Published in J Biol Chem on August 31, 2010
Regression of fibrosis and reversal of cirrhosis in rats by galectin inhibitors in thioacetamide-induced liver disease. PLoS One (2013) 1.04
LPS-induced galectin-3 oligomerization results in enhancement of neutrophil activation. PLoS One (2011) 1.01
Ligand induced galectin-3 protein self-association. J Biol Chem (2012) 1.00
Therapy of experimental NASH and fibrosis with galectin inhibitors. PLoS One (2013) 0.92
Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay. Autophagy (2015) 0.90
The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins. J Biol Chem (2011) 0.84
Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells. BMC Cancer (2014) 0.80
The detection and discovery of glycan motifs in biological samples using lectins and antibodies: new methods and opportunities. Adv Cancer Res (2015) 0.79
Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose. Sci Rep (2016) 0.79
Inhibition mechanism of human galectin-7 by a novel galactose-benzylphosphate inhibitor. FEBS J (2011) 0.77
Galectin-3: a potential target for cancer prevention. Trends Carbohydr Res (2011) 0.76
Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans. J Biol Chem (2016) 0.76
Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8. Sci Rep (2016) 0.75
Galectin-3 guides intracellular trafficking of some human serotransferrin glycoforms. J Biol Chem (2013) 0.75
Immunochemiluminescent detection of galectin-3 in tumoral tissue from prostate. Int J Clin Exp Pathol (2013) 0.75
O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer. Oncotarget (2016) 0.75
Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration. Nat Commun (2017) 0.75
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl (1968) 60.35
Galectins as modulators of tumour progression. Nat Rev Cancer (2005) 5.30
Galectins. Structure and function of a large family of animal lectins. J Biol Chem (1994) 4.29
Galectin-3: an open-ended story. Biochim Biophys Acta (2006) 4.10
Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol (2009) 3.22
Respiratory burst in human neutrophils. J Immunol Methods (1999) 3.16
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol (2007) 3.07
The mystery of nonclassical protein secretion. A current view on cargo proteins and potential export routes. Eur J Biochem (2003) 2.95
Galectins: structure, function and therapeutic potential. Expert Rev Mol Med (2008) 2.61
N-Glycans in cancer progression. Glycobiology (2008) 2.35
Introduction to galectins. Glycoconj J (2004) 2.30
Roles of galectins in infection. Nat Rev Microbiol (2009) 2.25
Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res (1997) 2.22
Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem (2008) 2.02
X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution. J Biol Chem (1998) 1.99
Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion. J Biol Chem (2006) 1.84
Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell Microbiol (2009) 1.79
Innate immune lectins kill bacteria expressing blood group antigen. Nat Med (2010) 1.78
The regulation of inflammation by galectin-3. Immunol Rev (2009) 1.76
Structure of sialylated fucosyl lactosaminoglycan isolated from human granulocytes. J Biol Chem (1984) 1.65
The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death. J Biol Chem (2002) 1.61
Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian beta-galactosides. J Biol Chem (1986) 1.60
Galectin-glycan lattices regulate cell-surface glycoprotein organization and signalling. Biochem Soc Trans (2008) 1.57
Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectin. J Biol Chem (1992) 1.52
L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity. Biochemistry (1993) 1.47
Phylogenetic analysis of the vertebrate galectin family. Mol Biol Evol (2004) 1.46
Apical sorting by galectin-3-dependent glycoprotein clustering. Traffic (2007) 1.45
The role of galectins in protein trafficking. Traffic (2009) 1.37
Galectin-3 activates the NADPH-oxidase in exudated but not peripheral blood neutrophils. Blood (1998) 1.36
Multiple soluble beta-galactoside-binding lectins from human lung. J Biol Chem (1987) 1.36
Novel polyfucosylated N-linked glycopeptides with blood group A, H, X, and Y determinants from human small intestinal epithelial cells. J Biol Chem (1989) 1.31
Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells. J Biol Chem (1986) 1.27
