Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover.

PubWeight™: 1.96‹?› | Rank: Top 2%

🔗 View Article (PMC 525627)

Published in Proc Natl Acad Sci U S A on May 01, 1992

Authors

S Dauvois1, P S Danielian, R White, M G Parker

Author Affiliations

1: Molecular Endocrinology Laboratory, Imperial Cancer Research Fund, London, United Kingdom.

Articles citing this

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J (1995) 4.23

ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Mol Cell Biol (2004) 2.46

pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. Mol Cell Biol (1998) 2.01

Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region. EMBO J (1993) 1.99

Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α. J Natl Cancer Inst (2011) 1.84

Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization. Mol Cell Biol (1999) 1.60

Coactivator AIB1 links estrogen receptor transcriptional activity and stability. Proc Natl Acad Sci U S A (2004) 1.54

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Exp Biol Med (Maywood) (2010) 1.50

Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone. Proc Natl Acad Sci U S A (1993) 1.30

Hormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expression. EMBO J (1992) 1.30

Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol Cell Biol (2005) 1.25

Specific mutations in the estrogen receptor change the properties of antiestrogens to full agonists. Proc Natl Acad Sci U S A (1995) 1.19

Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Mol Cell Biol (1995) 1.17

Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer. Br J Cancer (1996) 1.12

Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter. Mol Cell Biol (2009) 1.09

Estrogen receptor α AF-2 mutation results in antagonist reversal and reveals tissue selective function of estrogen receptor modulators. Proc Natl Acad Sci U S A (2011) 1.08

Back to your heart: ubiquitin proteasome system-regulated signal transduction. J Mol Cell Cardiol (2011) 1.05

IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis. Mol Cancer Ther (2010) 1.04

Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer (2008) 0.99

Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer. Horm Mol Biol Clin Investig (2011) 0.97

COUP-TF II homodimers are formed in preference to heterodimers with RXR alpha or TR beta in intact cells. Nucleic Acids Res (1995) 0.96

Phosphorylation by p38 mitogen-activated protein kinase promotes estrogen receptor α turnover and functional activity via the SCF(Skp2) proteasomal complex. Mol Cell Biol (2012) 0.96

The role of amphiregulin in exemestane-resistant breast cancer cells: evidence of an autocrine loop. Cancer Res (2008) 0.95

Estrogen receptor-alpha 36 mediates mitogenic antiestrogen signaling in ER-negative breast cancer cells. PLoS One (2012) 0.94

Retracted Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells. Proc Natl Acad Sci U S A (2009) 0.94

The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules. Reprod Biol Endocrinol (2003) 0.94

Endocrine resistance in breast cancer - An overview and update. Mol Cell Endocrinol (2015) 0.93

The oestrogen-like effect of 4-hydroxytamoxifen on induction of transforming growth factor alpha mRNA in MDA-MB-231 breast cancer cells stably expressing the oestrogen receptor. Br J Cancer (1998) 0.91

Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens. PLoS One (2013) 0.91

Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs). J Med Chem (2010) 0.90

Differential regulation of specific genes in MCF-7 and the ICI 182780-resistant cell line MCF-7/182R-6. Br J Cancer (1999) 0.90

The interaction between ER and NFκB in resistance to endocrine therapy. Breast Cancer Res (2012) 0.90

Induction of the CLOCK gene by E2-ERα signaling promotes the proliferation of breast cancer cells. PLoS One (2014) 0.90

The estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor α AF-2 is modified. Proc Natl Acad Sci U S A (2014) 0.90

17-beta-oestradiol-induced vasorelaxation in vitro is mediated by eNOS through hsp90 and akt/pkb dependent mechanism. Br J Pharmacol (2002) 0.89

Mechanisms of resistance to structurally diverse antiestrogens differ under premenopausal and postmenopausal conditions: evidence from in vitro breast cancer cell models. Endocrinology (2009) 0.89

Estradiol attenuates directed migration of vascular smooth muscle cells in vitro. Am J Pathol (1996) 0.89

