1
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PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.
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Oncogene
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2005
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4.07
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2
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Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
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Clin Cancer Res
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2006
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1.98
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3
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Increased expression of histone deacetylase 2 is found in human gastric cancer.
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APMIS
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2005
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1.77
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4
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Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
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Cancer Res
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2003
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1.73
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5
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Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck.
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Clin Cancer Res
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2005
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1.70
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6
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Inactivating mutations of caspase-8 gene in colorectal carcinomas.
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Gastroenterology
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2003
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1.56
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7
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Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.
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Hepatology
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2013
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1.49
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8
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Somatic mutations of the ERBB4 kinase domain in human cancers.
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Int J Cancer
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2006
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1.38
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9
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BRAF and KRAS mutations in stomach cancer.
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Oncogene
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2003
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1.27
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10
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Genetic alterations of the KLF6 gene in gastric cancer.
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Oncogene
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2005
|
1.26
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11
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ArrayCyGHt: a web application for analysis and visualization of array-CGH data.
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Bioinformatics
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2005
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1.23
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12
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Altered expression of the KLF4 in colorectal cancers.
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Pathol Res Pract
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2006
|
1.23
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13
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CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas.
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Cancer Res
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2005
|
1.20
|
14
|
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.
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Virchows Arch
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2005
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1.20
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15
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ERBB2 kinase domain mutation in the lung squamous cell carcinoma.
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Cancer Lett
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2005
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1.19
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16
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MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer.
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Cancer Lett
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2013
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1.17
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17
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Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas.
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Pathology
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2006
|
1.16
|
18
|
Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins.
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PLoS One
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2011
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1.12
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19
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Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis.
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Liver Int
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2005
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1.11
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20
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Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.
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Oncogene
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2005
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1.09
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21
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Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma.
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J Cell Biochem
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2010
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1.07
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22
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Loss of caspase-2, -6 and -7 expression in gastric cancers.
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APMIS
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2004
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1.06
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23
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Correlation of KIT and platelet-derived growth factor receptor alpha mutations with gene activation and expression profiles in gastrointestinal stromal tumors.
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Oncogene
|
2005
|
1.06
|
24
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Somatic mutations of CASP3 gene in human cancers.
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Hum Genet
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2004
|
1.05
|
25
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Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer.
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APMIS
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2003
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1.05
|
26
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Inactivation of the Gastrokine 1 gene in gastric adenomas and carcinomas.
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J Pathol
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2011
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1.04
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27
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Supported core@shell electrocatalysts for fuel cells: close encounter with reality.
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Sci Rep
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2013
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1.03
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28
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Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers.
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J Cancer Res Clin Oncol
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2011
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1.01
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29
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PDCD4 expression inversely correlated with miR-21 levels in gastric cancers.
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J Cancer Res Clin Oncol
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2012
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1.01
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30
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Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas.
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Oncology
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2006
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1.00
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31
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Genetic alterations of the ATBF1 gene in gastric cancer.
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Clin Cancer Res
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2007
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0.99
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32
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GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle.
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Clin Cancer Res
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2013
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0.97
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33
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Inactivating mutations of CASPASE-7 gene in human cancers.
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Oncogene
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2003
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0.96
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34
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Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma.
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J Gastroenterol Hepatol
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2006
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0.95
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35
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HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins.
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J Cell Biochem
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2012
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0.95
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36
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Hypermethylation of the RUNX3 gene in hepatocellular carcinoma.
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Exp Mol Med
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2005
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0.93
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37
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ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas.
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Int J Cancer
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2006
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0.92
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38
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Inactivating mutations of the Siah-1 gene in gastric cancer.
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Oncogene
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2004
|
0.92
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39
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Different gene expression profiles between microsatellite instability-high and microsatellite stable colorectal carcinomas.
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Oncogene
|
2004
|
0.92
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40
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Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: involvement of autotaxin inhibition.
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Int J Oncol
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2012
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0.92
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41
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Increased expression of Gab2, a scaffolding adaptor of the tyrosine kinase signalling, in gastric carcinomas.
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Pathology
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2007
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0.92
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42
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Differential gene expression profiles of metastases in paired primary and metastatic colorectal carcinomas.
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Oncology
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2008
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0.92
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43
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DBC1 does not function as a negative regulator of SIRT1 in liver cancer.
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Oncol Lett
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2012
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0.91
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44
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HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer.
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PLoS One
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2012
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0.91
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45
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Mechanisms of enhanced sulfur tolerance on samarium (Sm)-doped cerium oxide (CeO2) from first principles.
