PubRank

L Kedes

Author PubWeight™ 228.40‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 GEL, a DNA sequencing project management system. Nucleic Acids Res 1982 18.85
2 Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol Cell Biol 1983 11.06
3 Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Res 1984 6.56
4 A human beta-actin expression vector system directs high-level accumulation of antisense transcripts. Proc Natl Acad Sci U S A 1987 6.36
5 Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif. Mol Cell Biol 1986 4.59
6 Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes. Mol Cell Biol 1985 4.30
7 Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution. Mol Cell Biol 1983 4.01
8 Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1. Genes Dev 1990 3.62
9 Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol 1997 3.62
10 Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol Cell 1997 3.54
11 Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs. Proc Natl Acad Sci U S A 1985 3.51
12 Expression and organization of histone genes. Annu Rev Genet 1983 3.35
13 Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol Cell 1999 3.30
14 Twist is a potential oncogene that inhibits apoptosis. Genes Dev 1999 3.14
15 Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell 1999 2.90
16 Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis. Mol Cell 2001 2.69
17 Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. Mol Cell Biol 1988 2.62
18 Duplicated CArG box domains have positive and mutually dependent regulatory roles in expression of the human alpha-cardiac actin gene. Mol Cell Biol 1987 2.62
19 Isolation and characterization of human actin genes. Proc Natl Acad Sci U S A 1981 2.56
20 Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes. Nucleic Acids Res 1986 2.54
21 Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein. Mol Cell Biol 1985 2.51
22 Molecular cloning and characterization of mutant and wild-type human beta-actin genes. Mol Cell Biol 1984 2.41
23 Chromosomal location of the co-expressed human skeletal and cardiac actin genes. Proc Natl Acad Sci U S A 1984 2.36
24 Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro. Mol Cell Biol 1984 2.33
25 Human cytoplasmic actin proteins are encoded by a multigene family. Mol Cell Biol 1982 2.33
26 alpha-skeletal and alpha-cardiac actin genes are coexpressed in adult human skeletal muscle and heart. Mol Cell Biol 1983 2.29
27 Orphons: dispersed genetic elements derived from tandem repetitive genes of eucaryotes. Cell 1981 2.26
28 Two-level regulation of cardiac actin gene transcription: muscle-specific modulating factors can accumulate before gene activation. Mol Cell Biol 1986 2.13
29 The sarcomeric actin CArG-binding factor is indistinguishable from the c-fos serum response factor. Mol Cell Biol 1989 2.05
30 Multiple 5'-flanking regions of the human alpha-skeletal actin gene synergistically modulate muscle-specific expression. Mol Cell Biol 1987 2.00
31 Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters. Nature 1988 1.95
32 Evolution of the human sarcomeric-actin genes: evidence for units of selection within the 3' untranslated regions of the mRNAs. J Mol Evol 1984 1.94
33 HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol 2001 1.85
34 Smooth muscle alpha-action is a transformation-sensitive marker for mouse NIH 3T3 and Rat-2 cells. Nature 1985 1.84
35 Identification of multiple proteins that interact with functional regions of the human cardiac alpha-actin promoter. Mol Cell Biol 1989 1.82
36 HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol 2001 1.77
37 Expression of human cardiac actin in mouse L cells: a sarcomeric actin associates with a nonmuscle cytoskeleton. Cell 1984 1.75
38 GENESIS, a knowledge-based genetic engineering simulation system for representation of genetic data and experiment planning. Nucleic Acids Res 1982 1.70
39 Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro. Proc Natl Acad Sci U S A 1990 1.59
40 The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol 1997 1.56
41 A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes. J Biol Chem 1997 1.54
