Published in J Allergy Clin Immunol on February 01, 2005
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Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma. Am J Respir Crit Care Med (2015) 1.58
The role of antimicrobial peptides at the ocular surface. Ophthalmic Res (2008) 1.32
Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals. Curr HIV Res (2008) 1.14
Gene-environment interactions in asthma: with apologies to William of Ockham. Proc Am Thorac Soc (2007) 1.00
Role of urinary cathelicidin LL-37 and human β-defensin 1 in uncomplicated Escherichia coli urinary tract infections. Infect Immun (2014) 0.97
Genome-wide association study of lung function phenotypes in a founder population. J Allergy Clin Immunol (2013) 0.97
Association of variants in innate immune genes with asthma and eczema. Pediatr Allergy Immunol (2011) 0.93
Reversible control by vitamin D of granulocytes and bacteria in the lungs of mice: an ovalbumin-induced model of allergic airway disease. PLoS One (2013) 0.91
Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain. J Neuroinflammation (2013) 0.90
Genetic polymorphisms and associated susceptibility to asthma. Int J Gen Med (2013) 0.89
Unraveling the genetic basis of asthma and allergic diseases. Allergy Asthma Immunol Res (2010) 0.89
Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study. Respir Res (2006) 0.83
Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma. PLoS One (2014) 0.83
Histone deacetylase (HDAC) 1 controls the expression of beta defensin 1 in human lung epithelial cells. PLoS One (2012) 0.80
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Defensins and sepsis. Biomed Res Int (2014) 0.76
Role of infections in the induction and development of asthma: genetic and inflammatory drivers. Expert Rev Clin Immunol (2009) 0.76
A new statistical method for haplotype reconstruction from population data. Am J Hum Genet (2001) 59.30
Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet (2001) 22.07
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet (2003) 16.51
Replication validity of genetic association studies. Nat Genet (2001) 16.30
Implementing a unified approach to family-based tests of association. Genet Epidemiol (2000) 10.96
A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered (2000) 10.32
Long-term effects of budesonide or nedocromil in children with asthma. The Childhood Asthma Management Program Research Group. N Engl J Med (2000) 8.32
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A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet (1999) 6.94
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The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Childhood Asthma Management Program Research Group. Control Clin Trials (1999) 5.11
The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma. Eur Respir J (2003) 4.08
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Endotoxin exposure in allergy and asthma: reconciling a paradox. J Allergy Clin Immunol (2002) 2.77
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Defensins and host defense. Science (1999) 2.32
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Validation of self-reported chronic obstructive pulmonary disease in a cohort study of nurses. Am J Epidemiol (2002) 2.24
Prevalence and etiology of asthma. J Allergy Clin Immunol (2000) 2.19
A population-based study of bronchial asthma in adult twin pairs. Chest (1991) 2.04
Controlling the rate of Type I error over a large set of statistical tests. Br J Math Stat Psychol (2002) 1.97
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Development of wheezing disorders and asthma in preschool children. Pediatrics (2002) 1.57
Prospective study of postmenopausal hormone use and newly diagnosed asthma and chronic obstructive pulmonary disease. Arch Intern Med (2004) 1.52
Beta(2)-adrenoceptor polymorphism and body mass index are associated with adult-onset asthma in sedentary but not active women. Chest (2001) 1.49
Environmental tobacco smoke, indoor allergens, and childhood asthma. Environ Health Perspect (2000) 1.47
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Genetics, epigenetics, and the environment: switching, buffering, releasing. J Allergy Clin Immunol (2004) 1.38
Environmental factors influencing the development and progression of pediatric asthma. J Allergy Clin Immunol (2002) 1.29
Patient factors and medication guideline adherence among older women with asthma. Arch Intern Med (2002) 1.27
Defensins: key players or bystanders in infection, injury, and repair in the lung? J Allergy Clin Immunol (1999) 1.21
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Single-nucleotide polymorphisms and haplotype analysis in beta-defensin genes in different ethnic populations. Genet Test (2002) 1.11
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Something old, something new: indoor endotoxin, allergens and asthma. Paediatr Respir Rev (2004) 0.99
Role of gender and hormone-related events on IgE, atopy, and eosinophils in the Epidemiological Study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy. J Allergy Clin Immunol (2004) 0.91
Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. Eur Respir J (2003) 0.82
Multipoint linkage disequilibrium mapping approach: incorporating evidence of linkage and linkage disequilibrium from unlinked region. Genet Epidemiol (2003) 0.80
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Galaxy: a web-based genome analysis tool for experimentalists. Curr Protoc Mol Biol (2010) 17.00
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell (2012) 11.69
Extracting principal diagnosis, co-morbidity and smoking status for asthma research: evaluation of a natural language processing system. BMC Med Inform Decis Mak (2006) 9.98
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med (2010) 6.51
Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med (2006) 6.10
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med (2009) 4.64
Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol (2005) 4.50
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. Am J Hum Genet (2008) 4.31
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol (2004) 4.17
Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease. N Engl J Med (2015) 4.16
Instrumenting the health care enterprise for discovery research in the genomic era. Genome Res (2009) 4.13
Design of a national distributed health data network. Ann Intern Med (2009) 4.09
Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med (2011) 4.09
GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98
Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol (2007) 3.97
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 3.92
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr (2007) 3.89
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
A generalized linear mixed models approach for detecting incident clusters of disease in small areas, with an application to biological terrorism. Am J Epidemiol (2004) 3.71
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med (2005) 3.66
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
Tucson Children's Respiratory Study: 1980 to present. J Allergy Clin Immunol (2003) 3.41
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr (2007) 3.40
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation (2008) 3.30
Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of care. Med Care (2010) 3.29
Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort study. Lancet (2007) 3.22
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14
The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med (2007) 2.91
Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma. J Allergy Clin Immunol (2004) 2.80
Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol (2006) 2.79
Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet (2008) 2.70
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med (2008) 2.61
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet (2009) 2.56
Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol (2008) 2.56
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Farm living: effects on childhood asthma and allergy. Nat Rev Immunol (2010) 2.53
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Automated identification of acute hepatitis B using electronic medical record data to facilitate public health surveillance. PLoS One (2008) 2.45
Uric acid and the development of hypertension: the normative aging study. Hypertension (2006) 2.45
Morbidity and mortality associated with the restrictive spirometric pattern: a longitudinal study. Thorax (2010) 2.43
Obesity and asthma. Am J Respir Crit Care Med (2006) 2.43
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use. Am J Respir Crit Care Med (2013) 2.36
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. PLoS Genet (2009) 2.27
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24