1
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A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.
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Nature
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2006
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5.57
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2
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The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.
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Mol Cell Biol
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2004
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3.94
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3
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Premature aging in mice deficient in DNA repair and transcription.
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Science
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2002
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3.82
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4
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ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
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Mol Cell
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2003
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3.01
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5
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Fanconi anemia (cross)linked to DNA repair.
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Cell
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2005
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2.78
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6
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Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells.
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Eur J Immunol
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2002
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2.57
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7
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A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.
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Nat Genet
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2004
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2.54
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8
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Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.
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EMBO J
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2002
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2.52
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9
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Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage.
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EMBO J
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2002
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2.45
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10
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DNA damage and ageing: new-age ideas for an age-old problem.
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Nat Cell Biol
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2008
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2.44
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11
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DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.
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Genes Dev
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2006
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2.22
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12
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Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.
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Mol Cell Biol
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2005
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2.22
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13
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Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome.
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PLoS Biol
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2007
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2.21
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14
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First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.
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Am J Hum Genet
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2007
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2.14
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15
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A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.
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Genes Dev
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2003
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2.09
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16
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MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response.
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EMBO J
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2009
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2.06
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17
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Age to survive: DNA damage and aging.
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Trends Genet
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2008
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2.05
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18
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Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo.
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Mol Cell
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2002
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1.90
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19
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Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells.
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PLoS Biol
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2006
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1.89
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20
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ERCC1-XPF endonuclease facilitates DNA double-strand break repair.
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Mol Cell Biol
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2008
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1.88
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21
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Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
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Proc Natl Acad Sci U S A
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2008
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1.84
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22
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The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair.
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Structure
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2005
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1.80
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23
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Delayed and accelerated aging share common longevity assurance mechanisms.
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PLoS Genet
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2008
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1.76
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24
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Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions.
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Mol Cell Biol
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2003
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1.68
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25
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UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.
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Nat Genet
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2012
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1.63
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26
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Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration.
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Liver Transpl
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2011
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1.59
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27
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Glucose supplementation does not interfere with fasting-induced protection against renal ischemia/reperfusion injury in mice.
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Transplantation
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2011
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1.57
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28
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Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.
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Nat Cell Biol
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2009
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1.55
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29
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Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.
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PLoS Biol
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2006
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1.54
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30
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The structure of the XPF-ssDNA complex underscores the distinct roles of the XPF and ERCC1 helix- hairpin-helix domains in ss/ds DNA recognition.
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Structure
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2012
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1.54
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31
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Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice.
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DNA Repair (Amst)
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2003
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1.53
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32
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The CSB protein actively wraps DNA.
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J Biol Chem
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2004
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1.51
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33
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The role of DNA dependent protein kinase in synapsis of DNA ends.
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Nucleic Acids Res
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2003
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1.51
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34
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Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks.
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EMBO J
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2005
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1.48
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35
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Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice.
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Aging Cell
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2009
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1.47
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36
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Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.
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Mutat Res
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2006
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1.43
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37
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DNA damage stabilizes interaction of CSB with the transcription elongation machinery.
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J Cell Biol
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2004
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1.42
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38
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Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice.
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EMBO J
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2005
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1.42
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39
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Powerful skin cancer protection by a CPD-photolyase transgene.
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Curr Biol
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2005
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1.39
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40
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Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction.
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DNA Repair (Amst)
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2005
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1.38
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41
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Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations.
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Mol Cell Biol
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2005
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1.32
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42
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Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC.
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J Cell Sci
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2008
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1.30
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43
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The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice.
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Mol Cell Biol
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2004
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1.29
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44
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Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols.
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EMBO J
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2002
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1.28
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45
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Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH.
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Mol Cell Biol
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2006
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1.24
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46
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Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development.
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PLoS Genet
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2010
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1.21
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47
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An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.
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Cancer Cell
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2006
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1.21
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48
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DNA bending by the human damage recognition complex XPC-HR23B.
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DNA Repair (Amst)
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2003
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1.20
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49
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Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B.
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Mol Cell Biol
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2002
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1.20
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50
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Divide and conquer: nucleotide excision repair battles cancer and ageing.
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Curr Opin Cell Biol
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2003
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1.20
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51
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Nucleotide excision repair disorders and the balance between cancer and aging.
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Cell Cycle
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2006
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1.19
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52
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Translocation of Cockayne syndrome group A protein to the nuclear matrix: possible relevance to transcription-coupled DNA repair.
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Proc Natl Acad Sci U S A
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2002
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1.19
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53
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Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.
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PLoS Genet
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2006
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1.19
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54
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UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.
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DNA Repair (Amst)
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2002
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1.19
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55
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Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.
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Mol Cell Biol
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2003
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1.17
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56
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Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage.
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Mol Cell Biol
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2004
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1.17
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57
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Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways.
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DNA Repair (Amst)
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2002
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1.17
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58
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Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice.