Role of direct estrogen receptor signaling in wear particle-induced osteolysis. Biomaterials (2012) 0.89

Distinct signaling pathways mediate stimulation of cell cycle progression and prevention of apoptotic cell death by estrogen in rat pituitary tumor PR1 cells. Mol Biol Cell (2003) 0.88

Induced protein degradation: an emerging drug discovery paradigm. Nat Rev Drug Discov (2016) 0.88

Activation of the human estrogen receptor by the antiestrogens ICI 182,780 and tamoxifen in yeast genetic systems: implications for their mechanism of action. Proc Natl Acad Sci U S A (2000) 0.87

Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides. Org Biomol Chem (2012) 0.85

Proteomics analysis of the estrogen receptor alpha receptosome. Mol Cell Proteomics (2010) 0.85

Anti-Proliferative Effects of Evodiamine on Human Breast Cancer Cells. PLoS One (2013) 0.84

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover. Cell Death Dis (2015) 0.83

cDNA transfection followed by the isolation of a MCF-7 breast cell line resistant to tamoxifen in vitro and in vivo. Br J Cancer (1993) 0.82

Effects of antioestrogens on the DNA binding activity of oestrogen receptors in vitro. Nucleic Acids Res (1992) 0.80

Role of SUMOylation in full antiestrogenicity. Mol Cell Biol (2012) 0.80

The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors. J Transl Med (2014) 0.80

The ligand-mediated nuclear mobility and interaction with estrogen-responsive elements of estrogen receptors are subtype specific. J Mol Endocrinol (2012) 0.80

ER-α36: a novel biomarker and potential therapeutic target in breast cancer. Onco Targets Ther (2014) 0.78

Classification of breast cancer cells on the basis of a functional assay for estrogen receptor. Mol Med (1998) 0.78

Estrogen receptor α L543A,L544A mutation changes antagonists to agonists, correlating with the ligand binding domain dimerization associated with DNA binding activity. J Biol Chem (2013) 0.78

Selective estrogen receptor down-regulator and selective estrogen receptor modulators differentially regulate lactotroph proliferation. PLoS One (2010) 0.77

Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer. Interface Focus (2013) 0.77

Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget (2016) 0.77

Anticancer effect of metformin on estrogen receptor-positive and tamoxifen-resistant breast cancer cell lines. Oncol Rep (2016) 0.77

Targeted Protein Degradation by Small Molecules. Annu Rev Pharmacol Toxicol (2016) 0.77

Postoperative endocrine therapy for invasive breast cancer. Cancer Treat Res (2009) 0.76

MCF-7aro/ERE, a novel cell line for rapid screening of aromatase inhibitors, ERalpha ligands and ERRalpha ligands. Biochem Pharmacol (2008) 0.76

Estrogen receptor alpha is cell cycle-regulated and regulates the cell cycle in a ligand-dependent fashion. Cell Cycle (2016) 0.75

New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane. Int J Oncol (2015) 0.75

PSA Decrease with Fulvestrant Acetate in a Hormone-Resistant Metastatic Prostate Cancer Patient: A Case Report. Case Rep Oncol (2009) 0.75

Endogenous Estrogen Regulates Somatostatin-Induced Rebound GH Secretion in Postmenopausal Women. J Clin Endocrinol Metab (2016) 0.75

High Maternal Serum Estradiol Levels Induce Dyslipidemia in Human Newborns via a Hepatic HMGCR Estrogen Response Element. Sci Rep (2015) 0.75

Estrogen-like potentiation of ghrelin-stimulated GH secretion by fulvestrant, a putatively selective ER antagonist, in postmenopausal women. J Clin Endocrinol Metab (2014) 0.75

Antiestrogens: structure-activity relationships and use in breast cancer treatment. J Mol Endocrinol (2016) 0.75

Targeted Protein Degradation: from Chemical Biology to Drug Discovery. Cell Chem Biol (2017) 0.75