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Phys Chem Chem Phys
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2014
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0.90
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46
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Somatic mutations of the beta-TrCP gene in gastric cancer.
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APMIS
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2007
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0.90
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47
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Altered expression of KCNK9 in colorectal cancers.
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APMIS
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2004
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0.90
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48
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Overexpression of serine-threonine receptor kinase-associated protein in colorectal cancers.
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Pathol Int
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2007
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0.89
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49
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Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer.
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Hepatology
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2012
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0.89
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50
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Palladium catalysts for dehydrogenation of ammonia borane with preferential B-H activation.
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J Am Chem Soc
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2010
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0.88
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51
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Inactivating mutation of the pro-apoptotic gene BID in gastric cancer.
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J Pathol
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2004
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0.88
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52
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Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population.
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Knee
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2008
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0.88
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53
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TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthritis in a Korean Population.
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Korean J Pathol
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2012
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0.87
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54
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Targeted disruption of S100P suppresses tumor cell growth by down-regulation of cyclin D1 and CDK2 in human hepatocellular carcinoma.
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Int J Oncol
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2009
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0.87
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55
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Gastrokine 1 regulates NF-κB signaling pathway and cytokine expression in gastric cancers.
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J Cell Biochem
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2013
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0.87
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56
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Application of concave microwells to pancreatic tumor spheroids enabling anticancer drug evaluation in a clinically relevant drug resistance model.
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PLoS One
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2013
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0.87
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57
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Inactivating mutations of proapoptotic Bad gene in human colon cancers.
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Carcinogenesis
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2004
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0.87
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58
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ERBB2 kinase domain mutation in a gastric cancer metastasis.
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APMIS
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2005
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0.86
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59
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Functional analysis of the NH2-terminal hydrophobic region and BRICHOS domain of GKN1.
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Biochem Biophys Res Commun
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2013
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0.86
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60
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HDAC2 provides a critical support to malignant progression of hepatocellular carcinoma through feedback control of mTORC1 and AKT.
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Cancer Res
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2014
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0.86
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61
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Identification of frequently mutated genes with relevance to nonsense mediated mRNA decay in the high microsatellite instability cancers.
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Int J Cancer
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2010
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0.86
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62
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A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer.
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J Korean Med Sci
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2003
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0.86
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63
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Gene expression changes in patient-matched gastric normal mucosa, adenomas, and carcinomas.
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Exp Mol Pathol
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2010
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0.86
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64
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Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer.
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Int J Cancer
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2005
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0.86
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65
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Genetic analysis of the DBC2 gene in gastric cancer.
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Acta Oncol
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2007
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0.85
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66
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Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase.
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APMIS
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2004
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0.85
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67
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Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer.
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Mol Cancer Res
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2012
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0.85
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68
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GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity.
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J Cell Physiol
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2014
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0.85
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69
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Decreased expression of annexin A10 in gastric cancer and its overexpression in tumor cell growth suppression.
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Oncol Rep
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2010
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0.84
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70
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Activation-induced cytidine deaminase expression in gastric cancer.
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Tumour Biol
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2008
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0.84
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71
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Application of amplified RNA and evaluation of cRNA targets for spotted-oligonucleotide microarray.
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Biochem Biophys Res Commun
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2004
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0.84
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72
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Genetic and epigenetic analysis of the KLF4 gene in gastric cancer.
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APMIS
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2007
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0.84
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73
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Aberrant expression of SOX9 is associated with gastrokine 1 inactivation in gastric cancers.
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Gastric Cancer
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2013
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0.84
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74
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Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate.
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Biochem Biophys Res Commun
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2005
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0.83
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75
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Programmed cell death 6 (PDCD6) as a prognostic marker for gastric cancers.
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Tumour Biol
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2011
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0.83
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76
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Immunohistochemical and mutational analysis of apoptosis-inducing factor (AIF) in colorectal carcinomas.
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APMIS
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2006
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0.83
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77
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Immunohistochemical analysis of apoptosis-inducing factor (AIF) expression in gastric carcinomas.
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Pathol Res Pract
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2006
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0.83
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78
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Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
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APMIS
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2006
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0.83
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79
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Mutational analysis of the ARAF gene in human cancers.
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APMIS
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2005
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0.82
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80
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Association of IL-17A and IL-17F single nucleotide polymorphisms with susceptibility to osteoarthritis in a Korean population.
