Published in J Am Chem Soc on February 16, 2005
A medicinal chemist's guide to molecular interactions. J Med Chem (2010) 3.39
Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3. J Am Chem Soc (2010) 1.24
Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim Biophys Acta (2009) 1.14
Mutational tuning of galectin-3 specificity and biological function. J Biol Chem (2010) 1.01
The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics. Biochemistry (2011) 0.94
Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand. Mol Pharmacol (2010) 0.92
Structural basis for distinct binding properties of the human galectins to Thomsen-Friedenreich antigen. PLoS One (2011) 0.88
A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction. Angew Chem Int Ed Engl (2014) 0.88
How accurate are continuum solvation models for drug-like molecules? J Comput Aided Mol Des (2009) 0.84
Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose. Biochemistry (2009) 0.84
Multivalent scaffolds induce galectin-3 aggregation into nanoparticles. Beilstein J Org Chem (2014) 0.80
X-ray structures of human galectin-9 C-terminal domain in complexes with a biantennary oligosaccharide and sialyllactose. J Biol Chem (2010) 0.80
Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galβ1-3/4GlcNAc. PLoS One (2015) 0.80
Lactose-functionalized dendrimers arbitrate the interaction of galectin-3/MUC1 mediated cancer cellular aggregation. Chembiochem (2014) 0.79
Antibodies that bind complex glycosaminoglycans accumulate in the Golgi. Proc Natl Acad Sci U S A (2013) 0.79
Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides. Biochemistry (2015) 0.78
Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor. FEBS J (2011) 0.77
Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors. Sci Rep (2016) 0.76
A computational approach for exploring carbohydrate recognition by lectins in innate immunity. Front Immunol (2011) 0.76
Crystallization of Galectin-8 Linker Reveals Intricate Relationship between the N-terminal Tail and the Linker. Int J Mol Sci (2016) 0.75
Design and syntheses of hyaluronan oligosaccharide conjugates as inhibitors of CD44-Hyaluronan binding. Glycoconj J (2015) 0.75
Efficient O-Functionalization of Carbohydrates with Electrophilic Reagents. Angew Chem Int Ed Engl (2016) 0.75
Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C. Acta Crystallogr D Struct Biol (2016) 0.75
All-Atom Internal Coordinate Mechanics (ICM) Force Field for Hexopyranoses and Glycoproteins. J Chem Theory Comput (2015) 0.75
Galectin Binding to Neo-Glycoproteins: LacDiNAc Conjugated BSA as Ligand for Human Galectin-3. Biomolecules (2015) 0.75
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med (2008) 5.94
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science (2004) 3.06
Regulation of alternative macrophage activation by galectin-3. J Immunol (2008) 2.28
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med (2011) 2.09
Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem (2008) 2.02
Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell Microbiol (2009) 1.79
N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic. J Cell Biol (2009) 1.54
Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol (2008) 1.51
Phylogenetic analysis of the vertebrate galectin family. Mol Biol Evol (2004) 1.46
Physical properties of Escherichia coli P pili measured by optical tweezers. Biophys J (2004) 1.45
Apical sorting by galectin-3-dependent glycoprotein clustering. Traffic (2007) 1.45
Galectin-4 in normal tissues and cancer. Glycoconj J (2004) 1.42
Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins. J Immunol (2007) 1.34
Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3. J Am Chem Soc (2010) 1.24
Structural insight into magnetochrome-mediated magnetite biomineralization. Nature (2013) 1.22
Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. Glycobiology (2007) 1.21
A papain-like enzyme at work: native and acyl-enzyme intermediate structures in phytochelatin synthesis. Proc Natl Acad Sci U S A (2005) 1.20
Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells. Glycobiology (2005) 1.18
Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus. J Gen Virol (2006) 1.16
Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin Cancer Res (2003) 1.15
Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology (2012) 1.12
The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing. J Biol Chem (2012) 1.12
Crystal structures of an Extracytoplasmic Solute Receptor from a TRAP transporter in its open and closed forms reveal a helix-swapped dimer requiring a cation for alpha-keto acid binding. BMC Struct Biol (2007) 1.12
Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins. Glycobiology (2008) 1.07
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett (2010) 1.04
Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. Glycobiology (2008) 1.04
Activation of the neutrophil nicotinamide adenine dinucleotide phosphate oxidase by galectin-1. J Immunol (2002) 1.03
Mutational tuning of galectin-3 specificity and biological function. J Biol Chem (2010) 1.01
Conformational differences in liganded and unliganded states of Galectin-3. Biochemistry (2003) 1.01
Ligand induced galectin-3 protein self-association. J Biol Chem (2012) 1.00
The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology (2002) 1.00
Simple piggyBac transposon-based mammalian cell expression system for inducible protein production. Proc Natl Acad Sci U S A (2013) 0.98
Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol (2002) 0.98
Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types. Biochim Biophys Acta (2012) 0.96
Cardiolipin-based respiratory complex activation in bacteria. Proc Natl Acad Sci U S A (2011) 0.95
The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics. Biochemistry (2011) 0.94
C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions. Angew Chem Int Ed Engl (2005) 0.94
Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res (2009) 0.93
Magnetochrome: a c-type cytochrome domain specific to magnetotatic bacteria. Biochem Soc Trans (2012) 0.93
C2-symmetric macrocyclic carbohydrate/amino acid hybrids through copper(I)-catalyzed formation of 1,2,3-triazoles. J Org Chem (2005) 0.93
Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries. Org Biomol Chem (2011) 0.93
X-ray crystal structures of rabbit N-acetylglucosaminyltransferase I (GnT I) in complex with donor substrate analogues. J Mol Biol (2006) 0.93
Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor. J Biol Chem (2011) 0.92
Immunogenicity of a receptor-binding domain of SARS coronavirus spike protein in mice: implications for a subunit vaccine. Vaccine (2006) 0.92
X-ray crystal structure of leukocyte type core 2 beta1,6-N-acetylglucosaminyltransferase. Evidence for a convergence of metal ion-independent glycosyltransferase mechanism. J Biol Chem (2006) 0.91
Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides. Chemistry (2008) 0.90
Taloside inhibitors of galectin-1 and galectin-3. Chem Biol Drug Des (2012) 0.90
Characterization of a novel Drosophila melanogaster galectin. Expression in developing immune, neural, and muscle tissues. J Biol Chem (2002) 0.90
Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients. PLoS One (2011) 0.89
Monovalent interactions of galectin-1. Biochemistry (2010) 0.89
3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3. Bioorg Med Chem Lett (2005) 0.88
Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual. Glycobiology (2012) 0.88
The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading. Glycobiology (2008) 0.88
Low micromolar inhibitors of galectin-3 based on 3'-derivatization of N-acetyllactosamine. Chembiochem (2002) 0.88
Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions. Anal Biochem (2004) 0.88
Intracellular sorting of galectin-8 based on carbohydrate fine specificity. Glycobiology (2007) 0.88
Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors. Carbohydr Res (2007) 0.88
Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med (2014) 0.87
1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors. Bioorg Med Chem (2010) 0.87
Variant size- and glycoforms of the scavenger receptor cysteine-rich protein gp-340 with differential bacterial aggregation. Glycoconj J (2007) 0.87
Synthesis of multivalent lactose derivatives by 1,3-dipolar cycloadditions: selective galectin-1 inhibition. Carbohydr Res (2006) 0.86
Cardiolipin binding in bacterial respiratory complexes: structural and functional implications. Biochim Biophys Acta (2012) 0.86
Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers. J Biomed Opt (2005) 0.86
Correcting for electrocatalyst desorption and inactivation in chronoamperometry experiments. Anal Chem (2009) 0.85
Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells. J Med Chem (2008) 0.85
Enhancement of bound-state residual dipolar couplings: conformational analysis of lactose bound to Galectin-3. Protein Sci (2006) 0.85
The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins. J Biol Chem (2011) 0.84
Superantigen- and TLR-dependent activation of tonsillar B cells after receptor-mediated endocytosis. J Immunol (2009) 0.84
Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain. J Mol Biol (2009) 0.84
Comparative genomic analysis provides insights into the evolution and niche adaptation of marine Magnetospira sp. QH-2 strain. Environ Microbiol (2013) 0.84
Inhibition of galectins with small molecules. Chimia (Aarau) (2011) 0.84
The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer. PLoS One (2013) 0.84