Articles cited by this

Genomic sequencing. Proc Natl Acad Sci U S A (1984) 92.36

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination. Biochemistry (1977) 38.82

Firefly luciferase gene: structure and expression in mammalian cells. Mol Cell Biol (1987) 26.70

The steroid and thyroid hormone receptor superfamily. Science (1988) 25.68

Gene regulation by steroid hormones. Cell (1989) 12.96

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell (1988) 6.59

Functional domains of the human estrogen receptor. Cell (1987) 6.52

The human estrogen receptor has two independent nonacidic transcriptional activation functions. Cell (1989) 6.24

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J (1992) 4.69

Activation of the human beta-interferon gene requires an interferon-inducible factor. Mol Cell Biol (1986) 4.38

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell (1988) 4.17

An amino-terminal fragment of GAL4 binds DNA as a dimer. J Mol Biol (1989) 3.65

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J (1990) 3.59

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell (1990) 3.37

Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Res (1989) 2.70

Structural organization and expression of the mouse estrogen receptor. Mol Endocrinol (1987) 2.54

The common 90-kd protein component of non-transformed '8S' steroid receptors is a heat-shock protein. EMBO J (1985) 2.50

Characterization of response elements for androgens, glucocorticoids and progestins in mouse mammary tumour virus. Nucleic Acids Res (1988) 2.28

Activation of the ovalbumin gene by the estrogen receptor involves the fos-jun complex. Cell (1990) 2.10

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. Proc Natl Acad Sci U S A (1990) 2.03

Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity. EMBO J (1989) 1.82

Biochemical pharmacology of antiestrogen action. Pharmacol Rev (1984) 1.74

The mechanism of ICI 164,384 antiestrogenicity involves rapid loss of estrogen receptor in uterine tissue. Endocrinology (1991) 1.62

Regulation of gene expression by nuclear hormone receptors. Curr Opin Cell Biol (1989) 1.37

Human estrogen receptor forms multiple protein-DNA complexes. J Biol Chem (1990) 1.24

Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Res (1989) 1.17

Antiestrogen can establish nonproductive receptor complexes and alter chromatin structure at target enhancers. Proc Natl Acad Sci U S A (1991) 1.14

Regulation of progesterone receptor mRNA by oestradiol and antioestrogens in breast cancer cell lines. J Steroid Biochem (1989) 1.07

ICI 164,384, a pure antagonist of estrogen-stimulated MCF-7 cell proliferation and invasiveness. Cancer Res (1989) 1.06

Estrogen receptor synthesis and turnover in MCF-7 breast cancer cells measured by a density shift technique. Endocrinology (1984) 1.03

Novel steroidal pure antiestrogens. Steroids (1989) 1.03

Biology and mode of action of pure antioestrogens. J Steroid Biochem (1988) 1.02

Effects of antioestrogens on the proliferation of MCF-7 human breast cancer cells. J Mol Endocrinol (1989) 1.01

Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element. Proc Natl Acad Sci U S A (1991) 1.01

A comparative study of the interaction of oestradiol and the steroidal pure antioestrogen, ICI 164,384, with the molybdate-stabilized oestrogen receptor. J Steroid Biochem (1990) 0.90

Up-regulation of estrogen receptors by nonsteroidal antiestrogens in human breast cancer. Cancer Res (1989) 0.86

The effect of anti-oestrogens on cell growth and progesterone receptor concentration in human endometrial cancer cells (Ishikawa). J Mol Endocrinol (1991) 0.81

Articles by these authors

The Gene Ontology (GO) database and informatics resource. Nucleic Acids Res (2004) 54.37

Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82

Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome. Genomics (1990) 13.23

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53

A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature (1997) 11.15

A highly polymorphic locus in human DNA. Proc Natl Acad Sci U S A (1980) 10.27

Incidence of and risk factors for atrial fibrillation in older adults. Circulation (1997) 8.18

