PubRank

Gabriel Nuñez

Author PubWeight™ 135.82‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005 11.31
2 NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010 10.60
3 Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 2003 9.37
4 Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 2010 8.87
5 The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009 7.80
6 Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol 2010 6.64
7 An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 2003 6.46
8 NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 2005 6.18
9 Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2009 5.83
10 NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol 2003 5.07
11 Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog 2007 4.73
12 NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol 2009 3.39
13 A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol 2002 3.38
14 Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev 2009 3.20
15 Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 2003 2.72
16 Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 2003 2.64
17 NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol 2008 2.45
18 Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe 2010 2.03
19 CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. Proc Natl Acad Sci U S A 2006 1.96
20 Nods: a family of cytosolic proteins that regulate the host response to pathogens. Curr Opin Microbiol 2002 1.93
21 ML -- a conserved domain involved in innate immunity and lipid metabolism. Trends Biochem Sci 2002 1.92
22 A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J Biol Chem 2005 1.81
23 T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii. Nat Immunol 2009 1.67
24 Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments. J Biol Chem 2006 1.55
25 Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection. J Biol Chem 2006 1.30
26 Peptidoglycan signaling in innate immunity and inflammatory disease. J Biol Chem 2005 1.25
27 A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Cell Host Microbe 2013 1.21
28 Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem 2011 1.20
29 Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death. J Neurosci 2004 1.18
30 TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages. J Immunol 2012 1.18
31 A novel caspase-1/toll-like receptor 4-independent pathway of cell death induced by cytosolic Shigella in infected macrophages. J Biol Chem 2005 1.16
32 Dysfunctional apoptosome activation in ovarian cancer: implications for chemoresistance. Cancer Res 2002 1.13
33 Crystal structure of the Nod1 caspase activation and recruitment domain. Biochem Biophys Res Commun 2006 1.10
34 The ever-expanding function of NOD2: autophagy, viral recognition, and T cell activation. Trends Immunol 2011 1.09
35 Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis. Arthritis Res Ther 2013 1.05
36 Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease. Genomics 2003 1.04
37 Apoptosome formation and caspase activation: is it different in the heart? J Mol Cell Cardiol 2004 1.04
38 Mechanism of impaired NLRP3 inflammasome priming by monophosphoryl lipid A. Sci Signal 2011 1.03
39 A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses. J Biol Chem 2007 1.01
40 Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response. PLoS Pathog 2012 0.97
41 Roles for homotypic interactions and transautophosphorylation in IkappaB kinase beta IKKbeta) activation [corrected]. J Biol Chem 2003 0.96
42 Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure. Infect Immun 2009 0.95
43 A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy. J Biol Chem 2012 0.94
44 The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology 2012 0.88
45 Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions. Cell Immunol 2011 0.87
46 Battling enteroinvasive bacteria: Nod1 comes to the rescue. Trends Microbiol 2004 0.83
47 TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen. J Clin Invest 2014 0.83
48 Mindin the fort. Nat Immunol 2004 0.83
49 AIM2 joins the gang of microbial sensors. Cell Host Microbe 2010 0.78
50 Selective Biological Responses of Phagocytes and Lungs to Purified Histones. J Innate Immun 2017 0.75