Effect of amino acid substitution by sited-directed mutagenesis on the carbohydrate recognition and stability of human 14-kDa beta-galactoside-binding lectin. J Biol Chem (1991) 1.24
LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition. J Immunol (2004) 1.22
Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. Glycobiology (2007) 1.21
Structure and functional analysis of the fungal galectin CGL2. Structure (2004) 1.20
Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells. Glycobiology (2005) 1.18
Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils. J Immunol (1999) 1.18
Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction. J Am Chem Soc (2005) 1.17
Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells. Cancer Res (2005) 1.16
Galectin-3 regulates T-cell functions. Immunol Rev (2009) 1.14
Carbohydrate-binding protein 35. I. Properties of the recombinant polypeptide and the individuality of the domains. J Biol Chem (1993) 1.13
Structural study of the sugar chains of human leukocyte cell adhesion molecules CD11/CD18. Biochemistry (1991) 1.10
Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins. Glycobiology (2008) 1.07
Structures of glycosphingolipids isolated from human granulocytes. The presence of a series of linear poly-N-acetyllactosaminylceramide and its significance in glycolipids of whole blood cells. J Biol Chem (1985) 1.05
Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. Glycobiology (2008) 1.04
Lipopolysaccharide-induced gelatinase granule mobilization primes neutrophils for activation by galectin-3 and formylmethionyl-Leu-Phe. Infect Immun (2001) 1.03
Cell surface counter receptors are essential components of the unconventional export machinery of galectin-1. J Cell Biol (2005) 1.02
Glycosylation of natural human neutrophil gelatinase B and neutrophil gelatinase B-associated lipocalin. Biochemistry (1999) 1.01
Carbohydrate-binding protein 35. II. Analysis of the interaction of the recombinant polypeptide with saccharides. J Biol Chem (1993) 1.01
Loss of galectin-3 impairs membrane polarisation of mouse enterocytes in vivo. J Cell Sci (2008) 1.00
Structural study of the sugar chains of human leukocyte common antigen CD45. Biochemistry (1993) 1.00
Galectin-3, a novel centrosome-associated protein, required for epithelial morphogenesis. Mol Biol Cell (2009) 0.98
Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol (2002) 0.98
Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res (2009) 0.93
Trafficking of galectin-3 through endosomal organelles of polarized and non-polarized cells. Eur J Cell Biol (2010) 0.93
Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell death. Blood (2006) 0.93
Structural basis for the tumor cell apoptosis-inducing activity of an antitumor lectin from the edible mushroom Agrocybe aegerita. J Mol Biol (2009) 0.93
Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils. J Leukoc Biol (2005) 0.90
Conformational entropy changes upon lactose binding to the carbohydrate recognition domain of galectin-3. J Biomol NMR (2009) 0.90
Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides. Chemistry (2008) 0.90
Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions. Anal Biochem (2004) 0.88
Intracellular sorting of galectin-8 based on carbohydrate fine specificity. Glycobiology (2007) 0.88
Effects of DNA methylation on galectin-3 expression in pituitary tumors. Cancer Res (2005) 0.88
Evidence for subsites in the galectins involved in sugar binding at the nonreducing end of the central galactose of oligosaccharide ligands: sequence analysis, homology modeling and mutagenesis studies of hamster galectin-3. Glycobiology (1998) 0.86
Structural study of the O-linked sugar chains of human leukocyte tyrosine phosphatase CD45. Eur J Biochem (1998) 0.84
Characterization of the Xenopus galectin family. Three structurally different types as in mammals and regulated expression during embryogenesis. J Biol Chem (2003) 0.83
Structural basis of a fungal galectin from Agrocybe cylindracea for recognizing sialoconjugate. J Mol Biol (2005) 0.83
Different glycosphingolipid composition in human neutrophil subcellular compartments. Glycoconj J (2001) 0.76
Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol (2008) 7.65
Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J Exp Med (2008) 5.94