42 Unusual structure, evolutionary conservation of non-coding sequences and numerous pseudogenes characterize the human H3.3 histone multigene family. Nucleic Acids Res 1987 1.52
43 A common factor regulates skeletal and cardiac alpha-actin gene transcription in muscle. Mol Cell Biol 1988 1.52
44 Sequence analysis and evolution of sea urchin (Lytechinus pictus and Strongylocentrotus purpuratus) histone H4 messenger RNAs. J Mol Biol 1976 1.50
45 Interaction of nuclear proteins with muscle-specific regulatory sequences of the human cardiac alpha-actin promoter. Mol Cell Biol 1988 1.50
46 DNA bending is induced by a transcription factor that interacts with the human c-FOS and alpha-actin promoters. Proc Natl Acad Sci U S A 1989 1.49
47 Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils. Circ Res 1998 1.46
48 A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes. J Mol Cell Cardiol 1999 1.41
49 Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin. Nature 1983 1.40
50 Differential patterns of transcript accumulation during human myogenesis. Mol Cell Biol 1987 1.39
51 Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter. Mol Cell Biol 1999 1.38
52 CArG boxes in the human cardiac alpha-actin gene are core binding sites for positive trans-acting regulatory factors. Proc Natl Acad Sci U S A 1987 1.38
53 Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains. Genomics 1988 1.37
54 Identification and order of sequential mutations in beta-actin genes isolated from increasingly tumorigenic human fibroblast strains. Proc Natl Acad Sci U S A 1985 1.36
55 An unusual transposon with long terminal inverted repeats in the sea urchin Strongylocentrotus purpuratus. Nature 1984 1.32
56 Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Mol Cell Biol 2000 1.31
57 Expression of transfected mutant beta-actin genes: alterations of cell morphology and evidence for autoregulation in actin pools. Mol Cell Biol 1987 1.23
58 Sea urchin nuclei use RNA polymerase II to transcribe discrete histone RNAs larger than messengers. Cell 1978 1.23
59 Regulation of the human cardiac/slow-twitch troponin C gene by multiple, cooperative, cell-type-specific, and MyoD-responsive elements. Mol Cell Biol 1993 1.22
60 Regulation of the human beta-actin promoter by upstream and intron domains. Nucleic Acids Res 1989 1.21
61 Alternative splicing generates variants in important functional domains of human slow skeletal troponin T. J Biol Chem 1987 1.16
62 Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins. Gene Ther 2001 1.16
63 Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts. J Cell Physiol 1990 1.16
64 Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes. Proc Natl Acad Sci U S A 1986 1.16
65 The human skeletal alpha-actin gene is regulated by a muscle-specific enhancer that binds three nuclear factors. Gene Expr 1992 1.15
66 Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy. Proc Natl Acad Sci U S A 1991 1.13
67 Myocardial activation of the human cardiac alpha-actin promoter by helix-loop-helix proteins. Proc Natl Acad Sci U S A 1992 1.11
68 Structure and expression of the human slow twitch skeletal muscle troponin I gene. J Biol Chem 1994 1.11
69 Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection. Mol Cell Biol 1996 1.09
70 Accumulation of individual histone mRNAs during embryogenesis of the sea urchin Strongylocentrotus purpuratus. Dev Biol 1982 1.08
71 MAXAMIZE. A DNA sequencing strategy advisor. Nucleic Acids Res 1982 1.06
72 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins. Gene Ther 2001 1.04
73 Identification and characterization of a factor that binds to two human sarcomeric actin promoters. J Biol Chem 1989 1.03
74 Avoidance of immune response prolongs expression of genes delivered to the adult rat myocardium by replication-defective adenovirus. Circulation 1996 1.03
75 The nucleotide and amino acid coding sequence of a gene for H1 histone that interacts with euchromatin. The early embryonic H1 gene of the sea urchin Strongylocentrotus purpuratus. J Biol Chem 1982 1.01
