Published in J Pharmacol Exp Ther on April 20, 2010
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Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci (2011) 1.43
Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. J Immunol (2011) 1.38
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Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem (2009) 1.27
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. J Neurosci (2009) 1.27
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Immunotherapy, vascular pathology, and microhemorrhages in transgenic mice. CNS Neurol Disord Drug Targets (2009) 1.20
COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma (2007) 1.20
APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiol Aging (2002) 1.20
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SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target. Blood (2011) 1.18
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. Am J Physiol Heart Circ Physiol (2003) 1.15
The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem (2010) 1.14
Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. J Pharmacol Exp Ther (2006) 1.14
Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia. Clin Cancer Res (2014) 1.12
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The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. J Biol Chem (2008) 1.08
Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. J Neurosci (2005) 1.07
The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury. J Neurotrauma (2007) 1.07
Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. Stroke (2008) 1.07
Apolipoprotein E isoform mediated regulation of nitric oxide release. Free Radic Biol Med (2002) 1.06
Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. Neurobiol Dis (2009) 1.06
Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. PLoS One (2009) 1.06
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Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. Stroke (2010) 1.05
Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. J Neurotrauma (2010) 1.05
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. Ann N Y Acad Sci (2002) 1.04
APOE genotype-specific differences in human and mouse macrophage nitric oxide production. J Neuroimmunol (2004) 1.04
Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. FASEB J (2002) 1.03
Sex steroids, APOE genotype and the innate immune system. Neurobiol Aging (2005) 1.02
Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. Antioxid Redox Signal (2003) 1.02
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Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. ASN Neuro (2011) 1.01
The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model. J Neurosci (2007) 1.00
The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. J Alzheimers Dis (2008) 0.99
Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage. Neurosurg Focus (2006) 0.98
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite. Arch Biochem Biophys (2002) 0.98
COG1410 improves cognitive performance and reduces cortical neuronal loss in the traumatically injured brain. J Neurotrauma (2009) 0.97
Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J (2006) 0.97
Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. J Neuroinflammation (2011) 0.95
A potential therapeutic application of SET/I2PP2A inhibitor OP449 for canine T-cell lymphoma. J Vet Med Sci (2012) 0.95
Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. Trends Pharmacol Sci (2011) 0.94
Interaction of NG2(+) glial progenitors and microglia/macrophages from the injured spinal cord. Glia (2010) 0.94
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. PLoS One (2012) 0.93
Reelin signals survival through Src-family kinases that inactivate BAD activity. J Neurochem (2007) 0.93
Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases. Biochemistry (2004) 0.92
The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol. Neurobiol Aging (2007) 0.92
Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype. Stroke (2008) 0.91
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Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical. Free Radic Biol Med (2004) 0.90
Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury. Neurosci Lett (2005) 0.90
Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1. J Neurochem (2012) 0.89
Androgen-mediated immune function is altered by the apolipoprotein E gene. Endocrinology (2007) 0.89
The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage. Neurocrit Care (2012) 0.89
Apolipoprotein mimetic peptides: a new approach for the treatment of asthma. Front Pharmacol (2012) 0.89
Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. J Neurosci (2008) 0.87
Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. Antioxid Redox Signal (2006) 0.87
CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease. Blood (2013) 0.86
Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. J Biol Chem (2012) 0.86
Function of tau protein in adult newborn neurons. FEBS Lett (2009) 0.85
Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. BMC Gastroenterol (2012) 0.85
COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. J Neurosci Res (2009) 0.84
ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Exp Neurol (2012) 0.83
COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat. Behav Brain Res (2010) 0.83
Compartmentalized nitrosation and nitration in mitochondria. Antioxid Redox Signal (2003) 0.83
p53-dependent control of transactivation of the Pen2 promoter by presenilins. J Cell Sci (2009) 0.82
Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage. Transl Stroke Res (2012) 0.82
Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase. J Proteome Res (2013) 0.80
The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. J Vet Med Sci (2015) 0.79
The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features. Neurodegener Dis (2012) 0.79
Selection of peptides binding to the amyloid b-protein reveals potential inhibitors of amyloid formation. Amyloid (2005) 0.79
Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice. J Alzheimers Dis (2012) 0.78
mNos2 deletion and human NOS2 replacement in Alzheimer disease models. J Neuropathol Exp Neurol (2014) 0.78
Redox regulation of neuronal migration in a Down Syndrome model. Free Radic Biol Med (2003) 0.77
NPY and chronic neurodegenerative disease. EXS (2006) 0.76
The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment. Mol Neurodegener (2014) 0.76
ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury. J Neurosci Res (2014) 0.76