Published in Antioxid Redox Signal on March 01, 2009
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal (2012) 5.65
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. Clin Epigenetics (2011) 1.31
Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis (2013) 1.31
Redox regulation of DNA repair: implications for human health and cancer therapeutic development. Antioxid Redox Signal (2010) 1.31
Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol Life Sci (2010) 1.21
Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev (2012) 1.13
Involvement of oxidatively damaged DNA and repair in cancer development and aging. Am J Transl Res (2010) 1.12
APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1. Curr Mol Pharmacol (2012) 1.10
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. Oncogene (2010) 1.09
Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancer. PLoS One (2013) 1.04
Mechanisms of endonuclease-mediated mRNA decay. Wiley Interdiscip Rev RNA (2011) 1.03
Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. J Biol Chem (2010) 1.01
Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression. Cancer Invest (2010) 1.00
Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability. Nucleic Acids Res (2011) 0.99
APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions. Exp Mol Med (2014) 0.97
Colon cancer progression is driven by APEX1-mediated upregulation of Jagged. J Clin Invest (2013) 0.96
DNA damage and base excision repair in mitochondria and their role in aging. J Aging Res (2010) 0.95
Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1. J Biol Chem (2010) 0.93
Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. J Med Chem (2012) 0.93
Mechanism of hypoxia-inducible factor 1 alpha-mediated Mcl1 regulation in Helicobacter pylori-infected human gastric epithelium. Am J Physiol Gastrointest Liver Physiol (2010) 0.91
APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival. PLoS One (2012) 0.90
Human apurinic/apyrimidinic endonuclease siRNA inhibits the angiogenesis induced by X-ray irradiation in lung cancer cells. Int J Med Sci (2013) 0.90
Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response. Mol Endocrinol (2009) 0.88
Posttranslational modification of mammalian AP endonuclease (APE1). Cell Mol Life Sci (2010) 0.87
All stressed out without ATM kinase. Sci Signal (2011) 0.87
Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes. Prog Mol Biol Transl Sci (2012) 0.87
S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity. J Mol Biol (2011) 0.86
Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms. Curr Med Chem (2012) 0.86
Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization. Redox Biol (2014) 0.86
NMR studies reveal an unexpected binding site for a redox inhibitor of AP endonuclease 1. Biochemistry (2011) 0.86
Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression. PLoS One (2013) 0.86
Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLoS One (2013) 0.85
The association of APE1 -656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies. BMC Cancer (2011) 0.85
Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair. Proc Natl Acad Sci U S A (2017) 0.84
Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons. Free Radic Biol Med (2012) 0.84
Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex. J Hypertens (2012) 0.84
Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines. PLoS One (2013) 0.83
New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins. Cell Mol Life Sci (2015) 0.83
A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease. Mol Cell Biochem (2011) 0.83
Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+ cofactor. Acta Crystallogr D Biol Crystallogr (2013) 0.82
Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1. Biomol NMR Assign (2009) 0.81
Apurinic/apyrimidinic endonuclease-1 is associated with angiogenesis and VEGF production via upregulation of COX-2 expression in esophageal cancer tissues. Am J Physiol Gastrointest Liver Physiol (2013) 0.81
Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2. J Biol Chem (2014) 0.81
Sequential treatment with AT-101 enhances cisplatin chemosensitivity in human non-small cell lung cancer cells through inhibition of apurinic/apyrimidinic endonuclease 1-activated IL-6/STAT3 signaling pathway. Drug Des Devel Ther (2014) 0.81
Unbiased proteomic analysis of proteins interacting with the HIV-1 5'LTR sequence: role of the transcription factor Meis. Nucleic Acids Res (2012) 0.80
Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation. Oncotarget (2016) 0.79
Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics. Mol Cancer Ther (2016) 0.79
Diametrically opposed effects of hypoxia and oxidative stress on two viral transactivators. Virol J (2010) 0.78
17β-Estradiol alters oxidative stress response protein expression and oxidative damage in the uterus. Mol Cell Endocrinol (2013) 0.78
