Published in Mol Cell on February 04, 2005
Mechanism and regulation of class switch recombination. Annu Rev Immunol (2008) 5.98
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res (2008) 3.48
The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal (2009) 2.43
Isolation of a small molecule inhibitor of DNA base excision repair. Nucleic Acids Res (2005) 1.98
Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxid Redox Signal (2009) 1.81
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination. J Exp Med (2007) 1.70
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. Mol Cell Biol (2009) 1.58
Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1. Antioxid Redox Signal (2008) 1.58
Participation of DNA repair in the response to 5-fluorouracil. Cell Mol Life Sci (2009) 1.44
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells. Nucleic Acids Res (2006) 1.36
Human apurinic/apyrimidinic endonuclease 1. Antioxid Redox Signal (2013) 1.34
Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway. PLoS One (2013) 1.34
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One (2009) 1.32
Redox regulation of DNA repair: implications for human health and cancer therapeutic development. Antioxid Redox Signal (2010) 1.31
Going ape as an approach to cancer therapeutics. Antioxid Redox Signal (2009) 1.25
Base excision repair and cancer. Cancer Lett (2012) 1.23
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells. Proteomics (2009) 1.23
MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1. J Invest Dermatol (2008) 1.23
Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration. Mol Cancer Ther (2008) 1.22
Human glyceraldehyde-3-phosphate dehydrogenase plays a direct role in reactivating oxidized forms of the DNA repair enzyme APE1. J Biol Chem (2008) 1.22
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res (2008) 1.22
Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol Life Sci (2010) 1.21
Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res (2010) 1.19
Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites. Mol Cancer Res (2009) 1.18
Direct and indirect roles of RECQL4 in modulating base excision repair capacity. Hum Mol Genet (2009) 1.18
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth. DNA Repair (Amst) (2007) 1.18
DNA repair proteins as molecular targets for cancer therapeutics. Anticancer Agents Med Chem (2008) 1.17
Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases. Part Fibre Toxicol (2007) 1.17
Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. Oncogene (2009) 1.15
APE1/Ref-1 regulates PTEN expression mediated by Egr-1. Free Radic Res (2008) 1.13
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death. Nat Cell Biol (2010) 1.12
Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells. Mol Biol Cell (2012) 1.12
Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination. Mol Cell Biol (2013) 1.11
Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles. Proc Natl Acad Sci U S A (2006) 1.10
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage. Nucleic Acids Res (2008) 1.09
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. DNA Repair (Amst) (2009) 1.07
Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin. J Biol Chem (2010) 1.06
Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era? Mol Cell Biol (2009) 1.05
A redox-sensitive cysteine in Zta is required for Epstein-Barr virus lytic cycle DNA replication. J Virol (2005) 1.04
Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression. Cancer Invest (2010) 1.00
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions. Nucleic Acids Res (2010) 1.00
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. Nucleic Acids Res (2011) 0.99
APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions. Exp Mol Med (2014) 0.97
Colon cancer progression is driven by APEX1-mediated upregulation of Jagged. J Clin Invest (2013) 0.96
Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease. PLoS Genet (2011) 0.95
Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy. PLoS One (2014) 0.95
Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function. Mol Biol Cell (2011) 0.94
Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance. Proc Natl Acad Sci U S A (2013) 0.94
Development of a novel assay for human tyrosyl DNA phosphodiesterase 2. Anal Biochem (2011) 0.93
SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements. Mol Biol Cell (2013) 0.92
Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway. J Mol Med (Berl) (2007) 0.92
Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice. Free Radic Biol Med (2009) 0.90
DNA repair protein involved in heart and blood development. Mol Cell Biol (2006) 0.90
Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited. Biochemistry (2013) 0.89
Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation. Proc Natl Acad Sci U S A (2014) 0.89
APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER. Mutat Res (2015) 0.88
ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis. Mol Cell Biol (2007) 0.88
Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors. Biochemistry (2012) 0.88
Posttranslational modification of mammalian AP endonuclease (APE1). Cell Mol Life Sci (2010) 0.87
Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms. Curr Med Chem (2012) 0.86
Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity. PLoS One (2010) 0.86
NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1. Biochemistry (2011) 0.86
Essential role of DNA base excision repair on survival in an acidic tumor microenvironment. Cancer Res (2009) 0.86
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection. Cancer Res (2010) 0.84
Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines. PLoS One (2013) 0.83
ARF induction in response to DNA strand breaks is regulated by PARP1. Nucleic Acids Res (2013) 0.83
Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs. Future Med Chem (2012) 0.83
Control of mitochondrial integrity in ageing and disease. Philos Trans R Soc Lond B Biol Sci (2014) 0.83
Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5. Nucleic Acids Res (2011) 0.82
Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+ cofactor. Acta Crystallogr D Biol Crystallogr (2013) 0.82
The prion protein is critical for DNA repair and cell survival after genotoxic stress. Nucleic Acids Res (2014) 0.82
The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate. PLoS One (2014) 0.81
Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection. PLoS One (2012) 0.81
A chemical and kinetic perspective on base excision repair of DNA. Acc Chem Res (2014) 0.81