Restriction sites containing CpG show a higher frequency of polymorphism in human DNA. Cell (1984) 8.14

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res (1995) 7.95

A closely linked genetic marker for cystic fibrosis. Nature (1985) 7.85

Construction of linkage maps with DNA markers for human chromosomes. Nature (1985) 6.38

Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat. Science (2000) 5.85

Report of the Committee on Methods of Linkage Analysis and Reporting. Cytogenet Cell Genet (1985) 5.61

Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58

Allelotype of colorectal carcinomas. Science (1989) 5.54

The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell (1990) 5.24

Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol (1997) 4.71

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J (1992) 4.69

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. EMBO J (1995) 4.23

A primary genetic map of markers of human chromosome 10. Genomics (1988) 4.23

Genetic mapping of the human X chromosome by using restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1984) 4.22

Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology (1994) 4.10

A primary genetic map of chromosome 13q. Am J Hum Genet (1986) 4.01

Isolation and regional localization of DNA segments revealing polymorphic loci from human chromosome 13. Am J Hum Genet (1984) 3.86

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell (1990) 3.56

Choice making to promote adaptive behavior for students with emotional and behavioral challenges. J Appl Behav Anal (1994) 3.50

A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ Health Perspect (1995) 3.47

The genetic linkage map of the human X chromosome. Science (1985) 3.42

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor. Cell (1990) 3.37

Coronary artery calcification: pathophysiology, epidemiology, imaging methods, and clinical implications. A statement for health professionals from the American Heart Association. Writing Group. Circulation (1996) 3.34

Genotyping and sequence analysis of apolipoprotein E isoforms. Genomics (1988) 3.20

Isolation and mapping of a polymorphic DNA sequence (pTHH22) on chromosome 9 [D9S12]. Nucleic Acids Res (1988) 3.17

Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes. Proc Natl Acad Sci U S A (1982) 3.11

Interaction of proteins with transcriptionally active estrogen receptors. Proc Natl Acad Sci U S A (1994) 3.10

The telomeric region of the human X chromosome long arm: presence of a highly polymorphic DNA marker and analysis of recombination frequency. Proc Natl Acad Sci U S A (1985) 2.88

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells. Oncogene (1995) 2.84

A mapped set of genetic markers for human chromosome 9. Genomics (1988) 2.80

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science (1999) 2.76

Identification of two transactivation domains in the mouse oestrogen receptor. Nucleic Acids Res (1989) 2.70

Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol (1994) 2.62

An enhanced-sensitivity branched-DNA assay for quantification of human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol (1996) 2.49

Homozygosity of chromosome 13 in retinoblastoma. N Engl J Med (1984) 2.49

A locus on chromosome 11p with multiple restriction site polymorphisms. Am J Hum Genet (1984) 2.48

Template-switching during DNA synthesis by Thermus aquaticus DNA polymerase I. Nucleic Acids Res (1995) 2.46

Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor. EMBO J (1998) 2.44

Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham Study. Neurology (1997) 2.43

Monitoring the AIDS epidemic using HIV prevalence data among young women attending antenatal clinics: prospects and problems. AIDS (2000) 2.40

Estrogen receptors alpha and beta form heterodimers on DNA. J Biol Chem (1997) 2.39

Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen. Mol Endocrinol (1993) 2.37

Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR. Virology (1994) 2.33

Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps. N Engl J Med (1990) 2.32

Simian immunodeficiency virus replicates to high levels in naturally infected African green monkeys without inducing immunologic or neurologic disease. J Virol (2001) 2.29

Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected]. JAMA (1989) 2.29

A detailed genetic map of the long arm of chromosome 11. Genomics (1990) 2.11

Dimer formation by an N-terminal coiled coil in the APC protein. Proc Natl Acad Sci U S A (1993) 2.05

The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. J Cell Sci (1993) 2.04

The ribosomal DNA of Calliphora erythrocephala; and analysis of hybrid plasmids containing ribosomal DNA. J Mol Biol (1980) 2.03