A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta. Nucleic Acids Res (2010) 0.78
Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease. DNA Repair (Amst) (2015) 0.78
Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure. Toxicol Appl Pharmacol (2013) 0.78
Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk. Dis Markers (2015) 0.78
8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis. DNA Repair (Amst) (2017) 0.77
Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity. Invest Ophthalmol Vis Sci (2014) 0.77
Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. J Biol Chem (2014) 0.77
Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction. Stem Cells Transl Med (2016) 0.76
Elevated level of acetylation of APE1 in tumor cells modulates DNA damage repair. Oncotarget (2016) 0.76
Endothelial cell tumor growth is Ape/ref-1 dependent. Am J Physiol Cell Physiol (2015) 0.76
Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions. Oncotarget (2016) 0.76
Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice. Mutat Res (2015) 0.75
G-quadruplex-forming promoter sequences enable transcriptional activation in response to oxidative stress. Proc Natl Acad Sci U S A (2017) 0.75
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog (2016) 0.75
Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis. Mol Cell Biochem (2013) 0.75
Functional analysis of tanshinone IIA that blocks the redox function of human apurinic/apyrimidinic endonuclease 1/redox factor-1. Drug Des Devel Ther (2014) 0.75
Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses. J Biol Chem (2016) 0.75
Molecular cloning and 3D structure modeling of APEX1, DNA base excision repair enzyme from the Camel, Camelus dromedarius. Int J Mol Sci (2012) 0.75
Redox Factor-1 Inhibits Cyclooxygenase-2 Expression via Inhibiting of p38 MAPK in the A549 Cells. Korean J Physiol Pharmacol (2010) 0.75
Association between APE1 Asp148Glu polymorphism and the risk of urinary cancers: a meta-analysis of 18 case-control studies. Onco Targets Ther (2016) 0.75
An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes. PLoS Pathog (2017) 0.75
Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells. J Biol Chem (2016) 0.75
Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity. Mol Cell Biol (2017) 0.75
Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells. Oncotarget (2016) 0.75
Identification and quantification of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human cells by liquid chromatography/isotope-dilution tandem mass spectrometry. PLoS One (2013) 0.75
Maternal diabetes modulates dental epithelial stem cells proliferation and self-renewal in offspring through apurinic/apyrimidinicendonuclease 1-mediated DNA methylation. Sci Rep (2017) 0.75
The extracellular role of DNA damage repair protein APE1 in regulation of IL-6 expression. Cell Signal (2017) 0.75
An in vitro study ascertaining the role of H2O2 and glucose oxidase in modulation of antioxidant potential and cancer cell survival mechanisms in glioblastoma U-87 MG cells. Metab Brain Dis (2017) 0.75
Curcumin revitalizes Amyloid beta (25-35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2. Metab Brain Dis (2017) 0.75
Atherosclerosis--an inflammatory disease. N Engl J Med (1999) 59.28
The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell (1996) 16.57
Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A (1993) 13.27
Oxidative stress, glutamate, and neurodegenerative disorders. Science (1993) 7.96
Repair of oxidative damage to DNA: enzymology and biology. Annu Rev Biochem (1994) 7.80
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol (2005) 7.25
Acetylation and deacetylation of non-histone proteins. Gene (2005) 6.87
Mutagenesis by apurinic/apyrimidinic sites. Annu Rev Genet (1986) 6.07
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J (1992) 5.23
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem (1996) 5.15
Redox redux: revisiting PTPs and the control of cell signaling. Cell (2005) 5.10
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]. Nature (2000) 4.40
DNA glycosylases in the base excision repair of DNA. Biochem J (1997) 3.99
Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity. EMBO J (1992) 3.98
Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300. EMBO J (1999) 3.70
XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. Cell (2001) 3.66
Going APE over ref-1. Mutat Res (2000) 3.63
Protein sulfenic acids in redox signaling. Annu Rev Pharmacol Toxicol (2004) 3.56
Reactions of oxyl radicals with DNA. Free Radic Biol Med (1995) 3.52
AP endonuclease-independent DNA base excision repair in human cells. Mol Cell (2004) 3.37
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A (1996) 3.34
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell (2002) 3.28
The enzymology of apurinic/apyrimidinic endonucleases. Mutat Res (1990) 3.21