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science (2004) 3.06
Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma. Neuroendocrinology (2007) 2.95
Combination chemotherapy in advanced adrenocortical carcinoma. N Engl J Med (2012) 2.82
Association of Inhalation Toxicologists (AIT) working party recommendation for standard delivered dose calculation and expression in non-clinical aerosol inhalation toxicology studies with pharmaceuticals. Inhal Toxicol (2008) 2.33
Regulation of alternative macrophage activation by galectin-3. J Immunol (2008) 2.28
Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors. Clin Cancer Res (2007) 2.16
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med (2011) 2.09
Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem (2008) 2.02
18F-FDG PET/CT Diagnosis of Bronchopulmonary Carcinoids Versus Pulmonary Hamartomas. Clin Nucl Med (2016) 1.94
Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell Microbiol (2009) 1.79
Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis. Arthritis Rheum (2011) 1.74
Gastrinoma (duodenal and pancreatic). Neuroendocrinology (2007) 1.55
N-glycans are direct determinants of CFTR folding and stability in secretory and endocytic membrane traffic. J Cell Biol (2009) 1.54
Cutaneous human papillomaviruses persist on healthy skin. J Invest Dermatol (2006) 1.53
Galectins as inflammatory mediators. Glycoconj J (2004) 1.52
Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol (2008) 1.51
Ligand recognition and activation of formyl peptide receptors in neutrophils. J Leukoc Biol (2005) 1.49
Phylogenetic analysis of the vertebrate galectin family. Mol Biol Evol (2004) 1.46
Physical properties of Escherichia coli P pili measured by optical tweezers. Biophys J (2004) 1.45
Apical sorting by galectin-3-dependent glycoprotein clustering. Traffic (2007) 1.45
Assessment of inactive, active and mixed atherosclerotic plaques by 18F-FDG-PET; an age group-based correlation with cardiovascular risk factors. Int J Cardiovasc Imaging (2008) 1.45
Galectin-4 in normal tissues and cancer. Glycoconj J (2004) 1.42
⁶⁸Ga-DOTA-TOC-PET/CT detects heart metastases from ileal neuroendocrine tumors. Endocrine (2013) 1.41
454 pyrosequencing analyses of bacterial and archaeal richness in 21 full-scale biogas digesters. FEMS Microbiol Ecol (2013) 1.38
ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms. Neuroendocrinology (2012) 1.38
Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins. J Immunol (2007) 1.34
Changes in activation states of murine polymorphonuclear leukocytes (PMN) during inflammation: a comparison of bone marrow and peritoneal exudate PMN. Clin Vaccine Immunol (2006) 1.34
Intracellular generation of superoxide by the phagocyte NADPH oxidase: how, where, and what for? Free Radic Biol Med (2010) 1.31
Individualized dosimetry in patients undergoing therapy with (177)Lu-DOTA-D-Phe (1)-Tyr (3)-octreotate. Eur J Nucl Med Mol Imaging (2009) 1.30
Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3. J Am Chem Soc (2010) 1.24
Individualized dosimetry of kidney and bone marrow in patients undergoing 177Lu-DOTA-octreotate treatment. J Nucl Med (2012) 1.24
Interobserver and intraobserver variability in the response evaluation of cancer therapy according to RECIST and WHO-criteria. Acta Oncol (2010) 1.23
Measurement of respiratory burst products generated by professional phagocytes. Methods Mol Biol (2007) 1.22
Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. Glycobiology (2007) 1.21
Galectin-3 contributes to neonatal hypoxic-ischemic brain injury. Neurobiol Dis (2010) 1.21
Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases. Pharmacol Ther (2003) 1.18
Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells. Glycobiology (2005) 1.18
Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles. Blood (2002) 1.18
Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction. J Am Chem Soc (2005) 1.17
Measurement of respiratory burst products, released or retained, during activation of professional phagocytes. Methods Mol Biol (2014) 1.17
Molecular profiling reveals low- and high-grade forms of primary melanoma. Clin Cancer Res (2012) 1.17
Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus. J Gen Virol (2006) 1.16
Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin Cancer Res (2003) 1.15