Assignment of first random restriction fragment length polymorphism (RFLP) locus ((D14S1) to a region of human chromosome 14. Am J Hum Genet (1982) 2.03

Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. Proc Natl Acad Sci U S A (1990) 2.03

17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells. Oncogene (1996) 2.01

The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol Cell Biol (1999) 2.00

Inheritance of allelic blueprints for methylation patterns. Cell (1988) 2.00

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev (1999) 1.95

The estrogenic activity of phthalate esters in vitro. Environ Health Perspect (1997) 1.94

Unequal crossingover between homologous chromosomes is not the major mechanism involved in the generation of new alleles at VNTR loci. Genomics (1989) 1.93

Analysis of hepatitis C virus capsid, E1, and E2/NS1 proteins expressed in insect cells. Virology (1993) 1.92

Strategies for detecting and characterizing restriction fragment length polymorphisms (RFLP's). Cytogenet Cell Genet (1982) 1.90

Notification of hepatitis A. BMJ (1991) 1.81

Diagnostic accuracy of self collected vaginal specimens for human papillomavirus compared to clinician collected human papillomavirus specimens: a meta-analysis. Sex Transm Infect (2005) 1.81

Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children. Am J Respir Crit Care Med (1998) 1.81

Construction of a map of the short arm of human chromosome 6. Proc Natl Acad Sci U S A (1986) 1.80

The Hospital Admission and Surveillance Program in Illinois. JAMA (1972) 1.79

Genomic organization of the neurofibromatosis 1 gene (NF1). Genomics (1995) 1.79

Plasma clearance of glycoproteins with terminal mannose and N-acetylglucosamine by liver non-parenchymal cells. Studies with beta-glucuronidase, N-acetyl-beta-D-glucosaminidase, ribonuclease B and agalacto-orosomucoid. Biochem J (1978) 1.78

Performance characteristics for the quantitation of plasma HIV-1 RNA using branched DNA signal amplification technology. J Acquir Immune Defic Syndr Hum Retrovirol (1995) 1.78

Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein. Mol Cell Biol (1995) 1.77

Use of a purified outer membrane protein F (porin) preparation of Pseudomonas aeruginosa as a protective vaccine in mice. Infect Immun (1984) 1.75

Infection of mouse liver by human adenovirus type 5. J Gen Virol (1978) 1.74

Characterization of eight VNTR loci by agarose gel electrophoresis. Genomics (1989) 1.74

Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element. Mol Endocrinol (1993) 1.72

Molecular characterization of a spontaneously generated new allele at a VNTR locus: no exchange of flanking DNA sequence. Genomics (1988) 1.72

Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps. Nat Genet (1998) 1.71

Linkage, physical mapping, and DNA sequence analysis of pseudoautosomal loci on the human X and Y chromosomes. Genomics (1987) 1.70

A CA repeat 30-70 KB downstream from the adenomatous polyposis coli (APC) gene. Nucleic Acids Res (1991) 1.69

Genetic heterozygosity in unreplicated bacteriophage lambda recombinants. Genetics (1975) 1.67

Peptide deformylase in Staphylococcus aureus: resistance to inhibition is mediated by mutations in the formyltransferase gene. Antimicrob Agents Chemother (2000) 1.67

A breast-ovarian cancer susceptibility gene maps to chromosome 17q21. Am J Hum Genet (1993) 1.66

Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium. Proc Natl Acad Sci U S A (1987) 1.64

Further linkage data on cystic fibrosis: the Utah Study. Am J Hum Genet (1986) 1.63

Three additional DNA polymorphisms in the met gene and D7S8 locus: use in prenatal diagnosis of cystic fibrosis. J Pediatr (1987) 1.63

Reduction mammaplasty: an outcome analysis. Ann Plast Surg (1995) 1.62

New approach for isolation of VNTR markers. Am J Hum Genet (1988) 1.61