Published in Int J Exp Pathol on August 27, 2010
Oxidative stress and myocardial injury in the diabetic heart. J Pathol (2013) 1.18
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene (2014) 1.11
Role of Bcl-3 in solid tumors. Mol Cancer (2011) 1.05
STAT3 interrupts ATR-Chk1 signaling to allow oncovirus-mediated cell proliferation. Proc Natl Acad Sci U S A (2014) 0.87
STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy. Cancers (Basel) (2014) 0.87
CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage. Nucleic Acids Res (2012) 0.84
Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein. Proc Natl Acad Sci U S A (2011) 0.84
Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques. J Immunol (2014) 0.83
Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage. Cell Death Differ (2012) 0.82
Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget (2016) 0.79
STAT3 as a new autophagy regulator. JAKSTAT (2013) 0.79
Cardiac preconditioning with sphingosine-1-phosphate requires activation of signal transducer and activator of transcription-3. Cardiovasc J Afr (2014) 0.77
Cetuximab induces eme1-mediated DNA repair: a novel mechanism for cetuximab resistance. Neoplasia (2014) 0.77
Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer. Oncotarget (2017) 0.76
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy. Oncotarget (2016) 0.76
Differential Protein Distribution between the Nucleus and Mitochondria: Implications in Aging. Front Genet (2016) 0.75
Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget (2016) 0.75
Stat3 accelerates Myc induced tumor formation while reducing growth rate in a mouse model of breast cancer. Oncotarget (2016) 0.75
Inhibition of STAT3 with the generation 2.5 antisense oligonucleotide, AZD9150, decreases neuroblastoma tumorigenicity and increases chemosensitivity. Clin Cancer Res (2016) 0.75
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06
STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer (2009) 15.45
Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33
ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol (2008) 11.86
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
The many substrates and functions of ATM. Nat Rev Mol Cell Biol (2000) 5.46
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
STAT proteins: novel molecular targets for cancer drug discovery. Oncogene (2000) 3.75
Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants. Cell Cycle (2006) 2.30
STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets (2004) 2.21
Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res (2006) 2.11
Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. Clin Cancer Res (2003) 2.01
Specific role of Chk1 phosphorylations in cell survival and checkpoint activation. Mol Cell Biol (2007) 1.87
DNA repair: the importance of phosphorylating histone H2AX. Curr Biol (2005) 1.86
Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis. J Biol Chem (2000) 1.65
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes. DNA Repair (Amst) (2004) 1.56
The STAT3 oncogene as a predictive marker of drug resistance. Trends Mol Med (2006) 1.43
Opposing actions of STAT-1 and STAT-3. Growth Factors (2005) 1.33
Role of the JAK-STAT pathway in myocardial injury. Trends Mol Med (2006) 1.32
Retracted STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci (2005) 1.17
Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line. Cancer Lett (2007) 1.14
STAT3 deletion sensitizes cells to oxidative stress. Biochem Biophys Res Commun (2009) 1.02
Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. FASEB J (2006) 0.94
Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene. Carcinogenesis (2002) 0.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science (2004) 15.91
Peripartum cardiomyopathy: a comprehensive review. Int J Cardiol (2007) 3.83
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell (2009) 3.17
p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem (2003) 2.69
Functional regulation of p73 and p63: development and cancer. Trends Biochem Sci (2003) 2.29
The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A (2006) 2.01
Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clin Cancer Res (2005) 1.99
Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proc Natl Acad Sci U S A (2012) 1.97
Molecular regulation of cardiac hypertrophy. Int J Biochem Cell Biol (2008) 1.95
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem (2006) 1.91
MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle (2011) 1.89
TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle (2007) 1.84
Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J Mol Cell Cardiol (2006) 1.83
STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis. J Biol Chem (2003) 1.79
Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Endocrinology (2003) 1.76
Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress. Am J Physiol Heart Circ Physiol (2007) 1.70
A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann Neurol (2006) 1.61
Antibodies to apolipoprotein A-I, high-density lipoprotein, and C-reactive protein are associated with disease activity in patients with systemic lupus erythematosus. Arthritis Rheum (2010) 1.60
microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A (2011) 1.60
miR-34: from bench to bedside. Oncotarget (2014) 1.59
Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A (2011) 1.58
Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. Cancer Biol Ther (2004) 1.57
Enhanced IL-17 signalling following myocardial ischaemia/reperfusion injury. Int J Cardiol (2011) 1.52
FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy. Cell Cycle (2008) 1.52
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. J Biol Chem (2002) 1.45
STAT-1: a novel regulator of apoptosis. Int J Exp Pathol (2003) 1.43
p73 induces apoptosis by different mechanisms. Biochem Biophys Res Commun (2005) 1.42
Current Strategies in the Evaluation and Management of Cocaine-Induced Chest Pain. Cardiol Rev (2015) 1.39
Referencing for reviews: How to distinguish unwillingness from mission impossible. Int J Cardiol (2007) 1.38
p63 is upstream of IKK alpha in epidermal development. J Cell Sci (2006) 1.35
Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. J Alzheimers Dis (2009) 1.34
PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73. Mol Cell Biol (2004) 1.33
p73 in Cancer. Genes Cancer (2011) 1.33
Role of the JAK-STAT pathway in myocardial injury. Trends Mol Med (2006) 1.32
GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation. Cell Cycle (2013) 1.32
Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. FASEB J (2004) 1.31
p53 is cleaved by caspases generating fragments localizing to mitochondria. J Biol Chem (2006) 1.30
miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro. Biochem Biophys Res Commun (2010) 1.29
p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun (2010) 1.25
The neuroprotective effects of heat shock protein 27 overexpression in transgenic animals against kainate-induced seizures and hippocampal cell death. J Biol Chem (2003) 1.24
Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux. J Cell Sci (2009) 1.20
Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Circ Res (2002) 1.18
Retracted STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci (2005) 1.17
Neurocardiogenic syncope. BMJ (2004) 1.16
BAG-1: a multi-functional pro-survival molecule. Int J Biochem Cell Biol (2005) 1.14
miR-146a is modulated in human endothelial cell with aging. Atherosclerosis (2011) 1.14
Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. J Am Coll Cardiol (2004) 1.12
Binding of antiphospholipid antibodies to discontinuous epitopes on domain I of human beta(2)-glycoprotein I: mutation studies including residues R39 to R43. Arthritis Rheum (2007) 1.12
Differential altered stability and transcriptional activity of ΔNp63 mutants in distinct ectodermal dysplasias. J Cell Sci (2011) 1.11
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression. Neurobiol Dis (2007) 1.11
Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun (2003) 1.10
HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells. J Neurochem (2004) 1.09
Clinical implications of apoptosis in ischemic myocardium. Curr Probl Cardiol (2006) 1.09
Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. J Mol Cell Cardiol (2002) 1.09
Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovasc Res (2002) 1.09
Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proc Natl Acad Sci U S A (2010) 1.08
p73: a multifunctional protein in neurobiology. Mol Neurobiol (2011) 1.07
Molecular basis of Parkinson's disease. Neuroreport (2009) 1.06
Whole serum 3D LC-nESI-FTMS quantitative proteomics reveals sexual dimorphism in the milieu intérieur of overweight and obese adults. J Proteome Res (2014) 1.06
Neuroprotective effects of HSP70 overexpression after cerebral ischaemia--an MRI study. Exp Neurol (2005) 1.05
Cell death pathology: cross-talk with autophagy and its clinical implications. Biochem Biophys Res Commun (2011) 1.04
Human rhinovirus selectively modulates membranous and soluble forms of its intercellular adhesion molecule-1 (ICAM-1) receptor to promote epithelial cell infectivity. J Biol Chem (2003) 1.04
What causes a broken heart--molecular insights into heart failure. Int Rev Cell Mol Biol (2010) 1.04
The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription. Oncogene (2003) 1.04
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. Hum Mol Genet (2007) 1.03
Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate. J Biol Chem (2004) 1.02
IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes. Cardiovasc Res (2005) 1.02
STAT3 deletion sensitizes cells to oxidative stress. Biochem Biophys Res Commun (2009) 1.02