1
|
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.
|
Oncogene
|
2005
|
4.07
|
2
|
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
|
Clin Cancer Res
|
2006
|
1.98
|
3
|
Increased expression of histone deacetylase 2 is found in human gastric cancer.
|
APMIS
|
2005
|
1.77
|
4
|
Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck.
|
Clin Cancer Res
|
2005
|
1.70
|
5
|
Inactivating mutations of caspase-8 gene in colorectal carcinomas.
|
Gastroenterology
|
2003
|
1.56
|
6
|
Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.
|
Hepatology
|
2013
|
1.49
|
7
|
Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling.
|
Hepatology
|
2005
|
1.48
|
8
|
Somatic mutations of the ERBB4 kinase domain in human cancers.
|
Int J Cancer
|
2006
|
1.38
|
9
|
Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.
|
Blood
|
2002
|
1.30
|
10
|
BRAF and KRAS mutations in stomach cancer.
|
Oncogene
|
2003
|
1.27
|
11
|
Genetic alterations of the KLF6 gene in gastric cancer.
|
Oncogene
|
2005
|
1.26
|
12
|
Nod1, a CARD protein, enhances pro-interleukin-1beta processing through the interaction with pro-caspase-1.
|
Biochem Biophys Res Commun
|
2002
|
1.23
|
13
|
ArrayCyGHt: a web application for analysis and visualization of array-CGH data.
|
Bioinformatics
|
2005
|
1.23
|
14
|
Altered expression of the KLF4 in colorectal cancers.
|
Pathol Res Pract
|
2006
|
1.23
|
15
|
CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas.
|
Cancer Res
|
2005
|
1.20
|
16
|
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.
|
Virchows Arch
|
2005
|
1.20
|
17
|
ERBB2 kinase domain mutation in the lung squamous cell carcinoma.
|
Cancer Lett
|
2005
|
1.19
|
18
|
MiR-145 functions as a tumor suppressor by directly targeting histone deacetylase 2 in liver cancer.
|
Cancer Lett
|
2013
|
1.17
|
19
|
Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas.
|
Pathology
|
2006
|
1.16
|
20
|
Aberrant regulation of HDAC2 mediates proliferation of hepatocellular carcinoma cells by deregulating expression of G1/S cell cycle proteins.
|
PLoS One
|
2011
|
1.12
|
21
|
Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis.
|
Liver Int
|
2005
|
1.11
|
22
|
Immunohistochemical expression of integrins and extracellular matrix proteins in non-small cell lung cancer: correlation with lymph node metastasis.
|
Lung Cancer
|
2003
|
1.11
|
23
|
Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.
|
Oncogene
|
2005
|
1.09
|
24
|
Increased expression of FLIP, an inhibitor of Fas-mediated apoptosis, in stomach cancer.
|
APMIS
|
2003
|
1.08
|
25
|
Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma.
|
J Cell Biochem
|
2010
|
1.07
|
26
|
Loss of caspase-2, -6 and -7 expression in gastric cancers.
|
APMIS
|
2004
|
1.06
|
27
|
Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer.
|
APMIS
|
2003
|
1.05
|
28
|
Somatic mutations of CASP3 gene in human cancers.
|
Hum Genet
|
2004
|
1.05
|
29
|
Inactivation of the Gastrokine 1 gene in gastric adenomas and carcinomas.
|
J Pathol
|
2011
|
1.04
|
30
|
Comparing fluorescence in situ hybridization and chromogenic in situ hybridization methods to determine the HER2/neu status in primary breast carcinoma using tissue microarray.
|
Mod Pathol
|
2003
|
1.04
|
31
|
Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers.
|
J Cancer Res Clin Oncol
|
2011
|
1.01
|
32
|
PDCD4 expression inversely correlated with miR-21 levels in gastric cancers.
|
J Cancer Res Clin Oncol
|
2012
|
1.01
|
33
|
Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas.
|
Oncology
|
2006
|
1.00
|
34
|
Genetic alterations of the ATBF1 gene in gastric cancer.
|
Clin Cancer Res
|
2007
|
0.99
|
35
|
GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle.
|
Clin Cancer Res
|
2013
|
0.97
|
36
|
Genetic analysis of the liver putative tumor suppressor (LPTS) gene in hepatocellular carcinomas.
|
Cancer Lett
|
2002
|
0.97
|
37
|
Inactivating mutations of CASPASE-7 gene in human cancers.
|
Oncogene
|
2003
|
0.96
|
38
|
Non-small cell lung cancers frequently express phosphorylated Akt; an immunohistochemical study.
|
APMIS
|
2002
|
0.95
|
39
|
Genetic and epigenetic alterations of the KLF6 gene in hepatocellular carcinoma.
|
J Gastroenterol Hepatol
|
2006
|
0.95
|
40
|
HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins.
