Published in Proc Natl Acad Sci U S A on May 01, 1992
The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol (1997) 1.56
E-box sites and a proximal regulatory region of the muscle creatine kinase gene differentially regulate expression in diverse skeletal muscles and cardiac muscle of transgenic mice. Mol Cell Biol (1996) 1.54
Transcription of the dominant-negative helix-loop-helix protein Id1 is regulated by a protein complex containing the immediate-early response gene Egr-1. Mol Cell Biol (1996) 1.44
Muscle-specific expression of SRF-related genes in the early embryo of Xenopus laevis. EMBO J (1992) 1.44
Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression. Mol Cell Biol (1997) 1.37
Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle. Mol Cell Biol (1993) 1.34
The loop region of the helix-loop-helix protein Id1 is critical for its dominant negative activity. Mol Cell Biol (1993) 1.30
Regulation of the human cardiac/slow-twitch troponin C gene by multiple, cooperative, cell-type-specific, and MyoD-responsive elements. Mol Cell Biol (1993) 1.22
E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res (1996) 1.21
EFIA/YB-1 is a component of cardiac HF-1A binding activity and positively regulates transcription of the myosin light-chain 2v gene. Mol Cell Biol (1995) 1.17
Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Mol Cell Biol (1994) 1.15
Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions. Biochem J (2000) 1.05
Positive regulatory elements (HF-1a and HF-1b) and a novel negative regulatory element (HF-3) mediate ventricular muscle-specific expression of myosin light-chain 2-luciferase fusion genes in transgenic mice. Mol Cell Biol (1994) 1.03
A mutation in the dystrophin gene selectively affecting dystrophin expression in the heart. J Clin Invest (1995) 0.97
Serum response factor and protein-mediated DNA bending contribute to transcription of the dystrophin muscle-specific promoter. Mol Cell Biol (1997) 0.91
Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle. Mol Cell Biol (1995) 0.86
Novel muscle-specific enhancer sequences upstream of the cardiac actin gene. Mol Cell Biol (1994) 0.82
The virtue of just enough stress: a molecular model. Trans Am Clin Climatol Assoc (2012) 0.75
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell (1989) 21.54
The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell (1990) 15.36
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell (1989) 14.24
The myoD gene family: nodal point during specification of the muscle cell lineage. Science (1991) 9.53
MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer. Cell (1989) 6.94
Transcription factor interactions: selectors of positive or negative regulation from a single DNA element. Science (1990) 6.72
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48
A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program. Genes Dev (1989) 5.91
LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev (1990) 4.98
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif. Science (1990) 4.93
An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers. Cell (1991) 4.80
Positive autoregulation of the myogenic determination gene MyoD1. Cell (1989) 4.28
Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1. Genes Dev (1990) 3.62
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev (1990) 3.50
DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally. Cell (1990) 3.44
Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the Myf gene products. EMBO J (1989) 2.88
Developmental expression of Sp1 in the mouse. Mol Cell Biol (1991) 2.73
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev (1990) 2.46
B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol Cell Biol (1991) 2.28
Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins. Mol Cell Biol (1991) 2.25
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. Genes Dev (1991) 2.21
Identification of multiple proteins that interact with functional regions of the human cardiac alpha-actin promoter. Mol Cell Biol (1989) 1.82
The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila. Genes Dev (1988) 1.53
Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy. Proc Natl Acad Sci U S A (1991) 1.13
GEL, a DNA sequencing project management system. Nucleic Acids Res (1982) 18.85
Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol Cell Biol (1983) 11.06
Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Res (1984) 6.56
A human beta-actin expression vector system directs high-level accumulation of antisense transcripts. Proc Natl Acad Sci U S A (1987) 6.36
Upstream regions of the human cardiac actin gene that modulate its transcription in muscle cells: presence of an evolutionarily conserved repeated motif. Mol Cell Biol (1986) 4.59
Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes. Mol Cell Biol (1985) 4.30
Human actin genes are single copy for alpha-skeletal and alpha-cardiac actin but multicopy for beta- and gamma-cytoskeletal genes: 3' untranslated regions are isotype specific but are conserved in evolution. Mol Cell Biol (1983) 4.01
Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1. Genes Dev (1990) 3.62
Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol Cell Biol (1997) 3.62
Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol Cell (1997) 3.54
Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs. Proc Natl Acad Sci U S A (1985) 3.51
Expression and organization of histone genes. Annu Rev Genet (1983) 3.35
Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol Cell (1999) 3.30
Twist is a potential oncogene that inhibits apoptosis. Genes Dev (1999) 3.14
Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell (1999) 2.90
Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis. Mol Cell (2001) 2.69
Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. Mol Cell Biol (1988) 2.62
Duplicated CArG box domains have positive and mutually dependent regulatory roles in expression of the human alpha-cardiac actin gene. Mol Cell Biol (1987) 2.62
Isolation and characterization of human actin genes. Proc Natl Acad Sci U S A (1981) 2.56
Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes. Nucleic Acids Res (1986) 2.54
Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein. Mol Cell Biol (1985) 2.51
Molecular cloning and characterization of mutant and wild-type human beta-actin genes. Mol Cell Biol (1984) 2.41
Chromosomal location of the co-expressed human skeletal and cardiac actin genes. Proc Natl Acad Sci U S A (1984) 2.36
Cardiac actin is the major actin gene product in skeletal muscle cell differentiation in vitro. Mol Cell Biol (1984) 2.33
Human cytoplasmic actin proteins are encoded by a multigene family. Mol Cell Biol (1982) 2.33
alpha-skeletal and alpha-cardiac actin genes are coexpressed in adult human skeletal muscle and heart. Mol Cell Biol (1983) 2.29
Expression of inducible nitric oxide synthase in human heart failure. Circulation (1996) 2.26
Orphons: dispersed genetic elements derived from tandem repetitive genes of eucaryotes. Cell (1981) 2.26
Two-level regulation of cardiac actin gene transcription: muscle-specific modulating factors can accumulate before gene activation. Mol Cell Biol (1986) 2.13
The sarcomeric actin CArG-binding factor is indistinguishable from the c-fos serum response factor. Mol Cell Biol (1989) 2.05
Multiple 5'-flanking regions of the human alpha-skeletal actin gene synergistically modulate muscle-specific expression. Mol Cell Biol (1987) 2.00
Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. J Biol Chem (2001) 1.96
Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters. Nature (1988) 1.95
Evolution of the human sarcomeric-actin genes: evidence for units of selection within the 3' untranslated regions of the mRNAs. J Mol Evol (1984) 1.94
HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol (2001) 1.85
Smooth muscle alpha-action is a transformation-sensitive marker for mouse NIH 3T3 and Rat-2 cells. Nature (1985) 1.84
Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circ Res (2001) 1.83
Identification of multiple proteins that interact with functional regions of the human cardiac alpha-actin promoter. Mol Cell Biol (1989) 1.82
HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol (2001) 1.77
Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand. Biochem Biophys Res Commun (1998) 1.77
Expression of human cardiac actin in mouse L cells: a sarcomeric actin associates with a nonmuscle cytoskeleton. Cell (1984) 1.75
Rapid activation of neutral sphingomyelinase by hypoxia-reoxygenation of cardiac myocytes. Circ Res (2000) 1.70
GENESIS, a knowledge-based genetic engineering simulation system for representation of genetic data and experiment planning. Nucleic Acids Res (1982) 1.70
Doxorubicin selectively inhibits muscle gene expression in cardiac muscle cells in vivo and in vitro. Proc Natl Acad Sci U S A (1990) 1.59
Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53. J Clin Invest (1999) 1.58
The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol (1997) 1.56
A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes. J Biol Chem (1997) 1.54
Unusual structure, evolutionary conservation of non-coding sequences and numerous pseudogenes characterize the human H3.3 histone multigene family. Nucleic Acids Res (1987) 1.52
A common factor regulates skeletal and cardiac alpha-actin gene transcription in muscle. Mol Cell Biol (1988) 1.52
Identification of alpha-adrenergic receptors in human platelets by [3H]dihydroergocryptine binding. J Clin Invest (1978) 1.51
Sequence analysis and evolution of sea urchin (Lytechinus pictus and Strongylocentrotus purpuratus) histone H4 messenger RNAs. J Mol Biol (1976) 1.50
Interaction of nuclear proteins with muscle-specific regulatory sequences of the human cardiac alpha-actin promoter. Mol Cell Biol (1988) 1.50
DNA bending is induced by a transcription factor that interacts with the human c-FOS and alpha-actin promoters. Proc Natl Acad Sci U S A (1989) 1.49
Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils. Circ Res (1998) 1.46
Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes. J Biol Chem (1993) 1.42
A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes. J Mol Cell Cardiol (1999) 1.41
