Jan H J Hoeijmakers

Author PubWeight™ 152.34‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006 5.57
2 The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol 2004 3.94
3 Premature aging in mice deficient in DNA repair and transcription. Science 2002 3.82
4 ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell 2003 3.01
5 Fanconi anemia (cross)linked to DNA repair. Cell 2005 2.78
6 Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol 2002 2.57
7 A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A. Nat Genet 2004 2.54
8 Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein. EMBO J 2002 2.52
9 Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. EMBO J 2002 2.45
10 DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol 2008 2.44
11 DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Genes Dev 2006 2.22
12 Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol 2005 2.22
13 Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol 2007 2.21
14 First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. Am J Hum Genet 2007 2.14
15 A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev 2003 2.09
16 MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J 2009 2.06
17 Age to survive: DNA damage and aging. Trends Genet 2008 2.05
18 Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo. Mol Cell 2002 1.90
19 Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. PLoS Biol 2006 1.89
20 ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol 2008 1.88
21 Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A 2008 1.84
22 The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair. Structure 2005 1.80
23 Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet 2008 1.76
24 Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions. Mol Cell Biol 2003 1.68
25 UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nat Genet 2012 1.63
26 Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration. Liver Transpl 2011 1.59
27 Glucose supplementation does not interfere with fasting-induced protection against renal ischemia/reperfusion injury in mice. Transplantation 2011 1.57
28 Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat Cell Biol 2009 1.55
29 Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles. PLoS Biol 2006 1.54
30 The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition. Structure 2012 1.54
31 Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice. DNA Repair (Amst) 2003 1.53
32 The CSB protein actively wraps DNA. J Biol Chem 2004 1.51
33 The role of DNA dependent protein kinase in synapsis of DNA ends. Nucleic Acids Res 2003 1.51
34 Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J 2005 1.48
35 Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice. Aging Cell 2009 1.47
36 Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res 2006 1.43
37 DNA damage stabilizes interaction of CSB with the transcription elongation machinery. J Cell Biol 2004 1.42
38 Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice. EMBO J 2005 1.42
39 Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol 2005 1.39
40 Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair (Amst) 2005 1.38
41 Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations. Mol Cell Biol 2005 1.32
42 Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC. J Cell Sci 2008 1.30
43 The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice. Mol Cell Biol 2004 1.29
44 Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols. EMBO J 2002 1.28
45 Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH. Mol Cell Biol 2006 1.24
46 Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development. PLoS Genet 2010 1.21
47 An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. Cancer Cell 2006 1.21
48 DNA bending by the human damage recognition complex XPC-HR23B. DNA Repair (Amst) 2003 1.20
49 Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B. Mol Cell Biol 2002 1.20
50 Divide and conquer: nucleotide excision repair battles cancer and ageing. Curr Opin Cell Biol 2003 1.20
51 Nucleotide excision repair disorders and the balance between cancer and aging. Cell Cycle 2006 1.19
52 Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair. Proc Natl Acad Sci U S A 2002 1.19
53 Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. PLoS Genet 2006 1.19
54 UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice. DNA Repair (Amst) 2002 1.19
55 Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase. Mol Cell Biol 2003 1.17
56 Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage. Mol Cell Biol 2004 1.17
57 Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst) 2002 1.17
58 Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis 2011 1.17
59 Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair. J Neurosci 2011 1.16
60 Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Res 2008 1.15
61 Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathol 2010 1.13
62 Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice. EMBO J 2002 1.09
63 Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo. J Cell Biol 2012 1.09
64 Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase. J Cell Sci 2004 1.08
65 Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome. Mol Cell Biol 2006 1.07
66 UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells. DNA Repair (Amst) 2009 1.05
67 MicroRNAs, the DNA damage response and cancer. Mutat Res 2011 1.03
68 Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex. DNA Repair (Amst) 2004 1.02
69 Analysis of mouse Rad54 expression and its implications for homologous recombination. DNA Repair (Amst) 2002 1.00
70 In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair. Proc Natl Acad Sci U S A 2004 1.00
71 Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression. J Invest Dermatol 2003 0.99
72 Differentiation driven changes in the dynamic organization of Basal transcription initiation. PLoS Biol 2009 0.99
73 A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells. J Cell Mol Med 2010 0.99
74 Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics 2012 0.99
75 Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts. DNA Repair (Amst) 2008 0.98
76 Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions. J Exp Med 2004 0.98
77 Dynamics of relative chromosome position during the cell cycle. Mol Biol Cell 2004 0.97
78 Genome stability, progressive kidney failure and aging. Nat Genet 2012 0.94
79 HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase. DNA Repair (Amst) 2011 0.94
80 MicroRNA responses and stress granule formation modulate the DNA damage response. Cell Cycle 2009 0.93
81 Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage. Mol Cell Biol 2008 0.93
82 Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet 2011 0.93
83 Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging. J Proteome Res 2012 0.91
84 Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair. DNA Repair (Amst) 2008 0.91
85 Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer. Mol Cell Biol 2006 0.89
86 Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex. J Cell Biol 2012 0.89
87 Cell biology: ageing nucleus gets out of shape. Nature 2006 0.89
88 The use of preoperative nutritional interventions to protect against hepatic ischemia-reperfusion injury. Liver Transpl 2009 0.88
89 Deciphering the RNA landscape by RNAome sequencing. RNA Biol 2015 0.88
90 Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks. PLoS One 2011 0.88
91 Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging. Mech Ageing Dev 2006 0.87
92 Pre-operative dietary restriction is feasible in live-kidney donors. Clin Transplant 2010 0.87
93 Dietary restriction modifies certain aspects of the postoperative acute phase response. J Surg Res 2010 0.86
94 Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice. Aging Cell 2009 0.86
95 The HhH domain of the human DNA repair protein XPF forms stable homodimers. Proteins 2008 0.85
96 DNA damage in normally and prematurely aged mice. Aging Cell 2013 0.85
97 Cockayne syndrome pathogenesis: lessons from mouse models. Mech Ageing Dev 2013 0.85
98 Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality. PLoS Genet 2013 0.84
99 Spatio-temporal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum. Mol Cell Proteomics 2013 0.84
100 Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy. Age (Dordr) 2010 0.84
101 Meiotic functions of RAD18. J Cell Sci 2011 0.83
102 Accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(δ/-) mouse. Mech Ageing Dev 2012 0.81
103 Nucleotide excision repair and its connection with cancer and ageing. Adv Exp Med Biol 2005 0.80
104 Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice. Age (Dordr) 2011 0.79
105 Expression and possible functions of DNA lesion bypass proteins in spermatogenesis. Int J Androl 2005 0.79
106 Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice. DNA Repair (Amst) 2005 0.78
107 Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models. DNA Repair (Amst) 2012 0.77
108 Aging on a different scale--chronological versus pathology-related aging. Aging (Albany NY) 2013 0.77
109 Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice. PLoS One 2012 0.76
110 DNA double strand break repair: zooming in on the focus. Cell Cycle 2009 0.76
111 Accelerated bone aging in the trichothiodystrophy mouse model. J Gerontol A Biol Sci Med Sci 2003 0.75
112 Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy. J Gerontol A Biol Sci Med Sci 2007 0.75