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. Proc Natl Acad Sci U S A (1997) 3.21
Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. J Clin Invest (2003) 3.02
Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol (1995) 2.95
The pleiotropic functions of the Y-box-binding protein, YB-1. Bioessays (2003) 2.91
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med (1997) 2.88
The intracellular localization of APE1/Ref-1: more than a passive phenomenon? Antioxid Redox Signal (2005) 2.75
Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding. Mol Cell Biol (1993) 2.73
Morphology, physiology, and molecular biology of renin secretion. Physiol Rev (1990) 2.71
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol (2001) 2.71
Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev (1997) 2.70
Histone acetyltransferase activity of CBP is controlled by cycle-dependent kinases and oncoprotein E1A. Nature (1998) 2.69
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol Cell Biol (2000) 2.61
The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci U S A (1994) 2.55
Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. J Biol Chem (2002) 2.54
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites. EMBO J (1997) 2.53
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene (2005) 2.53
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc Natl Acad Sci U S A (1998) 2.42
A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells. Mol Cell (2005) 2.32
Two essential but distinct functions of the mammalian abasic endonuclease. Proc Natl Acad Sci U S A (2005) 2.26
The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther (2006) 2.24
Regulation of gene expression by reactive oxygen. Annu Rev Pharmacol Toxicol (1999) 2.22
Two distinct human DNA diesterases that hydrolyze 3'-blocking deoxyribose fragments from oxidized DNA. Nucleic Acids Res (1991) 2.22
Control of Smad7 stability by competition between acetylation and ubiquitination. Mol Cell (2002) 2.18
The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target. Mol Aspects Med (2007) 2.01
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition. Mol Cancer Ther (2004) 1.99
Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst (1993) 1.97
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. EMBO J (2003) 1.94
A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res (1994) 1.89
Mitochondrial targeting of human DNA glycosylases for repair of oxidative DNA damage. Nucleic Acids Res (1998) 1.83
Thioredoxin-dependent redox regulation of p53-mediated p21 activation. J Biol Chem (1999) 1.83
Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium. J Hypertens (2003) 1.83
Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone. Circ Res (2004) 1.81
Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur J Biochem (1991) 1.77
The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications. Carcinogenesis (2003) 1.77
Endothelial cell apoptosis in angiogenesis and vessel regression. Circ Res (2000) 1.73
Overexpression of Ref-1 inhibits hypoxia and tumor necrosis factor-induced endothelial cell apoptosis through nuclear factor-kappab-independent and -dependent pathways. Circ Res (2001) 1.70
Altered expression of Ape1/ref-1 in germ cell tumors and overexpression in NT2 cells confers resistance to bleomycin and radiation. Cancer Res (2001) 1.64
The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair (Amst) (2005) 1.64
Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo. EMBO J (1999) 1.59
Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1. Antioxid Redox Signal (2008) 1.58
The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal. Structure (1996) 1.58
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Biochemistry (2001) 1.56
Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage. Toxicology (2003) 1.52
Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo. Mol Cell Biol (2006) 1.48
Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. Cancer Res (2000) 1.48
A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium. J Biol Chem (1994) 1.46
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism. Proc Natl Acad Sci U S A (2002) 1.45
Choreography of oxidative damage repair in mammalian genomes. Free Radic Biol Med (2002) 1.43
Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease. Mutat Res (1994) 1.42
Protein-protein interactions and posttranslational modifications in mammalian base excision repair. Free Radic Biol Med (2005) 1.42
Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species. Carcinogenesis (2000) 1.40
Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia. Mol Cell Biol (1994) 1.39
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer. Clin Cancer Res (2001) 1.37
Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1. Antioxid Redox Signal (2001) 1.36
Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo. J Biol Chem (2002) 1.36
