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1
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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
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Mol Cell
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2005
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13.59
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2
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Structural insights into the degradation of Mcl-1 induced by BH3 domains.
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Proc Natl Acad Sci U S A
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2007
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3.41
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3
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BCL-2 family antagonists for cancer therapy.
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Nat Rev Drug Discov
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2008
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3.24
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4
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To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
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Mol Cell
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2008
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2.97
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5
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Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
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Cell
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2013
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2.75
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6
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Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.
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J Mol Biol
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2004
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2.33
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7
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A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
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J Cell Biol
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2008
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2.04
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8
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The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
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Immunity
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2012
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1.89
|
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9
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Structure-guided design of a selective BCL-X(L) inhibitor.
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Nat Chem Biol
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2013
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1.68
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10
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Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.
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J Am Chem Soc
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2011
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1.49
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11
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A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
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Mol Cell
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2007
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1.47
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12
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High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL.
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Angew Chem Int Ed Engl
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2009
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1.34
|
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13
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Structural studies of the resistance of influenza virus neuramindase to inhibitors.
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J Med Chem
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2002
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1.20
|
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14
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Modelling the structure of the fusion protein from human respiratory syncytial virus.
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Protein Eng
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2002
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1.17
|
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15
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Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
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J Biol Chem
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2009
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1.09
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16
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Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
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Proc Natl Acad Sci U S A
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2011
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1.09
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17
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Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design.
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Chembiochem
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2011
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1.04
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18
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Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.
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J Biol Chem
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2009
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1.03
|
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19
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Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis.
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J Biol Chem
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2011
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1.02
|
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20
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Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
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PLoS Pathog
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2010
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1.02
|
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21
|
Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.
|
J Mol Biol
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2009
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0.95
|
|
22
|
Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum.
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Acta Crystallogr D Biol Crystallogr
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2005
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0.88
|
|
23
|
Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms.
|
J Mol Biol
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2006
|
0.86
|
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24
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Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins.
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Structure
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2011
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0.86
|
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25
|
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
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J Med Chem
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2013
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0.86
|
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26
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Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.
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J Virol
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2012
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0.82
|
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27
|
Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza.
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Angew Chem Int Ed Engl
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2003
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0.78
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28
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De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.
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J Med Chem
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2014
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0.78
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