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Gene
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2013
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0.82
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81
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Genetic alterations of the MYH gene in gastric cancer.
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Oncogene
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2004
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0.82
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82
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Systemic cell-cycle suppression by Apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells.
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Int J Mol Med
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2009
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0.81
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83
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Discriminating the molecular basis of hepatotoxicity using the large-scale characteristic molecular signatures of toxicants by expression profiling analysis.
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Toxicology
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2008
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0.81
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84
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The RNA-binding protein HuD regulates autophagosome formation in pancreatic β cells by promoting autophagy-related gene 5 expression.
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J Biol Chem
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2013
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0.81
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85
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BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.
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Pathology
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2006
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0.81
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86
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Genetic alterations of the KLF6 gene in colorectal cancers.
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APMIS
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2006
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0.81
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87
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Absence of E17K mutation in the pleckstrin homology domain of AKT1 in gastrointestinal and liver cancers in the Korean population.
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APMIS
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2008
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0.80
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88
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Altered expression of CDX2 in colorectal cancers.
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APMIS
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2006
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0.80
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89
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Mutational analysis of PDPK1 kinase domain in gastric, colorectal and lung carcinomas.
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Acta Oncol
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2006
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0.80
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90
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Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas.
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APMIS
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2006
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0.80
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91
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MYC-regulated genes involved in liver cell dysplasia identified in a transgenic model of liver cancer.
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J Pathol
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2012
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0.80
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92
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Expression of nuclear and cytoplasmic phosphorylated FADD in gastric cancers.
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Pathol Res Pract
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2007
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0.80
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93
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Mutational analysis of PTPRT phosphatase domains in common human cancers.
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APMIS
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2007
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0.80
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94
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Genetic alterations of the Cdx2 gene in gastric cancer.
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APMIS
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2008
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0.80
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95
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Kinase domain mutation of ERBB family genes is uncommon in acute leukemias.
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Leuk Res
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2005
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0.79
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96
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Effect of morphology of electrodeposited Ni catalysts on the behavior of bubbles generated during the oxygen evolution reaction in alkaline water electrolysis.
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Chem Commun (Camb)
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2013
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0.79
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97
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Lysyl oxidase G473A polymorphism is closely associated with susceptibility to gastric cancer in a South Korean population.
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APMIS
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2011
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0.79
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98
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Tetraglyme-mediated synthesis of Pd nanoparticles for dehydrogenation of ammonia borane.
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Chem Commun (Camb)
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2012
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0.79
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99
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JAK2 V617F mutation is uncommon in non-Hodgkin lymphomas.
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Leuk Lymphoma
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2006
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0.79
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100
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Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas.
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Exp Mol Med
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2006
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0.78
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101
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Identification of characteristic molecular signature for volatile organic compounds in peripheral blood of rat.
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Toxicol Appl Pharmacol
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2010
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0.78
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102
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SOCS5 and SOCS6 have similar expression patterns in normal and cancer tissues.
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Tumour Biol
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2011
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0.78
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103
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Mitochondrial microsatellite instability of colorectal cancer stroma.
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Int J Cancer
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2006
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0.78
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104
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Association of SOD1 and SOD2 single nucleotide polymorphisms with susceptibility to gastric cancer in a Korean population.
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APMIS
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2012
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0.78
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105
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Mutational analysis of the kinase domain of MYLK2 gene in common human cancers.
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Pathol Res Pract
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2006
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0.78
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106
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Genetic and epigenetic analysis of the EPHB2 gene in gastric cancers.
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APMIS
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2007
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0.78
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107
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Mutational analysis of MYC in common epithelial cancers and acute leukemias.
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APMIS
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2006
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0.78
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108
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Identification of large-scale molecular changes of Autotaxin(ENPP2) knock-down by small interfering RNA in breast cancer cells.
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Mol Cell Biochem
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2006
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0.78
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109
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Analysis of succinate dehydrogenase subunit B gene alterations in gastric cancers.
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Pathol Int
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2010
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0.78
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110
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Absence of DKC1 exon 3 mutation in common human cancers.
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Acta Oncol
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2006
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0.77
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111
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Identification of characteristic molecular signature of Müllerian inhibiting substance in human HPV-related cervical cancer cells.
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Int J Oncol
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2011
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0.77
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112
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Molecular integration of HoxB4 and STAT3 for self-renewal of hematopoietic stem cells: a model of molecular convergence for stemness.
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Stem Cells
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2014
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0.77
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113
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Somatic mutation of pro-apoptosis caspase-6 gene is rare in breast and lung carcinomas.
