Published in Ann Oncol on February 10, 2005
Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy. Proc Natl Acad Sci U S A (2007) 4.08
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol (2010) 3.43
Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. J Clin Oncol (2009) 3.39
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. J Transl Med (2007) 2.90
Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J Clin Oncol (2009) 2.48
Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy. Expert Opin Biol Ther (2008) 1.84
The evolving biology and treatment of prostate cancer. J Clin Invest (2007) 1.81
Biomarkers of angiogenesis and their role in the development of VEGF inhibitors. Br J Cancer (2009) 1.78
VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. Trends Mol Med (2007) 1.64
Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib. Cancer Res (2010) 1.58
Antiangiogenics: the potential role of integrating this novel treatment modality with chemoradiation for solid cancers. J Clin Oncol (2007) 1.23
Evaluation of KRAS mutations, angiogenic biomarkers, and DCE-MRI in patients with advanced non-small-cell lung cancer receiving sorafenib. Clin Cancer Res (2011) 1.16
Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide. J Neurooncol (2010) 1.02
Present and future evolution of advanced breast cancer therapy. Breast Cancer Res (2010) 1.01
Cytokine and angiogenic factors associated with efficacy and toxicity of pazopanib in advanced soft-tissue sarcoma: an EORTC-STBSG study. Br J Cancer (2012) 1.01
Biomarkers in tumor angiogenesis and anti-angiogenic therapy. Int J Mol Sci (2011) 1.01
Systems pharmacology approaches for optimization of antiangiogenic therapies: challenges and opportunities. Front Pharmacol (2015) 0.89
Phase II trial of vatalanib in patients with advanced or metastatic pancreatic adenocarcinoma after first-line gemcitabine therapy (PCRT O4-001). Cancer Chemother Pharmacol (2014) 0.87
Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas. Mol Cancer (2006) 0.86
A decrease in maternal plasma concentrations of sVEGFR-2 precedes the clinical diagnosis of preeclampsia. Am J Obstet Gynecol (2010) 0.85
Clinical implications of angiogenesis in cancers. Vasc Health Risk Manag (2006) 0.83
First-in-human phase I study of PRS-050 (Angiocal), an Anticalin targeting and antagonizing VEGF-A, in patients with advanced solid tumors. PLoS One (2013) 0.82
Antiangiogenic therapy in human gastrointestinal malignancies. Gut (2006) 0.79
Correlation of baseline biomarkers with clinical outcomes and response to fulvestrant with vandetanib or placebo in patients with bone predominant metastatic breast cancer: An OCOG ZAMBONEY sub-study. J Bone Oncol (2015) 0.78
Opportunities and challenges for successful use of bevacizumab in pediatrics. Front Oncol (2013) 0.75
Effect of PTK/ZK on the angiogenic switch in head and neck tumors. J Dent Res (2008) 0.75
A phase II open-label randomized multicenter trial of TSU-68 in combination with S-1 and oxaliplatin versus S-1 in combination with oxaliplatin in patients with metastatic colorectal cancer. Invest New Drugs (2014) 0.75
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature (1997) 13.09
Are the problems of primary care in inner cities fact or fiction? Br Med J (Clin Res Ed) (1983) 7.90
Effect of a self-management program on patients with chronic disease. Eff Clin Pract (2001) 7.46
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem (1993) 7.16
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest (1999) 6.73
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood (1996) 5.31
WHO multicentre randomised trial of misoprostol in the management of the third stage of labour. Lancet (2001) 5.25
Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (1993) 5.23
Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes (2000) 4.80
Smoking initiation by adolescent girls, 1944 through 1988. An association with targeted advertising. JAMA (1994) 4.74
The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr Biol (1997) 4.35
Diagnostic risk adjustment for Medicaid: the disability payment system. Health Care Financ Rev (1996) 4.34
Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. J Biol Chem (1987) 4.32
