Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.

PubWeight™: 1.55‹?› | Rank: Top 4%

🔗 View Article (PMC 2782455)

Published in Nat Cell Biol on April 12, 2009

Authors

George A Garinis1, Lieneke M Uittenboogaard, Heike Stachelscheid, Maria Fousteri, Wilfred van Ijcken, Timo M Breit, Harry van Steeg, Leon H F Mullenders, Gijsbertus T J van der Horst, Jens C Brüning, Carien M Niessen, Jan H J Hoeijmakers, Björn Schumacher

Author Affiliations

1: MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus Medical Center, PO Box 1738, Rotterdam 3000 DR, The Netherlands.

Articles citing this

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest (2011) 3.69

The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet (2012) 2.13

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature (2016) 1.52

Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. J Exp Med (2012) 1.42

Impact of genomic damage and ageing on stem cell function. Nat Cell Biol (2014) 1.33

Mammalian transcription-coupled excision repair. Cold Spring Harb Perspect Biol (2013) 1.32

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. Proc Natl Acad Sci U S A (2010) 1.21

Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis (2011) 1.17

Construction of a computable network model for DNA damage, autophagy, cell death, and senescence. Bioinform Biol Insights (2013) 1.08

The ageing epigenome: damaged beyond repair? Ageing Res Rev (2009) 1.05

To live or to die: a matter of processing damaged DNA termini in neurons. EMBO Mol Med (2011) 1.04

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage. Nat Cell Biol (2014) 1.03

The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells. DNA Repair (Amst) (2012) 1.00

A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways. Aging (Albany NY) (2010) 0.99

Genome maintenance and transcription integrity in aging and disease. Front Genet (2013) 0.95

Evidence for premature aging due to oxidative stress in iPSCs from Cockayne syndrome. Hum Mol Genet (2012) 0.94

Insights from the worm: the C. elegans model for innate immunity. Semin Immunol (2014) 0.94

Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake. Aging Cell (2015) 0.90

Systemic DNA damage responses: organismal adaptations to genome instability. Trends Genet (2014) 0.90

Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Nucleic Acids Res (2013) 0.89

Adult Stem Cells and Diseases of Aging. J Clin Med (2014) 0.88

Death and dessert: nutrient signalling pathways and ageing. Curr Opin Cell Biol (2011) 0.87

Nucleotide Excision Repair in Caenorhabditis elegans. Mol Biol Int (2011) 0.87

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A (2012) 0.86

Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy. Age (Dordr) (2010) 0.84

The thyroid hormone receptor β induces DNA damage and premature senescence. J Cell Biol (2014) 0.82

Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency. PLoS Genet (2014) 0.81

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms. Biomolecules (2015) 0.80

The DNA damage response: the omics era and its impact. DNA Repair (Amst) (2014) 0.80

Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing. Hum Mol Genet (2014) 0.79

Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice. Nat Commun (2014) 0.79

Systemic DNA damage responses in aging and diseases. Semin Cancer Biol (2016) 0.79

Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging? Aging (Albany NY) (2010) 0.79

BACH2: a marker of DNA damage and ageing. DNA Repair (Amst) (2013) 0.78

Longevity through DNA damage tolerance. Cell Cycle (2015) 0.77

Aging on a different scale--chronological versus pathology-related aging. Aging (Albany NY) (2013) 0.77

Loss of ercc1 results in a time- and dose-dependent reduction of proliferating early hematopoietic progenitors. Anemia (2012) 0.77

Quality control mechanisms in cellular and systemic DNA damage responses. Ageing Res Rev (2015) 0.76

Life can be stressful without ATR. Nat Genet (2009) 0.76

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging. PLoS One (2016) 0.75

Hormesis running hot and cold. Cell Cycle (2016) 0.75

Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Worm (2013) 0.75

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife (2016) 0.75

A simple answer to complex questions: C. elegans as an experimental model for examining the DNA damage response and disease genes. J Cell Physiol (2017) 0.75

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans. Cell Rep (2017) 0.75

Articles cited by this

A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61

Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature (2002) 10.52

The plasticity of aging: insights from long-lived mutants. Cell (2005) 9.88

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature (2002) 8.35

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene. Cell (1987) 8.23

Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19

Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11

DNA repair in an active gene: removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall. Cell (1985) 7.62