|
J Cell Biochem
|
2012
|
0.95
|
41
|
Hypermethylation of the RUNX3 gene in hepatocellular carcinoma.
|
Exp Mol Med
|
2005
|
0.93
|
42
|
ERBB3 kinase domain mutations are rare in lung, breast and colon carcinomas.
|
Int J Cancer
|
2006
|
0.92
|
43
|
Inactivating mutations of the Siah-1 gene in gastric cancer.
|
Oncogene
|
2004
|
0.92
|
44
|
Alterations of Fas-pathway genes associated with nodal metastasis in non-small cell lung cancer.
|
Oncogene
|
2002
|
0.92
|
45
|
Increased expression of Gab2, a scaffolding adaptor of the tyrosine kinase signalling, in gastric carcinomas.
|
Pathology
|
2007
|
0.92
|
46
|
Inactivating mutations of the caspase-10 gene in gastric cancer.
|
Oncogene
|
2002
|
0.92
|
47
|
HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer.
|
PLoS One
|
2012
|
0.91
|
48
|
DBC1 does not function as a negative regulator of SIRT1 in liver cancer.
|
Oncol Lett
|
2012
|
0.91
|
49
|
Altered expression of KCNK9 in colorectal cancers.
|
APMIS
|
2004
|
0.90
|
50
|
Somatic mutations of the beta-TrCP gene in gastric cancer.
|
APMIS
|
2007
|
0.90
|
51
|
Expression of HGF/SF and Met protein is associated with genetic alterations of VHL gene in primary renal cell carcinomas.
|
APMIS
|
2002
|
0.90
|
52
|
Overexpression of serine-threonine receptor kinase-associated protein in colorectal cancers.
|
Pathol Int
|
2007
|
0.89
|
53
|
Histone deacetylase 6 functions as a tumor suppressor by activating c-Jun NH2-terminal kinase-mediated beclin 1-dependent autophagic cell death in liver cancer.
|
Hepatology
|
2012
|
0.89
|
54
|
Inactivating mutation of the pro-apoptotic gene BID in gastric cancer.
|
J Pathol
|
2004
|
0.88
|
55
|
Aspartic acid repeat polymorphism of the asporin gene with susceptibility to osteoarthritis of the knee in a Korean population.
|
Knee
|
2008
|
0.88
|
56
|
TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthritis in a Korean Population.
|
Korean J Pathol
|
2012
|
0.87
|
57
|
Targeted disruption of S100P suppresses tumor cell growth by down-regulation of cyclin D1 and CDK2 in human hepatocellular carcinoma.
|
Int J Oncol
|
2009
|
0.87
|
58
|
Inactivating mutations of proapoptotic Bad gene in human colon cancers.
|
Carcinogenesis
|
2004
|
0.87
|
59
|
Gastrokine 1 regulates NF-κB signaling pathway and cytokine expression in gastric cancers.
|
J Cell Biochem
|
2013
|
0.87
|
60
|
ERBB2 kinase domain mutation in a gastric cancer metastasis.
|
APMIS
|
2005
|
0.86
|
61
|
Functional analysis of the NH2-terminal hydrophobic region and BRICHOS domain of GKN1.
|
Biochem Biophys Res Commun
|
2013
|
0.86
|
62
|
HDAC2 provides a critical support to malignant progression of hepatocellular carcinoma through feedback control of mTORC1 and AKT.
|
Cancer Res
|
2014
|
0.86
|
63
|
Absence of EGFR mutation in the kinase domain in common human cancers besides non-small cell lung cancer.
|
Int J Cancer
|
2005
|
0.86
|
64
|
A single nucleotide polymorphism in the E-cadherin gene promoter-160 is not associated with risk of Korean gastric cancer.
|
J Korean Med Sci
|
2003
|
0.86
|
65
|
Colorectal tumors frequently express phosphorylated mitogen-activated protein kinase.
|
APMIS
|
2004
|
0.85
|
66
|
Genetic analysis of the DBC2 gene in gastric cancer.
|
Acta Oncol
|
2007
|
0.85
|
67
|
Targeted inactivation of HDAC2 restores p16INK4a activity and exerts antitumor effects on human gastric cancer.
|
Mol Cancer Res
|
2012
|
0.85
|
68
|
GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity.
|
J Cell Physiol
|
2014
|
0.85
|
69
|
Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas.
|
APMIS
|
2003
|
0.84
|
70
|
Activation-induced cytidine deaminase expression in gastric cancer.
|
Tumour Biol
|
2008
|
0.84
|
71
|
Aberrant expression of SOX9 is associated with gastrokine 1 inactivation in gastric cancers.