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A (1994) 4.21
Curcumin: the story so far. Eur J Cancer (2005) 4.17
Capturing the patient's view of change as a clinical outcome measure. JAMA (1999) 4.11
Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: evidence from a phase III randomized trial. J Clin Oncol (2001) 4.09
Active versus expectant management of third stage of labour: the Hinchingbrooke randomised controlled trial. Lancet (1998) 4.01
Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol (2001) 3.92
Improving health-based payment for Medicaid beneficiaries: CDPS. Health Care Financ Rev (2000) 3.87
Weekend hospitalization and additional risk of death: an analysis of inpatient data. J R Soc Med (2012) 3.77
Preoperative treatment of postmenopausal breast cancer patients with letrozole: A randomized double-blind multicenter study. Ann Oncol (2001) 3.44
Does the underprivileged area index work? Br Med J (Clin Res Ed) (1985) 3.35
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. J Clin Oncol (1999) 3.30
Amphotericin B lipid complex for invasive fungal infections: analysis of safety and efficacy in 556 cases. Clin Infect Dis (1998) 3.09
Changes in population attitudes about where smoking should not be allowed: California versus the rest of the USA. Tob Control (2004) 3.06
Calmodulin activation of plant microsomal Ca uptake. Proc Natl Acad Sci U S A (1980) 2.94
Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J Virol (1990) 2.87
Structure and function of heparan sulphate proteoglycans. Biochem J (1986) 2.78
Red Light-enhanced Phytochrome Pelletability: Re-examination and Further Characterization. Plant Physiol (1976) 2.77
Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. J Clin Oncol (2002) 2.70
Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res (2001) 2.69
An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation. Br J Pharmacol (1985) 2.68
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc Natl Acad Sci U S A (2000) 2.65
Turnover of phytochrome in pumpkin cotyledons. Plant Physiol (1973) 2.58
Professional attitudes to patient participation groups: an exploratory study. J R Coll Gen Pract (1980) 2.56
Reliability of goniometric measurements. Phys Ther (1978) 2.52
Smoking initiation rates in adults and minors: United States, 1944-1988. Am J Epidemiol (1994) 2.52
Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosis. Clin Infect Dis (1999) 2.48
Low prevalence of Helicobacter pylori in an Australian duodenal ulcer population: NSAIDitis or the effect of ten years of H. pylori treatment? Aust N Z J Med (1998) 2.46
Can some in-hospital cardio-respiratory arrests be prevented? A prospective survey. Resuscitation (1998) 2.44
Differentiation of normal and abnormal airway protection during swallowing using the penetration-aspiration scale. Dysphagia (1999) 2.44
DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. J Clin Oncol (1998) 2.39
Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse. Ann Oncol (2001) 2.39
Randomized trial of periportal peritoneal bupivacaine for pain relief after laparoscopic cholecystectomy. Br J Surg (1996) 2.33
Prophylactic use of oxytocin in the third stage of labour. Cochrane Database Syst Rev (2001) 2.30
The occurrence of C-H...O hydrogen bonds in proteins. J Mol Biol (1995) 2.27
Targeted disruption of the acid alpha-glucosidase gene in mice causes an illness with critical features of both infantile and adult human glycogen storage disease type II. J Biol Chem (1998) 2.24
ATP-dependent Ca uptake into plant membrane vesicles. Proc Natl Acad Sci U S A (1978) 2.24
Epoetin alpha prevents anaemia and reduces transfusion requirements in patients undergoing primarily platinum-based chemotherapy for small cell lung cancer. Br J Cancer (1999) 2.22
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry (2010) 2.21
Molecular prognostic markers in pancreatic cancer: a systematic review. Eur J Cancer (2005) 2.20
Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease. Cancer (1999) 2.17
Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res (1996) 2.10
Rapid immune response to influenza vaccination. Lancet (1993) 2.09
Gemcitabine--a major advance? Ann Oncol (1998) 2.05
Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene (1994) 2.01