DNA Repair and Cancer Therapy: Targeting APE1/Ref-1 Using Dietary Agents. J Oncol (2012) 0.81
The Mutyh base excision repair gene influences the inflammatory response in a mouse model of ulcerative colitis. PLoS One (2010) 0.80
Base excision repair in early zebrafish development: evidence for DNA polymerase switching and standby AP endonuclease activity. Biochemistry (2009) 0.80
DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations. DNA Repair (Amst) (2013) 0.80
Mitochondrial translocation of APE1 relies on the MIA pathway. Nucleic Acids Res (2015) 0.80
ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. PLoS One (2013) 0.80
Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation. Oncotarget (2016) 0.79
Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo. Cell Death Differ (2015) 0.79
Reduced Nuclease Activity of Apurinic/Apyrimidinic Endonuclease (APE1) Variants on Nucleosomes: IDENTIFICATION OF ACCESS RESIDUES. J Biol Chem (2015) 0.78
Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer. Front Nutr (2015) 0.78
Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease. DNA Repair (Amst) (2015) 0.78
Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair. PLoS One (2015) 0.77
Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo. Proc Natl Acad Sci U S A (2015) 0.77
Endothelial cell tumor growth is Ape/ref-1 dependent. Am J Physiol Cell Physiol (2015) 0.76
Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis. Int J Mol Sci (2012) 0.76
Saccharomyces cerevisiae Apn1 mutation affecting stable protein expression mimics catalytic activity impairment: implications for assessing DNA repair capacity in humans. DNA Repair (Amst) (2012) 0.76
AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase β knockout mouse embryonic fibroblasts. J Radiat Res (2015) 0.75
Induction of chemoresistance by all-trans retinoic acid via a noncanonical signaling in multiple myeloma cells. PLoS One (2014) 0.75
Molecular cloning and 3D structure modeling of APEX1, DNA base excision repair enzyme from the Camel, Camelus dromedarius. Int J Mol Sci (2012) 0.75
Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1. Int J Clin Exp Pathol (2015) 0.75
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity. Mol Cell Biol (2017) 0.75
Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis. Mol Cell Biochem (2013) 0.75
Association of APE1 Gene Asp148Glu Variant with Digestive Cancer: A Meta-Analysis. Med Sci Monit (2015) 0.75
APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts. Oncotarget (2016) 0.75
Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry. PLoS One (2013) 0.75
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death. Mol Cell (2006) 2.21
Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates. Mol Cell (2008) 2.12
Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria. Mol Cell Biol (2008) 1.95
Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA. FEBS J (2006) 1.70
DNA repair in mammalian mitochondria: Much more than we thought? Environ Mol Mutagen (2010) 1.45
Terminally differentiated muscle cells are defective in base excision DNA repair and hypersensitive to oxygen injury. Proc Natl Acad Sci U S A (2007) 1.34
Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone. J Biol Chem (2002) 1.30
Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coli. Biochem Biophys Res Commun (2006) 1.18
Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta. J Biol Chem (2005) 1.14
DNA binding shifts the redox potential of the transcription factor SoxR. Proc Natl Acad Sci U S A (2008) 1.10
Modulation of the 5'-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1. J Biol Chem (2004) 1.09
Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA. Proc Natl Acad Sci U S A (2005) 1.08
Distinct roles of Ape1 protein in the repair of DNA damage induced by ionizing radiation or bleomycin. J Biol Chem (2010) 1.06
Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates. Antimicrob Agents Chemother (2005) 1.05
DNA-mediated redox signaling for transcriptional activation of SoxR. Proc Natl Acad Sci U S A (2009) 1.05
SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli. J Bacteriol (2003) 1.03
Modulation of the 3'-->5'-exonuclease activity of human apurinic endonuclease (Ape1) by its 5'-incised Abasic DNA product. J Biol Chem (2003) 1.00
Global adjustment of microbial physiology during free radical stress. Adv Microb Physiol (2002) 1.00
Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA. DNA Repair (Amst) (2003) 1.00
Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance. Proc Natl Acad Sci U S A (2013) 0.94
Functional analysis of SoxR residues affecting transduction of oxidative stress signals into gene expression. J Biol Chem (2004) 0.92
Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53. Cancer Res (2005) 0.88
Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation. Mol Cell Biol (2009) 0.88
ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis. Mol Cell Biol (2007) 0.88
Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair. DNA Repair (Amst) (2007) 0.88
Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae. Mutagenesis (2009) 0.86
Expression analysis of the fpr (ferredoxin-NADP+ reductase) gene in Pseudomonas putida KT2440. Biochem Biophys Res Commun (2006) 0.86
Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitrosative or alkylation stress. BMC Mol Biol (2007) 0.85
Transcription-defective soxR mutants of Escherichia coli: isolation and in vivo characterization. J Bacteriol (2003) 0.84
Carbon monoxide mediates protection against nitric oxide toxicity in HeLa cells. Free Radic Biol Med (2005) 0.83
A key role for heme oxygenase-1 in nitric oxide resistance in murine motor neurons and glia. Biochem Biophys Res Commun (2004) 0.83
Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation. J Biol Chem (2006) 0.83
Analysis of base excision DNA repair of the oxidative lesion 2-deoxyribonolactone and the formation of DNA-protein cross-links. Methods Enzymol (2006) 0.82
A DNA-based nanomechanical device used to characterize the distortion of DNA by Apo-SoxR protein. Biochemistry (2012) 0.79
Nitric oxide-mediated upregulation of the TGF-beta-inducible early response gene-1 (TIEG1) in human fibroblasts by mRNA stabilization independent of TGF-beta. Free Radic Biol Med (2003) 0.79
Biochemical evaluation of genotoxic biomarkers for 2-deoxyribonolactone-mediated cross-link formation with histones. J Toxicol Environ Health A (2009) 0.78
Community organizers and (bio)filmmaking. Nat Chem Biol (2008) 0.77