Distinct organizations and patterns of expression of early and late histone gene sets in the sea urchin. Nature (1983) 1.40
Differential patterns of transcript accumulation during human myogenesis. Mol Cell Biol (1987) 1.39
Myogenic basic helix-loop-helix proteins and Sp1 interact as components of a multiprotein transcriptional complex required for activity of the human cardiac alpha-actin promoter. Mol Cell Biol (1999) 1.38
CArG boxes in the human cardiac alpha-actin gene are core binding sites for positive trans-acting regulatory factors. Proc Natl Acad Sci U S A (1987) 1.38
Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains. Genomics (1988) 1.37
Atrial natriuretic peptide induces apoptosis in neonatal rat cardiac myocytes. J Biol Chem (1997) 1.37
Identification and order of sequential mutations in beta-actin genes isolated from increasingly tumorigenic human fibroblast strains. Proc Natl Acad Sci U S A (1985) 1.36
Oxidation of zinc finger transcription factors: physiological consequences. Antioxid Redox Signal (2001) 1.35
An unusual transposon with long terminal inverted repeats in the sea urchin Strongylocentrotus purpuratus. Nature (1984) 1.32
Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Mol Cell Biol (2000) 1.31
Physical and functional sensitivity of zinc finger transcription factors to redox change. Mol Cell Biol (1996) 1.26
Expression of transfected mutant beta-actin genes: alterations of cell morphology and evidence for autoregulation in actin pools. Mol Cell Biol (1987) 1.23
Sea urchin nuclei use RNA polymerase II to transcribe discrete histone RNAs larger than messengers. Cell (1978) 1.23
Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element. J Biol Chem (1998) 1.22
Regulation of the human cardiac/slow-twitch troponin C gene by multiple, cooperative, cell-type-specific, and MyoD-responsive elements. Mol Cell Biol (1993) 1.22
Regulation of the human beta-actin promoter by upstream and intron domains. Nucleic Acids Res (1989) 1.21
Alternative splicing generates variants in important functional domains of human slow skeletal troponin T. J Biol Chem (1987) 1.16
Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins. Gene Ther (2001) 1.16
Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts. J Cell Physiol (1990) 1.16
Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes. Proc Natl Acad Sci U S A (1986) 1.16
The human skeletal alpha-actin gene is regulated by a muscle-specific enhancer that binds three nuclear factors. Gene Expr (1992) 1.15
Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x. Circ Res (1999) 1.15
Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy. Proc Natl Acad Sci U S A (1991) 1.13
Structure and expression of the human slow twitch skeletal muscle troponin I gene. J Biol Chem (1994) 1.11
Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection. Mol Cell Biol (1996) 1.09
Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis. Circ Res (2001) 1.08
Accumulation of individual histone mRNAs during embryogenesis of the sea urchin Strongylocentrotus purpuratus. Dev Biol (1982) 1.08
MAXAMIZE. A DNA sequencing strategy advisor. Nucleic Acids Res (1982) 1.06
3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins. Gene Ther (2001) 1.04
Identification and characterization of a factor that binds to two human sarcomeric actin promoters. J Biol Chem (1989) 1.03
Avoidance of immune response prolongs expression of genes delivered to the adult rat myocardium by replication-defective adenovirus. Circulation (1996) 1.03
Beta adrenergic receptors in lymphocyte subpopulations. J Allergy Clin Immunol (1980) 1.02
Regulation of a human cardiac actin gene introduced into rat L6 myoblasts suggests a defect in their myogenic program. Mol Cell Biol (1986) 1.01
The nucleotide and amino acid coding sequence of a gene for H1 histone that interacts with euchromatin. The early embryonic H1 gene of the sea urchin Strongylocentrotus purpuratus. J Biol Chem (1982) 1.01
Monocistronic transcription is the physiological mechanism of sea urchin embryonic histone gene expression. Mol Cell Biol (1981) 1.01
Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D. J Biol Chem (2000) 1.01
cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I. Genomics (1990) 0.99
Cloning, structural analysis, and expression of the human slow twitch skeletal muscle/cardiac troponin C gene. J Biol Chem (1990) 0.98
Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene. J Biol Chem (1990) 0.98
Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes. Circ Res (1994) 0.97
Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts. J Mol Biol (1988) 0.97
Doxorubicin represses the function of the myogenic helix-loop-helix transcription factor MyoD. Involvement of Id gene induction. J Biol Chem (1994) 0.96
Codon usage in histone gene families of higher eukaryotes reflects functional rather than phylogenetic relationships. J Mol Evol (1986) 0.95
Messenger RNAs for individual histone proteins: fingerprint analysis and in vitro translation. Cold Spring Harb Symp Quant Biol (1974) 0.94