Comment on "observation of optical precursors in water".

Observation of optical precursors in water. Phys Rev Lett (2004) 2.12

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature (2010) 14.62

Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov (2009) 10.59

Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell (2007) 7.60

A histone H3 lysine 27 demethylase regulates animal posterior development. Nature (2007) 6.57

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature (2008) 6.04

The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04

A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature (2012) 5.23

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A (2005) 3.72

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell (2003) 3.33

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell (2003) 3.29

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discov (2013) 2.52

Human tumor mutants in the p110alpha subunit of PI3K. Cell Cycle (2006) 2.39

Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res (2004) 2.32

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A (2006) 2.23

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20

PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proc Natl Acad Sci U S A (2011) 2.14

Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nat Chem Biol (2006) 2.08

Retraction in amoeboid cell motility powered by cytoskeletal dynamics. Science (2003) 1.89

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell (2002) 1.86

Should individual PI3 kinase isoforms be targeted in cancer? Curr Opin Cell Biol (2009) 1.47

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci U S A (2004) 1.42

Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol (2008) 1.35

The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes Dev (2012) 1.32

The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet (2008) 1.30

Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology (2011) 1.22

Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov (2012) 1.22

Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci U S A (2007) 1.20

Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology (2008) 1.20

Functional genetics and experimental models of human cancer. Trends Mol Med (2004) 1.17

Surveillance mechanism linking Bub1 loss to the p53 pathway. Proc Natl Acad Sci U S A (2007) 1.17

K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PLoS One (2012) 1.16

PI3 kinases in cancer: from oncogene artifact to leading cancer target. Sci STKE (2006) 1.15

The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A (2004) 1.14

DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. J Biol Chem (2001) 1.13

PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem (2006) 1.13

A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One (2008) 1.08

Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion. Mol Biol Cell (2003) 1.03

A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm. J Cell Sci (2003) 1.02

The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol (2007) 1.01

A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc Natl Acad Sci U S A (2010) 1.01

Bub1: escapades in a cellular world. Cell Cycle (2007) 0.99

A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris. Mol Biol Cell (2007) 0.95

Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α. J Clin Invest (2014) 0.94

PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. Proc Natl Acad Sci U S A (2014) 0.93

Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm. Mol Biol Cell (2009) 0.93

Comparing the roles of the p110α and p110β isoforms of PI3K in signaling and cancer. Curr Top Microbiol Immunol (2010) 0.89

Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility. J Mol Biol (2005) 0.87

Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol (2005) 0.87

Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. J Virol (2011) 0.87

The role of filament-packing dynamics in powering amoeboid cell motility. Proc Natl Acad Sci U S A (2008) 0.86

2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans. J Mol Biol (2002) 0.85

Reconstitution of amoeboid motility in vitro identifies a motor-independent mechanism for cell body retraction. Curr Biol (2011) 0.84

Cytoskeleton dynamics powers nematode sperm motility. Adv Protein Chem (2005) 0.84

Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. J Virol (2011) 0.81

A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proc Natl Acad Sci U S A (2003) 0.78

Reconstitution in vitro of MSP-based filopodium extension in nematode sperm. Cell Motil Cytoskeleton (2007) 0.77

Corrigendum: Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis. Nature (2016) 0.75

Preparing to move: assembly of the MSP amoeboid motility apparatus during spermiogenesis in Ascaris. Cell Motil Cytoskeleton (2005) 0.75