Understanding the odd science of aging. Cell (2005) 6.50

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet (2003) 6.03

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57

DNA repair, genome stability, and aging. Cell (2005) 5.52

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol (2004) 4.87

Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72

Mechanisms of ageing: public or private? Nat Rev Genet (2002) 3.49

A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat Genet (2005) 3.29

DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie (2003) 2.96

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol Cell (2006) 2.84

Rapid accumulation of genome rearrangements in liver but not in brain of old mice. Nat Genet (1997) 2.74

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev (2008) 2.71

Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell Metab (2008) 2.71

Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab (2005) 2.59

Life extension in the dwarf mouse. Curr Top Dev Biol (2004) 2.48

DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44

DNA repair in terminally differentiated cells. DNA Repair (Amst) (2002) 2.30

Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts. J Biol Chem (1997) 2.26

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol (2007) 2.21

Genetic mouse models of extended lifespan. Exp Gerontol (2003) 2.15

Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J Alzheimers Dis (2005) 2.12

Transcription - guarding the genome by sensing DNA damage. Nat Rev Cancer (2004) 2.10

Age to survive: DNA damage and aging. Trends Genet (2008) 2.05

Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts. EMBO J (1995) 2.04

DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus. Cancer Res (2000) 1.97

Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Aging Cell (2007) 1.84

Cyclobutane pyrimidine dimers are responsible for the vast majority of mutations induced by UVB irradiation in mammalian cells. J Biol Chem (2001) 1.80

Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet (2008) 1.76

Role of insulin-like signalling in Drosophila lifespan. Trends Biochem Sci (2007) 1.70

RNA polymerase II bypass of oxidative DNA damage is regulated by transcription elongation factors. EMBO J (2006) 1.50

Additive regulation of hepatic gene expression by dwarfism and caloric restriction. Physiol Genomics (2004) 1.50

Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J (2005) 1.48

Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates. J Neurosci (2007) 1.47

A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan. Trends Genet (2002) 1.40

Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol (2005) 1.39

Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair (Amst) (2005) 1.38

Base-excision repair of oxidative DNA damage by DNA glycosylases. Mutat Res (2005) 1.34

Aging, tumor suppression and cancer: high wire-act! Mech Ageing Dev (2005) 1.32

In vivo analysis of growth hormone receptor signaling domains and their associated transcripts. Mol Cell Biol (2005) 1.31

Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum Genet (1982) 1.27

The case for 8,5'-cyclopurine-2'-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum. Neuroscience (2006) 1.26

Co-ordination of DNA single strand break repair. DNA Repair (Amst) (2006) 1.25

Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice. Exp Gerontol (2005) 1.23

The insulin-like growth factor 1 receptor in cancer: old focus, new future. Eur J Cancer (2007) 1.20

Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions. Cell Mol Life Sci (2007) 1.19

Longevity and the stress response in Drosophila. Exp Gerontol (2006) 1.19

Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst) (2002) 1.17

Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. J Gerontol A Biol Sci Med Sci (2006) 1.16

Stress resistance in long-lived mouse models. Exp Gerontol (2006) 1.16

Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation. EMBO J (2008) 1.09

Altered cholesterologenic and lipogenic transcriptional profile in livers of aging Snell dwarf (Pit1dw/dwJ) mice. Aging Cell (2004) 1.06

FOXO transcription factors in the regulatory networks of longevity. J Biochem (2007) 1.02

Nucleotide excision repair gene (ERCC1) deficiency causes G(2) arrest in hepatocytes and a reduction in liver binucleation: the role of p53 and p21. FASEB J (2000) 1.01

Longevity and ageing in parasitic and free-living nematodes. Biogerontology (2000) 1.01

Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. Mol Carcinog (2006) 1.01

Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats. Endocrinology (1994) 0.98

Dynamics of relative chromosome position during the cell cycle. Mol Biol Cell (2004) 0.97

Differential repair of the two major UV-induced photolesions in trichothiodystrophy fibroblasts. Cancer Res (2004) 0.91

Age-related differences in the des IGF-I-mediated activation of Akt-1 and p70 S6K in mouse skeletal muscle. Mech Ageing Dev (2003) 0.90

Growth hormone signal transduction. J Pediatr Endocrinol Metab (2002) 0.85

Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors. Drug Metab Dispos (2006) 0.80