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells. Nucleic Acids Res (2006) 1.36
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas. Clin Cancer Res (2001) 1.36
Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin, mitomycin C, and ultraviolet light. Cancer Res (1996) 1.33
Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP. Nucleic Acids Res (2005) 1.33
Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene. FASEB J (2004) 1.33
Nuclear expression of human apurinic/apyrimidinic endonuclease (HAP1/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome. Int J Radiat Oncol Biol Phys (2001) 1.32
Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells. Infect Immun (2007) 1.32
Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis. Cell Death Differ (2002) 1.27
Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation. Cancer Res (1998) 1.27
Synthesis of chemical probes to map sulfenic acid modifications on proteins. Bioconjug Chem (2005) 1.27
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). Nucleic Acids Res (2005) 1.26
Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310. Nucleic Acids Res (2007) 1.26
Mammalian DNA beta-polymerase in base excision repair of alkylation damage. Prog Nucleic Acid Res Mol Biol (2001) 1.24
The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation. Cancer Res (1997) 1.23
Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Res (1995) 1.23
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain. Blood (2006) 1.22
Negative regulation of the major human AP-endonuclease, a multifunctional protein. Biochemistry (1996) 1.22
A new APE1/Ref-1-dependent pathway leading to reduction of NF-kappaB and AP-1, and activation of their DNA-binding activity. Nucleic Acids Res (2008) 1.22
Redox regulation of protein-tyrosine phosphatases. Arch Biochem Biophys (2005) 1.20
Prognostic significance of Ape1/ref-1 subcellular localization in non-small cell lung carcinomas. Anticancer Res (2002) 1.20
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth. DNA Repair (Amst) (2007) 1.18
Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology (2004) 1.18
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res (2008) 3.48
AP endonuclease-independent DNA base excision repair in human cells. Mol Cell (2004) 3.37
Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proc Natl Acad Sci U S A (2002) 3.33
Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions. J Biol Chem (2002) 2.54
Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. J Biol Chem (2003) 2.53
ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest (2005) 2.34
Two essential but distinct functions of the mammalian abasic endonuclease. Proc Natl Acad Sci U S A (2005) 2.26
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. EMBO J (2003) 1.94
The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications. Carcinogenesis (2003) 1.77
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes. J Biol Chem (2007) 1.63
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev (2014) 1.57
Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage. Toxicology (2003) 1.52
Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo. Mol Cell Biol (2006) 1.48
NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. DNA Repair (Amst) (2006) 1.45
Long patch base excision repair in mammalian mitochondrial genomes. J Biol Chem (2008) 1.44
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1. J Biol Chem (2007) 1.38
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells. Nucleic Acids Res (2006) 1.36
Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. J Biol Chem (2012) 1.30
Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1. J Biol Chem (2008) 1.27
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). Nucleic Acids Res (2005) 1.26
Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases. Proc Natl Acad Sci U S A (2003) 1.26
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1. Mol Cell Biol (2008) 1.24
Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells. Proteomics (2009) 1.23
Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species. J Biol Chem (2005) 1.22
Multifaceted resistance of gliomas to temozolomide. Clin Cancer Res (2002) 1.22
Preferential repair of oxidized base damage in the transcribed genes of mammalian cells. J Biol Chem (2010) 1.22
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA. Nucleic Acids Res (2009) 1.20
Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair. J Biol Chem (2011) 1.18
Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology (2004) 1.18
Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity. Nucleic Acids Res (2004) 1.15
The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase. Nucleic Acids Res (2007) 1.14
p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor. Anticancer Res (2009) 1.13
Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases. Mech Ageing Dev (2012) 1.13
Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword. J Alzheimers Dis (2011) 1.13
APE1/Ref-1 regulates PTEN expression mediated by Egr-1. Free Radic Res (2008) 1.13
Stimulation of DNA glycosylase activity of OGG1 by NEIL1: functional collaboration between two human DNA glycosylases. Biochemistry (2004) 1.12
CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration. Carcinogenesis (2003) 1.11
The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe. Nucleic Acids Res (2004) 1.09
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage. Nucleic Acids Res (2008) 1.09
Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. Nucleic Acids Res (2002) 1.09
Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem (2010) 1.06
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress. Toxicology (2003) 1.04
Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins. Proc Natl Acad Sci U S A (2013) 1.04
Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein. J Biol Chem (2004) 1.02
Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis. Gastroenterology (2009) 1.02
RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures. DNA Repair (Amst) (2010) 1.00
Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution. Mech Ageing Dev (2004) 0.99
Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer. Cell Res (2011) 0.98
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. J Immunol (2006) 0.98
Functions of disordered regions in mammalian early base excision repair proteins. Cell Mol Life Sci (2010) 0.98
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. J Biol Chem (2013) 0.96
Effect of aging on intracellular distribution of abasic (AP) endonuclease 1 in the mouse liver. Mech Ageing Dev (2005) 0.95
Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells. Mitochondrion (2006) 0.95
Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1. J Mol Biol (2008) 0.94
Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme. DNA Repair (Amst) (2008) 0.93
Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury. Mech Ageing Dev (2010) 0.93
The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions. J Mol Biol (2013) 0.93
Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction. J Biol Chem (2012) 0.92
Systems approaches to modeling chronic mucosal inflammation. Biomed Res Int (2013) 0.91
Purification and characterization of NEIL1 and NEIL2, members of a distinct family of mammalian DNA glycosylases for repair of oxidized bases. Methods Enzymol (2006) 0.91
Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil. Biochem Biophys Res Commun (2007) 0.91
Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol (2011) 0.89
Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage. PLoS One (2013) 0.89
Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1. Cytokine (2009) 0.89
Oxidized base damage and single-strand break repair in mammalian genomes: role of disordered regions and posttranslational modifications in early enzymes. Prog Mol Biol Transl Sci (2012) 0.87
Human DNA Glycosylase NEIL1's Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival. Biomolecules (2012) 0.87
Solution structure of a DNA duplex containing 8-hydroxy-2'-deoxyguanosine opposite deoxyguanosine. J Mol Biol (2003) 0.86
Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle. Gastroenterology (2011) 0.86
Discrimination of lesion removal of N-methylpurine-DNA glycosylase revealed by a potent neutralizing monoclonal antibody. DNA Repair (Amst) (2007) 0.86
Binding of specific DNA base-pair mismatches by N-methylpurine-DNA glycosylase and its implication in initial damage recognition. J Mol Biol (2002) 0.86
Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression. PLoS One (2013) 0.86
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. J Biol Chem (2012) 0.85
Acetylation of human AP-endonuclease 1, a critical enzyme in DNA repair and transcription regulation. Methods Enzymol (2003) 0.84
Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex. J Hypertens (2012) 0.84
New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins. Cell Mol Life Sci (2015) 0.83
A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells. Jacobs J Radiat Oncol (2015) 0.82
Ginkgolide B revamps neuroprotective role of apurinic/apyrimidinic endonuclease 1 and mitochondrial oxidative phosphorylation against Aβ25-35 -induced neurotoxicity in human neuroblastoma cells. J Neurosci Res (2015) 0.81
Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction. J Neurosci Res (2012) 0.81
Effect of hormone replacement therapy in normalizing age related neuronal markers in different age groups of naturally menopausal rats. Biogerontology (2005) 0.80
MD simulation and experimental evidence for Mg²+ binding at the B site in human AP endonuclease 1. Bioinformation (2011) 0.80
Estradiol and progesterone treatments change the lipid profile in naturally menopausal rats from different age groups. Biogerontology (2004) 0.77