76 Regulation of a human cardiac actin gene introduced into rat L6 myoblasts suggests a defect in their myogenic program. Mol Cell Biol 1986 1.01
77 Monocistronic transcription is the physiological mechanism of sea urchin embryonic histone gene expression. Mol Cell Biol 1981 1.01
78 cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I. Genomics 1990 0.99
79 Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene. J Biol Chem 1990 0.98
80 Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene. J Biol Chem 1990 0.98
81 Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. J Mol Biol 1988 0.97
82 Doxorubicin represses the function of the myogenic helix-loop-helix transcription factor MyoD. Involvement of Id gene induction. J Biol Chem 1994 0.96
83 Codon usage in histone gene families of higher eukaryotes reflects functional rather than phylogenetic relationships. J Mol Evol 1986 0.95
84 Molecular mechanisms of doxorubicin-induced cardiomyopathy. Selective suppression of Reiske iron-sulfur protein, ADP/ATP translocase, and phosphofructokinase genes is associated with ATP depletion in rat cardiomyocytes. J Biol Chem 1997 0.94
85 Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis. Dev Biol 1995 0.94
86 Messenger RNAs for individual histone proteins: fingerprint analysis and in vitro translation. Cold Spring Harb Symp Quant Biol 1974 0.94
87 The c-fos cyclic AMP-responsive element conveys constitutive expression to a tissue-specific promoter. Mol Cell Biol 1990 0.93
88 Expression of transfected mutant beta-actin genes: transitions toward the stable tumorigenic state. Mol Cell Biol 1987 0.93
89 Myoblast transfer of human erythropoietin gene in a mouse model of renal failure. J Clin Invest 1995 0.92
90 Intramolecular regulation of MyoD activation domain conformation and function. Mol Cell Biol 1998 0.92
91 Structure and unusual characteristics of a new family of transposable elements in the sea urchin Strongylocentrotus purpuratus. Mol Cell Biol 1985 0.91
92 Individual histone messenger RNAs: identification by template activity. Cell 1975 0.91
93 Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis. Circ Res 1997 0.90
94 Sequence and expression of human myosin alkali light chain isoforms. Mol Cell Biochem 1989 0.89
95 Doxorubicin-induced Id2A gene transcription is targeted at an activating transcription factor/cyclic AMP response element motif through novel mechanisms involving protein kinases distinct from protein kinase C and protein kinase A. Mol Cell Biol 1995 0.88
96 Tsp transposons: a heterogeneous family of mobile sequences in the genome of the sea urchin Strongylocentrotus purpuratus. Mol Cell Biol 1985 0.87
97 Parathyroid hormone-parathyroid hormone related protein receptor messenger RNA is present in many tissues besides the kidney. Am J Nephrol 1993 0.86
98 Tissue-specific restriction of skeletal muscle troponin C gene expression. Gene Expr 1993 0.86
99 The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway. Gene Ther 2005 0.86
100 Tropomodulin in rat cardiac muscle. Localization of protein is independent of messenger RNA distribution during myofibrillar development. Circ Res 1994 0.85
101 Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2. Gene 1993 0.85
102 Antineoplastic agent doxorubicin inhibits myogenic differentiation of C2 myoblasts. J Biol Chem 1993 0.84
103 Isolation of full-length cDNAs encoding abundant adult human skeletal muscle mRNAs. Gene 1985 0.84
104 Modulation of microfilament protein composition by transfected cytoskeletal actin genes. Mol Cell Biol 1988 0.84
105 Murine tongue muscle displays a distinct developmental profile of MRF and contractile gene expression. Int J Dev Biol 1999 0.84
106 Assessing the binding and endocytosis activity of cellular receptors using GFP-ligand fusions. Biotechniques 2000 0.84
107 Persistent erythropoiesis by myoblast transfer of erythropoietin cDNA. Hum Gene Ther 1994 0.84
108 Genes for catecholamine biosynthesis: cloning by expression and identification of the cDNA for rat dopamine beta-hydroxylase. Proc Natl Acad Sci U S A 1983 0.83
109 PTH-PTHrP receptor mRNA is downregulated in chronic renal failure. Am J Nephrol 1994 0.83
