Published in Curr Biol on February 08, 2005
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell (2006) 6.15
PHF6 mutations in T-cell acute lymphoblastic leukemia. Nat Genet (2010) 2.66
Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. Sci Transl Med (2013) 2.37
H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy. J Nucleic Acids (2010) 1.69
Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat Res (2010) 1.50
Alternative cyclin D1 splice forms differentially regulate the DNA damage response. Cancer Res (2010) 1.45
Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genet (2008) 1.19
DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Mol Biol (2010) 1.19
Chemotherapy induced DNA damage response: convergence of drugs and pathways. Cancer Biol Ther (2013) 1.16
Chromatin structure and DNA damage repair. Epigenetics Chromatin (2008) 1.16
PARP inhibitors in the management of breast cancer: current data and future prospects. BMC Med (2015) 1.16
Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents. Proc Natl Acad Sci U S A (2011) 1.12
HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response. Nucleic Acids Res (2013) 1.11
Distinct roles of the ATR kinase and the Mre11-Rad50-Nbs1 complex in the maintenance of chromosomal stability in Arabidopsis. Plant Cell (2010) 1.10
Inhibition of transcription at radiation-induced nuclear foci of phosphorylated histone H2AX in mammalian cells. Chromosome Res (2007) 1.08
A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint. Proc Natl Acad Sci U S A (2009) 1.04
Unzipped and loaded: the role of DNA helicases and RFC clamp-loading complexes in sister chromatid cohesion. J Cell Biol (2005) 1.01
Histone variants and epigenetics. Cold Spring Harb Perspect Biol (2015) 1.01
STAT3 modulates the DNA damage response pathway. Int J Exp Pathol (2010) 1.00
SOCS3 regulates p21 expression and cell cycle arrest in response to DNA damage. Cell Signal (2008) 0.98
Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair. Nat Commun (2014) 0.98
The ups and downs of DNA repair biomarkers for PARP inhibitor therapies. Am J Cancer Res (2010) 0.95
Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation. Infect Immun (2006) 0.94
Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells. Neoplasia (2007) 0.94
BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation. Chromosoma (2005) 0.92
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. J Proteome Res (2010) 0.90
p53 suppression overwhelms DNA polymerase eta deficiency in determining the cellular UV DNA damage response. DNA Repair (Amst) (2007) 0.88
Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer Res (2015) 0.87
Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. Proc Natl Acad Sci U S A (2014) 0.86
An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol (2008) 0.86
ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis. Oncogene (2013) 0.84
The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses. J Virol (2015) 0.84
Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines. PLoS One (2013) 0.83
DNA damage sensor γ -H2AX is increased in preneoplastic lesions of hepatocellular carcinoma. ScientificWorldJournal (2013) 0.83
Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism. Mol Cell Biol (2012) 0.83
New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environ Health Perspect (2007) 0.82
Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair. Neuroscience (2006) 0.81
Search for cellular stress biomarkers in lymphocytes from patients with multiple sclerosis: a pilot study. PLoS One (2012) 0.80
Genome-wide mapping of DNA strand breaks. PLoS One (2011) 0.80
Biological effect of an alternating electric field on cell proliferation and synergistic antimitotic effect in combination with ionizing radiation. Oncotarget (2016) 0.80
Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix. Gene Ther Mol Biol (2005) 0.79
Role of benzalkonium chloride in DNA strand breaks in human corneal epithelial cells. Graefes Arch Clin Exp Ophthalmol (2011) 0.78
Effect of ionizing radiation on the physical biology of head and neck squamous cell carcinoma cells. Cell Mol Bioeng (2015) 0.78
Successes and Challenges of PARP Inhibitors in Cancer Therapy. Front Oncol (2015) 0.77
Long-term quiescent fibroblast cells transit into senescence. PLoS One (2014) 0.77
The effects of selenium and the GPx-1 selenoprotein on the phosphorylation of H2AX. Biochim Biophys Acta (2013) 0.77
Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line. BMC Cancer (2014) 0.77
Formation of interference-sensitive meiotic cross-overs requires sufficient DNA leading-strand elongation. Proc Natl Acad Sci U S A (2015) 0.77
Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) promotes non-homologous end joining and inhibits homologous recombination repair upon DNA damage. J Biol Chem (2014) 0.76
Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey. J Assist Reprod Genet (2015) 0.76
High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast. PLoS Genet (2016) 0.76
The Structural Determinants behind the Epigenetic Role of Histone Variants. Genes (Basel) (2015) 0.76
Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair. Radiat Res (2016) 0.75
Inhibition of STAT3 with the generation 2.5 antisense oligonucleotide, AZD9150, decreases neuroblastoma tumorigenicity and increases chemosensitivity. Clin Cancer Res (2016) 0.75
DNA breaks and chromatin structural changes enhance the transcription of autoimmune regulator target genes. J Biol Chem (2017) 0.75
The Absence of the Arabidopsis Chaperone Complex CAF-1 Produces Mitotic Chromosome Abnormalities and Changes in the Expression Profiles of Genes Involved in DNA Repair. Front Plant Sci (2017) 0.75
Expression of long non-coding RNA-HOTAIR in oral squamous cell carcinoma Tca8113 cells and its associated biological behavior. Am J Transl Res (2016) 0.75
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma. PLoS Genet (2016) 0.75
The PHD Finger Protein MMD1/DUET Ensures the Progression of Male Meiotic Chromosome Condensation and Directly Regulates the Expression of the Condensin Gene CAP-D3. Plant Cell (2016) 0.75
Lysines 3241 and 3260 of DNA-PKcs are important for genomic stability and radioresistance. Biochem Biophys Res Commun (2016) 0.75
Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells. Cell Cycle (2017) 0.75
A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival. Nat Commun (2017) 0.75
Multiple approaches to study S. cerevisiae Rad9, a prototypical checkpoint protein. Methods Enzymol (2006) 0.79