|
Gastric Cancer
|
2013
|
0.84
|
72
|
Decreased expression of annexin A10 in gastric cancer and its overexpression in tumor cell growth suppression.
|
Oncol Rep
|
2010
|
0.84
|
73
|
Application of amplified RNA and evaluation of cRNA targets for spotted-oligonucleotide microarray.
|
Biochem Biophys Res Commun
|
2004
|
0.84
|
74
|
Genetic and epigenetic analysis of the KLF4 gene in gastric cancer.
|
APMIS
|
2007
|
0.84
|
75
|
Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate.
|
Biochem Biophys Res Commun
|
2005
|
0.83
|
76
|
Immunohistochemical and mutational analysis of apoptosis-inducing factor (AIF) in colorectal carcinomas.
|
APMIS
|
2006
|
0.83
|
77
|
Programmed cell death 6 (PDCD6) as a prognostic marker for gastric cancers.
|
Tumour Biol
|
2011
|
0.83
|
78
|
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
|
APMIS
|
2006
|
0.83
|
79
|
Immunohistochemical analysis of apoptosis-inducing factor (AIF) expression in gastric carcinomas.
|
Pathol Res Pract
|
2006
|
0.83
|
80
|
Mutational analysis of the ARAF gene in human cancers.
|
APMIS
|
2005
|
0.82
|
81
|
Genetic alterations of the MYH gene in gastric cancer.
|
Oncogene
|
2004
|
0.82
|
82
|
Association of IL-17A and IL-17F single nucleotide polymorphisms with susceptibility to osteoarthritis in a Korean population.
|
Gene
|
2013
|
0.82
|
83
|
Discriminating the molecular basis of hepatotoxicity using the large-scale characteristic molecular signatures of toxicants by expression profiling analysis.
|
Toxicology
|
2008
|
0.81
|
84
|
BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.
|
Pathology
|
2006
|
0.81
|
85
|
Genetic alterations of the KLF6 gene in colorectal cancers.
|
APMIS
|
2006
|
0.81
|
86
|
Systemic cell-cycle suppression by Apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells.
|
Int J Mol Med
|
2009
|
0.81
|
87
|
Mutational analysis of Noxa gene in human cancers.
|
APMIS
|
2003
|
0.81
|
88
|
Identification of large-scale characteristic genes of Müllerian inhibiting substance in human ovarian cancer cells.
|
Int J Mol Med
|
2009
|
0.80
|
89
|
Mutational analysis of PDPK1 kinase domain in gastric, colorectal and lung carcinomas.
|
Acta Oncol
|
2006
|
0.80
|
90
|
Altered expression of CDX2 in colorectal cancers.
|
APMIS
|
2006
|
0.80
|
91
|
Mutational analysis of PTPRT phosphatase domains in common human cancers.
|
APMIS
|
2007
|
0.80
|
92
|
Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas.
|
APMIS
|
2006
|
0.80
|
93
|
Expression of nuclear and cytoplasmic phosphorylated FADD in gastric cancers.
|
Pathol Res Pract
|
2007
|
0.80
|
94
|
Genetic alterations of the Cdx2 gene in gastric cancer.
|
APMIS
|
2008
|
0.80
|
95
|
Absence of E17K mutation in the pleckstrin homology domain of AKT1 in gastrointestinal and liver cancers in the Korean population.
|
APMIS
|
2008
|
0.80
|
96
|
Genetic alterations of the HCCS1 gene in Korean hepatocellular carcinoma.
|
APMIS
|
2003
|
0.79
|
97
|
Kinase domain mutation of ERBB family genes is uncommon in acute leukemias.
|
Leuk Res
|
2005
|
0.79
|
98
|
JAK2 V617F mutation is uncommon in non-Hodgkin lymphomas.
|
Leuk Lymphoma
|
2006
|
0.79
|
99
|
Stomach cancer highly expresses both initiator and effector caspases; an immunohistochemical study.
|
APMIS
|
2002
|
0.79
|
100
|
Lysyl oxidase G473A polymorphism is closely associated with susceptibility to gastric cancer in a South Korean population.
|
APMIS
|
2011
|
0.79
|
101
|
Mitochondrial microsatellite instability of colorectal cancer stroma.
|
Int J Cancer
|
2006
|
0.78
|
102
|
Mutational analysis of MYC in common epithelial cancers and acute leukemias.
|
APMIS
|
2006
|
0.78
|
103
|
Mutational analysis of the kinase domain of MYLK2 gene in common human cancers.
|
Pathol Res Pract
|
2006
|
0.78
|
104
|
Identification of characteristic molecular signature for volatile organic compounds in peripheral blood of rat.
|
Toxicol Appl Pharmacol
|
2010
|
0.78
|
105
|
Genetic and epigenetic analysis of the EPHB2 gene in gastric cancers.
