1
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Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity.
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Nat Med
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2011
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3.09
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2
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Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.
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J Biol Chem
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2003
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2.44
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3
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Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
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J Clin Invest
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2007
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2.22
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4
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Mitogen-actived protein kinase activation is an early event in melanoma progression.
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Clin Cancer Res
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2002
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2.18
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5
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Targeted therapy of oral hairy leukoplakia with gentian violet.
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J Am Acad Dermatol
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2008
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2.17
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6
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A key role for NOX4 in epithelial cell death during development of lung fibrosis.
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Antioxid Redox Signal
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1.79
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7
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Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice.
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J Invest Dermatol
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2006
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1.72
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8
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Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.
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J Clin Invest
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2009
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1.68
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9
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Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.
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Breast Cancer Res
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2012
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1.65
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10
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Honokiol, a multifunctional antiangiogenic and antitumor agent.
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Antioxid Redox Signal
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2009
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1.53
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11
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Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor.
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J Am Acad Dermatol
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2004
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1.52
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12
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Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.
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Clin Cancer Res
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2008
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1.43
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13
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Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling.
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J Biol Chem
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2003
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1.39
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14
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A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells.
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Proc Natl Acad Sci U S A
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2008
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1.33
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15
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Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.
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Mol Cancer Res
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2006
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1.32
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16
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The reactive oxygen-driven tumor: relevance to melanoma.
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Pigment Cell Melanoma Res
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2008
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1.31
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17
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Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase.
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Mol Med
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2002
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1.25
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18
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Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors.
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Clin Cancer Res
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2010
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1.25
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19
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Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma.
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Proc Natl Acad Sci U S A
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2004
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1.22
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20
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Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells.
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Cancer
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2007
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1.19
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21
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Honokiol is a potent scavenger of superoxide and peroxyl radicals.
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Biochem Pharmacol
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2008
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1.17
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22
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Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis.
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J Immunol
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2007
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1.16
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23
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Gentian violet: a 19th century drug re-emerges in the 21st century.
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Exp Dermatol
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2013
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1.13
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24
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AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo.
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Arch Dermatol
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2007
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1.12
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25
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Mammalian target of rapamycin (mTOR) is activated in cutaneous vascular malformations in vivo.
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Lymphat Res Biol
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2007
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1.12
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26
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Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway.
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Cancer Res
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2009
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1.12
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27
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Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma.
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Sci Transl Med
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2012
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1.12
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28
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Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain.
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J Biol Chem
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2004
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1.04
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29
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Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo.
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Clin Cancer Res
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2008
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1.03
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30
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Efficacy of topical application of eosin for ulcerated hemangiomas.
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J Am Acad Dermatol
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1.03
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31
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Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.
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Neurobiol Dis
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1.03
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32
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Effectiveness of gentian violet and similar products commonly used to treat pyodermas.
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Dermatol Clin
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2011
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1.01
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33
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Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.
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Cancer Res
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2009
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1.01
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34
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Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: are angiomyolipomas neoplasms of stem cells?
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Mol Med
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2007
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1.01
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35
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Angiomotin expression promotes hemangioendothelioma invasion.
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Oncogene
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0.99
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36
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Combination therapy of imiquimod and gentian violet for cutaneous melanoma metastases.
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J Am Acad Dermatol
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0.98
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37
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Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes.
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Free Radic Biol Med
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2011
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0.98
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38
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Expression of Wilms tumor 1 gene distinguishes vascular malformations from proliferative endothelial lesions.
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Arch Dermatol
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0.97
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39
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Synthesis and biological evaluation of aromatic enones related to curcumin.
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Bioorg Med Chem
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40
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Infectious angiogenesis: Bartonella bacilliformis infection results in endothelial production of angiopoetin-2 and epidermal production of vascular endothelial growth factor.
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Am J Pathol
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0.96
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41
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Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
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Int J Oncol
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0.96
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42
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Targeting NADPH oxidases for the treatment of cancer and inflammation.
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Cell Mol Life Sci
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43
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Rapamycin (sirolimus) as a steroid-sparing agent in dermatomyositis.
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J Am Acad Dermatol
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Curcumin as an inhibitor of angiogenesis.
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Adv Exp Med Biol
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45
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The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.
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Mol Cancer Ther
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0.94
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Weight loss-induced calciphylaxis: potential role of matrix metalloproteinases.
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J Dermatol
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The role of angiogenesis in the pathogenesis of psoriasis.
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Molecular pathogenesis of vascular anomalies: classification into three categories based upon clinical and biochemical characteristics.
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Lymphat Res Biol
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49
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Angiogenesis in cutaneous lesions of leprosy: implications for treatment.
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Arch Dermatol
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50
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Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth.
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Clin Cancer Res
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51
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Facile purification of honokiol and its antiviral and cytotoxic properties.
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J Med Chem
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Immunosuppression may be present within condyloma acuminata.
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J Am Acad Dermatol
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Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB.
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Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin.
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Bioorg Med Chem Lett
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JAMA
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Enhanced MCP-1 release by keloid CD14+ cells augments fibroblast proliferation: role of MCP-1 and Akt pathway in keloids.
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The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways.
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Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage.
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Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors.
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Bioorg Med Chem Lett
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Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa.
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The antidepressant sertraline downregulates Akt and has activity against melanoma cells.
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A nonsteroidal alternative to impetiginized eczema in the emergency room.
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Rapid improvement of nephrogenic systemic fibrosis with rapamycin therapy: possible role of phospho-70-ribosomal-S6 kinase.
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Combination therapy of doxycycline and topical tacrolimus for venous ulcers.
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Regulation of endothelial cell differentiation and transformation by H-Ras.
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