Published in Exp Neurol on March 01, 2005
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience (2010) 1.70
Altered lipid metabolism in brain injury and disorders. Subcell Biochem (2008) 1.69
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation (2008) 1.57
Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients. Am J Crit Care (2014) 1.42
Role of Lipids in Brain Injury and Diseases. Future Lipidol (2007) 1.23
Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx (2006) 1.21
Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury. J Neuroinflammation (2010) 1.15
The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem (2010) 1.14
Endothelial nitric oxide synthase mediates endogenous protection against subarachnoid hemorrhage-induced cerebral vasospasm. Stroke (2011) 1.07
Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. Stroke (2008) 1.07
An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. J Pharmacol Exp Ther (2010) 1.02
Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease. Exp Eye Res (2006) 0.98
COG1410 improves cognitive performance and reduces cortical neuronal loss in the traumatically injured brain. J Neurotrauma (2009) 0.97
Statins in traumatic brain injury. Neurotherapeutics (2010) 0.89
Effects of ketamine on endotoxin and traumatic brain injury induced cytokine production in the rat. J Trauma (2011) 0.89
Structural determinates for apolipoprotein E-derived peptide interaction with the alpha7 nicotinic acetylcholine receptor. Mol Pharmacol (2007) 0.88
Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. J Neurosci (2015) 0.87
Administration of COG1410 reduces axonal amyloid precursor protein immunoreactivity and microglial activation after controlled cortical impact in mice. J Neurotrauma (2012) 0.86
COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res (2009) 0.84
COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat. Behav Brain Res (2010) 0.83
Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage. Transl Stroke Res (2012) 0.82
Hippocampal infusions of apolipoprotein E peptides induce long-lasting cognitive impairment. Brain Res Bull (2009) 0.82
Inhibition of native and recombinant nicotinic acetylcholine receptors by the myristoylated alanine-rich C kinase substrate peptide. J Pharmacol Exp Ther (2008) 0.81
Hypothalamic-Pituitary Autoimmunity and Traumatic Brain Injury. J Clin Med (2015) 0.78
ApoE mimetic peptide decreases Abeta production in vitro and in vivo. Mol Neurodegener (2010) 0.78
Indomethacin protects rats from neuronal damage induced by traumatic brain injury and suppresses hippocampal IL-1β release through the inhibition of Nogo-A expression. J Neuroinflammation (2012) 0.78
Apolipoprotein E epsilon4 allele and outcomes of traumatic spinal cord injury. J Spinal Cord Med (2008) 0.78
Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model. Sci Rep (2017) 0.77
Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke. Ann Clin Transl Neurol (2017) 0.77
Apolipoprotein E epsilon4 offers protection against age-related macular degeneration. Med Hypotheses (2006) 0.77
Apolipoprotein E mimetic peptide protects against diffuse brain injury. Neural Regen Res (2014) 0.77
Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage. Sci Rep (2016) 0.76
Full-length apolipoprotein E protects against the neurotoxicity of an apoE-related peptide. Brain Res (2009) 0.75
APOE genotype and stress response - a mini review. Lipids Health Dis (2016) 0.75
Saikosaponin a protects TBI rats after controlled cortical impact and the underlying mechanism. Am J Transl Res (2016) 0.75
Peptide Pharmacological Approaches to Treating Traumatic Brain Injury: a Case for Arginine-Rich Peptides. Mol Neurobiol (2016) 0.75
Female gonadal hormone effects on microglial activation and functional outcomes in a mouse model of moderate traumatic brain injury. World J Crit Care Med (2017) 0.75
The role of APOE on lipid homeostasis and inflammation in normal brains. J Lipid Res (2017) 0.75
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Tau is essential to beta -amyloid-induced neurotoxicity. Proc Natl Acad Sci U S A (2002) 3.04
Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest (2004) 2.80
Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. J Am Chem Soc (2004) 2.79
Central nervous system injury associated with cardiac surgery. Lancet (2006) 2.27
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. J Neuroinflammation (2006) 2.23
Possible role for vascular cell proliferation in cerebral vasospasm after subarachnoid hemorrhage. Stroke (2003) 2.17
Brain oxygenation and energy metabolism: part I-biological function and pathophysiology. Neurosurgery (2002) 2.13
Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery. Stroke (2013) 2.05
Nitric oxide and redox mechanisms in the immune response. J Leukoc Biol (2011) 1.97
Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med (2007) 1.89
The neuroprotective effect of xenon administration during transient middle cerebral artery occlusion in mice. Anesthesiology (2003) 1.83
Novel diagnostic test for acute stroke. Stroke (2003) 1.82
APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. J Biol Chem (2003) 1.80
Transient global cerebral ischemia induces a massive increase in protein sumoylation. J Cereb Blood Flow Metab (2007) 1.74
APOE polymorphism is associated with risk of severe sepsis in surgical patients. Crit Care Med (2005) 1.70
Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology (2010) 1.68
Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit Care Med (2005) 1.66
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci (2008) 1.64
Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine. Anesth Analg (2004) 1.60
Statins and delirium during critical illness: a multicenter, prospective cohort study. Crit Care Med (2014) 1.60
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. Nature (2013) 1.59
Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. Stroke (2002) 1.57
A retrospective analysis of a remifentanil/propofol general anesthetic for craniotomy before awake functional brain mapping. Anesth Analg (2005) 1.55
Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. Proc Natl Acad Sci U S A (2002) 1.53
Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery. Psychosom Med (2006) 1.51
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J Cereb Blood Flow Metab (2008) 1.45
Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial. Stroke (2005) 1.44
Isoflurane provides long-term protection against focal cerebral ischemia in the rat. Anesthesiology (2007) 1.44
Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci (2011) 1.43
Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis. Neurol Res (2002) 1.43
Challenges in enrollment of minority, pediatric, and geriatric patients in emergency and acute care clinical research. Ann Emerg Med (2008) 1.42
Early biomarkers of stroke. Clin Chem (2003) 1.41
Altered perceptions after upper and lower extremity blocks: an initial investigation. Reg Anesth Pain Med (2003) 1.39
Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. J Immunol (2011) 1.38
Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Proc Natl Acad Sci U S A (2006) 1.29
Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. Anesthesiology (2004) 1.29
Preclinical models of intracerebral hemorrhage: a translational perspective. Neurocrit Care (2008) 1.29
Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem (2009) 1.27
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci (2009) 1.27
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol (2007) 1.26
Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proc Natl Acad Sci U S A (2007) 1.26
Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. Anesth Analg (2005) 1.21
COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma (2007) 1.20
APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiol Aging (2002) 1.20
Peripheral nerve block techniques for ambulatory surgery. Anesth Analg (2005) 1.19
SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target. Blood (2011) 1.18
Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. Free Radic Biol Med (2002) 1.17
Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. J Pharmacol Exp Ther (2006) 1.14
The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem (2010) 1.14
Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. Clin Cancer Res (2014) 1.12
Ambulatory discharge after long-acting peripheral nerve blockade: 2382 blocks with ropivacaine. Anesth Analg (2002) 1.12
Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat. Free Radic Biol Med (2009) 1.10
Paravertebral somatic nerve block compared with peripheral nerve blocks for outpatient inguinal herniorrhaphy. Reg Anesth Pain Med (2002) 1.10
A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. Neurocrit Care (2006) 1.09
Self-management programmes for people post stroke: a systematic review. Clin Rehabil (2013) 1.08
The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. J Biol Chem (2008) 1.08
Burkitt lymphoma arising in organ transplant recipients: a clinicopathologic study of five cases. Am J Surg Pathol (2003) 1.07
Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. J Neurosci (2005) 1.07
The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury. J Neurotrauma (2007) 1.07
Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. Stroke (2008) 1.07
Apolipoprotein E isoform mediated regulation of nitric oxide release. Free Radic Biol Med (2002) 1.06
Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis (2009) 1.06
Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. PLoS One (2009) 1.06
A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. Free Radic Biol Med (2012) 1.05
Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. J Neurosurg (2003) 1.05
The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery. Anesth Analg (2002) 1.05
Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions. Pharmacogenomics (2007) 1.05
Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. J Neurotrauma (2010) 1.05
Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol (2002) 1.05
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. Ann N Y Acad Sci (2002) 1.04
APOE genotype-specific differences in human and mouse macrophage nitric oxide production. J Neuroimmunol (2004) 1.04
Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. FASEB J (2002) 1.03
Magnesium neuroprotection is limited in humans with acute brain injury. Neurocrit Care (2005) 1.03
Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery. Stroke (2009) 1.02
An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. J Pharmacol Exp Ther (2010) 1.02
Sex steroids, APOE genotype and the innate immune system. Neurobiol Aging (2005) 1.02
Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurgery (2002) 1.02