Strand displacement amplification and homogeneous real-time detection incorporated in a second-generation DNA probe system, BDProbeTecET. Clin Chem (1999) 2.01
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer (2004) 1.97
Quality of life for people with dementia living in residential and nursing home care: the impact of performance on activities of daily living, behavioral and psychological symptoms, language skills, and psychotropic drugs. Int Psychogeriatr (2001) 1.96
Spread of HIV-1 to children in Cambodia. Lancet (1997) 1.95
Isolation of an antigen of Neisseria gonorrhoeae involved in the human immune response to gonococcal infection. J Bacteriol (1969) 1.95
Testicular implants and patient satisfaction: a questionnaire-based study of men after orchidectomy for testicular cancer. BJU Int (2001) 1.94
Etiology of acute conjunctivitis in children. J Pediatr (1981) 1.92
A VEGF-A splice variant defective for heparan sulfate and neuropilin-1 binding shows attenuated signaling through VEGFR-2. Cell Mol Life Sci (2006) 1.92
Regorafenib (BAY 73-4506) in advanced colorectal cancer: a phase I study. Br J Cancer (2012) 1.90
Novel cryopreservation method for dissociated human embryonic stem cells in the presence of a ROCK inhibitor. Hum Reprod (2008) 1.89
De novo synthesis of phytochrome in pumpkin hooks. Plant Physiol (1973) 1.89
Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. Cell Death Differ (2005) 1.89
Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor. Biochem Biophys Res Commun (1995) 1.87
The Southwestern Ontario Joint Replacement Pilot Project: electronic point-of-care data collection. Southwestern Ontario Study Group. Can J Surg (2001) 1.82
Age effects on lingual pressure generation as a risk factor for dysphagia. J Gerontol A Biol Sci Med Sci (1995) 1.82
A randomized trial of a lay person-led self-management group intervention for back pain patients in primary care. Spine (Phila Pa 1976) (1998) 1.81
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes (2001) 1.80
Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors. Proc Natl Acad Sci U S A (1992) 1.78
Iron-induced mucosal pathology of the upper gastrointestinal tract: a common finding in patients on oral iron therapy. Histopathology (2008) 1.78
NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J Immunol (2001) 1.76
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest (1998) 1.75
Systematic review of outcomes used to evaluate enhanced recovery after surgery. Br J Surg (2014) 1.74
Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis Rheum (2001) 1.74
A soybean seed urease-null produces urease in cell culture. Plant Physiol (1982) 1.73
In Vivo Properties of Membrane-bound Phytochrome. Plant Physiol (1974) 1.73
Learning rate for laparoscopic surgical skills on MIST VR, a virtual reality simulator: quality of human-computer interface. Ann R Coll Surg Engl (1999) 1.73
Particle-bound phytochrome from maize and pumpkin. Nat New Biol (1973) 1.72
Talampicillin: a new derivative of ampicillin. Br Med J (1976) 1.71
The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat. J Neuroimmunol (1995) 1.71
Activation of plant quinate:NAD 3-oxidoreductase by Ca and calmodulin. Proc Natl Acad Sci U S A (1983) 1.70
Timing of breast cancer surgery within the menstrual cycle: influence on lymph-node involvement, receptor status, postoperative metastatic spread and local recurrence. Ann Oncol (1991) 1.70
Lymphoid neoplasia associated with the acquired immunodeficiency syndrome (AIDS). The New York University Medical Center experience with 105 patients (1981-1986). Ann Intern Med (1988) 1.69
Estimation of agonist affinity and efficacy by direct, operational model-fitting. J Pharmacol Methods (1990) 1.67
A clinical assessment of nine pregnancies obtained by in vitro fertilization and embryo transfer. Fertil Steril (1981) 1.67
Phase I dose-escalation and pharmacokinetic study of temozolomide (SCH 52365) for refractory or relapsing malignancies. Br J Cancer (1999) 1.66
Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A. Proc Natl Acad Sci U S A (1979) 1.66
Secretory IgA antibodies in the urethral exudate of men with uncomplicated urethritis due to Neisseria gonorrhoeae. J Infect Dis (1973) 1.65