Nordic Guidelines 2010 for diagnosis and treatment of gastroenteropancreatic neuroendocrine tumours. Acta Oncol (2010) 1.15
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice. Hum Mol Genet (2008) 1.13
Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology (2012) 1.12
Prognostic impact of array-based genomic profiles in esophageal squamous cell cancer. BMC Cancer (2008) 1.12
The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing. J Biol Chem (2012) 1.12
In vivo binding of [68Ga]-DOTATOC to somatostatin receptors in neuroendocrine tumours--impact of peptide mass. Nucl Med Biol (2010) 1.12
Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses. J Immunol (2011) 1.12
[11C]metomidate positron emission tomography of adrenocortical tumors in correlation with histopathological findings. J Clin Endocrinol Metab (2006) 1.11
The role of PET in localization of neuroendocrine and adrenocortical tumors. Ann N Y Acad Sci (2002) 1.09
Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. BMC Pediatr (2010) 1.09
Serum amyloid A mediates human neutrophil production of reactive oxygen species through a receptor independent of formyl peptide receptor like-1. J Leukoc Biol (2007) 1.08
Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins. Glycobiology (2008) 1.07
Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion. Neuromuscul Disord (2010) 1.06
Positron emission tomography: a real-time tool to quantify early islet engraftment in a preclinical large animal model. Transplantation (2007) 1.05
Nordic guidelines 2014 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms. Acta Oncol (2014) 1.05
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett (2010) 1.04
ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: somatostatin receptor imaging with (111)In-pentetreotide. Neuroendocrinology (2009) 1.04
Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. Glycobiology (2008) 1.04
Capacitative Ca2+ influx and activation of the neutrophil respiratory burst. Different regulation of plasma membrane- and granule-localized NADPH-oxidase. J Leukoc Biol (2002) 1.04
Activation of the neutrophil nicotinamide adenine dinucleotide phosphate oxidase by galectin-1. J Immunol (2002) 1.03
NADPH-oxidase activation in murine neutrophils via formyl peptide receptors. Exp Cell Res (2003) 1.02
The feasibility of using Pareto fronts for comparison of treatment planning systems and delivery techniques. Acta Oncol (2009) 1.02
Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy. Biochem Pharmacol (2003) 1.02
Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II? Protein Sci (2010) 1.02
Comparative biodistribution and radiation dosimetry of 68Ga-DOTATOC and 68Ga-DOTATATE in patients with neuroendocrine tumors. J Nucl Med (2013) 1.01
Conformational differences in liganded and unliganded states of Galectin-3. Biochemistry (2003) 1.01
In vivo and in vitro characterization of [18F]-FE-(+)-DTBZ as a tracer for beta-cell mass. Nucl Med Biol (2010) 1.01
Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2-20), which activates formyl peptide receptor-like 1. Infect Immun (2002) 1.00
Localization of human neutrophil interleukin-8 (CXCL-8) to organelle(s) distinct from the classical granules and secretory vesicles. J Leukoc Biol (2005) 1.00
Ligand induced galectin-3 protein self-association. J Biol Chem (2012) 1.00
The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology (2002) 1.00
Simple piggyBac transposon-based mammalian cell expression system for inducible protein production. Proc Natl Acad Sci U S A (2013) 0.98
Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol (2002) 0.98
Malignant gastric ghrelinoma with hyperghrelinemia. J Clin Endocrinol Metab (2004) 0.97
High 18F-FDG Uptake in synthetic aortic vascular grafts on PET/CT in symptomatic and asymptomatic patients. J Nucl Med (2008) 0.97
Quantitative imaging of serotonergic biosynthesis and degradation in the endocrine pancreas. J Nucl Med (2014) 0.97
High success rate of parathyroid reoperation may be achieved with improved localization diagnosis. World J Surg (2008) 0.97
Pharmacological and genetic inhibition of NADPH oxidase does not reduce brain damage in different models of perinatal brain injury in newborn mice. Neurobiol Dis (2008) 0.96
Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types. Biochim Biophys Acta (2012) 0.96