Published in J Biol Chem on January 04, 2003
Inflammatory bowel disease. N Engl J Med (2009) 8.62
Inflammatory bowel disease. Annu Rev Immunol (2010) 7.10
Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). Annu Rev Immunol (2009) 5.91
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol (2010) 5.57
Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest (2004) 5.39
The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21
Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. PLoS Pathog (2006) 5.17
The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 5.12
Dysbiosis in inflammatory bowel disease. Gut (2004) 5.01
Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol (2013) 4.34
Dendritic cells in intestinal immune regulation. Nat Rev Immunol (2008) 4.20
Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18
Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A (2009) 3.58
Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol (2013) 3.55
Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20
The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity (2008) 3.19
Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis. J Clin Microbiol (2006) 3.02
A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest (2008) 2.88
ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology (2010) 2.83
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J (2004) 2.81
Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut (2003) 2.74
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep (2004) 2.64
Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev (2005) 2.50
Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion. Cell Host Microbe (2010) 2.49
The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity (2011) 2.47
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci U S A (2007) 2.46
NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol (2008) 2.45
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. Semin Immunopathol (2007) 2.42
Predominant role of host genetics in controlling the composition of gut microbiota. PLoS One (2008) 2.33
NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog (2009) 2.31
Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun (2005) 2.23
Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J (2004) 2.23
The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 2.21
SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis. Proc Natl Acad Sci U S A (2003) 2.18
Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? Gut (2005) 2.17
Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc Natl Acad Sci U S A (2003) 2.16
Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol (2003) 2.12
Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol (2007) 2.12
Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. Mol Cell Biol (2007) 2.06
Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol (2005) 2.03
NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology (2007) 2.03
Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J (2007) 1.98
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med (2006) 1.95
XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci U S A (2009) 1.95
Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus. Immunity (2014) 1.94
Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog (2007) 1.93
PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe (2009) 1.89
The Jekyll and Hyde functions of caspases. Dev Cell (2009) 1.87
Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe (2011) 1.86
Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol (2012) 1.86
Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2. Gut (2005) 1.84
Inflammatory bowel disease: past, present, and future. J Gastroenterol (2007) 1.83
Mycobacterium avium subsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: the way ahead. J Clin Microbiol (2005) 1.82
Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infect Immun (2004) 1.77
NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. J Leukoc Biol (2007) 1.73
NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel disease. J Gastroenterol (2006) 1.71
Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS Pathog (2008) 1.70
Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med (2009) 1.68
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem (2009) 1.68
Innate and adaptive immune responses to Listeria monocytogenes: a short overview. Microbes Infect (2007) 1.68
Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J Biol Chem (2009) 1.68
SGT1 is essential for Nod1 activation. Proc Natl Acad Sci U S A (2007) 1.56
Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs. Semin Immunopathol (2007) 1.54
Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice. J Clin Invest (2011) 1.53
Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun (2009) 1.49
Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin. Nat Med (2016) 1.45
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nat Immunol (2012) 1.45
COPs and POPs: modulators of inflammasome activity. J Immunol (2007) 1.45
Helminths and harmony. Gut (2004) 1.41
Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics. Front Immunol (2013) 1.41
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Rep (2005) 1.41
Unleashing the therapeutic potential of NOD-like receptors. Nat Rev Drug Discov (2009) 1.39
Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res (2006) 1.39
Deregulated inflammasome signaling in disease. Immunol Rev (2011) 1.39
Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses. Genes Dev (2010) 1.39
A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways. Proc Natl Acad Sci U S A (2006) 1.37
Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants. Proc Natl Acad Sci U S A (2014) 1.36
Layers of mutualism with commensal bacteria protect us from intestinal inflammation. Gut (2006) 1.36
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol (2009) 1.35
NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol (2012) 1.34
The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology (2006) 1.34
ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. Curr Biol (2009) 1.34
Endosomes are specialized platforms for bacterial sensing and NOD2 signalling. Nature (2014) 1.32
Paneth cells: their role in innate immunity and inflammatory disease. Gut (2005) 1.32
New pathophysiological insights and modern treatment of IBD. J Gastroenterol (2010) 1.31
TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem (2007) 1.30
A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity. PLoS Biol (2004) 1.29
Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease. PLoS One (2012) 1.28
Immunopathogenesis of inflammatory bowel disease. World J Gastroenterol (2008) 1.28
Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun (2006) 1.27
Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs. Infect Immun (2006) 1.26
Inflammatory bowel disease: pathogenesis. World J Gastroenterol (2014) 1.26
Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J Immunol (2009) 1.26
MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet (2003) 1.26
Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP. J Biol Chem (2012) 1.26
Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? World J Gastroenterol (2014) 1.25
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature (2010) 10.60
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol (2010) 8.87
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol (2009) 7.80
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22
sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. J Bacteriol (2002) 6.71
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat Immunol (2010) 6.64
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol (2003) 6.46
NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem (2005) 6.18
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med (2009) 5.77
NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol (2003) 5.07
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med (2007) 4.95
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog (2007) 4.73
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol (2006) 4.70
Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science (2007) 4.01
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol (2006) 3.89
Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol (2008) 3.78
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med (2006) 3.76
NOD-like receptors: role in innate immunity and inflammatory disease. Annu Rev Pathol (2009) 3.39
A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.38
Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation. J Biol Chem (2002) 3.27
Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J (2004) 2.81
Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity (2004) 2.77
Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology (2003) 2.72
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72
Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology (2002) 2.71
Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology (2003) 2.64
NOD-like receptors (NLRs): bona fide intracellular microbial sensors. Curr Opin Immunol (2008) 2.45
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med (2003) 2.39
Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene (2002) 2.32
The inflammasome in pathogen recognition and inflammation. J Leukoc Biol (2007) 2.28
Phase variation of Campylobacter jejuni 81-176 lipooligosaccharide affects ganglioside mimicry and invasiveness in vitro. Infect Immun (2002) 2.28
The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin. Cell Host Microbe (2007) 2.27
TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity. Immunobiology (2008) 2.19
Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. J Immunol (2003) 2.18
Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH). BMC Genomics (2009) 2.17
MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake. Mol Microbiol (2002) 2.07
GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. Crit Care Med (2005) 2.05
Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe (2010) 2.03
Cell wall peptidoglycan architecture in Bacillus subtilis. Proc Natl Acad Sci U S A (2008) 2.02
Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage. J Infect Dis (2006) 1.99
CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. Proc Natl Acad Sci U S A (2006) 1.96
Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med (2006) 1.95
Nods: a family of cytosolic proteins that regulate the host response to pathogens. Curr Opin Microbiol (2002) 1.93
Bacterial infections promote T cell recognition of self-glycolipids. Immunity (2005) 1.92
ML -- a conserved domain involved in innate immunity and lipid metabolism. Trends Biochem Sci (2002) 1.92
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int Immunol (2004) 1.91
Catalase (KatA) and alkyl hydroperoxide reductase (AhpC) have compensatory roles in peroxide stress resistance and are required for survival, persistence, and nasal colonization in Staphylococcus aureus. J Bacteriol (2006) 1.86
A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J Biol Chem (2005) 1.81
Surface adhesins of Staphylococcus aureus. Adv Microb Physiol (2006) 1.77
Manganese: elemental defence for a life with oxygen. Trends Microbiol (2002) 1.75
Peginterferon-alfa2a plus ribavirin for 48 versus 72 weeks in patients with detectable hepatitis C virus RNA at week 4 of treatment. Gastroenterology (2006) 1.75
Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol Immunol (2007) 1.74
Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase. J Biol Chem (2003) 1.74
Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll-like receptor 4. Infect Immun (2004) 1.72
Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product. Biochem Biophys Res Commun (2003) 1.71
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun (2003) 1.70
The role and regulation of the extracellular proteases of Staphylococcus aureus. Microbiology (2004) 1.70
Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering. J Immunol (2006) 1.69
T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii. Nat Immunol (2009) 1.67
MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol (2007) 1.67
Insulin reduces the multiple organ injury and dysfunction caused by coadministration of lipopolysaccharide and peptidoglycan independently of blood glucose: role of glycogen synthase kinase-3beta inhibition. Crit Care Med (2006) 1.66
High pathological risk of recurrence after surgical resection for hepatocellular carcinoma: an indication for salvage liver transplantation. Liver Transpl (2004) 1.65
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proc Natl Acad Sci U S A (2012) 1.63
Analysis of Ebh, a 1.1-megadalton cell wall-associated fibronectin-binding protein of Staphylococcus aureus. Infect Immun (2002) 1.63
Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol (2007) 1.60
Analysis of spore cortex lytic enzymes and related proteins in Bacillus subtilis endospore germination. Microbiology (2002) 1.58
Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat. Crit Care Med (2004) 1.57
Role and regulation of the superoxide dismutases of Staphylococcus aureus. Microbiology (2003) 1.57
Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments. J Biol Chem (2006) 1.55
Sleep apnea obstructive syndrome: a new complication previously undescribed in cirrhotic patients with ascites. Am J Gastroenterol (2003) 1.53
Combinational clustering of receptors following stimulation by bacterial products determines lipopolysaccharide responses. Biochem J (2004) 1.52