|
1
|
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.
|
Cell
|
2012
|
11.69
|
|
2
|
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|
Am J Hum Genet
|
2008
|
4.31
|
|
3
|
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
|
Proc Natl Acad Sci U S A
|
2011
|
3.14
|
|
4
|
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations.
|
Am J Respir Cell Mol Biol
|
2005
|
2.08
|
|
5
|
Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition.
|
Mol Cancer Ther
|
2009
|
1.98
|
|
6
|
Critical role for hypothalamic mTOR activity in energy balance.
|
Cell Metab
|
2009
|
1.90
|
|
7
|
IL10 gene polymorphisms are associated with asthma phenotypes in children.
|
Genet Epidemiol
|
2004
|
1.64
|
|
8
|
Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex.
|
Pediatrics
|
2006
|
1.40
|
|
9
|
Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis.
|
Mol Cancer
|
2009
|
1.16
|
|
10
|
Catalytic asymmetric allylation of ketones and a tandem asymmetric allylation/diastereoselective epoxidation of cyclic enones.
|
J Am Chem Soc
|
2004
|
1.10
|
|
11
|
Functional assessment of variants in the TSC1 and TSC2 genes identified in individuals with Tuberous Sclerosis Complex.
|
Hum Mutat
|
2011
|
1.08
|
|
12
|
AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.
|
Cancer Res
|
2008
|
1.07
|
|
13
|
Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.
|
Oncogene
|
2002
|
1.06
|
|
14
|
Association of defensin beta-1 gene polymorphisms with asthma.
|
J Allergy Clin Immunol
|
2005
|
1.03
|
|
15
|
Esophageal perforation and pneumothorax after routine intraoperative orogastric tube placement.
|
A A Case Rep
|
2014
|
0.97
|
|
16
|
Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation.
|
J Clin Invest
|
2004
|
0.97
|
|
17
|
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
|
J Exp Med
|
2014
|
0.97
|
|
18
|
Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice.
|
Am J Respir Cell Mol Biol
|
2003
|
0.95
|
|
19
|
Identification of a region required for TSC1 stability by functional analysis of TSC1 missense mutations found in individuals with tuberous sclerosis complex.
|
BMC Med Genet
|
2009
|
0.92
|
|
20
|
A phase I clinical trial of sequentially administered doxorubicin and topotecan in refractory solid tumors.
|
Clin Cancer Res
|
2002
|
0.80
|
|
21
|
TSC1, TSC2, TSC3? Or mosaicism?
|
Eur J Hum Genet
|
2005
|
0.80
|
|
22
|
Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis.
|
J Child Neurol
|
2004
|
0.77
|
|
23
|
Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
|
Hum Gene Ther
|
2005
|
0.75
|