Articles by these authors

Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature (2006) 5.57

Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci (2005) 4.44

Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell (2010) 4.16

Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One (2010) 3.96

The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol (2004) 3.94

Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects. Cell Res (2008) 3.83

Premature aging in mice deficient in DNA repair and transcription. Science (2002) 3.82

A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82

Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64

Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity (2011) 3.40

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell (2003) 3.01

Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol Cell (2006) 2.84

Fanconi anemia (cross)linked to DNA repair. Cell (2005) 2.78

The cryptochromes: blue light photoreceptors in plants and animals. Annu Rev Plant Biol (2011) 2.76

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J (2005) 2.72

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab (2010) 2.58

Different types of V(D)J recombination and end-joining defects in DNA double-strand break repair mutant mammalian cells. Eur J Immunol (2002) 2.57

Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet (2011) 2.56

Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A (2004) 2.54

A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A. Nat Genet (2004) 2.54

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA. Genes Dev (2011) 2.53

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein. EMBO J (2002) 2.52

Central insulin action in energy and glucose homeostasis. J Clin Invest (2006) 2.51

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Nat Genet (2010) 2.50

The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation. Genes Dev (2010) 2.47

Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. EMBO J (2002) 2.45

DNA damage and ageing: new-age ideas for an age-old problem. Nat Cell Biol (2008) 2.44

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol (2011) 2.38

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci (2011) 2.36

Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6. Nat Med (2009) 2.30

Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. Dev Cell (2005) 2.30

Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity (2010) 2.29

Heterochromatin protein 1 is recruited to various types of DNA damage. J Cell Biol (2009) 2.26

A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest (2013) 2.23

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. Genes Dev (2006) 2.22

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol (2005) 2.22

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol (2007) 2.21

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature (2013) 2.19

First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. Am J Hum Genet (2007) 2.14

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature (2013) 2.13

The p53 network: cellular and systemic DNA damage responses in aging and cancer. Trends Genet (2012) 2.13

A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev (2003) 2.09

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol Cell (2010) 2.09

MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response. EMBO J (2009) 2.06

Age to survive: DNA damage and aging. Trends Genet (2008) 2.05

The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development (2006) 2.04

The role of insulin receptor signaling in the brain. Trends Endocrinol Metab (2005) 2.01

Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest (2008) 2.00

Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth. Diabetes (2008) 1.97

Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation. J Invest Dermatol (2006) 1.91

Rapid switching of TFIIH between RNA polymerase I and II transcription and DNA repair in vivo. Mol Cell (2002) 1.90

Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. PLoS Biol (2006) 1.89

Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner. Mol Cell (2007) 1.89

ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol (2008) 1.88

MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab (2013) 1.87

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med (2010) 1.86

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A (2008) 1.84

CNS leptin and insulin action in the control of energy homeostasis. Ann N Y Acad Sci (2010) 1.81

The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair. Structure (2005) 1.80

A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair. Mol Cell (2010) 1.79

Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest (2004) 1.79

Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet (2008) 1.76

Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions. Mol Cell Biol (2003) 1.68

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1. Neuron (2013) 1.67

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci U S A (2010) 1.67

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. Proc Natl Acad Sci U S A (2008) 1.64

Reversible gene knockdown in mice using a tight, inducible shRNA expression system. Nucleic Acids Res (2007) 1.64

Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol (2006) 1.63

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nat Genet (2012) 1.63

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metab (2008) 1.63

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. Nature (2009) 1.62

Preoperative fasting protects mice against hepatic ischemia/reperfusion injury: mechanisms and effects on liver regeneration. Liver Transpl (2011) 1.59

High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab (2013) 1.57

Glucose supplementation does not interfere with fasting-induced protection against renal ischemia/reperfusion injury in mice. Transplantation (2011) 1.57

The DNA-binding protein CTCF limits proximal Vκ recombination and restricts κ enhancer interactions to the immunoglobulin κ light chain locus. Immunity (2011) 1.57

The UV-damaged DNA binding protein mediates efficient targeting of the nucleotide excision repair complex to UV-induced photo lesions. DNA Repair (Amst) (2005) 1.57

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nat Neurosci (2013) 1.57

Measurement of internal body time by blood metabolomics. Proc Natl Acad Sci U S A (2009) 1.56