110 Dopamine beta-hydroxylase rat mRNA: structure, regulation, and tissue localization. Cold Spring Harb Symp Quant Biol 1983 0.83
111 The anti-cancer agent distamycin A displaces essential transcription factors and selectively inhibits myogenic differentiation. Mol Cell Biochem 1997 0.83
112 In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function. J Cell Biol 1988 0.82
113 Muscle-specific gene expression. A comparison of cardiac and skeletal muscle transcription strategies. Circ Res 1993 0.82
114 Sequences from sea urchin TU transposons are conserved among multiple eucaryotic species, including humans. Mol Cell Biol 1986 0.82
115 Chicken skeletal muscle tropomodulin: novel localization and characterization. Cell Tissue Res 1996 0.82
116 Direct DNA injection into mouse tongue muscle for analysis of promoter function in vivo. Somat Cell Mol Genet 1993 0.81
117 Neural tropomodulin: developmental expression and effect of seizure activity. Brain Res Dev Brain Res 1994 0.81
118 Evolution of late H2A, H2B, and H4 histone genes of the sea urchin, Strongylocentrotus purpuratus. Nucleic Acids Res 1987 0.80
119 Adenovirus-mediated gene transfer into infarcted myocardium: feasibility, timing, and location of expression. J Mol Cell Cardiol 1996 0.80
120 Lens tropomodulin: developmental expression during differentiation. Exp Eye Res 1996 0.80
121 Doxorubicin inhibits Tat-dependent transactivation of HIV type 1 LTR. AIDS Res Hum Retroviruses 1996 0.79
122 Impaired agonist-induced calcium signaling in hepatocytes from chronic renal failure rats. Kidney Int 1995 0.79
123 Developmental regulation of contractile protein genes. Annu Rev Physiol 1989 0.79
124 Molecular cloning of rabbit CARP cDNA and its regulated expression in adriamycin-cardiomyopathy. Biochim Biophys Acta 1999 0.79
125 Serum-inducible factors binding to an activating transcription factor motif regulate transcription of the Id2A promoter during myogenic differentiation. J Biol Chem 1994 0.79
126 Cell-cycle-specific transcription termination within the human histone H3.3 gene is correlated with specific protein-DNA interactions. Genet Res 1997 0.78
127 Upregulation of angiotensin II type 1 receptor gene expression in chronic renovascular hypertension. J Surg Res 1995 0.78
128 Simultaneous expression of early and late histone messenger RNAs in individual cells during development of the sea urchin embryo. Dev Biol 1985 0.78
129 The myogenic regulatory circuit that controls cardiac/slow twitch troponin C gene transcription in skeletal muscle involves E-box, MEF-2, and MEF-3 motifs. Gene Expr 1999 0.78
130 Assignment of the human skeletal muscle alpha actin gene (ACTA1) to 1q42 by fluorescence in situ hybridisation. Cytogenet Cell Genet 1994 0.77
131 Regulation of contractile protein gene family mRNA pool sizes during myogenesis. Dev Biol 1990 0.77
132 Ischemic/reperfused myocardium can express recombinant protein following direct DNA or retroviral injection. J Mol Cell Cardiol 1996 0.77
133 Tissue restricted gene expression assayed by direct DNA injection into cardiac and skeletal muscle. J Mol Cell Cardiol 1994 0.76
134 Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions. Exp Cell Res 1993 0.76
135 Sequences of the 5'-flanking region of the human helix-loop-helix protein-encoding Id2A gene, and promoter activity regulated by serum and c-Jun/AP-1. Gene 1995 0.76
136 Assignment of the human slow skeletal muscle troponin gene (TNNI1) to 1q32 by fluorescence in situ hybridisation. Cytogenet Cell Genet 1993 0.75
137 Differential expression of troponin C genes during tongue myogenesis. Dev Dyn 1997 0.75
138 Can a few good cells now mend a broken heart? J Clin Invest 1993 0.75
139 Two-step delivery of retroviruses to postmitotic, terminally differentiated cells. Hum Gene Ther 1997 0.75
140 Renal mRNA of PTH-PTHrP receptor, [Ca2+]i and phosphaturic response to PTH in phosphate depletion. Miner Electrolyte Metab 1997 0.75
141 Histone gene organization: paradigm lost. Nature 1981 0.75
142 The human beta-actin multigene family. Trans Assoc Am Physicians 1985 0.75