| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.
|
Biol Psychiatry
|
2010
|
1.39
|
|
2
|
Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth).
|
Addiction
|
2008
|
1.32
|
|
3
|
Opioid receptors and legal highs: Salvia divinorum and Kratom.
|
Clin Toxicol (Phila)
|
2008
|
1.28
|
|
4
|
Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.
|
Curr Pharm Des
|
2007
|
1.26
|
|
5
|
N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers.
|
Proc Natl Acad Sci U S A
|
2011
|
1.05
|
|
6
|
Sigma receptors and cocaine abuse.
|
Curr Top Med Chem
|
2011
|
1.02
|
|
7
|
Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity.
|
Curr Top Med Chem
|
2011
|
0.99
|
|
8
|
A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice.
|
J Pharmacol Exp Ther
|
2010
|
0.98
|
|
9
|
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.
|
J Med Chem
|
2008
|
0.97
|
|
10
|
Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor.
|
J Med Chem
|
2008
|
0.97
|
|
11
|
Determination of mitragynine in rat plasma by LC-MS/MS: application to pharmacokinetics.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2009
|
0.94
|
|
12
|
Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents.
|
AAPS J
|
2011
|
0.94
|
|
13
|
A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist.
|
J Comput Aided Mol Des
|
2006
|
0.93
|
|
14
|
A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist.
|
FEBS J
|
2006
|
0.90
|
|
15
|
Early development of sigma-receptor ligands.
|
Future Med Chem
|
2011
|
0.90
|
|
16
|
The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats.
|
Neuropharmacology
|
2007
|
0.90
|
|
17
|
Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.
|
Eur Neuropsychopharmacol
|
2012
|
0.89
|
|
18
|
CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice.
|
Neuropharmacology
|
2011
|
0.89
|
|
19
|
SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation.
|
Exp Neurol
|
2013
|
0.88
|
|
20
|
Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A.
|
Nat Prod Commun
|
2009
|
0.87
|
|
21
|
The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.
|
Int J Neuropsychopharmacol
|
2012
|
0.86
|
|
22
|
Opioid receptor function in social attachment in young domestic fowl.
|
Behav Brain Res
|
2005
|
0.85
|
|
23
|
CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain.
|
Pharmacol Biochem Behav
|
2011
|
0.83
|
|
24
|
Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label.
|
Biochemistry
|
2005
|
0.83
|
|
25
|
Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics.
|
Biomed Chromatogr
|
2013
|
0.82
|
|
26
|
Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists.
|
J Mol Graph Model
|
2008
|
0.81
|
|
27
|
Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine.
|
AAPS J
|
2011
|
0.81
|
|
28
|
Herbal medicines for the management of opioid addiction: safe and effective alternatives to conventional pharmacotherapy?
|
CNS Drugs
|
2011
|
0.81
|
|
29
|
Antidepressive effects of the κ-opioid receptor agonist salvinorin A in a rat model of anhedonia.
|
Behav Pharmacol
|
2012
|
0.81
|
|
30
|
Structure-activity relationships of neuropeptide FF and related peptidic and non-peptidic derivatives.
|
Peptides
|
2006
|
0.81
|
|
31
|
Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study.
|
J Chromatogr B Analyt Technol Biomed Life Sci
|
2011
|
0.81
|
|
32
|
Evaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET.
|
J Nucl Med
|
2013
|
0.81
|
|
33
|
A 96-well filtration method for radioligand binding analysis of σ receptor ligands.
|
J Pharm Biomed Anal
|
2012
|
0.80
|
|
34
|
Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations.
|
J Comput Aided Mol Des
|
2007
|
0.79
|
|
35
|
Comparative protein modeling of 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme from Plasmodium falciparum: a potential target for antimalarial drug discovery.
|
J Chem Inf Model
|
2006
|
0.78
|
|
36
|
Synthesis and characterization of [³H]-SN56, a novel radioligand for the σ₁ receptor.
|
Eur J Pharmacol
|
2010
|
0.78
|
|
37
|
Heteroatom analogues of hydrocodone: synthesis and biological activity.
|
J Org Chem
|
2013
|
0.78
|
|
38
|
Solution-phase parallel synthesis of spirohydantoins.
|
J Comb Chem
|
2005
|
0.77
|
|
39
|
Nonpeptide ligands of neuropeptide FF: current status and structural insights.
|
Future Med Chem
|
2012
|
0.77
|
|
40
|
Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus.
|
Eur J Pharmacol
|
2012
|
0.77
|
|
41
|
Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions.
|
J Agric Food Chem
|
2009
|
0.77
|
|
42
|
Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors.
|
J Med Chem
|
2014
|
0.77
|
|
43
|
σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation.
|
Pharmacol Rep
|
2013
|
0.76
|
|
44
|
Structure activity relationship study of benzo[d]thiazol-2(3H)one based σ receptor ligands.
|
Bioorg Med Chem Lett
|
2013
|
0.75
|
|
45
|
Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.
|
Eur J Med Chem
|
2011
|
0.75
|
|
46
|
Computational Study on the Conformations of Mitragynine and Mitragynaline.
|
Theochem
|
2010
|
0.75
|
|
47
|
Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study.
|
Biomed Chromatogr
|
2013
|
0.75
|
|
48
|
SAR analysis of new dual targeting fluoroquinolones. Implications of the benzenesulfonyl group.
|
Med Chem
|
2012
|
0.75
|
|
49
|
Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood-brain barrier.
|
J Drug Target
|
2005
|
0.75
|
|
50
|
o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label.
|
J Med Chem
|
2007
|
0.75
|
|
51
|
Strategies to treat substance abuse and addiction.
|
Curr Top Med Chem
|
2011
|
0.75
|
|
52
|
Ligand macromolecule interactions: theoretical principles of molecular recognition.
|
Methods Mol Biol
|
2009
|
0.75
|
|
53
|
Opioid receptor-like 1 (ORL1) molecular "road map" to understanding ligand interaction and selectivity.
|
Curr Top Med Chem
|
2005
|
0.75
|