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Pathobiol Aging Age Relat Dis
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2011
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1.17
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59
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Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.
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J Neurosci
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2011
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1.16
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60
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Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.
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Cancer Res
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2008
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1.15
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61
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Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice.
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Acta Neuropathol
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2010
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1.13
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62
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Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice.
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EMBO J
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2002
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1.09
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63
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Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo.
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J Cell Biol
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2012
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1.09
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64
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Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase.
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J Cell Sci
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2004
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1.08
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65
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Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome.
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Mol Cell Biol
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2006
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1.07
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66
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UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells.
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DNA Repair (Amst)
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2009
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1.05
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67
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MicroRNAs, the DNA damage response and cancer.
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Mutat Res
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2011
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1.03
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68
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Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.
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DNA Repair (Amst)
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2004
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1.02
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69
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Analysis of mouse Rad54 expression and its implications for homologous recombination.
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DNA Repair (Amst)
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2002
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1.00
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70
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In vivo dynamics of chromatin-associated complex formation in mammalian nucleotide excision repair.
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Proc Natl Acad Sci U S A
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2004
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1.00
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71
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Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.
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J Invest Dermatol
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2003
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0.99
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72
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Differentiation driven changes in the dynamic organization of Basal transcription initiation.
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PLoS Biol
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2009
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0.99
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73
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A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells.
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J Cell Mol Med
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2010
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0.99
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74
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Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing.
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BMC Genomics
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2012
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0.99
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75
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Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.
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DNA Repair (Amst)
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2008
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0.98
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76
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Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions.
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J Exp Med
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2004
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0.98
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77
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Dynamics of relative chromosome position during the cell cycle.
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Mol Biol Cell
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2004
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0.97
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78
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Genome stability, progressive kidney failure and aging.
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Nat Genet
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2012
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0.94
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79
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HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase.
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DNA Repair (Amst)
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2011
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0.94
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80
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MicroRNA responses and stress granule formation modulate the DNA damage response.
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Cell Cycle
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2009
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0.93
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81
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Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.
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Mol Cell Biol
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2008
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0.93
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82
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Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology.
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PLoS Genet
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2011
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0.93
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83
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Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging.
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J Proteome Res
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2012
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0.91
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84
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Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair.
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DNA Repair (Amst)
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2008
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0.91
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85
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Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.
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Mol Cell Biol
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2006
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0.89
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86
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Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
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J Cell Biol
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2012
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0.89
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87
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Cell biology: ageing nucleus gets out of shape.
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Nature
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2006
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0.89
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88
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The use of preoperative nutritional interventions to protect against hepatic ischemia-reperfusion injury.
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Liver Transpl
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2009
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0.88
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Deciphering the RNA landscape by RNAome sequencing.
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RNA Biol
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2015
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0.88
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Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks.
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PLoS One
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2011
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0.88
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91
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Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging.
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Mech Ageing Dev
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2006
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0.87
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92
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Pre-operative dietary restriction is feasible in live-kidney donors.
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Clin Transplant
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2010
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0.87
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93
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Dietary restriction modifies certain aspects of the postoperative acute phase response.
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J Surg Res
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2010
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0.86
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94
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Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice.
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Aging Cell
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2009
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The HhH domain of the human DNA repair protein XPF forms stable homodimers.
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Proteins
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2008
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DNA damage in normally and prematurely aged mice.
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Aging Cell
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2013
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Cockayne syndrome pathogenesis: lessons from mouse models.
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Mech Ageing Dev
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2013
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Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality.
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PLoS Genet
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2013
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0.84
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Spatio-temporal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum.
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Mol Cell Proteomics
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2013
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0.84
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100
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Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy.
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Age (Dordr)
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2010
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0.84
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101
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Meiotic functions of RAD18.
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J Cell Sci
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2011
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0.83
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102
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Accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(δ/-) mouse.
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Mech Ageing Dev
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2012
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Nucleotide excision repair and its connection with cancer and ageing.
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Adv Exp Med Biol
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2005
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Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice.
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Age (Dordr)
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2011
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Expression and possible functions of DNA lesion bypass proteins in spermatogenesis.
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Int J Androl
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2005
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0.79
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Repair characteristics and differentiation propensity of long-term cultures of epidermal keratinocytes derived from normal and NER-deficient mice.
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DNA Repair (Amst)
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2005
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Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models.
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DNA Repair (Amst)
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2012
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Aging on a different scale--chronological versus pathology-related aging.
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2013
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Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice.
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PLoS One
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2012
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DNA double strand break repair: zooming in on the focus.
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2009
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Accelerated bone aging in the trichothiodystrophy mouse model.
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J Gerontol A Biol Sci Med Sci
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2003
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Physicochemical composition of osteoporotic bone in the trichothiodystrophy premature aging mouse determined by confocal Raman microscopy.
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J Gerontol A Biol Sci Med Sci
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2007
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0.75
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