|
APMIS
|
2007
|
0.78
|
106
|
Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas.
|
Exp Mol Med
|
2006
|
0.78
|
107
|
Analysis of succinate dehydrogenase subunit B gene alterations in gastric cancers.
|
Pathol Int
|
2010
|
0.78
|
108
|
Association of SOD1 and SOD2 single nucleotide polymorphisms with susceptibility to gastric cancer in a Korean population.
|
APMIS
|
2012
|
0.78
|
109
|
Identification of large-scale molecular changes of Autotaxin(ENPP2) knock-down by small interfering RNA in breast cancer cells.
|
Mol Cell Biochem
|
2006
|
0.78
|
110
|
Comparative analysis of expression profiling of early-stage carcinogenesis using nodule-in-nodule-type hepatocellular carcinoma.
|
Eur J Gastroenterol Hepatol
|
2006
|
0.77
|
111
|
Characteristic molecular signature for the early detection and prediction of polycyclic aromatic hydrocarbons in rat liver.
|
Toxicol Lett
|
2012
|
0.77
|
112
|
Absence of DKC1 exon 3 mutation in common human cancers.
|
Acta Oncol
|
2006
|
0.77
|
113
|
Somatic mutation of pro-apoptosis caspase-6 gene is rare in breast and lung carcinomas.
|
Pathology
|
2006
|
0.77
|
114
|
Genetic alterations and expression pattern of CEACAM1 in colorectal adenomas and cancers.
|
Pathol Oncol Res
|
2010
|
0.77
|
115
|
Identification of post-generation effect of 3,4-methylenedioxymethamphetamine on the mouse brain by large-scale gene expression analysis.
|
Toxicol Lett
|
2010
|
0.76
|
116
|
Transcriptomic configuration of mouse brain induced by adolescent exposure to 3,4-methylenedioxymethamphetamine.
|
Toxicol Appl Pharmacol
|
2009
|
0.76
|
117
|
Genetic and epigenetic analysis of the VHL gene in gastric cancers.
|
Acta Oncol
|
2008
|
0.76
|
118
|
Characteristic molecular signature for early detection and prediction of persistent organic pollutants in rat liver.
|
Environ Sci Technol
|
2012
|
0.76
|
119
|
Molecular signature for early detection and prediction of polycyclic aromatic hydrocarbons in peripheral blood.
|
Environ Sci Technol
|
2010
|
0.76
|
120
|
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
|
J Appl Toxicol
|
2014
|
0.76
|
121
|
Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB.
|
Korean J Hepatol
|
2009
|
0.76
|
122
|
Absence of JAK2 V617F mutation in gastric cancers.
|
Acta Oncol
|
2006
|
0.76
|
123
|
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.
|
APMIS
|
2003
|
0.75
|
124
|
Mutational analysis of P-loop domains of proapoptotic Nod1 and ARTS genes in colon carcinomas.
|
Acta Oncol
|
2006
|
0.75
|
125
|
Absence of the ERBB2 kinase domain mutation in lung adenocarcinomas in Korean patients.
|
Int J Cancer
|
2005
|
0.75
|
126
|
Pin1 gene mutation is a rare event in gastric cancer.
|
APMIS
|
2006
|
0.75
|
127
|
Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin.
|
APMIS
|
2011
|
0.75
|
128
|
Kinase domain mutation of MAP2K4 is rare in gastric, colorectal and lung carcinomas.
|
Pathology
|
2006
|
0.75
|
129
|
Down-regulation of transforming growth factor beta receptor type III in hepatocellular carcinoma is not directly associated with genetic alterations or loss of heterozygosity.
|
Oncol Rep
|
2009
|
0.75
|
130
|
Kinase domain mutation of NTRK3 gene is uncommon in gastric carcinomas.
|
Acta Oncol
|
2005
|
0.75
|
131
|
SMAC/DIABLO mutation is uncommon in gastric and colorectal carcinomas.
|
Pathology
|
2006
|
0.75
|
132
|
Mutation of FADD gene is rare in human colon and stomach cancers.
|
APMIS
|
2004
|
0.75
|
133
|
Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver.
|
Biomarkers
|
2013
|
0.75
|
134
|
Absence of BH3 domain mutations in the proapoptotic Bcl-2 gene family in non-Hodgkin lymphomas.
|
Acta Haematol
|
2006
|
0.75
|
135
|
Mutational analysis of Fas ligand gene in human non-Hodgkin lymphoma.
|
APMIS
|
2003
|
0.75
|
136
|
Mutational analysis of salvador gene in human carcinomas.
|
APMIS
|
2003
|
0.75
|
137
|
Absence of the mutation of serine/threonine kinase genes AKT2 and MYLK2 in acute leukemias.
|
Eur J Haematol
|
2006
|
0.75
|