of calcium or magnesium. Cell Calcium (2008) 0.94
Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. PLoS Genet (2011) 0.93
Iron deprivation in Synechocystis: inference of pathways, non-coding RNAs, and regulatory elements from comprehensive expression profiling. G3 (Bethesda) (2012) 0.93
The interaction of biological and noxious transition metals with the zinc probes FluoZin-3 and Newport Green. Anal Biochem (2008) 0.93
Simulations of allosteric motions in the zinc sensor CzrA. J Am Chem Soc (2011) 0.93
Differential expression of the three multicopper oxidases from Myxococcus xanthus. J Bacteriol (2007) 0.92
Folding and unfolding in the blue copper protein rusticyanin: role of the oxidation state. Bioinorg Chem Appl (2007) 0.92
The roles of metal ions in regulation by riboswitches. Met Ions Life Sci (2011) 0.92
Characterization of the survival ability of Cupriavidus metallidurans and Ralstonia pickettii from space-related environments. Microb Ecol (2012) 0.91
Variations in methanobactin structure influences copper utilization by methane-oxidizing bacteria. Proc Natl Acad Sci U S A (2012) 0.91
Staphylococcal response to oxidative stress. Front Cell Infect Microbiol (2012) 0.90
In vivo folding of recombinant metallo-beta-lactamase L1 requires the presence of Zn(II). Protein Sci (2004) 0.90
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. Proc Natl Acad Sci U S A (2006) 3.30
Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR. Science (2003) 3.08
Oxygen-induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS. EMBO J (2004) 2.55
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Cu(I) recognition via cation-pi and methionine interactions in CusF. Nat Chem Biol (2007) 2.28
Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice. Proc Natl Acad Sci U S A (2006) 2.22
Amyotrophic lateral sclerosis mutations have the greatest destabilizing effect on the apo- and reduced form of SOD1, leading to unfolding and oxidative aggregation. J Biol Chem (2005) 2.19
The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status. J Biol Chem (2004) 1.97
Factors controlling the uptake of yeast copper/zinc superoxide dismutase into mitochondria. J Biol Chem (2003) 1.83
Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy. ACS Nano (2010) 1.82
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Zinc availability regulates exit from meiosis in maturing mammalian oocytes. Nat Chem Biol (2010) 1.76
Complete loss of post-translational modifications triggers fibrillar aggregation of SOD1 in the familial form of amyotrophic lateral sclerosis. J Biol Chem (2008) 1.69
Emission ratiometric imaging of intracellular zinc: design of a benzoxazole fluorescent sensor and its application in two-photon microscopy. J Am Chem Soc (2004) 1.66
Fluxes in "free" and total zinc are essential for progression of intraerythrocytic stages of Plasmodium falciparum. Chem Biol (2012) 1.59
A place for thioether chemistry in cellular copper ion recognition and trafficking. Nat Chem Biol (2008) 1.46
Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A (2004) 1.45
Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs. ACS Chem Biol (2011) 1.37
Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis. Antioxid Redox Signal (2006) 1.36
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide. Mol Cancer Ther (2009) 1.27
Lipid encapsulation of arsenic trioxide attenuates cytotoxicity and allows for controlled anticancer drug release. J Am Chem Soc (2006) 1.27
Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation. Science (2009) 1.21
"Clickable" polymer-caged nanobins as a modular drug delivery platform. J Am Chem Soc (2009) 1.18
Polymer-caged lipsomes: a pH-responsive delivery system with high stability. J Am Chem Soc (2007) 1.16
A novel nanoparticulate formulation of arsenic trioxide with enhanced therapeutic efficacy in a murine model of breast cancer. Clin Cancer Res (2010) 1.12
The PcoC copper resistance protein coordinates Cu(I) via novel S-methionine interactions. J Am Chem Soc (2003) 1.12
Zinc requirement during meiosis I-meiosis II transition in mouse oocytes is independent of the MOS-MAPK pathway. Biol Reprod (2010) 1.10
Development of novel therapeutics targeting the urokinase plasminogen activator receptor (uPAR) and their translation toward the clinic. Curr Pharm Des (2011) 1.05
Coencapsulation of arsenic- and platinum-based drugs for targeted cancer treatment. Angew Chem Int Ed Engl (2009) 1.04
A zinc-dependent mechanism regulates meiotic progression in mammalian oocytes. Biol Reprod (2012) 1.04
Spectroscopy of Cu(II)-PcoC and the multicopper oxidase function of PcoA, two essential components of Escherichia coli pco copper resistance operon. Biochemistry (2002) 1.02
Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release. Angew Chem Int Ed Engl (2010) 0.98
An atypical linear Cu(I)-S2 center constitutes the high-affinity metal-sensing site in the CueR metalloregulatory protein. J Am Chem Soc (2003) 0.98
A new zinc-protein coordination site in intracellular metal trafficking: solution structure of the Apo and Zn(II) forms of ZntA(46-118). J Mol Biol (2002) 0.98
Role of CTR4 in the Virulence of Cryptococcus neoformans. MBio (2012) 0.96
Crystal structure and dimerization equilibria of PcoC, a methionine-rich copper resistance protein from Escherichia coli. J Biol Inorg Chem (2002) 0.95
Polymer-caged nanobins for synergistic cisplatin-doxorubicin combination chemotherapy. J Am Chem Soc (2010) 0.94
Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function. J Endocrinol (2010) 0.90
Zinc maintains prophase I arrest in mouse oocytes through regulation of the MOS-MAPK pathway. Biol Reprod (2012) 0.89
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Nano-encapsulation of arsenic trioxide enhances efficacy against murine lymphoma model while minimizing its impact on ovarian reserve in vitro and in vivo. PLoS One (2013) 0.88
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Accumulation of cadmium in insulin-producing β cells. Islets (2012) 0.85
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A copper hyperaccumulation phenotype correlates with pathogenesis in Cryptococcus neoformans. Metallomics (2013) 0.79
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Design, Implementation, Simulation, and Visualization of a Highly Efficient RIM Microfluidic Mixer for Rapid Freeze-Quench of Biological Samples. Appl Magn Reson (2011) 0.78
Triggered release of pharmacophores from [Ni(HAsO₃)]-loaded polymer-caged nanobin enhances pro-apoptotic activity: a combined experimental and theoretical study. ACS Nano (2011) 0.78
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