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Pathology
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2006
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0.77
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114
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Characteristic molecular signature for the early detection and prediction of polycyclic aromatic hydrocarbons in rat liver.
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Toxicol Lett
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2012
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0.77
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115
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Genetic alterations and expression pattern of CEACAM1 in colorectal adenomas and cancers.
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Pathol Oncol Res
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2010
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0.77
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116
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Absence of JAK2 V617F mutation in gastric cancers.
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Acta Oncol
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2006
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0.76
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117
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Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB.
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Korean J Hepatol
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2009
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0.76
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118
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Identification of post-generation effect of 3,4-methylenedioxymethamphetamine on the mouse brain by large-scale gene expression analysis.
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Toxicol Lett
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2010
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0.76
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119
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Characteristic molecular signature for early detection and prediction of persistent organic pollutants in rat liver.
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Environ Sci Technol
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2012
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0.76
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120
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Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
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J Appl Toxicol
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2014
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0.76
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121
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Genetic and epigenetic analysis of the VHL gene in gastric cancers.
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Acta Oncol
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2008
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0.76
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122
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Molecular signature for early detection and prediction of polycyclic aromatic hydrocarbons in peripheral blood.
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Environ Sci Technol
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2010
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0.76
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123
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Transcriptomic configuration of mouse brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine.
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Toxicol Appl Pharmacol
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2009
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0.76
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124
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O⁶-methylguanine-DNA-methyltransferase promoter methylation assessment by microdissection-assisted methylation-specific PCR and high resolution melting analysis in patients with glioblastomas.
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J Neurooncol
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2011
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0.76
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125
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Mutation of FADD gene is rare in human colon and stomach cancers.
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APMIS
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2004
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0.75
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126
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Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver.
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Biomarkers
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2013
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0.75
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127
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Carbon dioxide conversion into hydrocarbon fuels on defective graphene-supported Cu nanoparticles from first principles.
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Nanoscale
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2014
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0.75
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128
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A highly active and durable Co-N-C electrocatalyst synthesized using exfoliated graphitic carbon nitride nanosheets.
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Nanoscale
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2015
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0.75
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129
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Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin.
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APMIS
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2011
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0.75
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130
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Kinase domain mutation of MAP2K4 is rare in gastric, colorectal and lung carcinomas.
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Pathology
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2006
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0.75
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131
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Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas.
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Acta Oncol
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2006
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0.75
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132
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Highly efficient and durable TiN nanofiber electrocatalyst supports.
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Nanoscale
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2015
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0.75
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133
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Kinase domain mutation of NTRK3 gene is uncommon in gastric carcinomas.
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Acta Oncol
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2005
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0.75
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134
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Mutational analysis of salvador gene in human carcinomas.
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APMIS
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2003
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0.75
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135
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Absence of the mutation of serine/threonine kinase genes AKT2 and MYLK2 in acute leukemias.
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Eur J Haematol
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2006
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0.75
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136
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Absence of BH3 domain mutations in the proapoptotic Bcl-2 gene family in non-Hodgkin lymphomas.
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Acta Haematol
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2006
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0.75
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137
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Absence of the ERBB2 kinase domain mutation in lung adenocarcinomas in Korean patients.
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Int J Cancer
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2005
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0.75
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138
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Extension of the surfactant bridge model for the electrorheological effects of surfactant-activated suspensions.
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J Colloid Interface Sci
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2004
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0.75
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139
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Pin1 gene mutation is a rare event in gastric cancer.
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APMIS
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2006
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0.75
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140
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Enhanced Selectivity to H2 Formation in Decomposition of HCOOH on the Ag19@Pd60 Core-Shell Nanocluster from First-Principles.
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J Nanosci Nanotechnol
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2015
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0.75
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141
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Down-regulation of transforming growth factor beta receptor type III in hepatocellular carcinoma is not directly associated with genetic alterations or loss of heterozygosity.
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Oncol Rep
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2009
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0.75
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142
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Metal-free, polyether-mediated H2-release from ammonia borane: roles of hydrogen bonding interactions in promoting dehydrogenation.
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Phys Chem Chem Phys
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2013
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0.75
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143
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SMAC/DIABLO mutation is uncommon in gastric and colorectal carcinomas.
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Pathology
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2006
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0.75
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144
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Convenient metal embedment into mesoporous silica channels for high catalytic performance in AB dehydrogenation.
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Chem Commun (Camb)
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2013
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0.75
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